TN4606 |
Myriceric acid C
|
162059-94-1
|
98%
|
|
Myriceric acid C has cytotoxic activity against human lung carcinoma and breast carcinoma.
|
TQ0282 |
Avosentan
|
290815-26-8
|
98%
|
|
Avosentan (Ro 67-0565) is an effective and selective antagonist of the endothelin receptor (ETA receptor).
|
TP1220L |
Carperitide acetate
|
1366000-58-9
|
98%
|
|
Carperitide acetateis a 28-amino acid hormone. Carperitide acetate is normally produced and secreted by the human heart in response to cardiac injury and mechani...
|
T19309L1 |
Endothelin 1 (swine, human) acetate
|
T19309L1
|
|
|
Endothelin 1 (swine, human) acetate is a synthetic peptide with the sequence of human and swine Endothelin 1. Endothelin 1 is a potent endogenous vasoconstrictor...
|
T21790 |
BMS 182874 hydrochloride
|
1215703-04-0
|
|
|
BMS 182874 hydrochloride is a nonpeptide endothelin (El) receptor antagonist.
|
T6264 |
Bosentan
|
147536-97-8
|
100%
|
|
Bosentan is a sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endothelin A receptor than end...
|
T15595L |
IRL-1620 acetate
|
T15595L
|
96.64%
|
|
IRL-1620 acetate is an effective and selective agonist of Endothelin B receptor (ETB) with a Ki of 16 pM which is more selective than ETA with a Ki of 19 μM.
|
T5458 |
Darusentan
|
171714-84-4
|
97.26%
|
|
Darusentan is a potent inhibitor of endothelin signaling and function in both large and small arteries
|
T6792 |
BQ-123
|
136553-81-6
|
98%
|
|
BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.
|
T15596 |
IRL 2500
|
169545-27-1
|
98.29%
|
|
IRL 2500 is an antagonist of Endothelin receptor with IC50s of 1.3 and 94 nM for Endothelin A receptor and Endothelin B receptor.
|
TQ0270 |
Atrasentan hydrochloride
|
195733-43-8
|
98.64%
|
|
Atrasentan hydrochloride (ABT-627 hydrochloride) is an endothelin receptor antagonist (IC50: 0.0551 nM for ETA).
|
T3194 |
Ro 46-2005
|
150725-87-4
|
98.8%
|
|
Ro 46-2005 is a synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA recep...
|
T5355 |
Sparsentan
|
254740-64-2
|
98.81%
|
|
Sparsentan is a first-in-class orally active and highly potent dual endothelin A and angiotensin II receptor antagonist(Ki of 9.3 and 0.8 nM, respectively)
|
T6672 |
Sitaxsentan sodium
|
210421-74-2
|
99%
|
|
Sitaxsentan (sodium) is a highly selective antagonist of endothelin A receptors.
|
TQ0259 |
Atrasentan
|
173937-91-2
|
99.08%
|
|
Atrasentan (ABT-627) is an endothelin receptor antagonist (IC50: 0.0551 nM for ETA).
|
T7817 |
Aprocitentan
|
1103522-45-7
|
99.17%
|
|
Aprocitentan is ETA and ETB antagonist .
|
T2561 |
Macitentan
|
441798-33-0
|
99.52%
|
|
Macitentan is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH).
|
T6265 |
Bosentan (hydrate)
|
157212-55-0
|
99.75%
|
|
Bosentan is a competitive and dual antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors.
|
T3474 |
RO 46-8443
|
175556-12-4
|
99.77%
|
|
RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms...
|
T1655 |
Ambrisentan
|
177036-94-1
|
99.85%
|
|
Ambrisentan is an endothelin receptor antagonist used in the therapy of pulmonary arterial hypertension (PAH). Ambrisentan has been associated with a low rate of...
|