d-13

D13 is an acylhydrazone antifungal.1 It is active against C. neoformans in vitro (MIC80 = 0.06 μg/ml). D13 (20 mg/kg per day, p.o.) increases survival in mouse models of C. neoformans, C. albicans, or A. fumigatus infection. |1. Lazzarini, C., Haranahalli, K., Rieger, R., et al. Acylhydrazones as antifungal agents targeting the synthesis of fungal sphingolipids. Antimicrob. Agents Chemother. 62(5), e00156-00118 (2018).

Colfosceril miristate-D13 (DMPC-D13) is the deuterated form of Colfosceril miristate. Colfosceril miristate (T9525) (DMPC) is a synthetic phospholipid utilized in the study of liposomes and lipid bilayers. It is employed for research on lipid monolayers and bilayers.

Choline-D13 Bromide (N,N,N-trimethyl-D9; 1,1,2,2-D4) is a deuterated compound of Choline Bromide. Choline Bromide (TYD-01307) has a CAS number of 1927-06-6.

Guanosine-D13 is the deuterated form of Guanosine. Guanosine (T6523) (DL-Guanosine) is a type of nucleoside composed of guanine linked to a ribose ring through a β-N9-glycosidic bond. It exhibits activity against HSV (herpes simplex virus).

MES-D13 is the deuterated form of MES. MES (2-Morpholinoethanesulphonic acid) serves as a zwitterionic buffer with an effective buffering range of pH 5.5-7.0. As a Good's buffer, MES is extensively used in biochemistry and molecular biology experiments, including cell culture, enzyme activity assays, electrophoresis, and protein research.

1,2-Distearoyl-sn-glycero-3-phosphorylcholine-D13 is the deuterated variant of 1,2-Distearoyl-sn-glycero-3-phosphorylcholine. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (T9510) (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a lipid utilized in liposome synthesis and serves as a lipid component in lipid nanoparticle (LNP) systems.

Choline-D13 chloride is a deuterated form of Choline chloride (T1039). Choline chloride, an organic compound and a quaternary ammonium salt, acts as both a substrate for acyl receptors and choline acetyltransferase. It serves as a photosynthesis enhancer in plants and is also used as a feed additive for poultry and livestock to boost egg and offspring production.

Thymol-D13 is the deuterated analog of Thymol. Thymol (T3S0717) is a major monoterpenol found in essential oils derived from plants belonging to the Lamiaceae family, as well as other families such as Verbenaceae, Scrophulariaceae, and Ranunculaceae. It exhibits antioxidant, anti-inflammatory, antibacterial, and antifungal properties.

Palmitoleic acid-D13 is the deuterated form of Palmitoleic acid (T4872). Palmitoleic acid, a component of fatty acids, has the potential to prevent death from cerebrovascular diseases in SHRSP rats.

Acetylcholine-D13 bromide is the deuterated form of Acetylcholine bromide (T20344).

Adenosine-D13 is a deuterium-labeled form of Adenosine. Adenosine (T0853) (Adenine riboside) is a widely present endogenous secretion that exerts effects via four G-protein-coupled receptors (A1, A2A, A2B, and A3). It influences nearly all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.

2'-Deoxyguanosine-D13 is a deuterium-labeled form of 2'-Deoxyguanosine (T22218) (Deoxyguanosine), also known as guanine deoxyriboside.

Lusutrombopag-D13 is a deuterated compound of Lusutrombopag. Lusutrombopag (TQ0223) has a CAS number of 1110766-97-6. Lusutrombopag (TQ0223) is an orally bioavailable, small molecule thrombopoietin (TPO) receptor agonist for chronic liver disease (CLD) patients with thrombocytopenia prior to elective invasive surgery.

Alachlo-D13 (2,6-diethylphenyl-D13) is a deuterated compound of Alachlo.

Acetylcholine-[D13] Bromide (N,N,N-Trimethyl-D9; 1,1,2,2-D4) (Standard) is a reference standard of Acetylcholine-[D13] Bromide (N,N,N-Trimethyl-D9; 1,1,2,2-D4) intended for quantitative analysis, quality control, and related biochemical research applications.

Heptanoic-D13 Acid (Standard) is a reference standard of Heptanoic-D13 Acid intended for quantitative analysis, quality control, and related biochemical research applications.

Palmitoleic Acid-D13 (Standard) is a reference standard of Palmitoleic Acid-D13 intended for quantitative analysis, quality control, and related biochemical research applications. Palmitoleic acid-d13 is the deuterated form of Palmitoleic acid. Palmitoleic acid, a component of fatty acids, has the potential to prevent death from cerebrovascular diseases in SHRSP rats.

VVD-130037 is a small molecule activator specifically targeting Kelch-like ECH-associated protein 1 (KEAP1) with potential antitumor activity.VVD-130037 inhibits tumor growth in advanced solid tumors by degrading NRF2.

AZD-1305 is a novel anti-arrhythmic compound that primarily blocks the fast component of IKr, l-type calcium currents and intra-ward sodium currents in mammalian cells and ventricular cardiomyocytes and can be used in studies to reverse arrhythmias.

JD-13 is a novel and potent Hsp90α inhibitor that binds to the ATP-binding pocket of Hsp90α (Kd = 1.60 μM), downregulates the Akt/β-catenin pathway, inhibits both wild-type and acyclovir-resistant HSV-1 infections, and alleviates skin lesions in guinea pigs caused by HSV-1 infection.

NPD1335, a potent inhibitor of Trypanosoma brucei phosphodiesterase B1 (TbrPDEB1), exhibits submicromolar activity against T. brucei parasites and an improved cytotoxicity profile. By elevating intracellular cAMP levels, NPD1335 disrupts the cell cycle, leading to cell death [1].

EMD 132338 is a GPIIb/IIIa antagonist.

SMARCA2 ligand-13 is a ligand for the target protein in PROTAC (Proteolysis Targeting Chimera). It serves as a component for synthesizing PROTAC constructs.

CRBN ligand-13, a CRBN-type E3 ubiquitin ligase ligand, is applicable in the preparation of PROTAC.