en6

EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative agent in frontotemporal dementia, in a lysosome-dependent manner. EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v-ATPase).

3-[(3S,3aR,6S,7S,9aR,9bR)-3-[(2S,4E)-2-({5-[(acetyloxy)methyl]-3,4-dihydroxyoxolan-2-yl}oxy)-6-methoxy-6-methylhept-4-en-2-yl]-4-hydroxy-6,9a,9b-trimethyl-7-(prop-1-en-2-yl)-dodecahydro-1H-cyclopenta[a]naphthalen-6-yl]propanoic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

methyl 3-[(4R,6S,7S,9aR,9bR)-3-[(2S,4E)-2-hydroxy-6-methylhepta-4,6-dien-2-yl]-6,9a,9b-trimethyl-7-(prop-1-en-2-yl)-4-{[(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]oxy}-dodecahydro-1H-cyclopenta[a]naphthalen-6-yl]propanoate is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

5-[(1E)-2-(3,5-dimethoxyphenyl)ethenyl]-9-methyl-12-(prop-1-en-2-yl)-8-oxatricyclo[7.3.1.0^{2,7}]trideca-2(7),3,5-trien-6-ol is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

5-(butan-2-yl)-3-[(8R)-8-ethyl-2,3,8-trimethyl-4,7-dioxo-7,8-dihydro-4H-chromen-6-yl]-3-hydroxypyrrolidine-2,4-dione is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

(2R,3S,6R,13aR)-13-(acetyloxy)-3-(benzoyloxy)-13a-hydroxy-2,5,9,9,12-pentamethyl-8-oxo-1H,2H,3H,3aH,6H,7H,8H,9H,12H,13H,13aH-cyclopenta[12]annulen-6-yl benzoate is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

3-[3-(5-hydroperoxy-2-hydroxy-6-methylhept-6-en-2-yl)-6,9a,9b-trimethyl-7-(prop-1-en-2-yl)-dodecahydro-1H-cyclopenta[a]naphthalen-6-yl]propanoic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

3-{3-[(4E)-6-hydroperoxy-2-hydroxy-6-methylhept-4-en-2-yl]-6,9a,9b-trimethyl-7-(prop-1-en-2-yl)-dodecahydro-1H-cyclopenta[a]naphthalen-6-yl}propanoic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

3-[3-(2-{[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy}-5-hydroxy-6-methylhept-6-en-2-yl)-4-hydroxy-6,9a,9b-trimethyl-7-(prop-1-en-2-yl)-dodecahydro-1H-cyclopenta[a]naphthalen-6-yl]propanoic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

3-{3-[(4E)-2-{[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy}-6-hydroxy-6-methylhept-4-en-2-yl]-4-hydroxy-6,9a,9b-trimethyl-7-(prop-1-en-2-yl)-dodecahydro-1H-cyclopenta[a]naphthalen-6-yl}propanoic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

3-{3-[(4E)-2-({5-[(acetyloxy)methyl]-3,4-dihydroxyoxolan-2-yl}oxy)-6-hydroperoxy-6-methylhept-4-en-2-yl]-4-hydroxy-6,9a,9b-trimethyl-7-(prop-1-en-2-yl)-dodecahydro-1H-cyclopenta[a]naphthalen-6-yl}propanoic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

3-{3-[2-({5-[(acetyloxy)methyl]-3,4-dihydroxyoxolan-2-yl}oxy)-5-hydroxy-6-methylhept-6-en-2-yl]-4-hydroxy-6,9a,9b-trimethyl-7-(prop-1-en-2-yl)-dodecahydro-1H-cyclopenta[a]naphthalen-6-yl}propanoic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

3-[(3S,4R,6S,7S,9aR,9bR)-3-[(2S)-2-{[(2S,3R,4R,5S)-5-[(acetyloxy)methyl]-3,4-dihydroxyoxolan-2-yl]oxy}-5-hydroperoxy-6-methylhept-6-en-2-yl]-4-hydroxy-6,9a,9b-trimethyl-7-(prop-1-en-2-yl)-dodecahydro-1H-cyclopenta[a]naphthalen-6-yl]propanoic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

3-[(4R,6S,7S,9aR,9bR)-3-[(2S,4E)-2-{[(2S,3R,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy}-6-hydroperoxy-6-methylhept-4-en-2-yl]-4-hydroxy-6,9a,9b-trimethyl-7-(prop-1-en-2-yl)-dodecahydro-1H-cyclopenta[a]naphthalen-6-yl]propanoic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

3-[(3S,4R,6S,7S,9aR,9bR)-3-[(2S)-2-{[(2S,3R,4R,5S)-5-[(acetyloxy)methyl]-3,4-dihydroxyoxolan-2-yl]oxy}-5,6-dihydroxy-6-methylheptan-2-yl]-4-hydroxy-6,9a,9b-trimethyl-7-(prop-1-en-2-yl)-dodecahydro-1H-cyclopenta[a]naphthalen-6-yl]propanoic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

3-[(3S,4R,6S,7S,9aR,9bR)-3-[(2S,5S)-2,5-dihydroxy-6-methylhept-6-en-2-yl]-4-hydroxy-6,9a,9b-trimethyl-7-(prop-1-en-2-yl)-dodecahydro-1H-cyclopenta[a]naphthalen-6-yl]propanoic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

3-[(3S,4R,6S,7S,9aR,9bR)-3-[(2S)-2-{[(2S,3R,4R,5S)-5-[(acetyloxy)methyl]-3,4-dihydroxyoxolan-2-yl]oxy}-6-methyl-5-oxohept-6-en-2-yl]-4-hydroxy-6,9a,9b-trimethyl-7-(prop-1-en-2-yl)-dodecahydro-1H-cyclopenta[a]naphthalen-6-yl]propanoic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

3-{4-hydroxy-3-[(4E)-2-hydroxy-6-methoxy-6-methylhept-4-en-2-yl]-6,9a,9b-trimethyl-7-(prop-1-en-2-yl)-dodecahydro-1H-cyclopenta[a]naphthalen-6-yl}propanoic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

3-{3-[(4E)-2,6-dihydroxy-6-methylhept-4-en-2-yl]-6,9a,9b-trimethyl-7-(3-oxoprop-1-en-2-yl)-4-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}-dodecahydro-1H-cyclopenta[a]naphthalen-6-yl}propanoic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

3-[3-(2-{[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy}-5,6-dihydroxy-6-methylheptan-2-yl)-4-hydroxy-6,9a,9b-trimethyl-7-(prop-1-en-2-yl)-dodecahydro-1H-cyclopenta[a]naphthalen-6-yl]propanoic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

3-{3-[(4E)-2,6-dihydroxy-6-methylhept-4-en-2-yl]-6,9a,9b-trimethyl-7-(3-oxoprop-1-en-2-yl)-4-{[(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]oxy}-dodecahydro-1H-cyclopenta[a]naphthalen-6-yl}propanoic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

3-[3-(5-hydroperoxy-6-methyl-2-{[(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]oxy}hept-6-en-2-yl)-4-hydroxy-6,9a,9b-trimethyl-7-(prop-1-en-2-yl)-dodecahydro-1H-cyclopenta[a]naphthalen-6-yl]propanoic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

3-[(4R,6S,7S,9aR,9bR)-3-[(2S,4E)-2,6-dihydroxy-6-methylhept-4-en-2-yl]-6,9a,9b-trimethyl-7-(prop-1-en-2-yl)-4-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-dodecahydro-1H-cyclopenta[a]naphthalen-6-yl]propanoic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

3-{3-[(4E)-2-hydroxy-6-methoxy-6-methylhept-4-en-2-yl]-6,9a,9b-trimethyl-7-(prop-1-en-2-yl)-4-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-dodecahydro-1H-cyclopenta[a]naphthalen-6-yl}propanoic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.