sulfhydryl

N-Ethylmaleimide (NEM) is a reagent for alkylation of free sulfhydryl groups, a cysteine protease inhibitor used in experimental biochemistry. N-Ethylmaleimide is also a deubiquitinating enzyme inhibitor that specifically inhibits phosphate transport in mitochondria.

N-Succinimidyl-S-acetylthioacetate (SATA) is a protein modification agent that introduces thiol-groups into protein molecules and adds sulfhydryl groups in a protected form to proteins and other amine-containing molecules for later reaction with sulfhydryl reactive crosslinkers such as Sulfo-SMCC, Sulfo-MBS, etc.

Perindopril erbumine (S9490-3) is the tert-butylamine salt of perindopril, the ethyl ester of a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Upon hydrolysis, Perindopril erbumine (S9490-3) is converted to its active form perindoprilat, inhibiting ACE and the conversion of angiotensin I to angiotensin II; consequently, angiotensin II-mediated vasoconstriction and angiotensin II-stimulated aldosterone secretion from the adrenal cortex are inhibited and diuresis and natriuresis ensue.

2,2′-Dipyridyl disulfide (Aldrithiol 2) is a useful reagent for the determination of sulfhydryl groups. It acts as a peptide coupling reagent and as an oxidizing agent. 2,2′-Dipyridyl disulfide (Aldrithiol 2) is also used for the activation of glycosides.

Glutathione oxidized (L(-)-Glutathione) is a GLUTATHIONE dimer formed by a disulfide bond between the cysteine sulfhydryl side chains during the course of being oxidized.

Sodium 2-mercaptoethanesulfonate (Uromitexan) is a sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from antineoplastic agents, such as ifosfamide or cyclophosphamide.

Tinidazole (CP12574)a is a 5-nitroimidazole derivative with the antiprotozoal property. Although the mechanism of action has not been fully elucidated, it has been suggested that tinidazole is metabolized and yields nitrite anions and metronidazole. Metronidazole's nitro group, in turn, is reduced via the parasite ferredoxin, thereby generating a series of free nitro radicals including nitro anions. Toxicity is achieved via depletion of sulfhydryl groups and DNA strand breaks with multiple hits having an additive effect and ultimately leading to cell death.

Biotin-HPDP (Pyridyldithiol-biotin) is a sulfhydryl reactive biotinylation reagent.

Tiopronin (Acadione), a sulfhydryl acylated derivative of glycine, leads to a reduction in urinary cystine concentration and subsequently reduces cystine stone formation.

AMAS is a non-claevable heterobifunctional crosslinker with NHS ester and maleimide groups that enables covalent conjugation of amine- and sulfhydryl-containing molecules.

Bucillamine (DE019) protects against Ischemia reperfusion injury in high-risk organ transplants and inhibits the production of VEGF. Bucillamine is an orally active sulfhydryl donor and antioxidant with antirheumatic and antiangiogenic properties. Bucillamine can be used for studies about choroidal neovascularization and rheumatoid arthritis.

SMPB crosslinker is a heterobifunctional protein crosslinking reagent that is reactive toward sulfhydryl and amino groups. The SMPB protein crosslinker is an extended chain length analog of MBS crosslinker. SMPB crosslinker's spacer arm is non-cleavable.

Zofenopril calcium (SQ26991) is an antioxidant that acts as an angiotensin-converting enzyme inhibitor. ACE Zofenopril is a pro-drug designed to undergo metabolic hydrolysis yielding the active free sulfhydryl compound zofenoprilat, which is an angiotensin converting enzyme (ACE) inhibitor . Zofenopril promotes the regeneration of peripheral nerve injuries in rat models . Zofenopril increases SR calcium cycling and stimulates active calcium uptake into the SR .

MTSEA hydrobromide is a sulfhydryl-reactive compound that modifies free cysteine residues, producing a positively charged side chain similar in size to lysine.

Rev 6207 is a non-sulfhydryl ACE-inhibitor.

Biotin-PEG3-SH is a PROTAC linker consisting of biotin, PEG and sulfhydryl groups for the synthesis of PROTAC.

Moexipril ethyl ester is a long-acting, non-sulfhydryl angiotensine-converting enzyme inhibitor.

Rebimastat is a sulfhydryl-based second-generation matrix metalloproteinase (MMP) inhibitor with potential antineoplastic activity. Rebimastat selectively inhibits several MMPs (MMP 1, 2, 8, 9, and 14), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis.

Maleimide-PEG4-NHS is a sulfhydryl and amine reactive heterofuncational PEG linker. The chemical bonds formed through Maleimide-PEG4-NHS linker are stable and are not cleavable. The NHS ester reacts with amino groups at pH 7-9 to form stable amide bond wh

Trandolaprilat is an inhibitor of non-sulfhydryl angiotensin-converting enzyme.

Rev 6134 is an ACE-inhibitor with non-sulfhydryl containing.

Sulfo-SMPB sodium is a non-cleavable, heterobifunctional chemical cross-linking reagent that combines N-hydroxysuccinimide ester and maleimide groups, enabling the covalent conjugation of molecules possessing (amine) and (sulfhydryl) functionalities.

CB10-277 is a synthetic derivative of dimethylphenyl-triazene related to dacarbazine, with antineoplastic properties. Related to the agent dacarbazine, CB10-277 is converted in vivo to a monomethyl triazene form that alkylates DNA, resulting in inhibition of DNA replication and repair; in addition, this agent may act as a purine analogue, resulting in inhibition of DNA synthesis, and may interact with protein sulfhydryl groups.

Iodoacetyl-LC-Biotin reacts with sulfhydryl groups to form stable thioether linkages.