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kca

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  • Inhibitors & Agonists
    11
    TargetMol | Inhibitors_Agonists
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    TargetMol | Peptide_Products
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KCA-1490
KCA 1490,KCA1490
T24257909719-71-7
KCA-1490 is an inhibitor of dual PDE3/4.
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8-10 weeks
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BKCa activator-1
T205564
BKCa activator-1 (Compound 51b) is an orally active activator of BKCa calcium-activated potassium channels with an EC50 of 2.82 μM. It promotes K+ efflux, leading to cell membrane hyperpolarization and inhibition of smooth muscle contraction. In a spontaneous hypertensive rat (SHR) model, it alleviates urinary incontinence and exhibits antitussive effects in a guinea pig cough model.
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KCa2 channel modulator 1
T609851019106-73-0
KCa2 channel modulator 1 (compound 2o) is an effective, subtype-selective K Ca2 channel positive modulator that potentiates rat KCa2.2 channels with an EC50 value of 0.99 μM and human KCa2.3 channels with an EC50 value of 0.19 μM [1].
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6-8 weeks
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KCa2 channel modulator 2
T60986
KCa2 channel modulator 2 (compound 2q) is an effective, subtype-selective K Ca 2 channel positive modulator with similar potency on the human K Ca 2.3 channel and rat K Ca 2.2a subtypes, exhibiting EC50 values of 0.60 μM and 0.64 μM, respectively [1].
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10-14 weeks
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KCa1.1 channel activator-1
T72194
KCa1.1 Channel Activator-1, a hybrid derivative of Quercetin, selectively stimulates the vascular KCa1.1 channels while also blocking CaV1.2 channels. Additionally, it demonstrates weak myorelaxant activity.
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8-10 weeks
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KCa1.1 channel activator-2
T72195
KCa1.1 channel activator-2, a hybrid derivative of Quercetin, selectively stimulates the vascular KCa1.1 channels. This compound demonstrates significant myorelaxant activity.
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6-8 weeks
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kCAL01
TP30231364717-03-2
kCAL01 is a CAL inhibitor with a Ki value of 2.3 μM and holds potential for research in cystic fibrosis (CF).
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Tipelukast
MN 001, KCA 757
T15647125961-82-2In house
Tipelukast (KCA 757) is a novel, orally available leukotriene receptor antagonist with anti-inflammatory properties, capable of reducing fibrosis and down-regulating TIMP-1 and type 1 collagen. Tipelukast is utilized in asthma research.
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10-14 weeks
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Hydrochlorothiazide
HCTZ
T144958-93-5
Hydrochlorothiazide (HCTZ) is a Thiazide Diuretic. The physiologic effect of hydrochlorothiazide is by means of Increased Diuresis.
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Scyllatoxin
T76184142948-19-4
Scyllatoxin (Leiurotoxin I), a peptide toxin derived from the venom of the scorpion (Leiurus quinquestriatus hebraeus), acts as a blocker of small-conductance K Ca (SK) channels. It notably enhances the release of norepinephrine (NE) and epinephrine (Epi) in vivo [1].
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Hydrochlorothiazid-d2
TMID-02381219798-89-6
Hydrochlorothiazid-d2 is a deuterated compound of Hydrochlorothiazid. Hydrochlorothiazid has a CAS number of 58-93-5. Hydrochlorothiazide is a Thiazide Diuretic. The physiologic effect of hydrochlorothiazide is by means of Increased Diuresis.
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35 days
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