en-6

EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative agent in frontotemporal dementia, in a lysosome-dependent manner. EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v-ATPase).

1-hydroxy-3-(hydroxymethyl)-4,8,11,11-tetramethyl-2-oxatricyclo[5.3.1.0^{3,8}]undec-4-en-6-one is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

3,5,7-Trihydroxy-p-menth-1-en-6-one, 5-Tigloyl, 3 is a useful organic compound for research related to life sciences and the catalog number is T130192.

2-Methoxy-5-acetoxy-furanogermacr-1(10)-en-6-one is a natural product

11-Hydroxydrim-7-en-6-one is a natural product for research related to life sciences. The catalog number is TN2584 and the CAS number is 74635-87-3.

9alpha,11,12-Trihydroxydrim-7-en-6-one is a natural product for research related to life sciences. The catalog number is TN3331 and the CAS number is 192566-65-7.

9alpha,11-Dihydroxydrim-7-en-6-one is a natural product for research related to life sciences. The catalog number is TN3332 and the CAS number is 127681-58-7.

3-Hydroxy-p-menth-1-en-6-one is a natural product for research related to life sciences. The catalog number is TN5861 and the CAS number is 61570-82-9.

7,10-dimethoxy-2,2-dimethyl-8-pentyl-2H,7H,8H,10H-pyrano[4,3-h]chromen-6-ol is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

3,8a-dihydroxy-3,8-dimethyl-5-(propan-2-ylidene)-1,2,3,3a,4,5,6,8a-octahydroazulen-6-one is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

1,3-dihydroxy-1-(7-methoxy-2-oxo-2H-chromen-6-yl)-3-methylbutan-2-yl 3-methylbutanoate is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

2,3-dihydroxy-1-(7-methoxy-2-oxo-2H-chromen-6-yl)-3-methylbutyl 3-methylbut-2-enoate is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

1,3-dihydroxy-1-(7-methoxy-2-oxo-2H-chromen-6-yl)-3-methylbutan-2-yl 3-methylbut-2-enoate is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

2,3-dihydroxy-1-(7-methoxy-2-oxo-2H-chromen-6-yl)-3-methylbutyl (2Z)-2-methylbut-2-enoate is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

2,3,7-trihydroxy-9-methoxy-4a-methyl-2H,3H,4H,4aH,6H-benzo[c]chromen-6-one is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

3,11-Dihydroxy-7-drimen-6-one is a useful organic compound for research related to life sciences and the catalog number is T130890.

AUTEN-67 is a specific inhibitor of MTMR14 and autophagy enhancer with potent antiaging and neuroprotective effects. AUTEN-67 also delays the onset and decreases the severity of Huntington's disease.

Furanogermacra-1(10)Z,4Z-dien-6-one, a furanosesquiterpenoid, is found in Commiphora myrrha [1].

4-Pregnen-6α-Methyl-17-Ol-3,20-Dione-D7 (Standard) is a reference standard of 4-Pregnen-6α-Methyl-17-Ol-3,20-Dione-D7 intended for quantitative analysis, quality control, and related biochemical research applications.

4-Pregnen-6α-Methyl-17-Ol-3,20-Dione 17-Acetate-D3 (Standard) is a reference standard of 4-Pregnen-6α-Methyl-17-Ol-3,20-Dione 17-Acetate-D3 intended for quantitative analysis, quality control, and related biochemical research applications.

4,6-Pregnadien-6-Methyl-17α-Ol-3,20-Dione Acetate-D3 (Standard) is a reference standard of 4,6-Pregnadien-6-Methyl-17α-Ol-3,20-Dione Acetate-D3 intended for quantitative analysis, quality control, and related biochemical research applications.

4,6-Pregnadien-6-Me-16-Methylene-17-Ol-3,20-Dione-D2 Ac (Standard) is a reference standard of 4,6-Pregnadien-6-Me-16-Methylene-17-Ol-3,20-Dione-D2 Ac intended for quantitative analysis, quality control, and related biochemical research applications.

4,6-Pregnadien-6-Methyl-17α-Ol-3,20-Dione-D5 (Standard) is a reference standard of 4,6-Pregnadien-6-Methyl-17α-Ol-3,20-Dione-D5 intended for quantitative analysis, quality control, and related biochemical research applications.

4-Pregnen-6α-Methyl-17-Ol-3,20-Dione-D7 17-Acetate (Standard) is a reference standard of 4-Pregnen-6α-Methyl-17-Ol-3,20-Dione-D7 17-Acetate intended for quantitative analysis, quality control, and related biochemical research applications.