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hdac 4

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    39
    TargetMol | Inhibitors_Agonists
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    1
    TargetMol | PROTAC
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    TargetMol | Natural_Products
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    TargetMol | Isotope_Products
HDAC-IN-4
T115421252003-13-6
HDAC-IN-4, a selective HDAC6 and HDAC10 inhibitor (pIC50s: 7.2 and 6.8 in the BRET assay), exhibits antitumoral activity.
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7-10 days
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c-Met/HDAC-IN-4
T200367
c-Met HDAC-IN-4, a dual inhibitor of c-Met HDAC, exhibits an IC 50 value of 28.92 nM for c-Met. This compound effectively induces G 0 G 1 phase cell cycle arrest and apoptosis in MDA-MB-231 breast cancer cells. Additionally, c-Met HDAC-IN-4 suppresses both the proliferation and invasion of breast cancer cell lines.
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CDK/HDAC-IN-4
T200504
CDK HDAC-IN-4 is a highly selective dual inhibitor of cyclin-dependent kinase (CDK) and histone deacetylase (HDAC), with IC50 values of 88.4 nM and 168.9 nM, respectively. This compound exhibits antiproliferative effects in both hematologic and solid tumor cells. Additionally, CDK HDAC-IN-4 induces apoptosis and S-phase cell cycle arrest in MV-4-11 cells. It has also demonstrated significant antitumor efficacy in an MV-4-11 xenograft model.
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JAK/HDAC-IN-4
T201233
JAK HDAC-IN-4 (compound 11 i) is a dual inhibitor targeting both JAK2 and HDAC6, with IC50 values of 0.49 nM and 12 nM respectively. It inhibits cell proliferation and the production of nitric oxide. In a mouse model induced by Imiquimod, JAK HDAC-IN-4 ameliorates psoriasiform skin lesions with low toxicity.
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HDAC/HSP90-IN-4
T64261
HDAC HSP90-IN-4 significantly inhibited HDAC and HSP90 activity, with compound 20 (HDACIC50= 194 nM; HSP90αIC50= 153 nM) and compound 26 ((HDACIC50= 360 nM; HSP90αIC50= 77 nM) having the strongest HDAC and HSP90α inhibition. effect. Both compounds induced HSP90 expression and down-regulated HSP90 client proteins, which play an important role in the regulation of cancer cell survival and invasion.
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10-14 weeks
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HDAC-IN-4-d4
TMIH-0260
HDAC-IN-4-d4 is a deuterated compound of HDAC-IN-4.
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7-10 days
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Tasquinimod
ABR-215050
T6695254964-60-8
Tasquinimod (ABR-215050) is an oral antiangiogenic agent with potential antitumor activity. It is also an S100A9 inhibitor and binds to the HDAC4Zn2+ binding structural domain with Kd values between 10 and 30 nM.
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TargetMol | Inhibitor Hot
Quisinostat
JNJ-26481585
T6055875320-29-9
Quisinostat (JNJ-26481585) (JNJ-26481585) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM, modest potent to HDACs 2, 4, 10, and 11; greater than 30-fold selectivity against HDACs 3, 5, 8, and 9 and lowest potency to HDACs 6 and 7.
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SantacruzaMate A
CAY-10683
T22661477949-42-0
SantacruzaMate A (CAY-10683) is a potent and selective HDAC inhibitor.
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TMP195
TMP 195, TFMO 2
T39831314891-22-9
TMP195 (TFMO 2) is a selective class IIa histone deacetylase (HDAC) inhibitor.
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TMP269
T18571314890-29-3
TMP269 is an effective, specific class IIa HDAC inhibitor for HDAC4 (IC50: 157 nM), HDAC5 (IC50: 97 nM), HDAC7 (IC50: 43 nM), and HDAC9 (IC50: 23 nM), respectively.
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TargetMol | Inhibitor Sale
Quisinostat dihydrochloride
Quisinostat 2HCl, Quisinostat (JNJ-26481585) 2HCl, JNJ26854165(Quisinostat) 2HCl, JNJ-26481585 2HCl
T6865875320-31-3
Quisinostat dihydrochloride (JNJ26854165(Quisinostat) 2HCl) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay, modest potent to HDACs 2, 4, 10, and 11; greater than 30-fold selectivity against HDACs 3, 5, 8, and 9 and lowest potency to HDACs 6 and 7. Phase 2.
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Pracinostat
SB939
T1890929016-96-6
Pracinostat (SB939) is a novel HDAC inhibitor with improved in vivo properties compared to other HDAC inhibitors currently in Clinicalal trials, allowing oral dosing. Data demonstrate that Pracinostat is a potent and effective anti-tumor drug with potential as an oral therapy for a variety of human hematological and solid tumors.
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CUDC-101
CUDC101, CUDC 101
T31081012054-59-9
CUDC-101 is a potent inhibitor of HDAC, EGFR, and HER2 with IC50s of 4.4 nM, 2.4 nM, and 15.7 nM, respectively.
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TargetMol | Inhibitor Sale
LMK-235
LMK235
T60611418033-25-6
LMK-235 is a potent HDAC inhibitor, and is used in cancer research.
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TargetMol | Inhibitor Sale
BRD73954
T64211440209-96-0
BRD73954, an effective and specific HDAC inhibitor, which is with IC50 of 36 nM and 120 nM for HDAC6 and HDAC8, respectively.
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Vorinostat
suberoylanilide hydroxamic acid, SAHA, MK0683
T1583149647-78-9
Vorinostat (SAHA) is a pan-histone deacetylase (HDAC) inhibitor (IC50=10 nM) with inhibitory activity against HDAC1 2 3 6 7 11. Vorinostat has antitumor activity, induces cell differentiation, blocks the cell cycle and induces apoptosis.
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TargetMol | Inhibitor Hot
romidepsin
NSC 630176, FR 901228, FK 228, Depsipeptide
T6006128517-07-7
Romidepsin (FR 901228) is an HDAC inhibitor that inhibits HDAC1 2 4 6 (IC50=36 47 510 1400 nM). Romidepsin has antitumor activity and can be used for the treatment of peripheral T-cell lymphoma and cutaneous T-cell lymphoma.
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TargetMol | Inhibitor Hot
Trichostatin A
TSA
T627058880-19-6
Trichostatin A (TSA), a natural derivative of diene isohydroxamic acids, is a specific and reversible histone deacetylase inhibitor (IC50=1.8 nM) that induces hyperacetylation of core histones to regulate chromatin structure.
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TargetMol | Inhibitor Hot
CRA-026440 hydrochloride
CRA-026440 hydrochloride(847460-34-8 Free base)
T10883L847459-98-7In house
CRA-026440 hydrochloride is a potent and broad-spectrum HDAC inhibitor. CRA-026440 hydrochloride exhibits Ki values against recombinant HDAC isoenzymes HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10 are 4 nM, 14 nM, 11 nM, 15 nM, 7 nM, and 20 nM, respectively. CRA-026440 hydrochloride exhibits antitumor and antiangiogenic activities.
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Sodium 4-phenylbutyrate
TriButyrate, Sodium Phenylbutyrate, Buphenyl
T15351716-12-7
Sodium 4-phenylbutyrate (TriButyrate), a transcriptional regulator, reversibly inhibits class I and II histone deacetylases (HDACs )resulting in a global increase in gene expression, decreased cellular proliferation, increased cell differentiation, and the induction of apoptosis in susceptible tumor cell populations.
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2-hexyl-4-Pentynoic Acid
T2155196017-59-3
2-hexyl-4-Pentynoic Acid, a valproic acid (VPA) derivatives, is a potent and robust HDACs inhibitor with IC50 value of 13 μM.
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Panobinostat
NVP-LBH589, LBH589
T2383404950-80-7
Panobinostat (NVP-LBH589) is a broad-spectrum HDAC inhibitor (IC50=5 nM) with oral activity and non-selectivity. Panobinostat has antitumor activity and induces apoptosis and autophagy.
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4-Phenylbutyric acid
Benzenebutyric acid
T58861821-12-1
4-Phenylbutyric acid (Benzenebutyric acid) is a histone deacetylase (HDAC) inhibitor and an endoplasmic reticulum stress (ERS) inhibitor. 4-Phenylbutyric acid can be used to treat urea cycle disorders.
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