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PAFR

The platelet-activating factor receptor is a G-protein coupled receptor which binds platelet-activating factor. The PAF receptor shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.[supplied by OMIM][7] Its pathogenetic role in chronic kidney failure has also been reported recently.
Cat No. product name
TN1254 3'-Methoxydaidzein 3'-Methoxydaidzein has antioxidant activity, it and geraldol have antiplatelet aggregation activity and appear to be specific against collagen€induce platelet a...
TN3348 (+)-Acuminatin (-)-Acuminatin exerts hepatoprotective activities, perhaps by serving as a potent antioxidant. (+)-trans-Acuminatin, and (+)-cis-acuminatin show weak activity ag...
TN4600 Myrianthic acid Myrianthic acid shows anticancer activity, it shows inhibitory activities on foam cell formation in human monocyte-derived macrophages induced by acetylated low-...
TN1271 Scutellarein tetramethyl ether 4',5,6,7-Tetramethoxyflavone has a hemostatic effect.
TN4795 Piperenone Piperenone is an insect antifeeding substance. It has anti-platelet-activating factor(PAF) activities, is a PAF-acether antagonist.
TN2087 Piperlotine C Piperlotine C shows potent antiplatelet aggregation activity.
TN1643 Ferulamide Ferulamide derivatives show potent inhibitory activity against arachidonic acid-induced platelet aggregation.
TN3979 Epiyangambin Epiyangambin is a phytotoxic lignan, it shows inhibition of seed germination of Agrostis stolonifera cv. penncross (Poaceae) and inhibition of development of Lac...
TN2086 Piperlotine A Piperlotine A shows potent antiplatelet aggregation activity.
TN4821 Pregomisin Pregomisin shows platelet-activating factor (PAF) antagonistic activity and the IC 50 value is 4.8x10(-5) M.
TN4660 Niranthin Niranthin is a potent anti-leishmanial agent, inhibits the relaxation activity of heterodimeric type IB topoisomerase of L. donovani and acts as a non-competitiv...
TN3443 Aristolactam AII Aristolactam AII has cytotoxic activity, it also shows platelet aggregation inhibitory activity.
TN4088 Futoenone Futoenone and a series of its derivatives have shown inhibitory activities against matrix metalloproteinases, the molecular modelings of these compounds indicate...
TN3740 Cyclocommunol Cyclocommunol exhibits cytotoxicity against hepatocellular carcinoma (SMMC-7721) and gastric carcinoma (BGC-823 and SGC-7901) cell lines. It also shows strong in...
TN3153 6-Acetyl-2,2-dimethylchroman-4-one 6-Acetyl-2,2-dimethylchroman-4-one and vanillin show anti-platelet aggregation activity induced by arachidonic acid in vitro.
TN2322 Yangambin Yangambin is a selective antagonist of the cardiovascular effects of platelet activating factor (PAF); it has hypotensive effect, which is probably due to a peri...
TN2329 Zingiberen newsaponin Zingiberensis newsaponin I exhibits induction effect on platelet aggregation.
TN4796 Piperlotine D Piperlotine D shows potent antiplatelet aggregation activity.
TL0014 Pinusolide Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, a...
TN3520 Bisdethiobis(methylthio)gliotoxin Bisdethiobis(methylthio)gliotoxin is a platelet activating factor (PAF) antagonist.
TN4181 Hancinone C Hancinone C shows inhibitory activity against the platelet aggregation caused by PAF.
TN1715 Guaiacin (+)-Guaiacin has significant neuroprotective, and anti-inflammatory activities, it can inhibit cyclooxygenase (COX)-1 and COX-2.
TN3445 Aristolactam BIII Aristolactam BIII possesses anti-platelet aggregation activity in vitro, it also shows significant cytotoxic activity (IC50 values < 4 microg/mL) against P-388, ...
TN1815 Kadsulignan L Kadsulignan L shows in vitro antiviral effects on hepatitis B virus. It also shows moderate platelet-activating factor (PAF) antagonistic activities with the IC5...
TN4367 Kadsurin A Kadsurin A 具有抗血小板活化因子活性。
TN1170 1-Cinnamoylpyrrolidine 1-Cinnamoylpyrrolidine shows inhibitory activity of platelet aggregation in vitro.
TMA2418 1-Methoxyphaseollidin 1-Methoxyphaseollidin exhibits anti-Helicobacter pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains. 1-Meth...
T6242 Rupatadine Fumarate Rupatadine Fumarate (UR-12592 Fumarate) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM.
TN3831 (-)-Denudatin B Denudatin B has nonspecific antiplatelet action at high concentration by inhibiting phosphoinositides breakdown induced by collagen and thrombin, it inhibits the...
TN4794 Pinusolidic acid Pinusolidic acid shows a potent inhibitory effect on platelet activating factor (PAF) binding to rabbit platelets (IC50 = 2.3 x 10(-5) M, 7.48 +/- 2.11 microgram...
TN5045 Spiradine F Spiradine F can significantly inhibit platelet-activating factor(PAF)-induced platelet aggregation in a concentration-dependent manner.
TN3723 Cryptomeridiol Cryptomeridiol is a potential skin-whitening agent, exhibits melanogenesis inhibitory activity on α-MSH-stimulated B16 melanoma cells. Cryptomeridiol has low act...
TN4797 Piperolactam C Piperolactam C possesses anti-platelet aggregation activity in vitro. It can inhibit the growth of the fungi Cladosporium sphaerospermum and C. cladosporioides.
TN3161 6-Deoxyjacareubin 6-Deoxyjacareubin possesses significant antioxidant activities, it also exhibits the cytotoxic activities against HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell...
T2751 Ginkgolide B Ginkgolide B is a PAFR antagonist(IC50=3.6 μM) isolated from Ginkgo biloba.
TN1654 Futoquinol Futoquinol is an anti-platelet activating factor principle from the stem part of Piper futokadsura (Piperaceae), the Chinese drug haifengteng.
T3P2855 Chamigrenal β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7 m...
TN2763 2-Hydroxy-3-methoxybenzoic acid glucose ester 2-Hydroxy-3-methoxybenzoic acid glucose ester shows a potent antagonistic activity against platelet activating factor (PAF), it can prevent the mice from the PAF...
3'-Methoxydaidzein
TN1254
3'-Methoxydaidzein has antioxidant activity, it and geraldol have antiplatelet aggregation activity and appear to be specific against collagen€induce platelet...
(+)-Acuminatin
TN3348
(-)-Acuminatin exerts hepatoprotective activities, perhaps by serving as a potent antioxidant. (+)-trans-Acuminatin, and (+)-cis-acuminatin show weak activity ag...
Myrianthic acid
TN4600
Myrianthic acid shows anticancer activity, it shows inhibitory activities on foam cell formation in human monocyte-derived macrophages induced by acetylated low-...
Scutellarein tetramethyl ether
TN1271
4',5,6,7-Tetramethoxyflavone has a hemostatic effect.
Piperenone
TN4795
Piperenone is an insect antifeeding substance. It has anti-platelet-activating factor(PAF) activities, is a PAF-acether antagonist.
Piperlotine C
TN2087
Piperlotine C shows potent antiplatelet aggregation activity.
Ferulamide
TN1643
Ferulamide derivatives show potent inhibitory activity against arachidonic acid-induced platelet aggregation.
Epiyangambin
TN3979
Epiyangambin is a phytotoxic lignan, it shows inhibition of seed germination of Agrostis stolonifera cv. penncross (Poaceae) and inhibition of development of Lac...
Piperlotine A
TN2086
Piperlotine A shows potent antiplatelet aggregation activity.
Pregomisin
TN4821
Pregomisin shows platelet-activating factor (PAF) antagonistic activity and the IC 50 value is 4.8x10(-5) M.
Niranthin
TN4660
Niranthin is a potent anti-leishmanial agent, inhibits the relaxation activity of heterodimeric type IB topoisomerase of L. donovani and acts as a non-competitiv...
Aristolactam AII
TN3443
Aristolactam AII has cytotoxic activity, it also shows platelet aggregation inhibitory activity.
Futoenone
TN4088
Futoenone and a series of its derivatives have shown inhibitory activities against matrix metalloproteinases, the molecular modelings of these compounds indicate...
Cyclocommunol
TN3740
Cyclocommunol exhibits cytotoxicity against hepatocellular carcinoma (SMMC-7721) and gastric carcinoma (BGC-823 and SGC-7901) cell lines. It also shows strong in...
6-Acetyl-2,2-dimethylchroman-4-one
TN3153
6-Acetyl-2,2-dimethylchroman-4-one and vanillin show anti-platelet aggregation activity induced by arachidonic acid in vitro.
Yangambin
TN2322
Yangambin is a selective antagonist of the cardiovascular effects of platelet activating factor (PAF); it has hypotensive effect, which is probably due to a peri...
Zingiberen newsaponin
TN2329
Zingiberensis newsaponin I exhibits induction effect on platelet aggregation.
Piperlotine D
TN4796
Piperlotine D shows potent antiplatelet aggregation activity.
Pinusolide
TL0014
Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, a...
Bisdethiobis(methylthio)gliotoxin
TN3520
Bisdethiobis(methylthio)gliotoxin is a platelet activating factor (PAF) antagonist.
Hancinone C
TN4181
Hancinone C shows inhibitory activity against the platelet aggregation caused by PAF.
Guaiacin
TN1715
(+)-Guaiacin has significant neuroprotective, and anti-inflammatory activities, it can inhibit cyclooxygenase (COX)-1 and COX-2.
Aristolactam BIII
TN3445
Aristolactam BIII possesses anti-platelet aggregation activity in vitro, it also shows significant cytotoxic activity (IC50 values < 4 microg/mL) against P-388, ...
Kadsulignan L
TN1815
Kadsulignan L shows in vitro antiviral effects on hepatitis B virus. It also shows moderate platelet-activating factor (PAF) antagonistic activities with the IC5...
Kadsurin A
TN4367
Kadsurin A 具有抗血小板活化因子活性。
1-Cinnamoylpyrrolidine
TN1170
1-Cinnamoylpyrrolidine shows inhibitory activity of platelet aggregation in vitro.
1-Methoxyphaseollidin
TMA2418
1-Methoxyphaseollidin exhibits anti-Helicobacter pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains. 1-Meth...
Rupatadine Fumarate
T6242
Rupatadine Fumarate (UR-12592 Fumarate) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM.
(-)-Denudatin B
TN3831
Denudatin B has nonspecific antiplatelet action at high concentration by inhibiting phosphoinositides breakdown induced by collagen and thrombin, it inhibits the...
Pinusolidic acid
TN4794
Pinusolidic acid shows a potent inhibitory effect on platelet activating factor (PAF) binding to rabbit platelets (IC50 = 2.3 x 10(-5) M, 7.48 +/- 2.11 microgram...
Spiradine F
TN5045
Spiradine F can significantly inhibit platelet-activating factor(PAF)-induced platelet aggregation in a concentration-dependent manner.
Cryptomeridiol
TN3723
Cryptomeridiol is a potential skin-whitening agent, exhibits melanogenesis inhibitory activity on α-MSH-stimulated B16 melanoma cells. Cryptomeridiol has low ac...
Piperolactam C
TN4797
Piperolactam C possesses anti-platelet aggregation activity in vitro. It can inhibit the growth of the fungi Cladosporium sphaerospermum and C. cladosporioides.
6-Deoxyjacareubin
TN3161
6-Deoxyjacareubin possesses significant antioxidant activities, it also exhibits the cytotoxic activities against HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell...
Ginkgolide B
T2751
Ginkgolide B is a PAFR antagonist(IC50=3.6 μM) isolated from Ginkgo biloba.
Futoquinol
TN1654
Futoquinol is an anti-platelet activating factor principle from the stem part of Piper futokadsura (Piperaceae), the Chinese drug haifengteng.
Chamigrenal
T3P2855
β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7 ...
2-Hydroxy-3-methoxybenzoic acid glucose ester
TN2763
2-Hydroxy-3-methoxybenzoic acid glucose ester shows a potent antagonistic activity against platelet activating factor (PAF), it can prevent the mice from the PAF...