Search Result

Search Results for " dual-specificity "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T2431	ID-8	ID8	DYRK
	ID-8, a DYRK inhibitor, sustains embryonic stem cell self-renewal in long-term culture.		DYRK
T15422	GSK-626616		DYRK
	GSK-626616 is a potent and orally bioavailable DYRK3 inhibitor (IC50: 0.7 nM). It inhibits other members of the DYRK family with similar potency. GSK-626616 is a potential therapy for the treatment of anemia.		DYRK
T6257	AZ191		DYRK
	AZ191（IC50 of 17 nM） is an effective and specific DYRK1B inhibitor. The specificity of AZ191 for DYRK1B is about 5- and 110-fold greater over DYRK1A and DYRK2, respectively.		DYRK
TQ0111	LDN-192960		DYRK , Haspin Kinase
	LDN-192960 is a potent inhibitor of Haspin and DYRK2 (IC50s: 10 nM and 48 nM).		DYRK , Haspin Kinase
T11447	GNF4877		GSK-3 , DYRK
	GNF4877 is a potent DYRK1A and GSK3β inhibitor (IC50s: 6 nM and 16 nM). It leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation cells.		GSK-3 , DYRK
T40187	GNF2133		DYRK
	GNF2133 is an effective and selective inhibitor of DYRK1A with IC50s of 6.2 nM. GNF2133 can be used in studies about type 1 diabetes.		DYRK
T14980	CLK-IN-T3		DYRK , CDK
	CLK-IN-T3 is an inhibitor of CLK1, CLK2, and CLK3 with IC50s of 0.67, 15, and 110 nM. CLK-IN-T3 exhibits anti-cancer activity.		DYRK , CDK
T7323	BCI-215		Phosphatase
	BCI-215 causes selective cancer cell cytotoxicity in part through non-redox-mediated activation of MAPK signaling		Phosphatase
T14364	AZ-Dyrk1B-33	3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine	DYRK
	AZ-Dyrk1B-33 (3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine) is a potent and selective Dyrk1B kinase inhibitor with an IC50 of 7 nM.		DYRK
T4636	Protein kinase inhibitors 1		Others , DYRK
	Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC50 of 74 nM and Kd of 9.5 nM.		Others , DYRK
T16357	DA-3003-1	NSC 663284	Phosphatase
	DA-3003-1 (DA-3003-1) is a membrane-permeable, potent and selective Cdc25 dual specificity phosphatase inhibitor with antitumor activity that inhibits Cdc25B2, Cdc25A, Cdc25B2 and Cdc25C.		Phosphatase
T4308	F1063-0967		Phosphatase
	F1063-0967 is a Dual-specificity phosphatase 26 (DUSP26) inhibitor with an IC50 of 11.62 μM.		Phosphatase
T12263L	NSC305787 hydrochloride	(Rac)-NSC305787 hydrochloride	Others
	NSC305787 hydrochloride ((Rac)-NSC305787 hydrochloride is a cell membrane permeable and selective and potent small molecule dual inhibitor of Cdc25 dual specificity phosphatase and EZR that displays antitumor activity in...		Others
T10486	BCI	(E)-BCI	Phosphatase
	BCI ((E)-BCI) is an allosteric inhibitor of dual-specificity phosphatase (DUSP; EC50s: 13.3 and 8.0 μM for DUSP6 and DUSP1 in cells) and does not inhibit DUSP5.		Phosphatase
T16350	NSC-87877		Apoptosis , Phosphatase
	NSC-87877 is an effective inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (IC50=0.318 μM, 0.355 μM of shp2 and shp1, respectively).It also inhibits dual-specificity phosphatase 26 (DUSP26).		Apoptosis , Phosphatase
T2381	Abemaciclib	CDK4/6 dual inhibitor,LY2835219	CDK
	Abemaciclib (LY2835219) is a dual inhibitor of CDK4/6 (IC50=2/10 nM) with selectivity and specificity. Abemaciclib has antitumor activity and is used to treat advanced or metastatic breast cancer.		CDK
T7078	NSC 95397		Apoptosis , Phosphatase
	NSC 95397 is a potent inhibitor of Cdc25 dual specificity phosphatase(Ki of 32, 96, and 40 nM for Cdc25A, Cdc25B, and Cdc25C, respectively).		Apoptosis , Phosphatase
T11139	(E/Z)-BCI	NSC 150117	Apoptosis , Phosphatase
	(E/Z)-BCI (NSC-150117), a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory properties, reduces LPS-induced inflammatory mediators and ROS production in macrophage cells by activating the Nrf2 signa...		Apoptosis , Phosphatase
T11830	LDN-192960 hydrochloride		Others
	LDN-192960 hydrochloride is an inhibitor of Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) and Haspin with IC50s of 48 nM and 10 nM, respectively.		Others
T10486L	BCI hydrochloride	(E)-BCI hydrochloride	Others
	BCI hydrochloride specifically inhibits DUSP6 and DUSP1 with EC50s of 13.3 and 8.0 μM in cells, respectively. BCI hydrochloride does not inhibit DUSP5. BCI hydrochloride is an allosteric inhibitor of dual specificity ph...		Others
T11132	DYRKs-IN-1		DYRK
	DYRKs-IN-1 has antitumor activity. DYRKs-IN-1 is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC50s of 9 nM and 5 nM for DYRK1B and DYRK1A, respectively.		DYRK
T40968	MLS-0437605
	MLS-0437605 is a potent and selective inhibitor of dual-specificity phosphatase 3 (DUSP3), with an IC50 of 3.7 μM. It exhibits higher selectivity towards DUSP3 in comparison to DUSP22 and other protein tyrosine phosphata...
T72242	DYRKs-IN-1 hydrochloride
	DYRKs-IN-1 hydrochloride is a potent inhibitor of Dual-specificity tyrosine-phosphorylation-regulated kinases (DYRKs), exhibiting IC50 values of 5 nM and 8 nM for DYRK1A and DYRK1B, respectively. This compound demonstrat...
T69826	U-0126
	U0126 is a highly selective inhibitor of both MEK1 and MEK2, a type of MAPK/ERK kinase. It was found to functionally antagonize AP-1 transcriptional activity via noncompetitive inhibition of the dual specificity kinase M...
T71163	Pimasertib HCl
	Pimasertib HCl is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. Pimasertib selectively binds to and inhibits the activity of MEK1/2, preventing the acti...
T60824	Dyrk1A-IN-3
	Dyrk1A-IN-3 (Compound 8b) is a highly selective inhibitor of dual-specificity tyrosine-regulated kinase 1A (DYRK1A). Dyrk1A-IN-3 has high binding affinity of DYRK1A with an IC 50 of 76 nM. Dyrk1A-IN-3 can be used in neur...

Compounds

Target: DYRK, Haspin Kinase

Synonym: 3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine

Target: DYRK

Protein kinase inhibitors 1

NSC305787 hydrochloride

T12263L

Synonym: (Rac)-NSC305787 hydrochloride

Target: Apoptosis, Phosphatase

Abemaciclib

T2381

Synonym: CDK4/6 dual inhibitor,LY2835219

Target: Apoptosis, Phosphatase

(E/Z)-BCI

T11139

Synonym: NSC 150117

Target: Apoptosis, Phosphatase

LDN-192960 hydrochloride

Synonym: (E)-BCI hydrochloride

DYRKs-IN-1 hydrochloride

Cat No.	Product Name	Synonyms	Targets
T1711	Harmine	Telepathine	MAO , 5-HT Receptor , DYRK
	Harmine (Telepathine) is an alkaloid isolated from seeds of Peganum harmala.		MAO , 5-HT Receptor , DYRK
T2811	Harmine hydrochloride	telepathine hydrochloride	5-HT Receptor , DYRK , GluR
	Harmine hydrochloride (telepathine hydrochloride) is extracted from Peganum Harmala Genus.		5-HT Receptor , DYRK , GluR
T10238	Aclacinomycin A hydrochloride	Aclarubicin hydrochloride	Proteasome
	Aclacinomycin A (Aclarubicin) hydrochloride is a fluorescent molecule and the first described non-peptidic inhibitor showing discrete specificity for the CTRL (chymotrypsin-like) activity of the 20S proteasome. Aclacinom...		Proteasome

Natural Products

Harmine

T1711

Synonym: Telepathine

Target: MAO, 5-HT Receptor, DYRK

Harmine hydrochloride

T2811

Synonym: telepathine hydrochloride

Target: 5-HT Receptor, DYRK, GluR

Aclacinomycin A hydrochloride

T10238

Synonym: Aclarubicin hydrochloride

Target: Proteasome

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-02127	DUSP3 Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	Vaccinia H1-related phosphatase (VHR) is classified as a dual-specificity phosphatase (DUSP), and the other name is dual-specificity phosphatase 3 (DUSP3). DUSPs are a heterogeneous group of protein phosphatases that can...
TMPY-03482	DUSP3 Protein, Human, Recombinant	Human	Baculovirus-Insect Cells
	Vaccinia H1-related phosphatase (VHR) is classified as a dual-specificity phosphatase (DUSP), and the other name is dual-specificity phosphatase 3 (DUSP3). DUSPs are a heterogeneous group of protein phosphatases that can...
TMPJ-00996	VHR Protein, Human, Recombinant (His)	Human	E. coli
	Human DUSP3 belongs to the dual specificity protein phosphatase subfamily. DUSPs are a heterogeneous group of protein phosphatases that can dephosphorylate both phosphotyrosine and phosphoserine/phosphothreonine residues...
TMPY-02595	DUSP14 Protein, Human, Recombinant (His & MBP)	Human	E. coli
	Dual specific phosphatase 14 / MAP-kinase phophatase-6 (DUSP14 / MKP6) is a member of Dual-specificity phosphatases that is a subclass of protein tyrosine phosphatases (PTP) families that can dephosphorylate bothe phosph...
TMPH-01703	CDC25C Protein, Human, Recombinant (His)	Human	E. coli
	Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly de...
TMPY-04380	DYRK3 Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	Dual specificity tyrosine-phosphorylation-regulated kinase 3, also known as Regulatory erythroid kinase, REDK and DYRK3, is a nucleus protein which belongs to theprotein kinase superfamily, CMGC Ser/Thr protein kinase...
TMPH-01251	DUSP26 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis...
TMPY-04572	MKK4 Protein, Mouse, Recombinant (His & GST)	Mouse	Baculovirus-Insect Cells
	Dual specificity mitogen-activated protein kinase kinase 4, also known as MAP kinase kinase 4, MAPKK4, JNK-activating kinase 1, MAPK/ERK kinase 4, SAPK/ERK kinase 1, c-Jun N-terminal kinase kinase 1, JNKK, and MAP2K4, is...
TMPY-04546	CLK3 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	Dual specificity protein kinase CLK3, also known as CDC-like kinase 3, and CLK3, is a member of CMGC Ser/Thr protein kinase family and Lammer subfamily. Mammalian CLK is the prototype for a family of dual specificity ...
TMPH-01250	MAP2K3 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that...
TMPY-04544	MEK2 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	Dual specificity mitogen-activated protein kinase kinase 2, also known as MAP kinase kinase 2, MAPKK2, ERK activator kinase 2, MAPK / ERK kinase 2, MEK2 and MAP2K2, is a member of the protein kinase superfamily, STE Ser/...
TMPH-03254	PDE1C Protein, Rat, Recombinant (His)	Rat	E. coli
	Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both c...
TMPY-04569	MEK1 Protein, Mouse, Recombinant (His & GST)	Mouse	Baculovirus-Insect Cells
	MEK1, also known as MAP2K1 and MKK1, is a member of the dual-specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kin...
TMPY-04756	MEK1 Protein, Mouse, Recombinant	Mouse	Baculovirus-Insect Cells
	MEK1, also known as MAP2K1 and MKK1, is a member of the dual-specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kin...
TMPY-05095	RAF1 Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	RAF1 gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds direct...
TMPY-04749	MKK6 Protein, Human, Recombinant (S207D, T211D)	Human	Baculovirus-Insect Cells
	Dual specificity mitogen-activated protein kinase kinase 6, also known as MAP kinase kinase 6, MAPKK 6, MAPK / ERK kinase 6, SAPKK3, MAP2K6, and MKK6, is a protein that belongs to the protein kinase superfamily, STE Ser ...
TMPY-04364	MKK6 Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	Dual specificity mitogen-activated protein kinase kinase 6, also known as MAP kinase kinase 6, MAPKK 6, MAPK / ERK kinase 6, SAPKK3, MAP2K6, and MKK6, is a protein that belongs to the protein kinase superfamily, STE Ser ...
TMPY-01819	PDE1B Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B, also known as Cam-PDE 1B and PDE1B, is a cytoplasm protein that belongs to the cyclic nucleotide phosphodiesterase family and PDE1 subfamily. Pho...
TMPY-04365	MKK6 Protein, Human, Recombinant (S207D, T211D, His & GST)	Human	Baculovirus-Insect Cells
	Dual specificity mitogen-activated protein kinase kinase 6, also known as MAP kinase kinase 6, MAPKK 6, MAPK / ERK kinase 6, SAPKK3, MAP2K6, and MKK6, is a protein that belongs to the protein kinase superfamily, STE Ser ...
TMPY-04748	MKK6 Protein, Human, Recombinant	Human	Baculovirus-Insect Cells
	Dual specificity mitogen-activated protein kinase kinase 6, also known as MAP kinase kinase 6, MAPKK 6, MAPK / ERK kinase 6, SAPKK3, MAP2K6, and MKK6, is a protein that belongs to the protein kinase superfamily, STE Ser ...
TMPY-02977	PDE1C Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	PDE1C belongs to the cyclic nucleotide phosphodiesterase family, PDE1 subfamily. Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3' cyclic phosphate bonds ...
TMPY-02081	PDE2A Protein, Human, Recombinant (aa 215-900, His)	Human	Baculovirus-Insect Cells
	cGMP-dependent 3',5'-cyclic phosphodiesterase, also known as cyclic GMP-stimulated phosphodiesterase and PDE2A, is a peripheral membrane protein that belongs to the cyclic nucleotide phosphodiesterase family and PDE2 sub...
TMPY-02519	BLVRB Protein, Human, Recombinant (His)	Human	E. coli
	Biliverdin reductase (hBVR) is a serine/threonine kinase that catalyzes reduction of the heme oxygenase (HO) activity product, biliverdin, to bilirubin. BVR consists of an N-terminal dinucleotide-binding domain (Rossmann...
TMPY-04539	ERK2 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, diffe...
TMPY-04571	ERK2 Protein, Mouse, Recombinant (His & GST)	Mouse	Baculovirus-Insect Cells
	MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, diffe...