kl 2

SEC inhibitor KL-2 (KL-2) is a potent and selective inhibitor of the super elongation complex (SEC), showing a dose-dependent inhibitory effect on the AFF4-CCNT1 interaction with a Ki of 1.50 μM.

NKL 22 (Histone Deacetylase Inhibitor IV) is an effective Histone Deacetylase Inhibitor.

SKL2001, an agonist of the Wnt/β-catenin pathway, can disrupt the Axin/β-catenin interaction.

CDK-IN-14 (Compound 9) serves as a potent and selective inhibitor of CDKL2 (Cyclin-dependent kinase-like 2), exhibiting an IC50 of 460 nM. Linked to biological processes such as tumor formation, development, and viral infections, CDKL2 is a substantial focus in the field. CDK-IN-14 holds promise as a powerful tool for the exploration of CDKL2s biological functions, potentially advancing research in areas like cancer and infectious diseases.

KL201, a circadian clock modulator, is an isoform-selective cryptochrome 1 (CRY1) stabilizer that lengthens the period of circadian rhythms in cells and tissues [1].

Anti-Mouse MHC Class II (β chain) Antibody (KL277) is an IgG antibody inhibitor sourced from hamster or mouse and targets mouse MHC Class II.

Biperiden Hydrochloride (KL 373 Hydrochloride) is an anticholinergic antiparkinsonian agent that selectively blocks central M1 cholinoreceptors while exerting atropine-like effects on peripheral parasympathetic structures. Biperiden Hydrochloride is approved for the adjunctive treatment of postencephalitic, idiopathic, and arteriosclerotic Parkinson’s disease, demonstrates minimal impairment of novelty preference compared with other anticholinergics in comparative cognitive studies, and is associated with known adverse effects including drowsiness, vertigo, headache, and dizziness.

KL-465, a MAGE-A3 PROTAC degrader, effectively degrades MAGE-A3 in HeLa cells with a DC50 of 2 μM. It also inhibits the proliferation of MAGE-A3-positive cancer cells, specifically in HCT116, A375, and HeLa cell lines.