Search Result

Search Results for " anti-angiogenic "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T8616	Fasentin	N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide	transporter
	Fasentin (N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide) is an inhibitor of GluT1.		transporter
T7541	PTP inhibitor 1	PTP Inhibitor II	Phosphatase
	PTP inhibitor 1 is an inhibitor of cell-permeable protein tyrosine phosphatase (PTP) that covalently binds the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)),with Ki of128 μM.		Phosphatase
T2160	Suramin Sodium Salt	BAY-205,Suramin hexasodium salt,NF-060	Apoptosis , Phosphatase , SARS-CoV , Sirtuin , Reverse Transcriptase , Topoisomerase , Parasite
	Suramin Sodium Salt (BAY-205) is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth f...
T7057	Methylstat		Histone Demethylase , Others
	Methylstat is a methyl ester prodrug of a Jumonji C domain-containing histone demethylase (JMJD) inhibitor that has favorable cell permeability. The free acid of methylstat inhibits JMJD2A, JMJD2C, JMJD2E, PHF8, and JMJD...		Histone Demethylase , Others
T24804	SM27	SM-27,NSC-37204,SM 27,NSC37204	FGFR
	SM27 is a fibroblast growth factor 2 (FGF2) inhibitor with anti-angiogenic activity and can be used to study tumours.		FGFR
T28911	Tafetinib	SIM-010603,SIM010603,SIM 010603	Tyrosine Kinases
	Tafetinib (SIM-010603) is a novel potent and orally available tyrosine kinase inhibitor with anti-angiogenic and anti-tumour activity.		Tyrosine Kinases
T12644L	(S)-Thalidomide	(S)-(-)-Thalidomide	Apoptosis
	(S)-Thalidomide ((S)-(-)-Thalidomide) is the S-isomer of Thalidomide with immunomodulatory, anti-inflammatory, anticancer, anti-angiogenic and pro-apoptotic activities, and is used in the study of leprosy erythema nodosu...		Apoptosis
T6279L	Givinostat hydrochloride	ITF2357 hydrochloride,Givinostat HCl,ITF2357,ITF 2357,ITF-2357,ITF2357 HCl	HDAC
	Givinostat hydrochloride (ITF2357 hydrochloride) is an inhibitor of HDAC with IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat hydrochloride exhibits anti-inflammatory, anti-angiogenic, and antineopla...		HDAC
T36712	BPHA	MMP-2/MMP-9 Inhibitor II	MMP
	BPHA (MMP-2/MMP-9 Inhibitor II) is a potent, selective and orally active inhibitor of MMP-2, MMP-9 and MMP-14 with IC50s of 12 nM, 16 nM and 17 nM, respectively.BPHA does not inhibit MMP-1, -3 and -7 (IC50s of 974, >1000...		MMP
T77728	Tubulin polymerization-IN-55		Microtubule Associated
	Tubulin polymerization-IN-55 is a potent Tubulin Polymerization inhibitor with potential anti-angiogenic and anti-tumour activity, showing anti-proliferative effects against A549, K562, HepG2, MDA-MB-231 and HFL-1.		Microtubule Associated
T0213	Thalidomide	Thalomid,Sedoval	Apoptosis , TNF , Autophagy , Ligand for E3 Ligase , Molecular Glues
	Thalidomide (Thalomid) is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic properties.
T24997	ABT-510 acetate	ABT 510 acetate	Apoptosis
	ABT-510 acetate is an endogenous anti-angiogenic TSP peptide inhibitor, a thrombospondin analog, with anti-inflammatory, anti-cancer and anti-angiogenic activity that induces apoptosis and inhibits ovarian tumor growth i...		Apoptosis
T2656	Fruquintinib	HMPL-013	VEGFR
	Fruquintinib (HMPL-013) is an orally available, small molecule inhibitor of vascular endothelial growth factor receptors (VEGFRs), with potential anti-angiogenic and antineoplastic activities.		VEGFR
T0153	Oltipraz	NSC 347901,RP 35972	HIF/HIF Prolyl-Hydroxylase , HIV Protease , Reverse Transcriptase , Nrf2 , HIF
	Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as glutathione S transferase (GST) and NAD(P)H: quin...
T2384	Pomalidomide	CC-4047	Apoptosis , TNF , Ligand for E3 Ligase , Molecular Glues
	Pomalidomide (CC-4047) inhibits TNF-α release in LPS stimulated human PBMCs (IC50: 13 nM). It is an anti-angiogenic agent and an immunomodulator.		Apoptosis , TNF , Ligand for E3 Ligase , Molecular Glues
T79860	TIE-2/VEGFR-2 kinase-IN-5		VEGFR , Tie-2
	TIE-2/VEGFR-2 kinase-IN-5 is a potent TIE-2 and VEGFR-2 tyrosine kinase receptor inhibitor with anti-angiogenic activity and is commonly used in biomedical research related to angiogenesis.		VEGFR , Tie-2
T9127	MYLS22		Others
	MYLS22 is a first-in-class and selective inhibitor of optic atrophy 1 (OPA1) . MYLS22 can target endothelial OPA1 to curtail tumor growth and inhibits angiogenesis by impinging on NFkB activity and on angiogenic gene exp...		Others
T10883	CRA-026440	PCI-34051	HDAC
	CRA-026440(PCI-34051) is a highly potent HDAC inhibitor with inhibitory effects on HDAC1, HDAC2, HDAC3, HDAC6, HDAC8 and HDAC10 with Ki values of 4,14,11,15,7 and 20 nM, respectively. CRA-026440 has anti-tumor and anti-a...		HDAC
T14366	AZ10606120 dihydrochloride		P2X Receptor
	AZ10606120 dihydrochloride is a selectable, potent, high-affinity receptor antagonist with K D values of 1.4 and 19 nM at human and rat P2X 7 receptors, respectively. AZ10606120 dihydrochloride inhibits tumor growth and ...		P2X Receptor
T11154L	EG01377 2HCl	EG01377 2HCl(2227996-00-9 Free base)	Complement System
	EG01377 2HCl is a potent, bioavailable and selective inhibitor of neuropilin-1 (NRP1) with a Kd value of 1.32 μM and an IC50 value of 609 nM for both EG01377 2HCl against NRP1-a1 and NRP1-b1.EG01377 exhibits anti-angioge...		Complement System
T1792	Regorafenib	BAY 73-4506,Fluoro-Sorafenib	Raf , VEGFR , c-RET , PDGFR , c-Kit , Autophagy
	Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orally active. Regorafenib has antitumor and anti-angiogenic activity.		Raf , VEGFR , c-RET , PDGFR , c-Kit , Autophagy
T4632	NSC 6038	4-chloro-N,N-dipropylbenzamide,4-Chloro-N,N-di-n-propylbenzaMide	Others
	NSC-6038 (4-chloro-N,N-dipropylbenzamide) is a benzamide-based bioactive compound with a wide range of biological activities and has been shown to possess anti-inflammatory, antioxidant and anti-angiogenic activities, an...		Others
T33701	NM-3	NM-3,isocoumarin,NM 3,Isocoumarin NM-3,NM3	Apoptosis , Reactive Oxygen Species
	NM-3 is an orally available anti-angiogenic inhibitor with anti-tumour activity.NM-3 is used as a radiation modulator in vitro and in vivo.NM-3 inhibits vascular endothelial growth factor (VEGF), thereby inhibiting the p...		Apoptosis , Reactive Oxygen Species
T1185	Rofecoxib	MK 966,MK-0966	COX
	Rofecoxib (MK 966) binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in an inhibition of the conversion of arachidonic acid to prostaglandins. Rofecoxib is a synthetic, nonsteroidal derivative of pheny...		COX
T70226	Amentoflavone hexaacetate
	Amentoflavone hexaacetate is a 3,5-cyclic nucleotide phosphodiesterase inhibitor. It has anti-angiogenic and anti-metastatic effects.
T11519	GW768505A free base		Others
	GW768505A free base is a potent dual inhibitor of VEGFR2 (KDR) and Tie-2 (pIC50: 7.81 for VEGFR2) with anti-angiogenic activity.		Others
T26469	A-176120
	A-176120 is a potent farnesyl pyrophosphate (FPP) analogues, it selectively inhibits farnesyltransferase. It has anti-angiogenic potential and may reduce H-ras NIH3T3 tumour growth.
T11325	Frondoside A		Others
	possesses anticancer, anti-invasive, anti-metastasis, anti-angiogenic and pro-apoptosis properties with high safety.Frondoside A, a natural glycoside extracted from the sea cucumber, Cucumaria frondosa,		Others
T10635	Burixafor hydrobromide	TG-0054 hydrobromide	CXCR
	Burixafor hydrobromide (TG-0054 hydrobromide) is an orally bioavailable and potent CXCR4 antagonist and an anti-angiogenic drug that is of potential value in treating choroid neovascularization.		CXCR
T36294	D-2-Aminoglutarimide (hydrochloride)
	D-2-Aminoglutarimide is a synthetic intermediate.1It has been used in the synthesis of hydantoins with anti-angiogenic and cancer cell differentiation-inducing activities. 1.Yamaguchi, J., Noguchi-Yachide, T., Sakaguchi,...
T13141	Thalidomide D4		Others
	Thalidomide D4 is a deuterium labeled Thalidomide, has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties.		Others
T82401	Fibulostatin 6.3
	Fibulostatin 6.3 is an anti-angiogenic peptide utilized in research related to angiogenesis inhibition [1].
T81549	Papilostatin-2
	Papilostatin-2 is an anti-angiogenic peptide utilized for research purposes in the study of angiogenesis inhibition [1].
T69599	ABT-510
	ABT-510 is synthetic peptide that mimics the anti-angiogenic activity of the endogenous protein thrombospondin-1 (TSP-1). ABT-510 inhibits the actions of several pro-angiogenic growth factors important to tumor neovascul...
T82776	Cartilostatin 1
	Cartilostatin 1, an anti-angiogenic peptide, has potential applications in research focused on angiogenesis inhibition [1].
T68935	BMS-645737
	BMS-645737 is an inhibitor of vascular endothelial growth factor (VEGF) receptor-2 and fibroblast growth factor (FGF) receptor-1. BMS-646737 has anti-angiogenic activity and was evaluated in nonclinical studies as a trea...
T71752	Metoprolol fumarate	Lopressor OROS,CGP 2175C,CGP 2175C ; Lopressor OROS
	Metoprolol fumarate (CGP 2175C) is a selectively active β1-adrenoceptor antagonist administered orally. It exhibits anti-inflammatory, antitumor, and anti-angiogenic properties.
T83170	Adamtsostatin 4
	Adamtsostatin 4, an anti-angiogenic peptide, is utilized in research related to angiogenesis inhibition [1].
T81188	Scospondistatin
	Scospondistatin, an anti-angiogenic peptide, inhibits both proliferation and migration of human umbilical vein endothelial cells in vitro [1].
T40614	LCKLSL
	LCKLSL, an N-terminal hexapeptide, acts as a competitive inhibitor of annexin A2 (AnxA2), effectively preventing the binding of tissue plasminogen activator (tPA) to AnxA2 while also inhibiting the generation of plasmin....
T40581	TIE-2/VEGFR-2 kinase-IN-2
	TIE-2/VEGFR-2 kinase-IN-2 is a powerful inhibitor of both VEGFR2 and Tie-2 kinases, displaying noteworthy pIC 50 values of 8.61 and 8.56, respectively. This compound acts as an anti-angiogenic agent, making it highly rel...
T62931	Antiangiogenic agent 2
	Antiangiogenic agent 2 (compound 3b) is a potent inhibitor of thymidine phosphorylase (IC50: 39.71 μM) and exhibits anti-angiogenic effects.
T82402	Fibulostatin 6.2
	Fibulostatin 6.2, an anti-angiogenic peptide, inhibits the migration of human umbilical vein endothelial cells in vitro [1].
T83171	Adamtsostatin 18
	Adamtsostatin 18, an anti-angiogenic peptide derived from proteins with type I thrombospondin motifs, suppresses cell migration and proliferation [1].
T37037	Vinflunine ditartrate
	Vinflunine ditartrate, a fluorinated microtubule inhibitor and member of the Vinca alkaloids family, exhibits anti-angiogenic, vascular-disrupting, and anti-metastatic properties. It presents a potential avenue for study...
T72191	Antiproliferative agent-20
	Antiproliferative Agent-20 is a potent, orally active anticancer compound exhibiting both antiproliferative and anti-angiogenic activities.
T74804	HIF-1 inhibitor-5
	HIF-1 inhibitor-5 (Compound 16e) is a potent inhibitor of HIF-1, exhibiting an IC50 value of 2.38 μM and demonstrating significant anti-angiogenic potential [1].
T61476	Thioridazine
	Thioridazine is a chemical compound characterized by its potent anti-psychotic and anti-anxiety activities. As an antagonist of the dopamine receptor D2 family proteins, it exhibits a strong inhibitory effect on the PI3K...
T72182	Combretastatin A1 phosphate	Oxi4503,CA1P,Oxi4503 ; CA1P ; Combretastatin A1 diphosphate,Combretastatin A1 diphosphate
	Combretastatin A1 phosphate, a potent vascular disruptive agent, exhibits anti-angiogenic effects on tumors and holds potential for research on pancreatic neuroendocrine tumors.
T64071	Antitumor agent-42
	Antitumor agent-42 inhibits microtubule multimerisation and NO release, exhibiting anti-angiogenic, colony-forming and apoptosis-inducing effects.

Compounds

Fasentin

T8616

Synonym: N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide

Target: transporter

PTP inhibitor 1

T7541

Synonym: PTP Inhibitor II

Target: Phosphatase

Suramin Sodium Salt

T2160

Synonym: BAY-205,Suramin hexasodium salt,NF-060

Target: Apoptosis, Phosphatase, SARS-CoV, Sirtuin, Reverse Transcriptase, Topoisomerase, Parasite

Methylstat

T7057

Synonym:

Target: Histone Demethylase, Others

SM27

T24804

Synonym: SM-27,NSC-37204,SM 27,NSC37204

Target: FGFR

Tafetinib

T28911

Synonym: SIM-010603,SIM010603,SIM 010603

Target: Tyrosine Kinases

(S)-Thalidomide

T12644L

Synonym: (S)-(-)-Thalidomide

Target: Apoptosis

Givinostat hydrochloride

T6279L

Synonym: ITF2357 hydrochloride,Givinostat HCl,ITF2357,ITF 2357,ITF-2357,ITF2357 HCl

Target: HDAC

BPHA

T36712

Synonym: MMP-2/MMP-9 Inhibitor II

Target: MMP

Tubulin polymerization-IN-55

T77728

Synonym:

Target: Microtubule Associated

Thalidomide

T0213

Synonym: Thalomid,Sedoval

Target: Apoptosis, TNF, Autophagy, Ligand for E3 Ligase, Molecular Glues

ABT-510 acetate

T24997

Synonym: ABT 510 acetate

Synonym: NSC 347901,RP 35972

Target: HIF/HIF Prolyl-Hydroxylase, HIV Protease, Reverse Transcriptase, Nrf2, HIF

Pomalidomide

T2384

Synonym: CC-4047

Target: Apoptosis, TNF, Ligand for E3 Ligase, Molecular Glues

TIE-2/VEGFR-2 kinase-IN-5

AZ10606120 dihydrochloride

Synonym: EG01377 2HCl(2227996-00-9 Free base)

Target: Complement System

Regorafenib

T1792

Synonym: BAY 73-4506,Fluoro-Sorafenib

Target: Raf, VEGFR, c-RET, PDGFR, c-Kit, Autophagy

NSC 6038

T4632

Synonym: 4-chloro-N,N-dipropylbenzamide,4-Chloro-N,N-di-n-propylbenzaMide

Target: Others

NM-3

T33701

Synonym: NM-3,isocoumarin,NM 3,Isocoumarin NM-3,NM3

Target: Apoptosis, Reactive Oxygen Species

Rofecoxib

T1185

Synonym: MK 966,MK-0966

Target: COX

Amentoflavone hexaacetate

Burixafor hydrobromide

T10635

Synonym: TG-0054 hydrobromide

Target: CXCR

D-2-Aminoglutarimide (hydrochloride)

Synonym: Lopressor OROS,CGP 2175C,CGP 2175C ; Lopressor OROS

TIE-2/VEGFR-2 kinase-IN-2

T40581

Synonym:

Target:

Antiangiogenic agent 2

Vinflunine ditartrate

T37037

Synonym:

Target:

Antiproliferative agent-20

Combretastatin A1 phosphate

T72182

Synonym: Oxi4503,CA1P,Oxi4503 ; CA1P ; Combretastatin A1 diphosphate,Combretastatin A1 diphosphate

Cat No.	Product Name	Synonyms	Targets
T2S1200	Sinapine		Antioxidant , P-gp , AChE
	1. Sinapine, an alkaloid from seeds of the cruciferous species, can be used as an effective natural compound for chemo-resistance. 2. Sinapine has antioxidant and radio-protective activities.		Antioxidant , P-gp , AChE
T3392	Sinapine thiocyanate		P-gp , AChE
	Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds. It is the choline ester of Sinapic Acid (S486800). It is also a phenolic-chloine conjugates, acting as anti-o...		P-gp , AChE
T0724	Formononetin	Biochanin B,Flavosil,Formononetol	Apoptosis , FGFR
	Formononetin (Flavosil) is an O-methylated isoflavone and a phytoestrogen from the root of Astragalus membranaceus.		Apoptosis , FGFR
T3803	Specnuezhenide	Nuzhenide,Nuezhenide	Others , NF-κB , Wnt/beta-catenin
	Specnuezhenide (Nuezhenide) significantly protects human neuroblastoma SH-SY5Y cells from 6-hydroxydopamine-induced neurotoxicity.Nuezhenide is the main inhibitory compound of fruits, it shows a clear inhibitory effect t...		Others , NF-κB , Wnt/beta-catenin
T2961	Notoginsenoside R1	Sanqi glucoside R1,Sanchinoside R1	Apoptosis , ERK , Beta Amyloid
	Notoginsenoside R1 (Sanchinoside R1) has been shown to exhibit antioxidant, antiapoptotic, anti-inflammatory, and immune-stimulatory properties.		Apoptosis , ERK , Beta Amyloid
T8846	Beta-Escin	B-escin,AESCINE	Immunology/Inflammation related
	beta-Escin is a natural mixture of triterpenoid saponins isolated from horse chestnut (Aesculus hippocastanum) seeds, can be used as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent.		Immunology/Inflammation related
T5726	Specneuzhenide	Nuezhenide	Others
	Specneuzhenide (Nuezhenide) is a phenol glycoside isolated from Ligustrum sinense. Specneuzhenide (Nuezhenide) possesses anti-tumor activity,has anti-angiogenic and vision improvement effects.		Others
T2883	Syringic acid	3,5-dimethyl ether Gallic Acid,SYRA,3,5-dimethoxy-4-hydroxy Benzoic Acid,NSC 2129	Others , Endogenous Metabolite , Antibacterial
	Syringic acid (3,5-dimethoxy-4-hydroxy Benzoic Acid) (SYRA) is a potential antioxidant used in traditional Chinese medicine and is an emerging nutraceutical. It has potential anti-angiogenic, anti-glycating, anti-hypergl...		Others , Endogenous Metabolite , Antibacterial
T5648	Purpurin	1,2,4-Trihydroxyanthraquinone,Hydroxylizaric acid,Verantin	MAO , Antibacterial , Antibiotic , Antifungal
	Purpurin (Verantin) was a reversible and competitive inhibitor of MAO-A with a Ki value of 0.422μM. it exhibits anti-angiogenic, antifungal, antibiotic, and antioxidative activities.		MAO , Antibacterial , Antibiotic , Antifungal
TN1421	Bacopaside II		Apoptosis
	Bacopaside II is a potential anti-angiogenic agent, it can reduce endothelial cell migration and tubulogenesis and induce apoptosis.		Apoptosis
TN1916	Matairesinol		ATPase , p38 MAPK , ROS
	Matairesinol has radical and superoxide scavenging activities,; it also has anti-angiogenic activity by suppressing mROS signaling , can decrease hypoxia-inducible factor-1α± in hypoxic HeLa cells.		ATPase , p38 MAPK , ROS
T3056	Bavachinin	Bavachinin A,7-O-Methylbavachin	PPAR
	Bavachinin (Bavachinin A)(7-O-Methylbavachin) is a natural compound isolated from the Chinese herb Fructus Psoraleae with potent anti-angiogenic activity.		PPAR
TN1087	Deoxypodophyllotoxin		Apoptosis , Microtubule Associated , Autophagy
	Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflammatory activities.		Apoptosis , Microtubule Associated , Autophagy
T3752	4-Hydroxybenzyl alcohol	4-Methylolphenol,P-Methylolphenol	Apoptosis , Endogenous Metabolite
	4-Hydroxybenzyl alcohol (P-Methylolphenol) exhibits beneficial effects in cerebral ischemic injury, has neuroprotective effect through upregulation of Nrf2, Prdx6, and PDI expression via the PI3K/Akt pathway. 4-Hydroxybe...		Apoptosis , Endogenous Metabolite
TN1828	Kahweol		Apoptosis , NF-κB , AMPK
	Kahweol has anticarcinogenic, anti-angiogenic,and anti-inflammatory activities, it can block the LPS-induced activation of NF-kappaB by preventing IkappaB degradation and inhibiting IkappaB kinase activity.		Apoptosis , NF-κB , AMPK
TN2429	Capsiate		Antioxidant , TRP/TRPV Channel
	Capsiate is an orally active TRPV1 agonist, a non-irritating capsaicin analog that acts as an antiallergic agent with anti-inflammatory, antioxidant, hypoglycemic, and inhibitory angiogenic activity.		Antioxidant , TRP/TRPV Channel
T1082	Benzyl isothiocyanate	Benzoylthiocarbimide,Isothiocyanic Acid Benzoyl Ester	Apoptosis , Antibacterial , Antibiotic
	Benzyl isothiocyanate (Benzoylthiocarbimide) (BITC) is an isothiocyanate originally found in cruciferous vegetables. It shows immunomodulatory, anti-parasitic, antibiotic, antioxidative, anti-atherosclerotic, anti-angiog...		Apoptosis , Antibacterial , Antibiotic
T67708	Thiolutin	Acetopyrrothin	Antibacterial , Antibiotic
	Thiolutin (Acetopyrrothin) is an inhibitor of endothelial cell adhesion and produced by Streptomyces. Thiolutin shows antibiotic and anti-angiogenic properties. Thiolutin induces the phosphorylation of Hsp27 rapidly.		Antibacterial , Antibiotic
T3391	Corosolic acid	Corsolic acid,2α-Hydroxyursolic acid,Glucosol,Colosolic acid,Colosic acid	FAK , Autophagy
	Corosolic acid (Colosic acid) contains anti-angiogenic activity that can suppress FAK signaling induced by angiopoietin-1. Corosolic acid exerts anticancer activities against HCC, colon, and colorectal Y cells, by induci...		FAK , Autophagy
TN1804	Isosilybin A		Apoptosis , Tyrosinase , PPAR , ABC
	Isosilybin A is a partial PPARγ agonist, it significantly induced ABCA1 protein expression, it inhibited both monophenolase (IC50=1.7-7.6μM) and diphenolase (IC50=12.1-44.9μM) of tyrosinase. Isosilybin A shows anti-angio...		Apoptosis , Tyrosinase , PPAR , ABC
T2860	Vanillyl Alcohol	4-Hydroxy-3-methoxybenzenemethanol,3-Methoxy-4-hydroxybenzyl alcohol,4-Hydroxy-3-methoxybenzyl alcohol,Vanillin alcohol,Vanillic alcohol	Apoptosis , Others
	Vanillyl Alcohol (3-Methoxy-4-hydroxybenzyl alcohol) possesses anti-angiogenic, anticonvulsive, anti-inflammatory, anti-oxidant, neuroprotective, and anti-nociceptive activities. Vanillyl alcohol can effectively inhibit ...		Apoptosis , Others
T36715	Tetrac	Tetraiodothyroacetic acid,3,3',5,5'-Tetraiodothyroacetic acid	Apoptosis , EGFR
	Tetrac (Tetraiodothyroacetic acid) is a derivative of L-thyroxine (T4), a thyroxine integrin receptor antagonist.Tetrac induces antiproliferation by blocking EGFR-mediated cell signaling in colorectal cancer cells.Tetrac...		Apoptosis , EGFR
T10619	Bromelain		Apoptosis , Others
	Bromelain is an anti-inflammatory drug derived from pineapple stem. It acts through down-regulation of plasma kininogen, degradation of advanced glycation end-product receptors, inhibition of Prostaglandin E2 expression,...		Apoptosis , Others
T3895	Polyphyllin I		Apoptosis , Akt , JNK , PDK , mTOR , Autophagy
	Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C, and cleaved-caspase-3 levels. Polyphyllin D ha...		Apoptosis , Akt , JNK , PDK , mTOR , Autophagy
TN2972	3-O-(E)-p-Coumaroylbetulin		Others
	3-β-O-trans-p-coumaroylbetulinol has anti-angiogenic effect, it possesses significant anti-proliferative activity with 66.7% inhibition at 100uM.		Others
TN4101	Ganoderenic acid H		Others
	Ganoderenic acid H is one compound of triterpenoids isolated from Ganoderma lucidum, triterpenoids exhibit a broad spectrum of anti-cancer properties, including anti-proliferative, anti-metastatic and anti-angiogenic act...		Others
TQ0112	Tubulysin A	TubA	Microtubule Associated
	Tubulysin A is a natural product from myxobacterial. It has many function in vitro assays, including anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, and anti-angiogenic.		Microtubule Associated
TN3139	5α-Hydroxycostic acid	5alpha-Hydroxycostic acid	ERK , FAK , Phospholipase , NOS , Akt , Src
	5alpha-Hydroxycostic acid possesses anti-angiogenic ability by interfering the VEGF- and Ang2-related pathways, and it may be a good drug candidate.		ERK , FAK , Phospholipase , NOS , Akt , Src
T38606	Sinapine hydroxide
	Sinapine hydroxide, an alkaloid derived from the seeds of cruciferous plants, demonstrates a variety of beneficial properties including anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic, and radio-protective e...
T70778	Depudecin
	Depudecin is a polyketide obtained from the fungus Alternaria brassicicola and having a highly unusual structure of an 11-carbon chain containing two epoxides and six stereogenic centres. It is an inhibitor of histone de...
TN5096	Tanshindiol B		Histone Methyltransferase
	Tanshindiol B possesses a unique anti-cancer activity whose mechanism involves the inhibition of EZH2 activity and would provide chemically valuable information for designing a new class of potent EZH2 inhibitors. It als...		Histone Methyltransferase
TN5153	Torilin		MMP , ERK , IκB/IKK , p38 MAPK , NF-κB , Tyrosinase , Reductase , DNA/RNA Synthesis , JNK
	Torilin is an inhibitor of testosterone 5 alpha-reductase, it (IC50 = 31.7 +/- 4.23 microM) shows a stronger inhibition of 5 alpha-reductase than alpha-linolenic acid (IC50 = 160.3 +/- 24.62 microM) but is weaker than fi...

Natural Products

Sinapine

T2S1200

Synonym:

Target: Antioxidant, P-gp, AChE

Synonym: Biochanin B,Flavosil,Formononetol

Target: Apoptosis, FGFR

Specnuezhenide

T3803

Synonym: Nuzhenide,Nuezhenide

Target: Others, NF-κB, Wnt/beta-catenin

Notoginsenoside R1

T2961

Synonym: Sanqi glucoside R1,Sanchinoside R1

Target: Apoptosis, ERK, Beta Amyloid

beta-Escin

T8846

Synonym: B-escin,AESCINE

Target: Immunology/Inflammation related

Synonym: 3,5-dimethyl ether Gallic Acid,SYRA,3,5-dimethoxy-4-hydroxy Benzoic Acid,NSC 2129

Target: Others, Endogenous Metabolite, Antibacterial

Purpurin

T5648

Synonym: 1,2,4-Trihydroxyanthraquinone,Hydroxylizaric acid,Verantin

Target: MAO, Antibacterial, Antibiotic, Antifungal

Target: ATPase, p38 MAPK, ROS

Bavachinin

T3056

Synonym: Bavachinin A,7-O-Methylbavachin

Target: Apoptosis, Microtubule Associated, Autophagy

4-Hydroxybenzyl alcohol

T3752

Synonym: 4-Methylolphenol,P-Methylolphenol

Target: Apoptosis, Endogenous Metabolite

Kahweol

TN1828

Synonym:

Target: Apoptosis, NF-κB, AMPK

Capsiate

TN2429

Synonym:

Target: Antioxidant, TRP/TRPV Channel

Benzyl isothiocyanate

T1082

Synonym: Benzoylthiocarbimide,Isothiocyanic Acid Benzoyl Ester

Target: Apoptosis, Antibacterial, Antibiotic

Thiolutin

T67708

Synonym: Acetopyrrothin

Target: Antibacterial, Antibiotic

Corosolic acid

T3391

Synonym: Corsolic acid,2α-Hydroxyursolic acid,Glucosol,Colosolic acid,Colosic acid

Target: FAK, Autophagy

Isosilybin A

TN1804

Synonym:

Target: Apoptosis, Tyrosinase, PPAR, ABC

Vanillyl Alcohol

T2860

Synonym: 4-Hydroxy-3-methoxybenzenemethanol,3-Methoxy-4-hydroxybenzyl alcohol,4-Hydroxy-3-methoxybenzyl alcohol,Vanillin alcohol,Vanillic alcohol

Target: Apoptosis, Others

Tetrac

T36715

Synonym: Tetraiodothyroacetic acid,3,3',5,5'-Tetraiodothyroacetic acid

Target: Apoptosis, EGFR

Bromelain

T10619

Synonym:

Target: Apoptosis, Others

Polyphyllin I

T3895

Synonym:

Target: Apoptosis, Akt, JNK, PDK, mTOR, Autophagy

3-O-(E)-p-Coumaroylbetulin

Target: Microtubule Associated

5α-Hydroxycostic acid

TN3139

Synonym: 5alpha-Hydroxycostic acid

Target: ERK, FAK, Phospholipase, NOS, Akt, Src

Target: Histone Methyltransferase

Torilin

TN5153

Synonym:

Target: MMP, ERK, IκB/IKK, p38 MAPK, NF-κB, Tyrosinase, Reductase, DNA/RNA Synthesis, JNK

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-02778	ENPP2 Protein, Human, Recombinant (His)	Human	HEK293
	ENPP2 (Ectonucleotide pyrophosphatase/phosphodiesterase family member 2), also referred as Autotaxin, is a secreted enzyme encoded by the ENPP2 gene. This gene product stimulates the motility of tumor cells, has angiogen...
TMPY-00463	ENPP2 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	ENPP2 (Ectonucleotide pyrophosphatase/phosphodiesterase family member 2), also referred as Autotaxin, is a secreted enzyme encoded by the ENPP2 gene. This gene product stimulates the motility of tumor cells, has angiogen...
TMPY-00979	HRG/HPRG Protein, Human, Recombinant (His)	Human	HEK293
	Histidine-rich glycoprotein, also known as HRG and HPRG, is a glycoprotein located in plasma and platelets and contains an unusually large amount of histidine and proline. In humans, five distinct domains are recognized ...
TMPY-00740	SDF-1 Protein, Human, Recombinant (hFc)	Human	HEK293
	The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF1 is expressed in two isoforms f...
TMPY-02591	SDF-1 Protein, Human, Recombinant	Human	E. coli
	The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF1 is expressed in two isoforms f...
TMPY-02820	SDF-1 Protein, Human, Recombinant (isoform a)	Human	E. coli
	The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF1 is expressed in two isoforms f...
TMPH-02591	COL4A3 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.; Tumstatin, a cleavage fragment cor...
TMPH-02590	COL4A2 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.; Canstatin, a cleavage product corr...
TMPY-00266	PEDF Protein, Rat, Recombinant (His)	Rat	HEK293
	Pigment epithelium-derived factor, also known as PEDF, Serpin F1, and SERPINF1, is a multiple functional protein that has both anti-angiogenic activity and neurotrophic activity at the same time. PEDF is a secreted glyco...
TMPY-01112	PEDF Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Pigment epithelium-derived factor, also known as PEDF, Serpin F1, and SERPINF1, is a multiple functional protein that has both anti-angiogenic activity and neurotrophic activity at the same time. PEDF is a secreted glyco...
TMPY-01328	PEDF Protein, Human, Recombinant (His)	Human	HEK293
	Pigment epithelium-derived factor, also known as PEDF, Serpin F1, and SERPINF1, is a multiple functional protein that has both anti-angiogenic activity and neurotrophic activity at the same time. PEDF is a secreted glyco...
TMPY-02055	ENPP2 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	ENPP2 (Ectonucleotide pyrophosphatase/phosphodiesterase family member 2), also referred as Autotaxin, is a secreted enzyme encoded by the ENPP2 gene. This gene product stimulates the motility of tumor cells, has angiogen...
TMPY-04788	HRG/HPRG Protein, Rat, Recombinant (His)	Rat	HEK293
	Histidine-rich glycoprotein, also known as HRG and HPRG, is a glycoprotein located in plasma and platelets and contains an unusually large amount of histidine and proline. In humans, five distinct domains are recognized ...
TMPY-02184	SDF-1 Protein, Rhesus, Recombinant (hFc)	Rhesus	HEK293
	The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF1 is expressed in two isoforms f...
TMPY-03289	SDF-1 Protein, Mouse, Recombinant	Mouse	E. coli
	The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF1 is expressed in two isoforms f...
TMPY-02749	SDF-1 Protein, Human, Recombinant (His)	Human	E. coli
	The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF1 is expressed in two isoforms f...
TMPY-03580	SDF-1 Protein, Canine, Recombinant	Canine	E. coli
	The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF1 is expressed in two isoforms f...