ppiase

PPIase-Parvulin Inhibitor is a cell-pemeable inhibitor of the Pin1 and Pin4.

KPT-6566 is a novel selective covalent pin1 inhibitor, KPT-6566 shows an IC50 of 640 nM and a Ki of 625.2 nM for PIN1 PPIase domain,and has anti-cancer activity.

ZX-J-19L, an inhibitor of Cyclophilin J (CyPJ) PPIase, demonstrates significant inhibition of tumor cell growth. Its potency is comparable to that of CsA and significantly surpasses that of 5-fluorouracil.

API32 is a potent Pin1 inhibitor that interacts with the Pin1 PPIase domain. It effectively suppresses cell proliferation and migration, making it a promising candidate for research in hepatocellular carcinoma (HCC).

C105SR is a cyclophilin D (CypD) inhibitor targeting peptidyl-prolyl cis-trans isomerase (PPIase). It has an IC50 value of 5 nM for inhibiting mitochondrial permeability transition pore (mPTP) opening. C105SR reduces apoptosis in hepatocytes induced by hypoxia-reoxygenation and boosts calcium retention capacity (CRC). It demonstrates hepatoprotective effects in a mouse model of ischemia-reperfusion injury (IRI).

SMCypIC31 is a non-peptide cyclophilin inhibitor that effectively inhibits peptidyl-prolyl cis/trans isomerase (PPIase) (IC50: 0.1 μM). SMCypI C31 has a pan-genotypic effect against HCV, with an EC50 range of 1.20-7.76 μM against genotypes 1a, 1b, 2a, 3a and 5a HCV-SGRs and chimeric genotypes 2a/4a HCV-SGRs.

AG-17724 is a potent peptidyl-prolyl isomerase (PPIase) Pin1 inhibitor.