ceramide 1 a

Ceramide 1 A is a waxy lipid compound that is a lipid in the top skin layer. It has a special molecular structure because it contains a linoleic acid linked to a long chain omega-hydroxy acid.

C16 Ceramide (d16:1,C16:0) is a bioactive sphingolipid that induces the formation and thermal stabilization of ordered phases and gel phases enriched in palmitoyl sphingomyelin domains within palmitoyl phosphatidylcholine (POPC) bilayers. It is found in human erythrocyte sphingomyelin.

Ceramide 1-phosphate, a bioactive lipid, is a critical component of sphingolipids. It plays versatile roles in various cellular behaviors, including differentiation, migration, proliferation, and apoptosis.

C16 Ceramide (Cer) (d18:1(14Z)/16:0) is a sphingolipid-derived ceramide composed of long-chain sphingoid base (d18:1) and palmitic acid (C16:0). It serves as a crucial lipid signaling molecule for apoptosis. Specifically, C16 ceramide is involved in cell cycle arrest, cell death, and the inhibition of insulin signaling.

C24 Ceramide (d18:1(14Z)/24:0) is a type of ceramide utilized in obesity research.

C18:1 Ceramide (d18:1/18:1(9Z)) is a ceramide, and C18:1-Ceramide levels are elevated in overweight and insulin-resistant mice and cattle, as well as in plasma and ovarian tissue of patients with advanced ovarian cancer.

C19 Ceramide is a naturally occurring ceramide that has been found in J. juncea extracts as well as rat brain and mouse heart.[1],[2],[3] It is elevated in adult and decreased in juvenile whole rat brain extracts by 114 and 37%, respectively, following chronic ethanol exposure.[2] C19 Ceramide is also increased in mouse hearts following administration of angiotensin II.[3]

C2 Ceramide (d14:1/2:0) is a bioactive sphingolipid that, when administered dietarily at 100 μM, induces lipotoxic cardiomyopathy by increasing diastolic and systolic diameter, reducing fractional shortening, and decreasing the number of normal cardiac contractile events in Drosophila.

C18 D-threoCeramide (d18:1/18:0) is a synthetic ceramide and stereoisomer of C18 ceramide .1It inhibits rat brain mitochondrial ceramidase (mt-CDase) with an IC50value of 16.6 μM.2[Matreya, LLC. Catalog No. 1855] 1.Koolath, S., Murai, Y., Suga, Y., et al.Chiral combinatorial preparation and biological evaluation of unique ceramides for inhibition of sphingomyelin synthaseChirality32(3)308-313(2019) 2.Usta, J., El Bawab, S., Roddy, P., et al.Structural requirements of ceramide and sphingosine based inhibitors of mitochondrial ceramidaseBiochemistry40(32)9657-9668(2001)

C4 Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. [1] [2] [3] It inhibits IL-4 production by 16% in EL4 T cells stimulated with phorbol 12-myristate 13-acetate when used at a concentration of 10 μM. [1] C4 Ceramide is cytotoxic to SK-BR-3 and MCF-7/Adr breast cancer cells (IC50s = 15.9 and 19.9 μM, respectively). [2] C4 Ceramide also increases maturation and stability of cystic fibrosis transmembrane conductance regulator (CFTR) proteins bearing the F508 deletion (F508del) mutation, enhances cAMP-activated chloride secretion, and suppresses secretion of IL-8 in primary epithelial cells isolated from patients with cystic fibrosis.[3]

C18 Ceramide-1-phosphate (d18:1/18:0) is a long-chain molecule identified in murine skin, promoting the migration of mouse bone marrow-derived multipotent stromal cells and human umbilical vein endothelial cells (HUVECs) at concentrations of 0.5 to 5 µM. It exhibits elevated levels in CFPAC-1 pancreatic ductal adenocarcinoma cells compared to pancreatic cancer stem cells, and its myocardial concentration is heightened in Langendorff isolated perfused mouse hearts under an ex vivo ischemia model.

C8 Ceramide-1-phosphate (d18:1/8:0) is a lipid molecule that can be used in life science related research. The CAS number of C8 Ceramide-1-phosphate (d18:1/8:0) is 158983-53-0.

C2 L-erythro Ceramide (d18:1/2:0) is a lipid molecule that can be used in life science related research. The CAS number of C2 L-erythro Ceramide (d18:1/2:0) is 150338-90-2.

C15 Ceramide (d18:1/15:0) is a lipid molecule that can be used in life science related research. The CAS number of C15 Ceramide (d18:1/15:0) is 67492-15-3.

C10 Ceramide (d18:1/10:0) is a lipid molecule that can be used in life science related research. The CAS number of C10 Ceramide (d18:1/10:0) is 111122-57-7.

C32 Ceramide (d18:1/32:0) is a lipid molecule that can be used in life science related research. The CAS number of C32 Ceramide (d18:1/32:0) is 34227-73-1.

C16 (2'(S)-hydroxy) Ceramide (d18:1/16:0) is a lipid molecule that can be used in life science related research. The CAS number of C16 (2'(S)-hydroxy) Ceramide (d18:1/16:0) is 890041-50-6.

C18 ((±)-2'-hydroxy) Ceramide (d18:1/18:0) is a lipid molecule that can be used in life science related research. The CAS number of C18 ((±)-2'-hydroxy) Ceramide (d18:1/18:0) is 34249-41-7.

C6 Biotin Ceramide (d18:1/6:0) is a lipid molecule that can be used in life science related research. The CAS number of C6 Biotin Ceramide (d18:1/6:0) is 192070-02-3.

C2 Ceramide-1-phosphate is a phospholipid known for its excellent biocompatibility and notable amphiphilic properties, making it an ideal and primary component in drug formulations to enhance therapeutic outcomes. It is particularly useful in the research of drug delivery systems.

C24:1 Ceramide-d7 is a deuterated compound of C24:1 Ceramide.

C22:1 Ceramide (d18:1(14Z)/22:1(13Z)) is a derivative of ceramide-1-phosphate (C1P).

C24:1 GD2 Ceramide (d18:1/24:1) is a type of sphingoid base linked to a fatty acid. It can interact with other membrane lipids, securing GD2 firmly on the cell surface.

1-O-Acyl ceramide (d18:1/18:1/16:0) is a type of 1-O-acyl ceramide. These compounds play a crucial role in inhibiting the function of the lipid layer barrier.