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Endothelin Receptor

There are at least four known endothelin receptors, ETA, ETB1, ETB2 and ETC, all of which are G protein-coupled receptors whose activation result in elevation of intracellular-free calcium, which constricts the smooth muscles of the blood vessels, raising blood pressure, or relaxes the smooth muscles of the blood vessels, lowering blood pressure, among other functions.
Cat. No. Product name CAS No. Purity Chemical Structure
TN4606 Myriceric acid C 162059-94-1 98%
Myriceric acid C has cytotoxic activity against human lung carcinoma and breast carcinoma.
TQ0282 Avosentan 290815-26-8 98%
Avosentan (Ro 67-0565) is an effective and selective antagonist of the endothelin receptor (ETA receptor).
TP1220L Carperitide acetate 1366000-58-9 98%
Carperitide acetateis a 28-amino acid hormone. Carperitide acetate is normally produced and secreted by the human heart in response to cardiac injury and mechani...
T19309L1 Endothelin 1 (swine, human) acetate T19309L1
Endothelin 1 (swine, human) acetate is a synthetic peptide with the sequence of human and swine Endothelin 1. Endothelin 1 is a potent endogenous vasoconstrictor...
T21790 BMS 182874 hydrochloride 1215703-04-0
BMS 182874 hydrochloride is a nonpeptide endothelin (El) receptor antagonist.
T6264 Bosentan 147536-97-8 100%
Bosentan is a sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endothelin A receptor than end...
T15595L IRL-1620 acetate T15595L 96.64%
IRL-1620 acetate is an effective and selective agonist of Endothelin B receptor (ETB) with a Ki of 16 pM which is more selective than ETA with a Ki of 19 μM.
T5458 Darusentan 171714-84-4 97.26%
Darusentan is a potent inhibitor of endothelin signaling and function in both large and small arteries
T6792 BQ-123 136553-81-6 98%
BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.
T15596 IRL 2500 169545-27-1 98.29%
IRL 2500 is an antagonist of Endothelin receptor with IC50s of 1.3 and 94 nM for Endothelin A receptor and Endothelin B receptor.
TQ0270 Atrasentan hydrochloride 195733-43-8 98.64%
Atrasentan hydrochloride (ABT-627 hydrochloride) is an endothelin receptor antagonist (IC50: 0.0551 nM for ETA).
T3194 Ro 46-2005 150725-87-4 98.8%
Ro 46-2005 is a synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA recep...
T5355 Sparsentan 254740-64-2 98.81%
Sparsentan is a first-in-class orally active and highly potent dual endothelin A and angiotensin II receptor antagonist(Ki of 9.3 and 0.8 nM, respectively)
T6672 Sitaxsentan sodium 210421-74-2 99%
Sitaxsentan (sodium) is a highly selective antagonist of endothelin A receptors.
TQ0259 Atrasentan 173937-91-2 99.08%
Atrasentan (ABT-627) is an endothelin receptor antagonist (IC50: 0.0551 nM for ETA).
T7817 Aprocitentan 1103522-45-7 99.17%
Aprocitentan is ETA and ETB antagonist .
T2561 Macitentan 441798-33-0 99.52%
Macitentan is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH).
T6265 Bosentan (hydrate) 157212-55-0 99.75%
Bosentan is a competitive and dual antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors.
T3474 RO 46-8443 175556-12-4 99.77%
RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms...
T1655 Ambrisentan 177036-94-1 99.85%
Ambrisentan is an endothelin receptor antagonist used in the therapy of pulmonary arterial hypertension (PAH). Ambrisentan has been associated with a low rate of...
Myriceric acid C
TN4606
Myriceric acid C has cytotoxic activity against human lung carcinoma and breast carcinoma.
Avosentan
TQ0282
Avosentan (Ro 67-0565) is an effective and selective antagonist of the endothelin receptor (ETA receptor).
Carperitide acetate
TP1220L
Carperitide acetateis a 28-amino acid hormone. Carperitide acetate is normally produced and secreted by the human heart in response to cardiac injury and mechani...
Endothelin 1 (swine, human) acetate
T19309L1
Endothelin 1 (swine, human) acetate is a synthetic peptide with the sequence of human and swine Endothelin 1. Endothelin 1 is a potent endogenous vasoconstrictor...
BMS 182874 hydrochloride
T21790
BMS 182874 hydrochloride is a nonpeptide endothelin (El) receptor antagonist.
Bosentan
T6264
Bosentan is a sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endothelin A receptor than end...
IRL-1620 acetate
T15595L
IRL-1620 acetate is an effective and selective agonist of Endothelin B receptor (ETB) with a Ki of 16 pM which is more selective than ETA with a Ki of 19 μM.
Darusentan
T5458
Darusentan is a potent inhibitor of endothelin signaling and function in both large and small arteries
BQ-123
T6792
BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.
IRL 2500
T15596
IRL 2500 is an antagonist of Endothelin receptor with IC50s of 1.3 and 94 nM for Endothelin A receptor and Endothelin B receptor.
Atrasentan hydrochloride
TQ0270
Atrasentan hydrochloride (ABT-627 hydrochloride) is an endothelin receptor antagonist (IC50: 0.0551 nM for ETA).
Ro 46-2005
T3194
Ro 46-2005 is a synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA recep...
Sparsentan
T5355
Sparsentan is a first-in-class orally active and highly potent dual endothelin A and angiotensin II receptor antagonist(Ki of 9.3 and 0.8 nM, respectively)
Sitaxsentan sodium
T6672
Sitaxsentan (sodium) is a highly selective antagonist of endothelin A receptors.
Atrasentan
TQ0259
Atrasentan (ABT-627) is an endothelin receptor antagonist (IC50: 0.0551 nM for ETA).
Aprocitentan
T7817
Aprocitentan is ETA and ETB antagonist .
Macitentan
T2561
Macitentan is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH).
Bosentan (hydrate)
T6265
Bosentan is a competitive and dual antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors.
RO 46-8443
T3474
RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms...
Ambrisentan
T1655
Ambrisentan is an endothelin receptor antagonist used in the therapy of pulmonary arterial hypertension (PAH). Ambrisentan has been associated with a low rate of...
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