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Search Result

Search Results for "liver"

Targets

Liver X Receptor

Libraries

Anti-Liver Cancer Compound Library Drug-induced Liver Injury (DILI) Compound Library Anti-Fibrosis Compound Library AMPK-Targeted Compound Library Orally Active Compound Library Selected Plant-Sourced Compound Library Gut Microbial Metabolite Library Glutamine Metabolism Compound Library
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Compounds

Cat No. Product Name
T61328 CO delivery molecule 1
CO delivery molecule 1 (compound 4) exhibits subcellular localization in the endoplasmic reticulum, mitochondria, and ly...
T35981 Biliverdin (hydrochloride)
Biliverdin is a green bile pigment produced from the oxidation of heme in a reaction catalyzed by heme oxygenase and is ...
T8254 Chrysoobtusin Others
Chrysoobtusin 是一种蒽醌衍生物，分离自决明子。其中决明子具有保肝、通便、明目的作用。
T16930 SR9238 Liver X Receptor
SR9238 是有效的肝 X 受体(LXR)反向激动剂，对LXRα和LXRβ的IC50分别为 214 nM 和 43 nM。
T1801 SR9243 Liver X Receptor
SR9243 是一种 liver-X-receptor 的反向激动剂，可诱导 LXR-辅阻遏物相互作用。
T7768 RGX-104 RGX-104 free Acid Liver X Receptor
RGX-104 是一种口服具有活力的肝X 核激素受体激动剂，通过 ApoE 基因的转录激活调节先天免疫。
T8733 Antrodin A (2-氯苯基)二苯基甲醇,camphorataanhydride A Others
Antrodin A 是固体发酵樟脑菌菌丝体的一种主要活性成分。它能够增强肝脏的抗炎及抗氧化能力，维持肠道菌群的稳定，避免酒精对肝脏的损伤。
T5178 AZ876 Liver X Receptor
AZ876 是高亲和力的 LXR 激动剂。它在人的 (h)LXRα 和 hLXRβ 比 GW3965 要分别强 25 和 2.5 倍。
T15427 GSK2033 Liver X Receptor
GSK2033 是LXR 的有效拮抗剂，抑制LXRα和LXRβ的pIC50分别为 7 和 7.4。
T5128 RGX-104 hydrochloride 盐酸RGX-104,SB742881,RGX-104 HCl Liver X Receptor
RGX-104 HCl 是小分子LXR 激动剂，利用 ApoE 基因的转录激活，调节先天免疫。
T10904 CWP232228 Wnt/beta-catenin
CWP232228 是一种高效的、选择性的Wnt/β-catenin 信号通路抑制剂，在细胞核中，拮抗 β-catenin 与 T 细胞因子结合。它能够抑制乳腺癌和肝癌干细胞的生长，抑制肿瘤的形成和转移，且没有毒性。
T19399 L-Ornithine L-aspartate Ornithine Aspartate,L-鸟氨酸 L-天冬氨酸 Others
L-Ornithine L-aspartate 由鸟氨酸和天冬氨酸组成。它能够减少血氨浓度，并消除与肝硬化相关的肝性脑病的症状。
T12075 ML-180 SR1848 Others
ML-180 是孤儿核受体肝受体同源物 1 (LRH-1;NR5A2) 的反向激动剂(IC50:3.7 µM)。它不抑制类固醇生成因子 1 (SF-1;NR5A1; IC50>10 µM)。 它具有潜在的抗依赖 LRH-1 癌症作用。
TQ0274 27-Hydroxycholesterol 27-羟基胆固醇,5,25R-胆甾烯-3BETA,26-二醇,25(R)-27-hydroxy Cholesterol Liver X Receptor , Estrogen/progestogen Receptor
27-Hydroxycholesterol 是一种有效的、选择性的雌激素受体调节剂和肝X 受体激动剂。
T1677 Montelukast 孟鲁司特,Singular LTR , Leukotriene Receptor , Lipoxygenase
Montelukast 是可口服的半胱氨酸白三烯受体1 选择性拮抗剂，可用于研究预防哮喘和肝损伤。它还可减少心脏损伤，在肠缺血-再灌注损伤中也具有抗氧化作用。
T1677L Montelukast sodium MK0476,孟鲁司特钠 Leukotriene Receptor , LTR
Montelukast sodium 是可口服的半胱氨酸白三烯受体1 选择性拮抗剂，可用于研究预防哮喘和肝损伤。它还可减少心脏损伤，在肠缺血-再灌注损伤中也具有抗氧化作用。
T3633 Crenigacestat LY3039478 Gamma-secretase
Crenigacestat 是一种口服具有活性的Notch 和γ-secretase 的抑制剂，其在多种肿瘤细胞中的IC50为 ∼1nM。
T1783 LXR-623 WAY 252623,LXR623 Liver X Receptor
LXR623 是一种LXRα部分激动剂和LXRβ完全激动剂，可透过血脑屏障，IC50分别为 179 nM 和 24 nM 。
T11991 Mefentrifluconazole Antifungal , P450
Mefentrifluconazole 是一种有效的、选择性的和具有口服活性的真菌 CYP51 (Kd= 0.5 nM) 抑制剂，但对人芳香酶的抑制活性较低，IC50值为0.92 μM。它是一种新型唑类衍生物，用作农用广谱抗真菌剂。
T6347 Ki16198 LPA Receptor , LPL Receptor
Ki16198 是一种可口服的 LPA 受体拮抗剂，是 Ki16425 的甲酯衍生物。它抑制 LPA1 和 LPA3 诱导的肌醇磷酸的Ki 值分别为 0.34 和 0.93 μM，可用于胰腺癌发生和转移的研究。
CO delivery molecule 1
T61328
synonym:
Target:
Biliverdin (hydrochloride)
T35981
synonym:
Target:
Chrysoobtusin
T8254
synonym:
Target:
SR9238
T16930
synonym:
Target:
SR9243
T1801
synonym:
Target:
RGX-104
T7768
synonym: RGX-104 free Acid
Target:
Antrodin A
T8733
synonym: (2-氯苯基)二苯基甲醇,camphorataanhydride A
Target:
AZ876
T5178
synonym:
Target:
GSK2033
T15427
synonym:
Target:
RGX-104 hydrochloride
T5128
synonym: 盐酸RGX-104,SB742881,RGX-104 HCl
Target:
CWP232228
T10904
synonym:
Target:
L-Ornithine L-aspartate
T19399
synonym: Ornithine Aspartate,L-鸟氨酸 L-天冬氨酸
Target:
ML-180
T12075
synonym: SR1848
Target:
27-Hydroxycholesterol
TQ0274
synonym: 27-羟基胆固醇,5,25R-胆甾烯-3BETA,26-二醇,25(R)-27-hydroxy Cholesterol
Target:
Montelukast
T1677
synonym: 孟鲁司特,Singular
Target:
Montelukast sodium
T1677L
synonym: MK0476,孟鲁司特钠
Target:
Crenigacestat
T3633
synonym: LY3039478
Target:
LXR-623
T1783
synonym: WAY 252623,LXR623
Target:
Mefentrifluconazole
T11991
synonym:
Target:
Ki16198
T6347
synonym:
Target:
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