en 6

EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative agent in frontotemporal dementia, in a lysosome-dependent manner. EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v-ATPase).

1-hydroxy-3-(hydroxymethyl)-4,8,11,11-tetramethyl-2-oxatricyclo[5.3.1.0^{3,8}]undec-4-en-6-one is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

3,5,7-Trihydroxy-p-menth-1-en-6-one, 5-Tigloyl, 3 is a useful organic compound for research related to life sciences and the catalog number is T130192.

2-Methoxy-5-acetoxy-furanogermacr-1(10)-en-6-one is a natural product

11-Hydroxydrim-7-en-6-one is a natural product for research related to life sciences. The catalog number is TN2584 and the CAS number is 74635-87-3.

9alpha,11,12-Trihydroxydrim-7-en-6-one is a natural product for research related to life sciences. The catalog number is TN3331 and the CAS number is 192566-65-7.

9alpha,11-Dihydroxydrim-7-en-6-one is a natural product for research related to life sciences. The catalog number is TN3332 and the CAS number is 127681-58-7.

3-Hydroxy-p-menth-1-en-6-one is a natural product for research related to life sciences. The catalog number is TN5861 and the CAS number is 61570-82-9.

Building block - others

6-(4-Hydroxyphenyl)-2-methylhept-2-en-4-one is a useful organic compound for research related to life sciences and the catalog number is T123873.

5α,8α-Epidioxyergost-6-en-3β-ol is a useful organic compound for research related to life sciences and the catalog number is T124161.

(S,E)-2-Methyl-6-(p-tolyl)hept-3-en-2-ol is a useful organic compound for research related to life sciences and the catalog number is T125520.

8-Oxoeremophil-6-en-12-oic aicd is a useful organic compound for research related to life sciences and the catalog number is T126063.

[4-(5,7-dihydroxy-6-methylidenehept-1-en-2-yl)-6-hydroxycyclohex-1-en-1-yl]methyl 2-methylpropanoate is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

5-[(5E)-7-hydroxy-6-methylhepta-1,5-dien-2-yl]-2-(hydroxymethyl)cyclohex-2-en-1-ol is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

(1S,4aS,5S)-1,4a-dimethyl-6-methylidene-5-[(1E)-3-oxobut-1-en-1-yl]-decahydronaphthalene-1-carboxylic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

6-[(1E)-2-(3,5-dimethoxyphenyl)ethenyl]-2-methoxy-3-[3-methyl-6-(prop-1-en-2-yl)cyclohex-2-en-1-yl]phenol is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

3-[2,4-dihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]-5,7-dihydroxy-6-(3-methylbut-2-en-1-yl)-4H-chromen-4-one is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

2,4-dihydroxy-5-[7-hydroxy-5-methoxy-6-(3-methylbut-2-en-1-yl)-2-oxo-2H-chromen-3-yl]benzoic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

2-hydroxy-6-[2-hydroxy-3-(hydroxymethyl)-5-methylphenoxy]-3-(3-methylbut-2-en-1-yl)benzoic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

3-hydroxy-2-(1-hydroxyethyl)-6-[(1E)-prop-1-en-1-yl]-2H,3H,4H-furo[3,2-c]pyran-4-one is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

5-[(1E)-but-1-en-1-yl]-6-(hydroxymethyl)-4-methoxy-2H-pyran-2-one is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

(2E)-6-hydroxy-6-(1-hydroxy-4-methylcyclohex-3-en-1-yl)-2-methylhept-2-enoic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

3,4,8a-trihydroxy-4-methyl-3-(3-methylbut-2-en-1-yl)-octahydro-1H-2-benzopyran-6-one is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.