c87

C 87 is a small-molecule TNF-α inhibitor. C 87 directly binds to TNFα, potently inhibits TNF-α-induced cytotoxicity (IC50 = 8.73 μM), and effectively blocks TNF-α-triggered signaling activities.

IC87201 is a nNOS-PDZ/PSD-95-PDZ inhibitor. IC87201 showed great promise in cellular experiments and animal models of ischemic stroke and pain.

IC87361 is a potent and specific inhibitor of DNA-PK.

UNC8732 is a Targeted Protein Degradation (TPD) agent. It acts by catalyzing the production of aldehyde metabolites through amine oxidase, which subsequently binds to the C326 of the ubiquitin E3 ligase FBXO22, recruiting the SCFFBXO22 Cullin complex. This recruitment leads to the further degradation of the histone methyltransferase and the oncogene NSD2.

(E)-2-Butenoic acid (Crotonic acid) is fatty acid formed by the action of fatty acid synthases from acetyl-CoA and malonyl-CoA precursors. Crotonic acid is involved in the fatty acid biosynthesis. Crotonic acid is also found in water extracts from carrot seeds (Daucus carota L.).

Combretastatin A4 (CA4) is a microtubule-targeting agent that binds β-tubulin (Kd: 0.4 μM).

NSC-87877 is an effective inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (IC50=0.318 μM, 0.355 μM of shp2 and shp1, respectively).It also inhibits dual-specificity phosphatase 26 (DUSP26).

Indican (Indoxyl-β-D-glucoside) is a natural protective compound that is used to protect the liver.

AXC-879 is a TLR agonist with an EC50 of 157.2 nM. It serves as an ADC cytotoxin utilized in the synthesis of ADCs.

IC-87114 is a specific PI3Kδ inhibitor(IC50=0.5 μM).

NSC-87877 disodium (NSC87877) is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively. It also inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.

UNC 8732 functions as a potent NSD2 degrader with a DC50 of 60 nM.