hydrocortisone

Hydrocortisone (Cortisol) is a glucocorticoid hormone secreted by the adrenocortex. Hydrocortisone agonizes the glucocorticoid receptor, which promotes proteolytic metabolism, gluconeogenesis, capillary wall stabilization, and renal calcium excretion, as well as suppressing immune and inflammatory responses.

Hydrocortisone acetate (Cortisol 21-acetate) is the synthetic acetate salt form of hydrocortisone, a corticosteroid with anti-inflammatory and immunosuppressive properties.

Tetrahydrocortisone, the inactive metabolite of cortisone, is a product of cortisone's involvement in the stress response and its enzymatic reduction, and can be used as an indicator of cortisol metabolism.

5β-Dihydrocortisone, a sterol metabolite derived from cortisone, is produced in the liver through the action of 5β-reductase (AKR1D1).

5β-Dihydrocortisone is a sterol metabolite of cortisone produced by 5β-reductase (AKR1D1) in the liver, existing as a mixture of isomers.