Search Result

Search Results for " replacement "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T1724	SCR7 pyrazine	SCR7	Apoptosis , DNA/RNA Synthesis , CRISPR/Cas9
	SCR7 pyrazine (SCR7) enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency in vitro up to 19-fold. Inhibits nonhomologous end-joining (NHEJ).		Apoptosis , DNA/RNA Synthesis , CRISPR/Cas9
T3340	SCR7		Apoptosis , DNA/RNA Synthesis , CRISPR/Cas9
	SCR7, a specific DNA Ligase IV inhibitor, blocks nonhomologous end-joining (NHEJ).		Apoptosis , DNA/RNA Synthesis , CRISPR/Cas9
T0040	Quinestrol	W-3566,Ethinylestradiol 3-cyclopentyl ether,EE2CPE	Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	Quinestrol (Ethinylestradiol 3-cyclopentyl ether) is a synthetic estrogen, applied in hormone replacement therapy, and occasionally to use in cancer and prostate cancer treatment.		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
T5965	Ditiocarb sodium	Sodium diethyldithiocarbamate	HIV Protease
	Ditiocarb sodium (Sodium diethyldithiocarbamate) (sodium diethiocarbamate) is a copper reagent, which reacts with Cu2 + solution to form a complex and improves the precipitation rate of copper replacement. Sodium diethyl...		HIV Protease
T8509	Danicopan	ACH-4471	Complement System
	Danicopan (ACH-4471) (ACH-4471) is a selective, orally active small molecule factor D inhibitor with high binding affinity to human factor D, with a Kd value of 0.54 nM. Danicopan (ACH-4471) inhibits the activity of the ...		Complement System
T29949	AMB
	AMB is an AB-PINACA analog characterized by the replacement of a primary amine with a methoxy group.
T33271	Medrogestone	R-13615,AY-62022,Medrogesterone,Colpro,Prothil
	Medrogestone is progesterone that is already used in hormone replacement therapy to treat menopausal symptoms and in the treatment of gynaecological conditions.
T20850	Hydroxy-PEG14-acid
	Hydroxy-PEG14-acid is a PEG derivative containing a hydroxyl group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or re...
T20108	Amino-nPEG-alcohol
	Amino-PEG12-alcohol is a PEG derivative containing an amino group with a hydroxyl group. PEG Linkers may be useful in the development of antibody-drug conjugates. The hydroxyl group enables further derivatization or repl...
T20860	Hydroxy-PEG12-t-butyl ester
	Hydroxy-PEG12-t-butyl ester is a PEG derivative containing a hydroxyl group and a t-butyl ester. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. Under acidic condi...
T80994	Therapeutic agent-1
	Therapeutic Agent-1, a heteroaryl compound, serves as an enzyme replacement therapy to enhance glucocerebrosidase activity in the treatment of Gaucher disease [1].
T32120	Hydroxy-PEG1-methylamine
	Hydroxy-PEG1-methylamine is a PEG derivative containing a hydroxyl group with a methylamine group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or re...
T32121	Hydroxy-PEG3-NHS
	Hydroxy-PEG3-NHS is a PEG derivative containing a hydroxyl group with an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with ...
T71551	KAI-1678
	KAI-1678 is an inhibitor of epsilon protein kinase C (εPKC). KAI-1678 is effective in the treatment of postoperative pain following total hip or total knee replacement.
T36304	Fluorescein-NAD+
	Fluoroscein NAD+ is a substrate for ADP-ribosylation, providing a convenient non-isotopic alternative to radiolabelled NAD for use in PARP assays. Allows direct measurement of NAD-dependent enzymes, such as PARP, by fluo...
T20849	Hydroxy-PEG3-acid
	Hydroxy-PEG3-acid is a PEG derivative containing a hydroxyl group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or rep...
T20973	Thiol-C2-PEG2-OH	Thiol-PEG3-alcohol,HS-PEG3-OH
	Thiol-PEG3-alcohol is a PEG derivative containing a hydroxyl group and a thiol group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement wit...
T32193	Iron sorbitex	Jectofer,Yectofer,Iron Sorbitol,HSDB 1967,Astra 1572
	Iron Sorbitex is used for the treatment of Iron Sorbitex deficiency anemia in patients with chronic kidney disease. Iron Sorbitex can be used as an Iron Sorbitex replacement product used for the treatment of Iron Sorbite...
T81656	Nomlabofusp
	Nomlabofusp, a cell-penetrating peptide (TAT-cpp 1-12), is utilized in frataxin replacement therapy research [1].
T24666	Propargyl-PEG14-alcohol
	Propargyl-PEG14-alcohol is a PEG derivative containing a hydroxyl group and a propargyl group. PEG Linkers are useful in the development of antibody drug conjugates. The hydroxyl group enables further derivatization or r...
T20946	Bismuth oxide	Bismuth sesquioxide,Bismuth trioxide,Bismutum-oxydatum,Bismuthous oxide
	Bismuth(III) oxide is a common starting point for bismuth chemistry. It is usually obtained as a by-product of the smelting of copper and lead ores. Bismuth trioxide is commonly used as a replacement of red lead to produ...
T37437	C17 Ceramide (d18:1/17:0)
	C17 Ceramide is a synthetic ceramide that contains a non-natural C17:0 fatty acid acylated to sphingosine. It has been used as a marker of arylsulfatase A and sphingolipid activator B activity in patients undergoing enzy...
T82477	Elosulfase alfa	Chondrosulfatase,Chondrosulfatases,BMN 110,Chondroitinase,Chondroitin sulfatase
	Elosulfase alfa (BMN 110), a recombinant human N-acetylgalactosamine-6-sulfatase (GALNS), serves as enzyme replacement therapy for mucopolysaccharidosis IVA (MPS IVA), commonly referred to as Morquio A syndrome [1].
T22551	ACSF		Others
	ACSF is often used as a replacement of CSF for perfusion of brain slices to preserve interneurons. ACSF is invented to reduce the incidence of cerebral edema and further suppress brain cell disorders. And ACSF is often u...		Others
T68219	Peraclopone
	Peraclopone is a hypolidemic drug. It is an inhibitor of 7-Dehydrocholesterol reductase. Peraclopone potently inhibits the final step in cholesterol biosynthesis. Feeding this agent to rats leads to a rapid replacement o...
T78520	CYT296		Others
	CYT296 is a chromatin de-condensation agent that enhances the efficiency of induced pluripotent stem cell (iPSC) generation mediated by defined factors (OSKM) and promotes an open chromatin state in Mouse Embryonic Fibro...		Others
T37215	5α,6β-Dihydroxycholestanol
	5α,6β-Dihydroxycholestanol is an oxysterol metabolite of cholesterol formed from conversion of cholesterol epoxides by 5,6-epoxysterol hydrolase. It inhibits NMDA-mediated calcium influx in HEK293 cells expressing NR1/NR...
T69994	BIM-46050
	BIM-46050 is a potent and specific inhibitor of human farnesyltransferase. BIM-46050 is free acidic form of BIM-46068. The IC50 values for in vitro inhibition of human brain FTase indicate that BIM-46050 and the ester fo...
T37129	MRS 2905
	Potent and selective P2Y14 receptor agonist (EC50 = 0.92 nM). Exhibits >2000-fold selectivity over P2Y6. Das et al (2010) Human P2Y14 receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and...
T70222	Ethonafide
	Ethonafide is an anthracene-containing derivative of amonafide that belongs to the azonafide series of anticancer agents. The lack of cross-resistance in multidrug-resistant cancer cell lines and the absence of a quinone...

Compounds

SCR7 pyrazine

T1724

Synonym: SCR7

Target: Apoptosis, DNA/RNA Synthesis, CRISPR/Cas9

SCR7

T3340

Synonym:

Target: Apoptosis, DNA/RNA Synthesis, CRISPR/Cas9

Quinestrol

T0040

Synonym: W-3566,Ethinylestradiol 3-cyclopentyl ether,EE2CPE

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

Ditiocarb sodium

T5965

Synonym: Sodium diethyldithiocarbamate

Target: Complement System

Synonym: R-13615,AY-62022,Medrogesterone,Colpro,Prothil

Hydroxy-PEG12-t-butyl ester

Hydroxy-PEG1-methylamine

Synonym: Thiol-PEG3-alcohol,HS-PEG3-OH

Target:

Iron sorbitex

T32193

Synonym: Jectofer,Yectofer,Iron Sorbitol,HSDB 1967,Astra 1572

Propargyl-PEG14-alcohol

Synonym: Bismuth sesquioxide,Bismuth trioxide,Bismutum-oxydatum,Bismuthous oxide

Target:

C17 Ceramide (d18:1/17:0)

Synonym: Chondrosulfatase,Chondrosulfatases,BMN 110,Chondroitinase,Chondroitin sulfatase

5α,6β-Dihydroxycholestanol

Cat No.	Product Name	Synonyms	Targets
T4884	Alpha-D-glucose	α-D-Glucose,alpha-Glucose,α-Dextrose	Others , Endogenous Metabolite
	alpha-D-glucose (α-Dextrose) is a primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutri...		Others , Endogenous Metabolite
T4238	Glycocyamine	2-Guanidinoacetic acid,Guanidoacetic acid	Others , Endogenous Metabolite
	Glycocyamine (2-Guanidinoacetic acid), a precursor of creatine, is a replacement of dietary arginine and could support overall energy homeostasis of the bird. Glycocyamine is an important marker for renal failure, kidney...		Others , Endogenous Metabolite
T3130	Testosterone phenylpropionate	Testosterone hydrocinnamate,Retandrol,Testosterone 17-phenylpropionate	Others
	Testosterone phenylpropionate (Testosterone 17-phenylpropionate)is a steroid indicated for testosterone replacement therapy in sterilization, missing testicle, hypopituitarism, and osteoporosis.		Others
T3033	Deoxycorticosterone acetate	DOC acetate,Cortexone acetate,11-Deoxycorticosterone acetate	Glucocorticoid Receptor , Endogenous Metabolite , Adrenergic Receptor
	Deoxycorticosterone acetate (Cortexone acetate) is the 21-acetate derivative of desoxycorticosterone, used for intramuscular injection for replacement therapy of the adrenocortical steroid.
T2752	2'-Deoxyadenosine monohydrate		Others , Endogenous Metabolite
	Deoxyadenosine, a deoxyribonucleoside, is a derivative of the nucleoside adenosine, differing from the latter by the replacement of a hydroxyl group (-OH) by hydrogen (-H) at the 2' position of its ribose sugar moiety.		Others , Endogenous Metabolite
T4712	H-D-cis-Hyp-OH	D-allo-Hydroxyproline,cis-4-Hydroxy-D-proline	Others , Endogenous Metabolite
	H-D-cis-Hyp-OH (D-allo-Hydroxyproline) belongs to the class of organic compounds known as proline and derivatives. Proline and derivatives are compounds containing proline or a derivative thereof resulting from a reactio...		Others , Endogenous Metabolite
T0887	D-Glucose	Dextrose,Glucopyranose,Grape sugar,D(+)-Glucose	Endogenous Metabolite
	D-Glucose (Glucopyranose) is a primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient...		Endogenous Metabolite
T4798	N-Acetyl-L-leucine		Others , Endogenous Metabolite
	N-Acetylleucine belongs to the class of organic compounds known as leucine and derivatives. Leucine and derivatives are compounds containing leucine or a derivative thereof resulting from reaction of leucine at the amino...		Others , Endogenous Metabolite
T8274	3-Methyl-L-histidine		Endogenous Metabolite
	3-Methylhistidine belongs to the class of organic compounds known as histidine and derivatives. Histidine and derivatives are compounds containing cysteine or a derivative thereof resulting from reaction of cysteine at t...		Endogenous Metabolite
T37298	Spinacine		Endogenous Metabolite
	Spinacine has been isolated from spinach and the roots of Panax ginseng. This conformationally constrained amino acid is a structural element in certain biologically active compounds as glucagon antagonists and angiotens...		Endogenous Metabolite
T21296	Desmopressin acetate trihydrate	Desmogalen,Adiuretin,Deamino Arginine Vasopressin,Vasopressin 1-Desamino-8-arginine
	Desmopressin acetate is a synthetic replacement for vasopressin, which reduces urine production. Medical use of Desmopressin acetate includes: (a) bed wetting; (b) diabetes insipidus; (c) nighttime urination; (d) clottin...
T37291	Lyso-Globotriaosylceramide (d18:1)	Lyso-Globotriaosylceramide (d18:1)
	Lyso-globotriaosylceramide is a form of globotriaosylceramide that is lacking the fatty acyl group. It binds to Shiga toxin 1 (Stx1) in the presence of cholesterol and phosphatidylcholine but does not bind Stx2. It also ...

Natural Products

alpha-D-glucose

T4884

Synonym: α-D-Glucose,alpha-Glucose,α-Dextrose

Target: Others, Endogenous Metabolite

Glycocyamine

T4238

Synonym: 2-Guanidinoacetic acid,Guanidoacetic acid

Target: Others, Endogenous Metabolite

Testosterone phenylpropionate

T3130

Synonym: Testosterone hydrocinnamate,Retandrol,Testosterone 17-phenylpropionate

Target: Others

Deoxycorticosterone acetate

T3033

Synonym: DOC acetate,Cortexone acetate,11-Deoxycorticosterone acetate

Target: Glucocorticoid Receptor, Endogenous Metabolite, Adrenergic Receptor

2'-Deoxyadenosine monohydrate

T2752

Synonym:

Target: Others, Endogenous Metabolite

H-D-cis-Hyp-OH

T4712

Synonym: D-allo-Hydroxyproline,cis-4-Hydroxy-D-proline

Target: Others, Endogenous Metabolite

D-Glucose

T0887

Synonym: Dextrose,Glucopyranose,Grape sugar,D(+)-Glucose

Target: Endogenous Metabolite

N-Acetyl-L-leucine

T4798

Synonym:

Target: Others, Endogenous Metabolite

3-Methyl-L-histidine

T8274

Synonym:

Target: Endogenous Metabolite

Spinacine

T37298

Synonym:

Target: Endogenous Metabolite

Desmopressin acetate trihydrate

T21296

Synonym: Desmogalen,Adiuretin,Deamino Arginine Vasopressin,Vasopressin 1-Desamino-8-arginine

Target:

Lyso-Globotriaosylceramide (d18:1)

T37291

Synonym: Lyso-Globotriaosylceramide (d18:1)

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-01727	GLA/alpha-Galactosidase A Protein, Human, Recombinant (His)	Human	HEK293
	Alpha-galactosidase A, also known as Alpha-D-galactoside galactohydrolase, Alpha-D-galactosidase A, Melibiase and GLA, is a member of the glycosyl hydrolase 27 family. GLA is used as a long-term enzyme replacement therap...
TMPY-01148	TREM-2 Protein, Human, Recombinant (His)	Human	HEK293
	Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the b...
TMPY-00432	TREM-2 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the b...
TMPY-01703	TREM-2 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the b...
TMPY-01012	P4HB Protein, Human, Recombinant (His)	Human	HEK293
	Protein disulfide-isomerase, also known as Cellular thyroid hormone-binding protein, Prolyl 4-hydroxylase subunit beta, p55 and P4HB, is a peripheral membrane protein that belongs to the protein disulfide isomerase famil...
TMPY-00767	Cystatin C Protein, Human, Recombinant (His)	Human	HEK293
	Cystatin C, also known as Cystatin-3 (CST3) is a secreted type 2 cysteine protease inhibitor synthesized in all nucleated cells, has been proposed as a replacement for serum creatinine for the assessment of renal functio...
TMPH-02694	GNG12 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GD...
TMPH-02615	CBS Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cystei...
TMPY-01900	Kallikrein 4/KLK4 Protein, Human, Recombinant (His)	Human	HEK293
	Kallikrein-4, also known as Enamel matrix serine proteinase 1, Kallikrein-like protein 1, KLK-L1, Serine protease 17, KLK4, PRSS17, and EMSP1, is a secreted protein that belongs to the peptidase S1 family and Kallikrein ...
TMPY-02802	GNG13 Protein, Human, Recombinant (His)	Human	E. coli
	GNG13 is a subunit of heterotrimeric G proteins which consist of alpha, beta, and gamma subunits. Heterotrimeric G proteins are membrane-bound GTPases that are linked to 7-TM receptors. They function as signal transducer...
TMPY-02805	GNGT1 Protein, Human, Recombinant (His)	Human	E. coli
	GNGT1 is a subunit of transducin. Heterotrimeric G proteins consist of alpha, beta, and gamma subunits. They are membrane-bound GTPases that are linked to 7-TM receptors. They function as signal transducers for the 7-tra...
TMPH-01380	ERCC3 Protein, Human, Recombinant (GST)	Human	E. coli
	ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged ...
TMPY-01290	CHIT1 Protein, Human, Recombinant (His)	Human	HEK293
	Chitotriosidase, also known as Chitinase-1 and CHIT1, is a member of the glycosyl hydrolase 18 family and Chitinase class II subfamily. It is a member of the mammalian chitinase family, structurally homologous to chitina...
TMPH-00775	IFN gamma Protein, Goat, Recombinant (His & Myc)	Goat	E. coli
	Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentatio...
TMPH-03495	IFN gamma Protein, Sheep, Recombinant (His)	Sheep	Yeast
	Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentatio...
TMPY-02857	GLA/alpha-Galactosidase A Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Alpha-galactosidase A, also known as Alpha-D-galactoside galactohydrolase, Alpha-D-galactosidase A, Melibiase and GLA, is a member of the glycosyl hydrolase 27 family. GLA is used as a long-term enzyme replacement therap...
TMPY-03442	MOB4A/MOB1B Protein, Human, Recombinant (GST)	Human	E. coli
	MST1 and MST2 are the mammalian Ste2-related protein kinases most closely related to Drosophila Hippo, a major regulator of cell proliferation and survival during development. Overexpression of MST1 or MST2 in mammalian ...
TMPY-02056	Cystatin C Protein, Rat, Recombinant (His)	Rat	HEK293
	Cystatin C, also known as Cystatin-3 (CST3) is a secreted type 2 cysteine protease inhibitor synthesized in all nucleated cells, has been proposed as a replacement for serum creatinine for the assessment of renal functio...
TMPY-01370	Cystatin C Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Cystatin C, also known as Cystatin-3 (CST3) is a secreted type 2 cysteine protease inhibitor synthesized in all nucleated cells, has been proposed as a replacement for serum creatinine for the assessment of renal functio...
TMPY-06598	TREM-2 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the b...
TMPY-06566	TREM-2 Protein, Human, Recombinant (hFc)	Human	HEK293
	Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the b...
TMPH-03494	IFN gamma Protein, Sheep, Recombinant (E. coli, His)	Sheep	E. coli
	Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentatio...
TMPY-01795	P4HB Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Protein disulfide-isomerase, also known as Cellular thyroid hormone-binding protein, Prolyl 4-hydroxylase subunit beta, p55 and P4HB, is a peripheral membrane protein that belongs to the protein disulfide isomerase famil...
TMPY-00640	Cystatin C Protein, Human, Recombinant	Human	HEK293
	Cystatin C, also known as Cystatin-3 (CST3) is a secreted type 2 cysteine protease inhibitor synthesized in all nucleated cells, has been proposed as a replacement for serum creatinine for the assessment of renal functio...
TMPH-01267	RNF13 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair protein...