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GPCR19

The G protein-coupled bile acid receptor 1 (GPBAR1) also known G-protein coupled receptor 19 (GPCR19), membrane-type receptor for bile acids (M-BAR) or TGR5 as is a protein that in humans is encoded by the GPBAR1 gene.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T8752 BAR 501 impurity 1632118-70-7 99.97%
BAR 501 impurity
BAR501 impurity is an impurity found in the preparation of BAR501 that acts as an agonist of the G protein-coupled bile acid-activated receptor (GP-BAR1). BAR501...
T1824 TGR5 Receptor Agonist 1197300-24-5 99.93%
TGR5  Receptor Agonist
TGR5 is a potent TGR5(GPCR19) agonist.
TQ0252 BAR502 1612191-86-2 99.91%
BAR502
BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 μM and 2 μM).
T11798 L-692429 145455-23-8 99.90%
L-692429
L-692429 (MK-0751) is a potent nonpeptidyl growth hormone secretagogue (GHS) agonist, a benzolactam derivative, which reverses the inhibition of GH secretion by ...
T11662L INT-777 1199796-29-6 99.89%
INT-777
INT-777 (S-EMCA) is a potent TGR5 agonist with an EC50 of 0.82 μM. INT-777 (S-EMCA) inhibits NLRP5-ASC inflammasome-mediated neuroinflammation via the TGR3/cAMP/...
T5077 Deoxycholic acid sodium salt 302-95-4 99.75%
Deoxycholic acid sodium salt
Deoxycholic acid sodium salt (Sodium deoxycholate) can activate the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermoge...
T7428 SBI-115 882366-16-7 99.67%
SBI-115
SBI-115 is an antagonist of TGR5. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5
T0843 Triamterene 396-01-0 99.49%
Triamterene
Triamterene is a pteridinetriamine compound that inhibits SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS.
T2965 Deoxycholic acid 83-44-3 99.35%
Deoxycholic acid
Deoxycholic acid (Cholanoic Acid) is a bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts...
T4083 BAR501 1632118-69-4 99.34%
BAR501
BAR501 is an effective and specific GPBAR1 agonist (EC50: 1 μM).
TP1949L PEN (human) aceate 99.25%
PEN (human) aceate
PEN (human) aceate, one of the most abundant hypothalamic neuropeptide and derived from the proprotein ProSAAS, is an endogenous ligand of GPR83.
T29078 Ursodeoxycholic acid sodium 2898-95-5 98.55%
Ursodeoxycholic acid sodium
Ursodeoxycholic acid sodium (Sodium Ursodeoxycholate) is a naturally occurring secondary bile acid with anti-inflammatory and cytoprotective activities. Ursodeox...
T4352 SB756050 447410-57-3 98.35%
SB756050
SB756050 is a specific TGR5 agonist.
T8818 TC-G 1005 1415407-60-1 98.2%
TC-G 1005
TC-G 1005 is a potent and selective GPBA agonist (EC50 :0.72 nM; hTGR5). Selective for TGR5 over FXR (farnesoid X receptor). Increases plasma GLP-1 levels and re...
T2968 Hyodeoxycholic acid 83-49-8 97.26%
Hyodeoxycholic acid
Hyodeoxycholic acid (NSC 60672) has been used in trials studying the treatment of Hypercholesterolemia.
T11661 INT-767 1000403-03-1 98%
INT-767
INT-767 is a potent farnesoid X receptor (FXR)/TGR5 dual agonist that prevents NASH and promotes visceral adipose brown lipogenesis and mitochondrial function fo...
BAR 501 impurity
T8752
BAR501 impurity is an impurity found in the preparation of BAR501 that acts as an agonist of the G protein-coupled bile acid-activated receptor (GP-BAR1). BAR501...
TGR5 Receptor Agonist
T1824
TGR5 is a potent TGR5(GPCR19) agonist.
BAR502
TQ0252
BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 μM and 2 μM).
L-692429
T11798
L-692429 (MK-0751) is a potent nonpeptidyl growth hormone secretagogue (GHS) agonist, a benzolactam derivative, which reverses the inhibition of GH secretion by ...
INT-777
T11662L
INT-777 (S-EMCA) is a potent TGR5 agonist with an EC50 of 0.82 μM. INT-777 (S-EMCA) inhibits NLRP5-ASC inflammasome-mediated neuroinflammation via the TGR3/cAMP/...
Deoxycholic acid sodium salt
T5077
Deoxycholic acid sodium salt (Sodium deoxycholate) can activate the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermoge...
SBI-115
T7428
SBI-115 is an antagonist of TGR5. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5
Triamterene
T0843
Triamterene is a pteridinetriamine compound that inhibits SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS.
Deoxycholic acid
T2965
Deoxycholic acid (Cholanoic Acid) is a bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts...
BAR501
T4083
BAR501 is an effective and specific GPBAR1 agonist (EC50: 1 μM).
PEN (human) aceate
TP1949L
PEN (human) aceate, one of the most abundant hypothalamic neuropeptide and derived from the proprotein ProSAAS, is an endogenous ligand of GPR83.
Ursodeoxycholic acid sodium
T29078
Ursodeoxycholic acid sodium (Sodium Ursodeoxycholate) is a naturally occurring secondary bile acid with anti-inflammatory and cytoprotective activities. Ursodeox...
SB756050
T4352
SB756050 is a specific TGR5 agonist.
TC-G 1005
T8818
TC-G 1005 is a potent and selective GPBA agonist (EC50 :0.72 nM; hTGR5). Selective for TGR5 over FXR (farnesoid X receptor). Increases plasma GLP-1 levels and re...
Hyodeoxycholic acid
T2968
Hyodeoxycholic acid (NSC 60672) has been used in trials studying the treatment of Hypercholesterolemia.
INT-767
T11661
INT-767 is a potent farnesoid X receptor (FXR)/TGR5 dual agonist that prevents NASH and promotes visceral adipose brown lipogenesis and mitochondrial function fo...
TargetMol