T14378 |
AZD5582
|
1258392-53-8
|
98.83%
|
|
AZD5582 is an inhibitor of IAPs, which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. It induces apoptosis.
|
T79247 |
Anticancer agent 127
|
2410953-19-2
|
98%
|
|
Anticancer agent 127 (142D6), an IAP inhibitor, covalently binds to the BIR3 domains of XIAP, cIAP1, and cIAP2, with IC50 values of 12 nM, 14 nM, and 9 nM, respe...
|
T79248 |
Anticancer agent 128
|
2941243-62-3
|
98%
|
|
Anticancer agent 128 (compound 1) is an IAP inhibitor that covalently binds to the BIR3 domains of XIAP, cIAP1, and cIAP2, exhibiting IC50 values of 24.9 nM, 19....
|
TN2091 |
Polygalacin D
|
66663-91-0
|
98%
|
|
Polygalacin D shows anti- proliferation, anti-inflammary, and hepatoprotective activities, it can inhibit the expression of lipopolysaccharide (LPS)-induced iNOS...
|
T12932 |
SM-164 Hydrochloride (957135-43-2 free base)
|
T12932
|
98%
|
|
SM-164 Hydrochloride is a cell-permeable Smac mimetic compound. SM-164 binds to XIAP protein containing both the BIR2 and BIR3 domains(IC50 value of 1.39 nM) and...
|
TN5263 |
1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one
|
569-83-5
|
99.79%
|
|
1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one (Xanthohumol) , prenylchacone flavonoid, is a natural product with...
|
T3653 |
MX69
|
1005264-47-0
|
99.78%
|
|
MX69 is the MDM2/XIAP inhibitor, blocking the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation.
|
T6763 |
Xevinapant
|
1071992-99-8
|
99.77%
|
|
Xevinapant (Debio-1143) is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3, cIAP1-B...
|
T2080 |
LCL161
|
1005342-46-0
|
99.46%
|
|
LCL161, a SMAC mimetic, effectivity binds to and inhibits multiple IAPs (i.e. XIAP, c-IAP).
|
T6299 |
GDC-0152
|
873652-48-3
|
99.32%
|
|
GDC-0152 is a potent inhibitor of IAPs.
|
TQ0029 |
ASTX660
|
1799328-86-1
|
99.08%
|
|
ASTX660 is an orally bioavailable dual antagonist of cIAP and XIAP.
|
T15018 |
CUDC-427
|
1446182-94-0
|
98.99%
|
|
CUDC-427 (GDC-0917) is an orally bioactive and pan antagonist of inhibitor of apoptosis proteins(IAPs). CUDC-427 can be used in research on cancers.
|
T36201L |
AZD5582 TFA
|
|
98.83%
|
|
AZD5582 TFA is a potent IAP antagonist that binds to the BIR3 domain of cIAP1, cIAP2, and XIAP with IC50 values of 15, 21, and 15 nM, respectively.AZD5582 TFA ...
|
T16522 |
Phenoxodiol
|
81267-65-4
|
98.07%
|
|
Phenoxodiol (Idronoxil) activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP) expre...
|
T3981 |
Acacetin
|
480-44-4
|
98%
|
|
Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an O-methylated flavone found in various plants, shows antinociceptive, anti-inflammatory, and antioxidant activity...
|
T14378L |
AZD5582 acetate (1258392-53-8 free base)
|
T14378L
|
97.76%
|
|
AZD5582 acetate is an inhibitor of IAPs, which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. AZD5582 induces ap...
|
T12932L |
SM-164
|
957135-43-2
|
97.25%
|
|
SM-164 binds to XIAP protein containing both the BIR2 and BIR3 domains (IC50: 1.39 nM). It acts as an extremely potent antagonist of XIAP.
|
T6007 |
Birinapant
|
1260251-31-7
|
97.08%
|
|
Birinapant (TL32711) is a synthetic small molecule that is both a peptidomimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IA...
|
T6485 |
Embelin
|
550-24-3
|
97.07%
|
|
Embelin (Embelic acid), isolated from the Japanese Ardisia herb, is an inhibitor of the X-linked inhibitor of apoptosis (IC50: 4.1 uM).
|
T18750 |
N-Deshydroxyethyl Dasatinib
|
910297-51-7
|
95.96%
|
|
N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825) is a metabolite of Dasatinib, a dasatinib-based molecule that degrades ABL by binding to the IAP ligan...
|