microvascular — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T21807	INCA-6	Triptycene-1,4-quinone	Others
	INCA-6 (Triptycene-1,4-quinone) is a cell-permeable NFAT inhibitor. INCA-6 inhibits of CN-NFAT signaling by targeting of NFAT(P) substrate to the calcineurin (CN) phosphatase site.		Others
T2690	Tranilast	MK 341,SB 252218	RAAS , Prostaglandin Receptor
	Tranilast (SB 252218), an antiallergic drug, suppresses lipid mediator and cytokine release from inflammatory cells, therefore utilized in the treatment of allergic disorders.		RAAS , Prostaglandin Receptor
T0259	Chromocarb	Chromone-2-carboxylic acid,Chromocarbe	Others
	Chromocarb (Chromone-2-carboxylic acid) is a vascular protective agent used to treat venous disorders and microvascular affections.		Others
T33389	Minalrestat	ARI509,WAY-121509,WAY121509,WAYARI-509,ARI-509,WAY-ARI-509	Reductase
	Minalrestat(ARI-509) is an orally active and potent aldose reductase inhibitor for the study of impaired microvascular reactivity in diabetic patients.		Reductase
T11318	Dopexamine hydrochloride	FPL60278AR	Adrenergic Receptor
	Dopexamine hydrochloride (FPL60278AR) is a β2-adrenergic receptor agonist. Dopexamine can attenuate the inflammatory response and protect against organ injury in the absence of significant effects on hemodynamics or regi...		Adrenergic Receptor
T0530	Flavanone	2-Phenyl-4-chromanone,4-Flavanone,2,3-Dihydroflavone,2-Phenylchroman-4-one	Others , Aromatase
	Flavanone (2-Phenylchroman-4-one)s from citrus fruits have also been shown to exert beneficial effects on human vascular function. In particular, chronic interventions with orange juice, or the pure flavanone hesperidin,...		Others , Aromatase
T60396	JMS-053		Phosphatase
	JMS-053 is a potent and selective inhibitor of the phosphatase DUSP3, inhibits PTP4A3, PTP4A1, PTP4A2 and CDC25B, inhibits cancer cell migration and sphere growth, and avoids disruption of the microvascular endothelial b...		Phosphatase
T3S1513	(20R)-Protopanaxadiol	Protopanaxadiol,20R-Protopanaxadiol,(20R)-Protopanaxdiol	Others , Antibacterial
	1. (20R)-Protopanaxadiol ((20R)-Protopanaxdiol) has the effect of anti-tumor through increasing the activity of body immunity, inhibiting tumor interstitial microvascular density and its proliferation activity, improving...		Others , Antibacterial
T5S2347	Deoxyshikonin	Arnebin 7	Others , HIF/HIF Prolyl-Hydroxylase , Antibacterial
	1. Deoxyshikonin (Arnebin 7) may be a new drug candidate for wound healing and treatment of lymphatic diseases. 2. Deoxyshikonin enhances the ability of human dermal lymphatic microvascular endothelial cells (HMVEC-dLy) ...		Others , HIF/HIF Prolyl-Hydroxylase , Antibacterial
T3560	Desmethylanethol trithione	ADT-OH	VEGFR , Akt
	Desmethylanethol trithione (ADT-OH) is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. In the in vitro glucose-oxygen deprivation (OGD) model, Desmethylanethol trithione markedly...		VEGFR , Akt
T40942	(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone
	(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone, an antiangiogenic homoisoflavonoid, exhibits activity against human retinal microvascular endothelial cells.
T71488	Cremastranone
	Cremastranone is a natural antiangiogenic homoisoflavanone. Cremastranone inhibits the proliferation, migration, and tube formation ability of human retinal microvascular endothelial cells.
T27790	Labradimil	RMP-7,ALK-01-040,Receptor-mediated permeabiliser-7,DRG0182,DRG 0182,DRG-0182
	Labradimil is a bradykinin B2 receptor agonist. Labradimil increases the permeability of human brain microvascular endothelial cell monolayers. Labradimil enhances delivery of hydrophilic chemotherapeutics and increases ...
TN1532	Crenulatin		BCL , Caspase
	Crenulatin has dual- direction effects on apoptosis of cerebral microvascular endothelial cells, inhibitive effect in 25 mg/L and stimulative effect in 100 mg/L group, respectively; the mechanism is related to the altera...		BCL , Caspase
TN5942	Dammarenediol II	Dammar-24-ene-3,20-diol
	Dammarenediol II may have the ability to prevent diabetic microvascular complications, including diabetic retinopathy, it can inhibit vascular endothelial growth factor (VEGF)-induced intracellular reactive oxygen specie...
T26589	Albifylline
	Albifylline is a xanthine derivates with anti-asthmatic activity. Albifylline may cause a significant reduction of shock-induced leukocyte adhesions to the sinusoidal endothelium in the liver after hemorrhagic shock. Alb...
T82526	Drotrecogin alfa (activated)
	Drotrecogin alfa (activated) (DrotAA), a recombinant human activated protein C (APC), mitigates smoke-induced elevations in pulmonary microvascular permeability and proinflammatory cytokine IL-1β levels in rats. It also ...
T81935	L-Glutamic γ-monohydroxamate
	L-Glutamic γ-monohydroxamate is an antitumor compound that impedes cell proliferation and selectively hinders L-histidine uptake in microvascular endothelial cells. Additionally, this compound serves as a vanadium ligand...
T36232	20-carboxy Arachidonic Acid
	20-carboxy Arachidonic acid (20-COOH-AA) is the major metabolite of 20-HETE that is produced in renal tubular epithelial, endothelial, and microvascular smooth muscle cell cultures. This ω-oxidation conversion can take p...
T35468	(±)19(20)-EDP Ethanolamide
	(±)19(20)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 108 and 280 nM for CB1 and CB2, respectively). It is produced through direct epoxygenation of docosahexaenoyl et...