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Endothelin Receptor

There are at least four known endothelin receptors, ETA, ETB1, ETB2 and ETC, all of which are G protein-coupled receptors whose activation result in elevation of intracellular-free calcium, which constricts the smooth muscles of the blood vessels, raising blood pressure, or relaxes the smooth muscles of the blood vessels, lowering blood pressure, among other functions.
Cat. No. Product name CAS No. Purity Chemical Structure
T34541 SB-209670 157659-79-5 98%
SB-209670 is a selective endothelin receptor antagonist that inhibits the activity of ET(B) receptors in rat vascular endothelium and vascular smooth muscle.
TP2262L IRL-1038 acetate TP2262L 98%
IRL-1038 acetate is a potent ETB endothelin receptor antagonist.
TN4606 Myriceric acid C 162059-94-1 98%
Myriceric acid C has cytotoxic activity against human lung carcinoma and breast carcinoma.
T6258 Zibotentan 186497-07-4 98%
Zibotentan (ZD4054) is a specific Endothelin (ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB. Phase 3.
T7817 Aprocitentan 1103522-45-7 98%
Aprocitentan is ETA and ETB antagonist .
TQ0282 Avosentan 290815-26-8 98%
Avosentan (Ro 67-0565) is an effective and selective antagonist of the endothelin receptor (ETA receptor).
T5355 Sparsentan 254740-64-2 98%
Sparsentan is a first-in-class orally active and highly potent dual endothelin A and angiotensin II receptor antagonist(Ki of 9.3 and 0.8 nM, respectively)
TQ0270 Atrasentan hydrochloride 195733-43-8 98%
Atrasentan hydrochloride (ABT-627 hydrochloride) is an endothelin receptor antagonist (IC50: 0.0551 nM for ETA).
T3474 RO 46-8443 175556-12-4 98%
RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms...
T15596 IRL 2500 169545-27-1 98%
IRL 2500 is an antagonist of Endothelin receptor with IC50s of 1.3 and 94 nM for Endothelin A receptor and Endothelin B receptor.
T6672 Sitaxsentan sodium 210421-74-2 98%
Sitaxsentan (sodium) is a highly selective antagonist of endothelin A receptors.
T6792 BQ-123 136553-81-6 98%
BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.
T12924 Sitaxsentan 184036-34-8 98%
Sitaxsentan is A selective endothelin A (ETA) receptor antagonist. Endothelin is an effective vasoconstrictor. Sitaxsentan blocks the binding of endothelin to it...
T5458 Darusentan 171714-84-4 98%
Darusentan is a potent inhibitor of endothelin signaling and function in both large and small arteries
T15595L IRL-1620 acetate T15595L 98%
IRL-1620 acetate is an effective and selective agonist of Endothelin B receptor (ETB) with a Ki of 16 pM which is more selective than ETA with a Ki of 19 μM.
T19309L1 Endothelin 1 (swine, human) acetate T19309L1 98%
Endothelin 1 (swine, human) acetate is a synthetic peptide with the sequence of human and swine Endothelin 1. Endothelin 1 is a potent endogenous vasoconstrictor...
T21790 BMS 182874 hydrochloride 1215703-04-0 98%
BMS 182874 hydrochloride is a nonpeptide endothelin (El) receptor antagonist.
T1655 Ambrisentan 177036-94-1 98%
Ambrisentan is an endothelin receptor antagonist used in the therapy of pulmonary arterial hypertension (PAH). Ambrisentan has been associated with a low rate of...
T2561 Macitentan 441798-33-0 98%
Macitentan is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH).
T6265 Bosentan (hydrate) 157212-55-0 98%
Bosentan is a competitive and dual antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors.
SB-209670
T34541
SB-209670 is a selective endothelin receptor antagonist that inhibits the activity of ET(B) receptors in rat vascular endothelium and vascular smooth muscle.
IRL-1038 acetate
TP2262L
IRL-1038 acetate is a potent ETB endothelin receptor antagonist.
Myriceric acid C
TN4606
Myriceric acid C has cytotoxic activity against human lung carcinoma and breast carcinoma.
Zibotentan
T6258
Zibotentan (ZD4054) is a specific Endothelin (ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB. Phase 3.
Aprocitentan
T7817
Aprocitentan is ETA and ETB antagonist .
Avosentan
TQ0282
Avosentan (Ro 67-0565) is an effective and selective antagonist of the endothelin receptor (ETA receptor).
Sparsentan
T5355
Sparsentan is a first-in-class orally active and highly potent dual endothelin A and angiotensin II receptor antagonist(Ki of 9.3 and 0.8 nM, respectively)
Atrasentan hydrochloride
TQ0270
Atrasentan hydrochloride (ABT-627 hydrochloride) is an endothelin receptor antagonist (IC50: 0.0551 nM for ETA).
RO 46-8443
T3474
RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms...
IRL 2500
T15596
IRL 2500 is an antagonist of Endothelin receptor with IC50s of 1.3 and 94 nM for Endothelin A receptor and Endothelin B receptor.
Sitaxsentan sodium
T6672
Sitaxsentan (sodium) is a highly selective antagonist of endothelin A receptors.
BQ-123
T6792
BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.
Sitaxsentan
T12924
Sitaxsentan is A selective endothelin A (ETA) receptor antagonist. Endothelin is an effective vasoconstrictor. Sitaxsentan blocks the binding of endothelin to it...
Darusentan
T5458
Darusentan is a potent inhibitor of endothelin signaling and function in both large and small arteries
IRL-1620 acetate
T15595L
IRL-1620 acetate is an effective and selective agonist of Endothelin B receptor (ETB) with a Ki of 16 pM which is more selective than ETA with a Ki of 19 μM.
Endothelin 1 (swine, human) acetate
T19309L1
Endothelin 1 (swine, human) acetate is a synthetic peptide with the sequence of human and swine Endothelin 1. Endothelin 1 is a potent endogenous vasoconstrictor...
BMS 182874 hydrochloride
T21790
BMS 182874 hydrochloride is a nonpeptide endothelin (El) receptor antagonist.
Ambrisentan
T1655
Ambrisentan is an endothelin receptor antagonist used in the therapy of pulmonary arterial hypertension (PAH). Ambrisentan has been associated with a low rate of...
Macitentan
T2561
Macitentan is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH).
Bosentan (hydrate)
T6265
Bosentan is a competitive and dual antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors.
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