o 11

O-11 is an analog of the fully saturated, 14-carbon fatty acid myristic acid, in which the methylene group at position 11 is replaced with oxygen. It is highly effective and selective at killingTrypanosoma brucei, the protozoan parasite responsible for African sleeping sickness, exhibiting an LD50of less than 1 μM in a cell culture assay.1,2The toxic effects of O-11 appear to be caused by its ability to inhibit the incorporation of a single myristate into the GPI anchor of the variant surface glycoprotein (VSG), a protein critical for evading the host immune response.1O-11 exhibits essentially no anti-fungal activity when assayed usingC. neoformans, but does have a minor inhibitory effect on HIV-1 replication in T-lymphocytes.3 1.Doering, T.L., Raper, J., Buxbaum, L.U., et al.An analog of myristic acid with selective toxicity for African trypanosomesScience2521851-1854(1991) 2.Doering, T.L., Lu, T., Werbovetz, K.A., et al.Toxicity of myristic acid analogs toward African trypanosomesProceedings of the National Academy of Sciences of the United States of America919735-9739(1994) 3.Langner, C.A., Lodge, J.K., Travis, S.J., et al.4-Oxatetradecanoic acid is fungicidal for Cryptococcus neoformans and inhibits replication of human immunodeficiency virus IThe Journal of Biological Chemisty267(24)17159-17169(1992)

1→4-β-oleandropyranosyl-11-O-isobutyryl-12-O-acetyltenacigenin B, a component of the plant Poria cocos, is identified as 3-O-β-Allopyranosyl-(1→4).

11-O-Galloylbergenin is isolated from of Mallotus philippinensis with antioxidant and antiplasmodial activities.

11-O-β-D-glucopyranosyl thamnosmonin is a coumarin glucoside extractable from the roots of Angelica apaensis that exhibits weak inhibitory effects on rabbit platelet aggregation induced by PAF, AA, and ADP [1].

11-O-Syringylbergenin, a bergenin derivative, has been isolated from the entire plant of Corylopsis willmottiae Rehd. et Wils [1].

11-Oxomogroside III is a natural product from Siraitia grosvenorii Swingle.

3-O-Acetyl-11-hydroxy-beta-boswellic acid, the precursor of 3-O-acetyl-9,11-dehydro-beta-boswellic acid (a 5-lipoxygenase inhibitor),

(1R,6R,9R)-6,9,11-Trihydroxy-4,7-megastigmadien-3-one 11-O-glucoside is a natural product for research related to life sciences. The catalog number is TN6201 and the CAS number is 289914-68-7.

11-O-Mogroside IIIA1 is a natural product that can be used in related research in the field of life sciences. Its product number is TN8824.

4-O-Demethyl-11-deoxydoxorubicin is an anthracycline antibiotic with antibacterial and antitumor properties. This compound exhibits cytotoxic effects against Hela cells.

LysoPalloT-NH-amide-C3-ph-m-O-C11 is an agonist of the GPR174 receptor with an EC50 value of 34 nM.

Thalidomide-O-C11-acid is a synthetic E3 ligase ligand-linker conjugate, featuring a cereblon ligand derived from Thalidomide and a single linker, and is utilized in the synthesis of PROTAC [Proteolysis Targeting Chimeras].

Thalidomide-O-amido-C11-COOH (Compound IMiD acid 1) is a compound that acts as an E3 ligase ligand and linker for the CRBN (Cereblon) conjugate. This compound is useful in synthesizing PROTACs targeting the degradation of DOT1L.

[Sar9,Met(O2)11]-Substance P TFA is a tachykinin NK 1 receptor selective agonist.

Thalidomide-5-O-C11-NH2 hydrochloride, a thalidomide-derived cereblon ligand, facilitates the recruitment of CRBN protein and can be conjugated to a protein ligand via a linker to synthesize PROTACs [1].

Thalidomide-4-O-C11-NH2 hydrochloride is a thalidomide-based cereblon ligand for CRBN protein recruitment, capable of conjugation to a protein ligand via a linker to create PROTACs [1].

11α-O-Tigloyl-12β-O-acetyltenacigenin B, an ester derivative isolated from Garcinia cambogia (MTC), modulates the antitumor effects of Aurora-A in lymphoma through its parent compound, Tenacigenin B.

11-Oxomogroside IIIE (Standard) is a reference standard for research and analysis in studies involving 11-Oxomogroside IIIE. 11-Oxomogroside IIIE is a cucurbitane triterpene glycoside isolated from Siraitia grosvenorii (Lo Han Kuo), a traditional Chinese fruit used as a pulmonary demulcent for conditions including dry cough, sore throat, thirst, and constipation. Triterpenoids from this plant were evaluated for inhibition of Epstein–Barr virus early antigen induction by TPA in Raji cells, a primary screen for antitumor promoters, amongst all tested compounds, 11-Oxomogroside IIIE exhibited strong suppression with 70–100% inhibition at 1 × 10³ mol ratio/TPA.

11-Oxomogroside IIIE is a cucurbitane triterpene glycoside isolated from Siraitia grosvenorii (Lo Han Kuo), a traditional Chinese fruit used as a pulmonary demulcent for conditions including dry cough, sore throat, thirst, and constipation. Triterpenoids from this plant were evaluated for inhibition of Epstein–Barr virus early antigen induction by TPA in Raji cells, a primary screen for antitumor promoters, amongst all tested compounds, 11-Oxomogroside IIIE exhibited strong suppression with 70–100% inhibition at 1 × 10³ mol ratio/TPA.

11-Oxomogroside IV, a natural product, is a triterpenoid glycoside found in the fruit of Siraitia grosvenorii (Monk fruit). It exhibits significant biochemical properties and is often studied for its potential health benefits and applications in sweetening due to its low-caloric content. [1-(a-L-Arabinopyranosyl)-2-[b-D-glucopyranosyl-(1->2)-b-D-glucopyranosyl)-oxomogroside].

11,12-Di-O-acetyltenacigenin B is a natural product for research related to life sciences. The catalog number is TN2577 and the CAS number is 857897-01-9.

19-O-beta-D-carboxyglucopyranosyl-12-O-beta-D-glucopyranosyl-11,16-dihydroxyabieta-8,11,13-triene is a natural product of Pinus, Pinaceae. The catalog number is TN6493 and the CAS number is 1011714-20-7. 19-O-beta-D-carboxyglucopyranosyl-12-O-beta-D-glucopyranosyl-11,16-dihydroxyabieta-8,11,13-triene can be used as a reference standard.

11,12-Di-O-methylcarnosol, also known as Comp 7, is a nolic diterpene lactone isolated from the leaves of Rosmarinus officinalis L. (rosemary) [1].

11α-O-Benzoyl-12β-O-acetyltenacigenin B, a derivative of Tenacigenin B from Marsdenia tenacissima, functions as an inhibitor of P-glycoprotein (Pgp). This compound has demonstrated its ability to counteract multidrug resistance (MDR) associated with the overexpression of P-glycoprotein (Pgp) in HepG2/Dox cells. It shows promise for applications in cancer research.