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Results for "

phosphodiesterase 3

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    63
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    2
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Vesnarinone
Piteranometozine, OPC-8212, Arkin
T346581840-15-5In house
Vesnarinone (Arkin) (INN) is a mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but minimal negative chronotropic activity. It also suppresses cell proliferation and induces apoptosis by inducing the expression of p21, an inhibitor of cyclin-dependent kinase activity in p53-mediated cell cycle arrest.
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IBMX
Methylisobutylxanthine, Isobutylmethylxanthine, 3-Isobutyl-1-methylxanthine, 1-Methyl-3-Isobutylxanthine
T171328822-58-4
IBMX (Methylisobutylxanthine) is a broad-spectrum phosphodiesterase (PDE) inhibitor with inhibitory activity against PDE3, PDE4, and PDE5 (IC50=6.5 26.3 31.7 μM). IBMX enhances the intracellular cAMP level.
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Parogrelil Free Base
NM-702 Free Base
T70793139145-27-0In house
Parogrelil Free Base (NM-702 Free Base) is a selective phosphodiesterase 3 inhibitor with bronchodilatory and anti-inflammatory effects, inhibits leukotriene (LT)D(4) and histamine-induced constriction of isolated guinea pig tracheal strips, and can be used in the study of bronchial asthma.
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6-8 weeks
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sp-cyclic amps (sodium salt)
T21697142439-95-0In house
Sp-cAMPS sodium salt is an analog of cAMP that serves as a potent activator of cAMP-dependent PKA I and PKA II, and as a competitive phosphodiesterase (PDE3A) inhibitor with a Ki of 47.6 μM. It also binds the PDE10 GAF domain with an EC50 of 40 μM [1] [2] [3].
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6-8 weeks
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Vesnarinone HCl
Vesnarinone HCl(81840-15-5 Free base), Synonym 2, OPC-8212 HCl
T3465L In house
Vesnarinone HCl (OPC-8212 HCl) is an orally active phosphodiesterase 3 (PDE3) inhibitor.Vesnarinone HCl modulates calcium and potassium ions, increasing calcium flux and decreasing potassium flux.Vesnarinone HCl is a new positive inotropic compound that enhances myocardial contractility and can be be used in heart failure studies.
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Amrinone
Inocor, Inamrinone, Wincoram
T126560719-84-8
Amrinone (Inocor) is a positive inotropic cardiotonic (cardiotonic agent) with vasodilator properties, phosphodiesterase 3 inhibitory activity.
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Cilostazol
OPC 21, OPC 13013
T046273963-72-1
Cilostazol (OPC 21) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of cilostazol is as a Phosphodiesterase 3 Inhibitor.
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Drotaverine hydrochloride
T8787985-12-6
Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor,and is an antispasmodic drug, used to enhance cervical dilation during childbirth. Drotaverine hydrochloride is structurally related to papaverine
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Milrinone
Win 47203
T109678415-72-2
Milrinone (Win 47203) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of milrinone is as a Phosphodiesterase 3 Inhibitor.
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Roflumilast
BYK 20869, BY 217, B9302-107, APTA 2217
T1024162401-32-3
Roflumilast (APTA 2217) is an orally available, long-acting inhibitor of phosphodiesterase (PDE) type 4 (PDE4), with anti-inflammatory and potential antineoplastic activities. Upon administration, roflumilast and its active metabolite roflumilast N-oxide selectively and competitively bind to and inhibit PDE4, which leads to an increase of both intracellular levels of cyclic-3', 5'-adenosine monophosphate (cAMP) and cAMP-mediated signaling.
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Rolipram
ZK 62711, (R,S)-Rolipram
T664461413-54-5
Rolipram (SB 95952) is a phosphodiesterase 4 inhibitor with antidepressant properties.
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NSP-805
T12267125068-54-4
NSP-805 is a potent and selective inhibitor of guinea pig cardiac phosphodiesterase 3 (PDE3).
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Olprinone
Loprinone
T5033106730-54-5
Olprinone (Loprinone)(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor.Olprinone has been reported to improve microcirculation and attenuate inflammation. Olprinone is often used to increase cardiac output after cardiopulmonary bypass (CPB).
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Enprofylline
Enprofyllinum, Enprofilina, 3-propylxanthine, 3-n-Propylxanthine
T2138941078-02-8
Enprofylline (Enprofilina), a bronchodilator, acts primarily as a competitive nonselective phosphodiesterase inhibitor. Enprofylline is used in asthma, chronic obstructive pulmonary disease, and in the management of sickle cell disease, diabetic neuropathy, and cerebrovascular insufficiency.
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Quinovic acid 3-O-alpha-L-rhamnopyranoside
TN4886104055-76-7
Quinovic acid 3-O-alpha-L-rhamnopyranoside shows significant inhibitory activity against snake venom phosphodiesterase-I.
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Indimilast
T321561038825-85-2
Indimilast is used to inhibit phosphodiesterase IV that regulates lung inflammation and causes bronchiectasis by increasing intracellular cyclic adenosine 3', 5'-monophosphate in airway smooth muscle and inflammatory cells. Potential to treat chronic obst
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8-10 weeks
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Milrinone Lactate
T1096L100286-97-3
Milrinone Lactate is a positive inotropic cardiotonic compound. Milrinone Lactate has vasodilator properties, inhibiting cAMP phosphodiesterase type 3 activity in the myocardium and vascular smooth muscle.
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1-2 weeks
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PDE7-IN-3
T78559908570-13-8
PDE7-IN-3 (Example 2) serves as an inhibitor of phosphodiesterase PDE7 and exhibits potential analgesic properties. It is applicable in the research of various pain types including inflammatory, neuropathic, visceral, and nociceptive pain [1].
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8-10 weeks
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CALP2 TFA
T75790
CALP2 TFA, a potent calmodulin (CaM) antagonist with a dissociation constant (Kd) of 7.9 µM, exhibits high affinity for the CaM EF-hand Ca2+-binding site. This compound effectively inhibits CaM-dependent phosphodiesterase activity and elevates intracellular Ca2+ concentrations. Furthermore, it significantly hinders adhesion and degranulation, while also acting as a robust activator of alveolar macrophages [1] [2] [3] [4].
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MY-5445
N-(3-chlorophenyl)-4-phenylphthalazin-1-amine
T1616478351-75-4
MY-5445 (N-(3-chlorophenyl)-4-phenylphthalazin-1-amine) is a specific inhibitor of phosphodiesterase type 5 (PDE5). MY-5445 selectively inhibits cGMP PDE (Ki:1.3 μM).
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Phosphodiesterase
T761389025-82-5
Phosphodiesterase (PDE), an enzyme capable of catalyzing the hydrolysis of the 3' ring phosphate bond in cyclic nucleotides, plays a crucial role in biochemical research and acts as a vital regulator in signal transduction processes involving the second messenger molecules cAMP and cGMP. Distinguished by their specificity to cyclic nucleotides, PDEs are categorized into different types ranging from PDE1 to PDE11, presenting potential significance in the study and treatment of various diseases [1].
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Anagrelide
Anagrelida, Xagrid, Anagrelidum
T016068475-42-3
Anagrelide (Xagrid) is a Platelet-reducing Agent. The mechanism of action of anagrelide is as a Phosphodiesterase 3 Inhibitor. The physiologic effect of anagrelide is by means of Decreased Platelet Production.
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3-O-Methylquercetin tetraacetate
TN29741486-69-7
Quercetin 3-O-methyl ether is a potent phosphodiesterase (PDE)3 4 inhibitor, it has potential for treating asthma against ovalbumin-induced airway hyperresponsiveness.
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ATX inhibitor 1
T104102225892-70-4
ATX inhibitor 1 is a potent ATX inhibitor with IC50 values of 1.23 nM (FS-3) and 2.18 nM (bis-pNPP).
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