Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty
Filter
Applied FilterClear all
TargetMol | Tags By Target
  • Endogenous Metabolite
    (3)
  • Calcium Channel
    (2)
  • Dehydrogenase
    (2)
  • Parasite
    (2)
  • Antifolate
    (1)
  • DNA/RNA Synthesis
    (1)
  • Others
    (12)
Filter
Search Result
Results for "

nadh dehydrogenase

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    18
    TargetMol | Inhibitors_Agonists
  • Peptide Products
    2
    TargetMol | Peptide_Products
  • Dye Reagents
    1
    TargetMol | Dye_Reagents
  • Natural Products
    4
    TargetMol | Natural_Products
  • Recombinant Protein
    9
    TargetMol | Recombinant_Protein
  • Isotope Products
    1
    TargetMol | Isotope_Products
  • Antibody Products
    2
    TargetMol | Antibody_Products
Ethyl 4-chloro-2-oxo-1,2-dihydroquinoline-3-carboxylate
T7764099429-64-8
ethyl 4-chloro-2-oxo-1,2-dihydroquinoline-3-carboxylate inhibits NAD(P)H: quinone oxidoreductase 1.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Sale
sn-Glycerol 3-phosphate
sn-Glycerol 3-phosphate lithium salt, Glycerol 3-phosphate
T1934317989-41-2
sn-Glycerol 3-phosphate, produced by the reduction of dihydroxyacetone phosphate by NADH formed during glycolysis of the cytoplasmic glycerol 3-phosphate dehydrogenase pathway.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Sale
Glycerol 3-phosphate biscyclohexylammonium salt
T19343L29849-82-9
Glycerol 3-phosphate biscyclohexylammonium salt is an endogenous metabolite produced by cytosolic glycerol 3-phosphate dehydrogenase pathway.
  • Inquiry Price
Size
QTY
NADH-IN-2
T20116967273-56-7
NADH-IN-2 (compound 8) is a Type II NADH dehydrogenase inhibitor.
  • Inquiry Price
2-4 weeks
Size
QTY
Aflatoxin G1-13C17
Aflatoxin G1-13C17
T355201217444-07-9
Aflatoxin G1-13C17is intended for use as an internal standard for the quantification of aflatoxin G1by GC- or LC-MS. Aflatoxin G1is a mycotoxin that has been found inA. terricola.1In vivo, aflatoxin G1is lethal to ducklings (LD50= 1.18 mg/kg).2It induces hepatocellular carcinoma tumor formation and lethality in rats when administered at doses of 1.4 and 3 mg/animal, respectively. Aflatoxin G1also inhibits liver and kidney succinate dehydrogenase and fumarase, as well as kidney cytochrome oxidase, NADH oxidase, α-glycerophosphate dehydrogenase, isocitrate dehydrogenase, and malate dehydrogenase in rats.3 1.Moubasher, A.H., el-Kady, I.A., and Shoriet, A.Toxigenic Aspergilli isolated from different sources in EgyptAnn. Nutr. Aliment.31(4-6)607-615(1977) 2.Wogan, G.N., Edwards, G.S., and Newberne, P.M.Structure-activity relationships in toxicity and carcinogenicity of aflatoxins and analogsCancer Res.31(12)1936-1942(1971) 3.Bai, N.J., Pai, M.R., and Venkitasubramanian, T.A.Mitochondrial function in aflatoxin toxicityIndian J. Biochem. Biophys.14(4)347-349(1977)
  • Inquiry Price
Size
QTY
Debutyldronedarone hydrochloride
SR35021 hydrochloride
T35712197431-02-0
N-Desbutyl dronedarone is an active metabolite of the antiarrhythmic agent dronedarone .1,2,3It is formed from dronedarone by cytochrome P450s (CYPs) and monoamine oxidase (MAO) in human hepatocyte preparations.4N-Desbutyl dronedarone inhibits the binding of 3,3',5-triiodo-L-thyronine to the thyroid hormone receptors TRα1and TRβ1(IC50s = 59 and 280 μM for the chicken and human receptors, respectively).1It inhibits CYP2J2-mediated formation of 14,15-EET from arachidonic acid and soluble epoxide hydrolase-mediated formation of 14,15-DHET from 14,15-EET (IC50s = 1.59 and 2.73 μM, respectively, in cell-free assays).2N-Desbutyl dronedarone decreases intracellular ATP levels in H9c2 rat cardiomyocytes (IC50= 1.07 μM) and inhibits mitochondrial complex I, also known as NADH dehydrogenase, and mitochondrial complex II, also known as succinate dehydrogenase, activities in isolated rat heart mitochondria (IC50s = 11.94 and 24.54 μM, respectively).3 1.Van Beeren, H.C., Jong, W.M.C., Kaptein, E., et al.Dronerarone acts as a selective inhibitor of 3,5,3'-triiodothyronine binding to thyroid hormone receptor-α1: in vitro and in vivo evidenceEndocrinology144(2)552-558(2003) 2.Karkhanis, A., Tram, N.D.T., and Chan, E.C.Y.Effects of dronedarone, amiodarone and their active metabolites on sequential metabolism of arachidonic acid to epoxyeicosatrienoic and dihydroxyeicosatrienoic acidsBiochem. Pharmacol.146188-198(2017) 3.Karkhanis, A., Leow, J.W.H., Hagen, T., et al.Dronedarone-induced cardiac mitochondrial dysfunction and its mitigation by epoxyeicosatrienoic acidsToxicol. Sci.163(1)79-91(2018) 4.Klieber, S., Arabeyre-Fabre, C., Moliner, P., et al.Identification of metabolic pathways and enzyme systems involved in the in vitro human hepatic metabolism of dronedarone, a potent new oral antiarrhythmic drugPharmacol. Res. Perspec.2(3)e00044(2014)
    7-10 days
    Inquiry
    IM-156 acetate
    HL271 acetate
    T364202043654-54-0
    IM-156 acetate, an activator of NADH dehydrogenase (IC50=2.2 μM) and AMP-activated protein kinase alpha (AMPKα), is an orally available and bioavailable inhibitor of mitochondrial oxidative phosphorylation (OxPhos).IM-156 acetate increases AMPKα activity and inhibits chlorhexadiene-induced peritoneal fibrosis and inhibit tumor growth in rats .
    • Inquiry Price
    6-8 weeks
    Size
    QTY
    sn-Glycerol 3-phosphate lithium
    T37502
    sn-Glycerol 3-phosphate lithium is synthesized via the cytosolic glycerol 3-phosphate dehydrogenase pathway, involving the conversion of dihydroxyacetone phosphate to sn-Glycerol 3-phosphate using NADH generated during glycolysis.
    • Inquiry Price
    Size
    QTY
    (R)-(-)-1,2-Propanediol
    T405294254-14-2
    (R)-(-)-1,2-Propanediol is the (R)-enantiomer of 1,2-Propanediol, derived from glucose via NADH-linked glycerol dehydrogenase gene expression in Escherichia coli.
    • Inquiry Price
    7-10 days
    Size
    QTY
    Proguanil hydrochloride
    Paludrine hydrochloride, Chlorguanide hydrochloride, Chloroquanil
    T4382637-32-1
    Proguanil hydrochloride (Chloroquanil) is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, Proguanil hydrochloride is converted to its active cyclic triazine metabolite, cycloguanil, by a cytochrome P450 dependent reaction. Cycloguanil selectively inhibits the bifunctional dihydrofolate reductase-thymidylate synthase of plasmodium parasite, thereby disrupting deoxythymidylate synthesis and ultimately blocking DNA and protein synthesis in the parasite.
    • Inquiry Price
    Size
    QTY
    Pyridaben
    T511496489-71-3
    Pyridaben is a METI acaricide that inhibits mitochondrial electron transport at complex I (METI; Ki = 0.36 nmol mg protein in rat brain mitochondria).
    • Inquiry Price
    Size
    QTY
    CBR-3465
    T610352225883-59-8
    CBR-3465 is an inhibitor of mycobacterium tuberculosis (Mtb) type II NADH dehydrogenase. The MIC of CBR-3465 against Mtb is 0.16 μM [1].
    • Inquiry Price
    6-8 weeks
    Size
    QTY
    CBR-6672
    T611922225885-40-3
    CBR-6672, a type II NADH dehydrogenase inhibitor, demonstrates potent antimycobacterial activity against mycobacterium tuberculosis (Mtb) with a minimum inhibitory concentration (MIC) of 0.14 μM [1].
    • Inquiry Price
    6-8 weeks
    Size
    QTY
    beta-Galactose dehydrogenase
    T762069028-54-0
    Beta-Galactose dehydrogenase catalyzes the conversion of galactose into galactonolactone, simultaneously reducing NAD to fluorescent NADH. This enzyme is useful for the determination of galactose [1].
    • Inquiry Price
    Size
    QTY
    Glucose dehydrogenase (GDH)
    T762079028-53-9
    Glucose dehydrogenase (GDH) is an oxidoreductase enzyme that facilitates the oxidation of β-D-glucose into β-D-glucono-1,5-lactone, while concurrently reducing cofactor NADP+ to NADPH, and to a lesser degree, NAD+ to NADH. It can utilize both NAD+ and NADP+ as cofactors and serves in the regeneration of NADH and NADPH [1] [2].
    • Inquiry Price
    7-10 days
    Size
    QTY
    Glyceraldehyde phosphate dehydrogenase
    GAPDH, GADPH, G3PDH
    T783609001-50-7
    Glyceraldehyde phosphate dehydrogenase, targeted by anti-thymocyte and anti-apoptotic agents, catalyzes the oxidation of reduced nicotinamide adenine dinucleotide (NADH) by perhydroxyl radicals [1] [2].
    • Inquiry Price
    7-10 days
    Size
    QTY
    HP661
    T83865
    HP661, a selective inhibitor of mitochondrial complex I (NADH dehydrogenase), impedes complex I activity by 77.6% at 1 µM, demonstrating lesser inhibition towards complex III (28.1%) and no inhibitory effects on complexes II and IV. It notably decreases the viability of human lung cancer cells—H460, NCI H441, and trametinib-resistant A549 cells (IC50s = 10.6, 29.7, and 15.1 nM, respectively)—which exhibit high levels of oxidative phosphorylation. In contrast, it shows minimal activity against NCI H358 lung cancer cells and non-cancerous HPNE and MRC-5 cells (IC50s = >10,000 nM for both), which have lower oxidative phosphorylation levels. Furthermore, in an H460 mouse xenograft model, HP661 at a dose of 30 mg/kg twice daily significantly reduces tumor volume and enhances the tumor-growth inhibitory effects of trametinib.
    • Inquiry Price
    Size
    QTY
    1-Methyl-2-pentyl-4(1H)-quinolinone
    1-methyl-2-pentylquinolin-4-one
    TN117522048-98-2
    1-Methyl-2-pentyl-4(1H)-quinolinone, a low toxic natural product containing a quinoline structure, is a specific inhibitor of Plasmodium falciparum type II NADH dehydrogenase (PfNDH2), significantly inhibits Plasmodium falciparum development in the mosquito stage and blocks malaria transmission.
    • Inquiry Price
    Size
    QTY