acid-sensitive

ML365 is a novel selective small molecule inhibitor of TASK1(KCNK3).

L-Lactic acid ((S)-2-Hydroxypropanoic acid) is a natural product produced by the anaerobic glycolysis of pyruvic acid. L-Lactic acid is a sensitive indicator of tissue hypoxia and can be used as a hemodynamic indicator in critically ill patients.

Dibutyryl-cGMP sodium (Bt2cGMP sodium) is a cell-permeable cGMP analog that preferentially activates cGMP-dependent protein kinase (PKG). It inhibits [3H]-arachidonic acid release in human platelets stimulated by gamma thrombin and can induce peripheral analgesia by activating ATP-sensitive K+ channels.

Upacicalcet HCl is an intravesical calcium mimetic that inhibits excessive parathyroid hormone (PTH) secretion by directly acting on calcium-sensitive receptors in parathyroid cell membranes, thereby lowering PTH levels in the blood.Upacicalcet HCl can be used for the treatment of blood Upacicalcet HCl is a novel compound for the treatment of secondary hyperparathyroidism, targeting amino acid-binding sites of calcium-sensitive receptors. binding sites.

Bumetanide (PF 1593) is a potent sulfamoylanthranilic acid derivative belonging to the class of loop diuretics. In the brain, bumetanide may prevent seizures in neonates by blocking the bumetanide-sensitive sodium-potassium-chloride cotransporter (NKCC1), thereby inhibiting chloride uptake thus, decreasing the internal chloride concentration in neurons and may block the excitatory effect of GABA in neonates.

3-Hydroxyisovaleric acid (Beta-Hydroxyisovaleric acid) is an endogenous metabolite excreted in the urine and can serve as an early and sensitive indicator of biotin deficiency.

HSL-IN-3 (HSL inhibitor 3) is a boronic acid derivative that is an inhibitor of hormone-sensitive lipase(HSL).

2-Iodobenzoic acid (o-Iodobenzoic acid) is the impact-sensitive intermediate in the synthesis of the Dess-Martin periodinane.

2-(4-Methoxyphenyl)acetic acid, a plasma metabolite, is highly sensitive and specific and can be used as a bioindicator to differentiate non-small cell carcinoma patients from healthy controls.

Divalproex Sodium (Valproate semisodium) binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentration of GABA and by inhibiting enzymes that catabolize GABA or block the reuptake of GABA into glia and nerve endings. It also is an HDAC inhibitor, Comprised of sodium valproate and valproic acid with anticonvulsant and antiepileptic activities. Divalproex may also work by suppressing repetitive neuronal firing through the inhibition of voltage-sensitive sodium channels.

5-Sulfosalicylic acid is a sulfonated salicylic acid derivative used to dope poly(2-chloroaniline)-based highly sensitive label-free electrochemical immunoassay (ECI) for detecting CA72-4, a key gastric cancer biomarker. This compound also demonstrates activity against breast cancer cell lines.

1. Pulegone ((+)-Pulegone) has cytotoxicity followed by regenerative cell proliferation is the MOA for Pulegone-induced urothelial tumors in female rats. 2. Pulegone induces a verapamil-sensitive psychostimulant effect that appears to independ on the opening of L-type calcium channels. 3. Pulegone has negative reinforcing properties and seems to possess anxiolytic-like actions unrelated to the benzodiazepine site of the γ-aminobutyric acid type A (GABAA) receptor.

Trans-caffeic acid (3,4-Dihydroxybenzeneacrylic acid) can be used as a highly sensitive fluorescent probe for the detection of laccase in food and can also stimulate the growth of germ tissue.

Acamprosate, an orally active neuromodulator, is used to study and treat alcohol dependence and alcoholism. Acamprosate is an analog of amino acid neurotransmitters (e.g., taurine and homocysteic acid) that modulates NMDA receptor activity via binding to a spermidine-sensitive site. Research indicates Acamprosate acts as a 'partial co-agonist' at NMDA receptors.

A2793 is a dual inhibitor of TWIK-associated acid-sensitive K+ channel 1 (TASK-1)/TRESK, with an IC50 for mTRESK of 6.8 μM. It is more selective for TRESK, and relatively weaker for TREK-1 and TALK-1.

GW9508(GW 9508) is a potent and selective agonist for FFA1 (GPR40), stimulates insulin secretion in a glucose-sensitive manner.

L-ANAP hydrochloride is a polarity-sensitive and genetically encodable fluorescent unnatural amino acid.

DNBS, also known as 2,4-Dinitrobenzenesulfonic Acid (sodium salt), is a hapten. At concentrations of 25, 50, or 100 ppm, it can induce the proliferation of primary lymphocytes and epithelial cells derived from guinea pigs that are sensitive to 2,4-dinitrochlorobenzene (2,4-DNCB).

SC-17599 exhibits dose-dependent analgesic effects in both the acetic acid-induced writhing test and the hot-water tail withdrawal test. This compound also induces a Straub tail reaction in a dose-dependent and naltrexone-sensitive manner, akin to morphine. However, unlike morphine, high doses of SC-17599 do not affect motor activity. Overall, SC-17599 demonstrates selective μ-opioid receptor agonism, showing behavior effects similar to morphine, with some differences.

Vancomycin prodrug (compound 13c) is a prodrug of Vancomycin. It exhibits antibacterial activity against Staphylococcus aureus (S. aureus) 330041, methicillin-resistant Staphylococcus aureus (MRSA) USA 300, and MRSA 3390, with minimum inhibitory concentrations (MICs) of 0.78 μM, 0.78 μM, and 1.56 μM, respectively. This prodrug can rapidly bind to the Cys-34 residue in plasma. It demonstrates therapeutic efficacy in mice infected with MRSA USA300, comparable to Vancomycin. As an albumin-binding, acid-sensitive prodrug, Vancomycin prodrug maintains Vancomycin's effectiveness against gram-positive bacterial infections while significantly reducing nephrotoxicity.

3,3'-(Propane-2,2-diylbis(sulfanediyl))dipropionic acid is a reactive oxygen species (ROS) sensitive degradable linker utilized in the synthesis of antibody-drug conjugates (ADC). This compound shows potential for application in the research of tumor drug delivery systems.

Cyclobutrifluram is a succinate dehydrogenase inhibitor (SDHI) with an average EC50 of 0.025 μg/mL against F. fujikuroi. It demonstrates excellent antifungal activity, significantly hindering the growth of sensitive F. fujikuroi mycelia. However, it may induce resistance, particularly in cases of amino acid substitutions in FfSdhB (H248L/Y) and FfSdhC2 (G80R or A83V). Cyclobutrifluram is applicable for research on rice bakanae disease (RBD).

UCM05 (G28UCM) is a potent inhibitor of fatty acid synthase (FASN) with efficacy against HER2+ breast cancer xenografts, including cell lines resistant to anti-HER2 drugs [1]. Additionally, it functions as an inhibitor of the Filamentous temperature-sensitive protein Z (FtsZ), selectively inhibiting the growth of the Gram-positive bacterium B. subtilis with minimum inhibitory concentration (MIC) values of 100 μM, while showing no activity against the Gram-negative bacterium E. coli [2].

inhibits [3H]-homoquinolinic acid binding to non-NMDA sensitive sites