en-6

EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative agent in frontotemporal dementia, in a lysosome-dependent manner. EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v-ATPase).

1-hydroxy-3-(hydroxymethyl)-4,8,11,11-tetramethyl-2-oxatricyclo[5.3.1.0^{3,8}]undec-4-en-6-one is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

3,5,7-Trihydroxy-p-menth-1-en-6-one, 5-Tigloyl, 3 is a useful organic compound for research related to life sciences and the catalog number is T130192.

2-Methoxy-5-acetoxy-furanogermacr-1(10)-en-6-one is a natural product

11-Hydroxydrim-7-en-6-one is a natural product for research related to life sciences. The catalog number is TN2584 and the CAS number is 74635-87-3.

9alpha,11,12-Trihydroxydrim-7-en-6-one is a natural product for research related to life sciences. The catalog number is TN3331 and the CAS number is 192566-65-7.

9alpha,11-Dihydroxydrim-7-en-6-one is a natural product for research related to life sciences. The catalog number is TN3332 and the CAS number is 127681-58-7.

3-Hydroxy-p-menth-1-en-6-one is a natural product for research related to life sciences. The catalog number is TN5861 and the CAS number is 61570-82-9.

7,10-dimethoxy-2,2-dimethyl-8-pentyl-2H,7H,8H,10H-pyrano[4,3-h]chromen-6-ol is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

3,8a-dihydroxy-3,8-dimethyl-5-(propan-2-ylidene)-1,2,3,3a,4,5,6,8a-octahydroazulen-6-one is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

1,3-dihydroxy-1-(7-methoxy-2-oxo-2H-chromen-6-yl)-3-methylbutan-2-yl 3-methylbutanoate is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

2,3-dihydroxy-1-(7-methoxy-2-oxo-2H-chromen-6-yl)-3-methylbutyl 3-methylbut-2-enoate is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

1,3-dihydroxy-1-(7-methoxy-2-oxo-2H-chromen-6-yl)-3-methylbutan-2-yl 3-methylbut-2-enoate is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

2,3-dihydroxy-1-(7-methoxy-2-oxo-2H-chromen-6-yl)-3-methylbutyl (2Z)-2-methylbut-2-enoate is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

2,3,7-trihydroxy-9-methoxy-4a-methyl-2H,3H,4H,4aH,6H-benzo[c]chromen-6-one is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

3,11-Dihydroxy-7-drimen-6-one is a useful organic compound for research related to life sciences and the catalog number is T130890.

AUTEN-67 is a specific inhibitor of MTMR14 and autophagy enhancer with potent antiaging and neuroprotective effects. AUTEN-67 also delays the onset and decreases the severity of Huntington's disease.

Furanogermacra-1(10)Z,4Z-dien-6-one, a furanosesquiterpenoid, is found in Commiphora myrrha [1].

[(1(10)E,2R,4R)]-2-methoxy-8,12-epoxygemacra-1(10),7,11-trien-6-one, a sesquiterpene from turmeric, is also known as (1(10)E,2R*,4R*)-2-Methoxy-8,12-epoxygermacra-1(10),7,11-trien-6-one.

1,3-dihydroxy-1-(7-methoxy-2-oxo-2H-chromen-6-yl)-3-methylbutan-2-yl (2Z)-2-methylbut-2-enoate is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

6-hydroxy-2-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)-2-methoxy-2,3-dihydro-1-benzofuran-3-one is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

7-ethyl-8-hydroxy-3,4,7-trimethyl-7,8-dihydro-6H-isochromen-6-one is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

7-ethyl-8-hydroxy-3-(hydroxymethyl)-4,7-dimethyl-7,8-dihydro-6H-isochromen-6-one is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

3β,5α,9α-Trihydroxy-ergosta-7,22-dien-6-one in the presence of NGF (20 ng/mL) exerts a significant increase in neurite-bearing cells.