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Apoptosis IAP

IAP

IAP (Inhibitors of Apoptosis) is a family of functionally and structurally related proteins, which serve as endogenous inhibitors of programmed cell death (apoptosis). A common feature of all IAPs is the presence of a BIR in one to three copies. The human IAP family consists of 8 members, and IAP homologs have been identified in numerous organisms. The members of the IAPs included IAPs, Cp-IAP, Op-IAP, XIAP, c-IAPl, C-IAP2, NAIP, Livin and Survivin. The best characterized IAP is XIAP, which binds caspase-9, caspase-3 and caspase 7, thereby inhibiting their activation and preventing apoptosis. Also cIAP1 and cIAP2 have been shown to bind caspases, although how the IAPs inhibit apoptosis mechanistically at the molecular level is not completely understood.
Cat No. product name
T11651 Indanidine Indanidine is an alpha-adrenergic agonist.
T12932 SM-164 Hydrochloride (957135-43-2 free base) SM-164 Hydrochloride is a cell-permeable Smac mimetic compound. SM-164 binds to XIAP protein containing both the BIR2 and BIR3 domains(IC50 value of 1.39 nM) an...
T12932L SM-164 SM-164 binds to XIAP protein containing both the BIR2 and BIR3 domains (IC50: 1.39 nM). It acts as an extremely potent antagonist of XIAP.
T14378L AZD5582 acetate (1258392-53-8 free base) AZD5582 acetate is an inhibitor of IAPs, which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. AZD5582 induces a...
T2080 LCL161 LCL161, a SMAC mimetic, effectivity binds to and inhibits multiple IAPs (i.e. XIAP, c-IAP).
T3299 AT-406 HCl AT-406, an orally active antagonist of multiple inhibitor of apoptosis proteins(IAP), inhibits progression of human ovarian Y binding to XIAP-BIR3, cIAP1-BIR3 a...
T3981 Acacetin Acacetin is an O-methylated flavone found in various plants, shows antinociceptive, anti-inflammatory, and antioxidant activity in various research models.
T6007 Birinapant Birinapant is a synthetic small molecule that is both a peptidomimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibi...
T6299 GDC0152 GDC-0152 is a potent inhibitor of IAPs.
T6428 BV6 BV6 is an antagonist of c-IAP1 and XIAP, members of the inhibitors of apoptosis (IAP) family.
T6485 Embelin Embelin, isolated from the Japanese Ardisia herb, is an inhibitor of the X-linked inhibitor of apoptosis (IC50: 4.1 uM).
T6763 AT406 AT406 (SM-406, ARRY-334543) is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3, cI...
TN2091 Polygalacin D Polygalacin D shows anti- proliferation, anti-inflammary, and hepatoprotective activities, it can inhibit the expression of lipopolysaccharide (LPS)-induced iNO...
TN5263 1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one Xanthohumol has anti-hepatitis C virus, anti-carcinogenic, free radical-scavenging, and anti-inflammatory activities, it can inhibit HIV-1 induced cytopathic ef...
TQ0029 ASTX660 ASTX660 is an orally bioavailable dual antagonist of cIAP and XIAP.
Indanidine
T11651CAS 85392-79-6
Indanidine is an alpha-adrenergic agonist.
SM-164 Hydrochloride (957135-43-2 free base)
T12932CAS T12932
SM-164 Hydrochloride is a cell-permeable Smac mimetic compound. SM-164 binds to XIAP protein containing both the BIR2 and BIR3 domains(IC50 value of 1.39 nM) an...
SM-164
T12932LCAS 957135-43-2
SM-164 binds to XIAP protein containing both the BIR2 and BIR3 domains (IC50: 1.39 nM). It acts as an extremely potent antagonist of XIAP.
AZD5582 acetate (1258392-53-8 free base)
T14378LCAS T14378L
AZD5582 acetate is an inhibitor of IAPs, which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. AZD5582 induces a...
LCL161
T2080CAS 1005342-46-0
LCL161, a SMAC mimetic, effectivity binds to and inhibits multiple IAPs (i.e. XIAP, c-IAP).
AT-406 HCl
T3299CAS 1071992-57-8
AT-406, an orally active antagonist of multiple inhibitor of apoptosis proteins(IAP), inhibits progression of human ovarian Y binding to XIAP-BIR3, cIAP1-BIR3 a...
Acacetin
T3981CAS 480-44-4
Acacetin is an O-methylated flavone found in various plants, shows antinociceptive, anti-inflammatory, and antioxidant activity in various research models.
Birinapant
T6007CAS 1260251-31-7
Birinapant is a synthetic small molecule that is both a peptidomimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibi...
GDC0152
T6299CAS 873652-48-3
GDC-0152 is a potent inhibitor of IAPs.
BV6
T6428CAS 1001600-56-1
BV6 is an antagonist of c-IAP1 and XIAP, members of the inhibitors of apoptosis (IAP) family.
Embelin
T6485CAS 550-24-3
Embelin, isolated from the Japanese Ardisia herb, is an inhibitor of the X-linked inhibitor of apoptosis (IC50: 4.1 uM).
AT406
T6763CAS 1071992-99-8
AT406 (SM-406, ARRY-334543) is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3, cI...
Polygalacin D
TN2091CAS 66663-91-0
Polygalacin D shows anti- proliferation, anti-inflammary, and hepatoprotective activities, it can inhibit the expression of lipopolysaccharide (LPS)-induced iNO...
1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one
TN5263CAS 569-83-5
Xanthohumol has anti-hepatitis C virus, anti-carcinogenic, free radical-scavenging, and anti-inflammatory activities, it can inhibit HIV-1 induced cytopathic ef...
ASTX660
TQ0029CAS 1799328-86-1
ASTX660 is an orally bioavailable dual antagonist of cIAP and XIAP.