b 61

JAK1-IN-B61 is a JAK1 inhibitor.

BI-665915 is a 5-lipoxygenase activating protein inhibitor.

HSD17B13-IN-61 (Compound 132) acts as an inhibitor against hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), featuring an IC50 value of ≤ 0.1 μM for estradiol. This compound is utilized in the study of various health conditions, including liver diseases, metabolic diseases, and cardiovascular diseases like NAFLD or NASH. It is also relevant in the investigation of drug-induced liver injury (DILI) [1].

SKLB610, a novel multi-targeted inhibitor, inhibits angiogenesis-related tyrosine kinase VEGFR2, FGFR2, and PDGFR at a rate of 97%, 65%, and 55%, respectively, at the concentration of 10 μM in biochemical kinase assays.

Arachidonylcyclopropylamide (AM1241) is a highly effective and selective agonist for the CB2R. This compound specifically targets the CB2 receptor, making it a valuable tool for research and therapeutic applications that exploit CB2-specific pathways without affecting CB1 receptors.

SB 611812 is an antagonist of urotensin-II (UT) and can be used in studies about the treatment of cardiovascular disease.

RB 6145 is a bifunctional nitroimidazole, a prodrug of the hypoxic cell radiosensitizer RSU 1069, which has reduced toxicity compared to RSU 1069. It has hypoxic cell preferential cytotoxicity and antitumor therapeutic activity.

M+B 6153 is a bioactive chemical.

CBLB 612 is both an auxiliary anti-radiation and an anti-tumor agent [1].

SB-616234-A is a selective, orally bioavailable antagonist of the 5-HT1B receptor with anxiolytic and antidepressant properties.

H3B-616, as a powerful allosteric inhibitor of Carbamoyl phosphate synthetase 1 (CPS1) with an IC50 of 66 nM, targets CPS1, identified as a potential synthetic lethal target in LKB1-deficient non-small cell lung cancer. This overexpression of CPS1 facilitates pyrimidine synthesis in these cancer cells.

(E/Z)-MCB-613 acts as a broad-spectrum steroid receptor coactivator (SRC) stimulator. It enhances SRC activity within cancer cells, leading to excessive production of reactive oxygen species (ROS), which causes cellular stress and paraptosis. This cytotoxic compound plays a significant role in cancer therapy.

NOP receptor antagonist

SB-612111 is a novel and potent human opiate receptor-like orphan receptor (ORL-1) antagonist with a high affinity for hORL-1 (Ki = 0.33 nM). It exhibits selectivity for μ-, κ-, and δ-receptors with Ki values of 57.6 nM, 160.5 nM, and 2109 nM, respectively. SB-612111 effectively antagonizes the pronociceptive action of Nociceptin in an acute pain model[1].

SB-612111 hydrochloride is a potent, novel orphan receptor for opioid receptors (ORL-1) antagonist with high affinity for hORL-1 and a Ki value of 0.33 nM. SB-612111 hydrochloride is able to act on mu-receptor (Ki: 57.6 nM), κ SB-612111 hydrochloride effectively antagonized the nociceptive effects of Nociceptin in an acute pain model.

MCB-613 is an effective steroid receptor coactivator (SRC) stimulator.

Sodium 2-mercaptobenzothiazole is the sodium salt of mercaptobenzothiazole, and is used as a copper corrosion inhibitor.

RNB-61 is an orally active cannabinoid CB2 receptor (CB2R) agonist, displaying a Ki range between 0.13 nM and 1.81 nM. It possesses renal protective and/or anti-fibrotic properties. Additionally, the permeability of RNB-61 into the brain is negligible.

7-Bromo-benzo[b]thiophene ,with CAS No. 1423-61-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 7-Bromo-benzo[b]thiophene provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Balicatib (AAE581) is a potent and selective inhibitor of cathepsin K, used in trials studying the treatment of osteoporosis.

AIC263282 is a potent capsid assembly modulator for the hepatitis B virus (HBV) with an EC50 of 3.8 nM. It exhibits an IC50 of 61 nM against hERG and effectively inhibits viral replication and hepatitis B surface antigen (HBsAG) in primary human hepatocytes.

Danusertib (PHA-739358) is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity. Danusertib binds to and inhibits the Aurora kinases, which may result in cell growth arrest and apoptosis in tumor cells in which Aurora kinases are overexpressed.

AT-61 is a nonnucleoside analogue inhibitor of hepatitis B virus (HBV) replication.

LSD1-IN-12 (compound 2) is an effective inhibitor of LSD1, with inhibitory Ki values of 1.1 μM (LSD1), 61 μM (LSD2), 2.3 μM (MAO-A), and 3.5 μM (MAO-B) [1].