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Endothelin Receptor

There are at least four known endothelin receptors, ETA, ETB1, ETB2 and ETC, all of which are G protein-coupled receptors whose activation result in elevation of intracellular-free calcium, which constricts the smooth muscles of the blood vessels, raising blood pressure, or relaxes the smooth muscles of the blood vessels, lowering blood pressure, among other functions.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
TP2262L IRL-1038 acetate TP2262L 97.51%
IRL-1038 acetate
IRL-1038 acetate is a potent ETB endothelin receptor antagonist.
T78096 BQ-3020 ammonium 98%
BQ-3020 ammonium
BQ-3020 ammonium, a selective endothelin receptor (ET B receptor) agonist, demonstrates inhibition of [125 I] ET-1 binding to ET B receptors with an IC50 of 0.2 ...
T80438 Atrial natriuretic peptide (3-28) (human) 102686-43-1 98%
Atrial natriuretic peptide (3-28) (human)
Atrial natriuretic peptide (3-28) (human) (ANP (3-28) (human)), a peptide hormone produced by the atrial myocardium, plays a critical role in the regulation of b...
T81538 Patecibart 2642374-04-5 98%
Patecibart
Patecibart is a humanized immunoglobulin G4-kappa monoclonal antibody that functions as an antagonist to the endothelin receptor A (EDNRA).
TN4606 Myriceric acid C 162059-94-1 98%
Myriceric acid C
Myriceric acid C has cytotoxic activity against human lung carcinoma and breast carcinoma.
T11934 Macitentan-d4 1258428-05-5 98%
Macitentan-d4
Macitentan-d4 (ACT-064992 D4) is a deuterated substitute for Macitentan and can be used as a dual antagonist of the non-peptides ETA and ETB (endothelin receptor...
T0750 Sulfisoxazole 127-69-5 99.98%
Sulfisoxazole
Sulfisoxazole (Sulfafurazole) is a short-acting sulfonamide antibacterial with activity against a wide range of gram-negative and gram-positive organisms.Sulfiso...
T1655 Ambrisentan 177036-94-1 99.85%
Ambrisentan
Ambrisentan (BSF 208075) is an endothelin receptor antagonist used in the therapy of pulmonary arterial hypertension (PAH). Ambrisentan has been associated with ...
T2561 Macitentan 441798-33-0 99.81%
Macitentan
Macitentan (ACT-064992) is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH).
T6265 Bosentan (hydrate) 157212-55-0 99.75%
Bosentan (hydrate)
Bosentan hydrate (Ro 47-0203) is a competitive and dual antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors.
TQ0282 Avosentan 290815-26-8 99.47%
Avosentan
Avosentan (Ro 67-0565) is an effective and selective antagonist of the endothelin receptor (ETA receptor).
T6258 Zibotentan 186497-07-4 99.34%
Zibotentan
Zibotentan (ZD4054) (ZD4054) is a specific Endothelin (ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB. Phase 3.
T34541 SB-209670 157659-79-5 99.24%
SB-209670
SB-209670 is a selective endothelin receptor antagonist that inhibits the activity of ET(B) receptors in rat vascular endothelium and vascular smooth muscle.
T7817 Aprocitentan 1103522-45-7 99.17%
Aprocitentan
Aprocitentan (ACT-132577) is ETA and ETB antagonist .
T5355 Sparsentan 254740-64-2 98.81%
Sparsentan
Sparsentan (DARA-a) is a first-in-class orally active and highly potent dual endothelin A and angiotensin II receptor antagonist(Ki of 9.3 and 0.8 nM, respective...
T3194 Ro 46-2005 150725-87-4 98.8%
Ro 46-2005
Ro 46-2005 is a synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA recep...
T31605 Edonentan 210891-04-6 98.69%
Edonentan
Edonentan is A potent endothelin A (ETA) receptor antagonist that can be used to study heart failure.
TQ0270 Atrasentan hydrochloride 195733-43-8 98.64%
Atrasentan hydrochloride
Atrasentan hydrochloride (ABT-627 hydrochloride) is an antagonist of the endothelin receptor(IC50 = 55.1 μM for ETA).
T3474 RO 46-8443 175556-12-4 98.5%
RO 46-8443
RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms...
T26841 BMS 182874 153042-42-3 98.38%
BMS 182874
BMS 182874 is an orally effective and highly selective endothelin receptor ETA antagonist with an IC50 value of 0.150 μM for ETA and a Ki value of 0.055 μM for E...
IRL-1038 acetate
TP2262L
IRL-1038 acetate is a potent ETB endothelin receptor antagonist.
BQ-3020 ammonium
T78096
BQ-3020 ammonium, a selective endothelin receptor (ET B receptor) agonist, demonstrates inhibition of [125 I] ET-1 binding to ET B receptors with an IC50 of 0.2 ...
Atrial natriuretic peptide (3-28) (human)
T80438
Atrial natriuretic peptide (3-28) (human) (ANP (3-28) (human)), a peptide hormone produced by the atrial myocardium, plays a critical role in the regulation of b...
Patecibart
T81538
Patecibart is a humanized immunoglobulin G4-kappa monoclonal antibody that functions as an antagonist to the endothelin receptor A (EDNRA).
Myriceric acid C
TN4606
Myriceric acid C has cytotoxic activity against human lung carcinoma and breast carcinoma.
Macitentan-d4
T11934
Macitentan-d4 (ACT-064992 D4) is a deuterated substitute for Macitentan and can be used as a dual antagonist of the non-peptides ETA and ETB (endothelin receptor...
Sulfisoxazole
T0750
Sulfisoxazole (Sulfafurazole) is a short-acting sulfonamide antibacterial with activity against a wide range of gram-negative and gram-positive organisms.Sulfiso...
Ambrisentan
T1655
Ambrisentan (BSF 208075) is an endothelin receptor antagonist used in the therapy of pulmonary arterial hypertension (PAH). Ambrisentan has been associated with ...
Macitentan
T2561
Macitentan (ACT-064992) is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH).
Bosentan (hydrate)
T6265
Bosentan hydrate (Ro 47-0203) is a competitive and dual antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors.
Avosentan
TQ0282
Avosentan (Ro 67-0565) is an effective and selective antagonist of the endothelin receptor (ETA receptor).
Zibotentan
T6258
Zibotentan (ZD4054) (ZD4054) is a specific Endothelin (ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB. Phase 3.
SB-209670
T34541
SB-209670 is a selective endothelin receptor antagonist that inhibits the activity of ET(B) receptors in rat vascular endothelium and vascular smooth muscle.
Aprocitentan
T7817
Aprocitentan (ACT-132577) is ETA and ETB antagonist .
Sparsentan
T5355
Sparsentan (DARA-a) is a first-in-class orally active and highly potent dual endothelin A and angiotensin II receptor antagonist(Ki of 9.3 and 0.8 nM, respective...
Ro 46-2005
T3194
Ro 46-2005 is a synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA recep...
Edonentan
T31605
Edonentan is A potent endothelin A (ETA) receptor antagonist that can be used to study heart failure.
Atrasentan hydrochloride
TQ0270
Atrasentan hydrochloride (ABT-627 hydrochloride) is an antagonist of the endothelin receptor(IC50 = 55.1 μM for ETA).
RO 46-8443
T3474
RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms...
BMS 182874
T26841
BMS 182874 is an orally effective and highly selective endothelin receptor ETA antagonist with an IC50 value of 0.150 μM for ETA and a Ki value of 0.055 μM for E...
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TargetMol