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HCN Channel

Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels are integral membrane proteins that serve as nonselective voltage-gated cation channels in the plasma membranes of heart and brain cells. HCN channels are sometimes referred to as pacemaker channels because they help to generate rhythmic activity within groups of heart and brain cells. HCN channels are activated by membrane hyperpolarization, are permeable to Na+ and K+, and are constitutively open at voltages near the resting membrane potential.[2] HCN channels are encoded by four genes (HCN1, 2, 3, 4) and are widely expressed throughout the heart and the central nervous system.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T7516 ZD7288 133059-99-1 98%
ZD7288
ZD7288 (ICI D7288), a selective hyperpolarization-activated cyclic nucleotide-gated channel blocker, inhibits hippocampal synaptic plasticity.
T10813 Cilobradine hydrochloride 186097-54-1 97.46%
Cilobradine hydrochloride
Cilobradine hydrochloride (DK-AH 269) is an HCN Channel blocker and an open channel blocker of neuronal Ih and related cardiac If channels.
T13387L Zatebradine hydrochloride 91940-87-3 97%
Zatebradine hydrochloride
Zatebradine hydrochloride (UL-FS-49CL) is a highly effective and effective HCN Channel inhibitor (IC50:1.96 µM). HCN Channel is an effective hyperpolarization ac...
ZD7288
T7516
ZD7288 (ICI D7288), a selective hyperpolarization-activated cyclic nucleotide-gated channel blocker, inhibits hippocampal synaptic plasticity.
Cilobradine hydrochloride
T10813
Cilobradine hydrochloride (DK-AH 269) is an HCN Channel blocker and an open channel blocker of neuronal Ih and related cardiac If channels.
Zatebradine hydrochloride
T13387L
Zatebradine hydrochloride (UL-FS-49CL) is a highly effective and effective HCN Channel inhibitor (IC50:1.96 µM). HCN Channel is an effective hyperpolarization ac...
TargetMol