human papillomavirus

Vorinostat (SAHA) is a pan-histone deacetylase (HDAC) inhibitor (IC50=10 nM) with inhibitory activity against HDAC1/2/3/6/7/11. Vorinostat has antitumor activity, induces cell differentiation, blocks the cell cycle and induces apoptosis.

Larixyl acetate is a bioactive chemical.

Retro-2 cycl is a dihydroquinazolinone (DHQZ) retrograde trafficking inhibitor. Retro-2 cycl (RN 1-001) inhibits JCPyV and HPV16 pseudovirus(IC50s of 54 μM and 160 μM, respectively),with antiviral agent.

TPCK is an irreversible inhibitor of chymotrypsin-like proteases that affect cell proliferation, apoptosis, and tumorigenesis

Human Papillomavirus (HPV) E7 protein (49-57) is the H-2d-restricted HPV E749-57 epitope.

Imiquimod (R 837) is an immune response modifier and a toll-like receptor 7 (TLR7) agonist with antiviral and antitumor effects. It is used in the study of external genital warts, perianal warts, cancer, and COVID-19, and is commonly employed to induce psoriasis models.

DSHS00884 is a potent inhibitor of human papillomavirus E6 (IC50: 10 μM).

DSPE-PEG(2000)-mannose, a pegylated and mannosylated derivative of 1,2-DSPE, has been employed in both in vitro and in vivo studies for delivering peptides, oligodeoxynucleotides, and siRNA via liposomes and lipid nanoparticles (LNPs). Fluorescently labeled LNPs containing DSPE-PEG(2000)-mannose predominantly accumulate in the liver and spleen of mice, significantly more so than in the brain, lungs, heart, kidneys, and pancreas. In immunization studies, liposomes encapsulating Human Papillomavirus type 16 (HPV16) E7 peptides with CpG oligodeoxynucleotides as an adjuvant led to reduced tumor volume and decreased numbers of CD4+ or CD8+ T cells and angiogenesis within tumors in a mouse lung cancer model using TC-1 cells.

PMEG-DP disodium is an effective inhibitor of DNA polymerase (IC50=2.5 μM), exerting strong inhibitory effects particularly on DNA polymerases α and δ. As the active metabolite of GS-9191, it efficiently impedes the growth of cell lines infected with human papillomavirus (HPV). PMEG-DP disodium is useful in research related to HPV-associated diseases.

RH02007 is an inhibitor of the human papillomavirus (HPV) E6 oncoprotein.

A2ti-1 is a highly selective inhibitor of annexin A2/S100A10 heterotetramer (A2t) (IC50: 24 μM) that inhibits ARV-mediated activation of Src and p38 mitogen-activated protein kinase (MAPK). A2ti-1 can be used to study human papillomavirus type 16 (HPV16) infection.

A2ti-2 is a low affinity and selective inhibitor of the membrane-bound protein A2/S100A10 heterotetramer (A2t) (IC50 : 230 μM).A2ti-2 exhibits antiviral activity by selectively disrupting protein interactions between A2 and S100A10, and protects against human papillomavirus type 16 (HPV16) infection.

C12 Galactosylceramide is a bioactive sphingolipid. It inhibits IL-4 production by 53.84% in EL4 T cells when used at a concentration of 10 μM. C12 Galactosylceramide reduces the growth of human papillomavirus type 16-associated tumors in mice and reduces tumor recurrence following surgical removal or chemotherapy. It also reduces natural killer T cell activity, delays the onset of proteinuria, and improves survival in a mouse model of systemic lupus.

Lig3 is an inhibitor against high-risk strains of human papillomavirus (HPV) E6 oncoprotein.

Verpasep caltespen (HspE7), a recombinant fusion protein, originates from the Mycobacterium bovis Calmette-Guérin heat shock protein 65 (Hsp65) and is covalently bonded at its C-terminal end to the E7 protein of HPV16. This compound has applications in researching both precancerous and cancerous lesions linked to the human papillomavirus (HPV) [1] [2].

E6-272, an inhibitor of HPV 16 (human papillomavirus 16), induced early and late apoptosis in HPV16-positive cervical cancer cells and inhibited the proliferation of HPV16-infected cells SiHa and CaSki with GI50 values of 32.56 and 62.09 nM, respectively.

The Anti-HPV18 L1 Antibody (H18L1-A) is a humanized antibody designed to target the L1 protein of Human Papillomavirus type 18 (HPV18). It functions by blocking the binding of HPV18 to cell surface receptors, thereby neutralizing viral activity and inhibiting viral infection of cells. This antibody holds potential for research in HPV-related diseases.

Hydroxymycotrienin B is an ansamycin antibiotic that exhibits activity against human neck tumor cell lines, showing stronger inhibitory effects on human papillomavirus (HPV) gene-positive neck tumor cells, such as HeLa, CaSKi, and SiHa, compared to HPV gene-negative cells.