en6

EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative agent in frontotemporal dementia, in a lysosome-dependent manner. EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v-ATPase).

3,5,7-Trihydroxy-p-menth-1-en-6-one, 5-Tigloyl, 3 is a useful organic compound for research related to life sciences and the catalog number is T130192.

(E)-3-(1H-Imidazol-4-ylmethylen)-6-(1H-indol-3-ylm is a useful organic compound for research related to life sciences and the catalog number is T130795.

3,11-Dihydroxy-7-drimen-6-one is a useful organic compound for research related to life sciences and the catalog number is T130890.

Sulcatol is classified as a secondary alcohol with documented pheromonal activity. Sulcatol has been identified in various organisms including Daphne odora and Hypnogyra angularis.

AUTEN-67 is a specific inhibitor of MTMR14 and autophagy enhancer with potent antiaging and neuroprotective effects. AUTEN-67 also delays the onset and decreases the severity of Huntington's disease.

L-Lysine, N6,N6'-(1,8-dioxo-1,8-octanediyl)bis- is a bioactive chemical.

GNE-6776 is a selective USP7 inhibitor.

NSC243928 mesylate binds to human lymphocyte antigen 6 (LY6), a cell growth inhibitor with anticancer activity, and induces cell death in triple-negative breast cancer cells in a LY6K-dependent manner.

Furanogermacra-1(10)Z,4Z-dien-6-one, a furanosesquiterpenoid, is found in Commiphora myrrha [1].

6-Biotin-17-NAD+ sodium (Biotin-LC-NAD+ sodium) is a biotinylated derivative of NAD+ and can be used to measure NADH dehydrogenase activity.

6β-hydroxy Testosterone （4-Androsten-6β,17β-diol-3-one） is a 17β-hydroxy steroid, an androgen and endogenous metabolite, obtained by metabolizing testosterone.

[(1(10)E,2R,4R)]-2-Methoxy-8,12-epoxygermacra-1(10),7,11-trien-6-one, a sesquiterpene from turmeric, is also known as (1(10)E,2R*,4R*)-2-Methoxy-8,12-epoxygermacra-1(10),7,11-trien-6-one.

2-Methoxy-5-acetoxy-furanogermacr-1(10)-en-6-one is a natural product

11-Hydroxydrim-7-en-6-one is a natural product for research related to life sciences. The catalog number is TN2584 and the CAS number is 74635-87-3.

9alpha,11,12-Trihydroxydrim-7-en-6-one is a natural product for research related to life sciences. The catalog number is TN3331 and the CAS number is 192566-65-7.

9alpha,11-Dihydroxydrim-7-en-6-one is a natural product for research related to life sciences. The catalog number is TN3332 and the CAS number is 127681-58-7.

3β,5α,9α-Trihydroxy-ergosta-7,22-dien-6-one in the presence of NGF (20 ng/mL) exerts a significant increase in neurite-bearing cells.

3β,5α-Dihydroxy-(22E,24R)-ergosta-7,22-dien-6-one exhibits strong or moderate cytotoxic activities against MCF-7, A549, Hela and KB cell lines with IC50 values 4.98 (MCF-7), 1.95 (A549), 0.68(Hela), and 1.50 uM (KB), respectively.

3-Hydroxy-p-menth-1-en-6-one is a natural product for research related to life sciences. The catalog number is TN5861 and the CAS number is 61570-82-9.

1,2-Epoxy-10(14)-furanogermacren-6-one is a natural product for research related to life sciences. The catalog number is TN6491 and the CAS number is 383368-24-9.

(1E)-3-methoxy-8,12-epoxygermacra-1,7,10,11-tetraen-6-one is a natural product for research related to life sciences. The catalog number is TN6492 and the CAS number is 1393342-06-7.

Building block - others

Acetyl tetrapeptide-3 is a bioactive chemical.