benzimidazole

2-Chloro-1-(4-fluorobenzyl)benzimidazole is an inhibitor of aldose reductase (ALR2).

1,3-Dimethyl-2-oxobenzimidazole-5-carbaldehyde serves as an intermediate.

2-(2-Hydroxyphenyl)-1H-benzimidazole has been used as a catalyst for the synthesis of polymers and other materials.

Emedastine (LY188695) is a second generation, selective histamine H1 receptor antagonist with anti-allergic activity. Emedastine reversibly and competitively blocks histamine by binding to H1 receptors, thus blocking its downstream activity. As a result this agent interferes with mediator release from mast cells either by inhibiting calcium ion influx across mast cell/basophil plasma membrane or by inhibiting intracellular calcium ion release within the cells. In addition, emedastine may also inhibit the late-phase allergic reaction mediated through leukotrienes or prostaglandins, or by producing an anti-platelet activating factor effect. Upon ocular administration, emedastine causes a dose-dependent inhibition of histamine-stimulated vascular permeability in the conjunctiva. Emedastine does not affect adrenergic, dopamine, or serotonin receptors.

Thiabendazole (2-(4-Thiazolyl)benzimidazole) is a benzimidazole derivative with anthelminthic property.

Carbendazim (Mercarzole) is a broad-spectrum benzimidazole antifungal with potential antimitotic and antineoplastic activities. Although the exact mechanism of action is unclear, carbendazim appears to binds to an unspecified site on tubulin and suppresses microtubule assembly dynamic. This results in cell cycle arrest at the G2/M phase and an induction of apoptosis.

WAY-230563 is a serine/threonine kinase inhibitor that blocks CHK1/CHK2-mediated cell cycle checkpoints, leading to G2/M phase arrest in tumour cells following DNA damage.

Sepin-1 is a noncompetitive inhibitor of separase (IC50 = 14.8 µM). Sepin-1 can inhibit the growth of breast cancer xenograft tumors in mice and human cancer cell lines by inhibiting cell proliferation and inducing apoptosis.

MCHB-1, a potent agonist of the human cannabinoid 2 (CB2) receptor (EC50= 0.52 nM), demonstrates high selectivity for CB2 over CB1 (Kis = 3.7 and 110 nM, respectively), distinguishing itself from similar benzimidazole compounds that significantly alleviate peripheral pain while minimizing central nervous system side effects in mice.

AI-10-47 (1H-Benzimidazole, 2-(2-pyridinyl)-6-(trifluoromethoxy)-AI-10-47) is a small molecule inhibitor of CBFβ-RUNX binding(IC50 : 3.2 μM).

1H-Benzimidazole-2-methanamine, 6-chloro-, dihydrochloride, with CAS No. 1185297-00-0, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1H-Benzimidazole-2-methanamine, 6-chloro-, dihydrochloride provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

2-PYRROLIDIN-2-YL-1H-BENZIMIDAZOLE DIHYDROCHLORIDE, with CAS No. 1049751-43-0, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2-PYRROLIDIN-2-YL-1H-BENZIMIDAZOLE DIHYDROCHLORIDE provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Compound 15788-16-6, with CAS No. 15788-16-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound 15788-16-6 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

4-Hydroxy-N,N,2-trimethyl-1H-benzimidazole-6-carboxamide is a pharmaceutical intermediate employed in the synthesis of various active compounds.

1H-Benzimidazole-6-carboxamide, N-[3-(aminocarbonyl)-4,5,6,7-tetrahydrobenzo[b]thien-2-yl]- may have antitumor activity.

2-(Trifluoromethyl)benzimidazole a novel in vitro and in vivo inducer of iron death with antiparasitic activity.

2-(3-HYDROXYPROPYL)BENZIMIDAZOLE, with CAS No. 2403-66-9, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2-(3-HYDROXYPROPYL)BENZIMIDAZOLE provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

1H-Benzimidazole-6-carboxylic acid is a GLP-1 receptor agonist.

Compound Fr14210, with CAS No. 934-32-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound Fr14210 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

2-Hydroxybenzimidazole (2-Benzimidazolinone) is used as an intermediate in industry.

2-AMINO-1-METHYLBENZIMIDAZOLE, with CAS No. 1622-57-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2-AMINO-1-METHYLBENZIMIDAZOLE provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

2-Benzimidazolebutyricacid,1-methyl-(8CI), with CAS No. 802044-51-5, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2-Benzimidazolebutyricacid,1-methyl-(8CI) provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

2-Propylbenzimidazole, with CAS No. 5465-29-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2-Propylbenzimidazole provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

4,5,6,7-Tetrabromobenzimidazole is a selective, ATP-competitive inhibitor of protein kinase CK2 [1].