yn1

YN1 is an inhibitor of PFKFB3.

Anti-Mouse CD54 Antibody is a rat-derived IgG2b inhibitor targeting mouse CD54.

YN14-H is a PROTAC degrader that targets KRASG12C. It effectively inhibits the growth of NCI-H358 and MIA PaCa-2 cells, with IC50 values of 0.042 μM and 0.021 μM, respectively, and DC50 values of 28.9 nM and 18.1 nM. YN14-H significantly induces apoptosis and suppresses cell migration. It demonstrates favorable pharmacokinetics and excellent in vivo antitumor activity.

YN14, a mixture of diastereomers, is a PROTAC (proteolysis-targeting chimera) specifically designed for the KRASG12C protein. It acts as an efficient and selective degrader of KRASG12C, forming a stable KRASG12C:YN14:VHL ternary complex with low binding free energy (ΔG). YN14 exhibits antiproliferative properties, significantly inhibiting the growth of cancer cells with the KRASG12C mutation.

QPyN16Th is an N-palmitoylated cationic thiazolidine antibiotic. It exhibits selective activity against Gram-positive bacteria such as Enterococcus faecalis, Staphylococcus aureus, and methicillin-resistant Staphylococcus aureus (MRSA), with a MIC of 1.95 μM for Gram-negative bacteria. QPyN16Th can induce membrane permeabilization and depolarization in MRSA, along with ROS generation. It improves survival rates in a zebrafish model with intramuscular MRSA infection.

YN14 is a highly potent and selective KRASG12C proteolysis targeting chimera (PROTAC) capable of forming a stable KRASG12C: YN14: VHL ternary complex with low binding free energy (ΔG). It exhibits antiproliferative effects, significantly inhibiting the growth of KRASG12C-mutant cancer cells, and demonstrates tumor regression with tumor growth inhibition (TGI%) rates exceeding 100% in the MIA PaCa-2 xenograft model.

SYN1143 (AMG-1) is a potent inhibitor of human RON and c-Met.In vitro kinase assays showed that compound I is a potent inhibitor of human RON and c-Met with IC50s of 9 and 4 nmol/L, respectively.

Z13,YN11-16:OH (7) is an insect pheromone used to attract and capture the oak processionary moth (Thaumetopoea processionea L), aiding in the control of these defoliating pests.

Landipirdine (RO-5025181) is a selective 5-HT6R antagonist for the study of central nervous system disorders such as dementia.

(Iso)-Landipirdine((Iso)-RO5025181) is a selective and potent 5-HT6R antagonist. (Iso)-Landipirdine has a significant effect on the hERG pharmacophore and can be used to study neurological disorders in the Alzheimer's disease class.

(R)-Crinecerfont is an enantiomeric counterpart of SSR-125543. SSR-125543 is a potent CRF-R1 antagonist with Ki = 1.0 nM for human CRF-R1.

KYN-101 is an orally active and selective aryl hydrocarbon receptor (AHR) inhibitor with anticancer activity. KYN-101 decreases CYP1A1 mRNA expression and can be used in the study of breast cancer and acute myeloid leukemia. KYN-101 is an orally active and selective aryl hydrocarbon receptor (AHR) inhibitor with anticancer activity.

Endo-1,4-β-xylanase (Xylanase), a glycoside hydrolase enzyme that degrades arabinoxylan (AX), is commonly utilized in biochemical research. It specifically hydrolyzes the β-xylosidic bonds linking two d-xylopyranosyl residues in a β-(1,4) configuration [1].

1,3,5-Triazine-2(1H)-thione, 5-(1,1-dimethyl-2-propyn-1-yl)tetrahydro- ,with CAS No. 218156-64-0, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1,3,5-Triazine-2(1H)-thione, 5-(1,1-dimethyl-2-propyn-1-yl)tetrahydro- provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

1,3,5-Triazine, 1-(1,1-dimethyl-2-propyn-1-yl)-1,2,3,6-tetrahydro-4-(methylthio)-, hydriodide (1:1) ,with CAS No. 218157-38-1, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1,3,5-Triazine, 1-(1,1-dimethyl-2-propyn-1-yl)-1,2,3,6-tetrahydro-4-(methylthio)-, hydriodide (1:1) provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

N-ε-propargyloxycarbonyl-L-lysine hydrochloride (N6-((Prop-2-yn-1-yloxy)carbonyl)-L-lysine hydrochloride) is a modified amino acid for cancer therapy development.

Tozadenant (SYN115) is an adenosine A2A receptor antagonist(Ki of 11.5 nM and 6 nM on human and rhesus,respectively)

4-Diethylamino-2-butyn-1-ol is used as pharmaceutical intermediates.

(2S,3R,4S,5S,6R)-2-{[(2R,3R,4S,5S,6R)-2-(deca-4,6,8-triyn-1-yloxy)-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

3-(hexadec-15-en-7-yn-1-yl)-4-hydroxy-5-methyloxolan-2-one is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

2-[(2S,4bR,7S)-7-{[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-2-yl]oxy}-2,4b-dimethyl-2-(prop-1-yn-1-yl)-1,2,3,4,4a,4b,5,6,7,8,10,10a-dodecahydrophenanthren-1-yl]acetic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

2-[(2S,4bR,7S)-7-{[(2R,3R,4S,5S,6R)-4-hydroxy-6-(hydroxymethyl)-3,5-bis({[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy})oxan-2-yl]oxy}-2,4b-dimethyl-2-(prop-1-yn-1-yl)-1,2,3,4,4a,4b,5,6,7,8,10,10a-dodecahydrophenanthren-1-yl]acetic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

3-(5-phenylthiophen-2-yl)prop-2-yn-1-yl acetate is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

(3R,4R,5R)-3-[(11E)-hexadeca-11,15-dien-9-yn-1-yl]-4-hydroxy-5-methyloxolan-2-one is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.