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Search Results for " vegfr3 "

Targets

37

Compounds

1

Natural Products

7

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T21593 AAL-993 VEGFR
AAL-993 is a potent VEGFR inhibitor with IC50s of 130 nM, 23 nM and 18 nM for VEGFR1, VEGFR2 and VEGFR3, respectively. AAL993 has a weak inhibitory effect on other tyrosine kinases. AAL993 also shows potent antiangiogeni...
T35570 Chiauranib CS2164 c-Fms , VEGFR , FLT , PDGFR , c-Kit , Aurora Kinase
Chiauranib is a multi-target inhibitor against tumor angiogenesis and exhibits potent anticancer effects. Chiauranib potently inhibits the angiogenesis-related kinases (VEGFR1, VEGFR2, VEGFR3, PDGFRα and c-Kit), mitosis-...
T6479 Dovitinib lactate hydrate Dovitinib (TKI258) Lactate,Dovitinib Lactate,TKI258 VEGFR , FGFR , FLT , PDGFR , c-Kit
Dovitinib lactate hydrate (TKI258) is the Lactate of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) R...
T4349 Sitravatinib MG516,MGCD516 Discoidin Domain Receptor (DDR) , VEGFR , FLT , Trk receptor , TAM Receptor , c-Kit , Ephrin Receptor
Sitravatinib (MGCD516) (MGCD516) is an inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Met, c-Kit, PDGFRα/β, PDGFR, and Axl.
T72924 VEGFR-3-IN-1 VEGFR
VEGFR-3-IN-1 is a novel potent and selective VEGFR3 inhibitor with an IC50 of 110.4 nM.VEGFR-3-IN-1 possesses antitumor activity, inactivates the VEGFR3 signaling pathway, and inhibits the proliferation and migration of ...
T1656 Vandetanib ZD6474 Apoptosis , EGFR , VEGFR , Autophagy
Vandetanib (ZD6474) is a potent inhibitor of VEGFR2 (IC50: 40 nM). It also inhibits VEGFR3 and EGFR.
T15185 Lucitanib E-3810 VEGFR , FGFR
Lucitanib (E-3810) is a novel VEGFR and FGFR inhibitor. It potently and selectively inhibits VEGFR1, VEGFR2, VEGFR3, FGFR1 and FGFR2 (IC50s: 7 nM, 25 nM, 10 nM, 17.5 nM, and 82.5 nM, respectively).
T6012 SAR131675 SAR 131675 VEGFR
SAR131675 is a potent and selective VEGFR3 inhibitor with an IC50 of 23 nM.
T6137 KRN-633 KRN633 VEGFR
KRN-633 is an effective VEGFR inhibitor. The IC50s of KRN-633(KRN633) for VEGFR1, VEGFR2, and VEGFR3 is 170, 160 and 125 nM, respectively.
T2358 ENMD-2076 Apoptosis , VEGFR , FGFR , FLT , c-RET , PDGFR , Src , Aurora Kinase
ENMD-2076, a multi-targeted kinase inhibitor, has specific activity against Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα.
T16975 TAK-593 VEGFR , PDGFR
TAK-593 is an effective VEGFR and PDGFR family inhibitor (IC50s: 3.2, 0.95, 1.1, 4.3, and 13 nM for VEGFR1, VEGFR2, VEGFR3, PDFGRα, and PDFGRβ, respectively).
T1452 Axitinib AG-013736 VEGFR , PDGFR , c-Kit
Axitinib (AG-013736) is an orally bioavailable tyrosine kinase inhibitor with IC50s of 0.1, 0.2, 0.1-0.3, 1.7, 1.6 nM for VEGFR1, VEGFR2, VEGFR3, c-kit, and PDGFRβ, respectively.
T6720 Vatalanib dihydrochloride CGP-797870 dihydrochloride,ZK-222584 dihydrochloride,Vatalanib 2HCl,PTK787 dihydrochloride,Vatalanib (PTK787) 2HCl,CGP-79787 dihydrochloride Apoptosis , VEGFR , PDGFR
Vatalanib dihydrochloride (PTK787 dihydrochloride)(IC50=37 nM) is an inhibitor of VEGFR2/KDR. It exhibits less effective against VEGFR1/Flt-1 and 18-fold against VEGFR3/Flt-4.
T6930 Pazopanib Hydrochloride GW786034,Pazopanib HCl,GW786034 HCl,Votrient HCl,Armala c-Fms , VEGFR , FGFR , PDGFR , c-Kit , Autophagy
Pazopanib Hydrochloride (Votrient HCl) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM in cell-free assays, resp...
T0520 Lenvatinib E7080 VEGFR , FGFR , c-RET , PDGFR , c-Kit
Lenvatinib (E7080) is a multi-target receptor tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, KIT, PDGFR, and RET, and has oral activity. Lenvatinib has the strongest inhibitory activity on VEGFR2 and VEGFR3 (...
T1777 Nintedanib BIBF 1120,Intedanib VEGFR , FGFR , FLT , PDGFR , Src
Nintedanib (Intedanib) is a triple vascular kinase inhibitor that inhibits VEGFR1, VEGFR2, and VEGFR3 (IC50=34/13/13 nM), FGFR1, FGFR2, and FGFR3 (IC50=69/37/108 nM), PDGFRα, and PDGFRβ (IC50=59/65 nM). Nintedanib has an...
T0093L Sorafenib Bay 43-9006 Apoptosis , Raf , VEGFR , FLT , Ferroptosis , PDGFR , c-Kit , Autophagy
Sorafenib (Bay 43-9006) is a multikinase inhibitor that inhibits Raf-1, B-Raf, VEGFR2, VEGFR3, VEGFR4, PDGFRβ, FLT3, c-Kit, and others (IC50=6/22/90/15/20/20/57/58 nM) with oral activity. Sorafenib has antitumor activity...
T1792L Regorafenib monohydrate Raf , VEGFR , c-RET , PDGFR , c-Kit , Autophagy
Regorafenib Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murine VEGFR3, PDGFR-β, KIT, RET, RAF-1, B-RAF and B-RAF(V600E) respect...
T6166 Telatinib Bay 57-9352 VEGFR , PDGFR , c-Kit
Telatinib (Bay 57-9352) is an effective inhibitor of VEGFR2/3, c-Kit, and PDGFRα. The IC50s of Telatinib forVEGFR2/3, c-Kit and PDGFRα are 6 nM/4 nM, 1 nM, and 15 nM, respectively.
T5001 Nintedanib esylate Intedanib,BIBF 1120 (esylate),Nintedanib Ethanesulfonate Salt,BIBF 1120 VEGFR , FGFR , PDGFR
Nintedanib esylate (BIBF 1120 esylate) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β
T0093 Sorafenib tosylate Bay 43-9006 Apoptosis , Raf , VEGFR , FLT , Ferroptosis , PDGFR , c-Kit , Autophagy
Sorafenib tosylate (Bay 43-9006) is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-3/B-Raf).
T0097L Pazopanib GW786034 VEGFR , FGFR , PDGFR , c-Kit , Autophagy
Pazopanib (GW786034), a small molecule inhibitor, inhibits multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibits VEGFR-1, -2 and -3, c-kit and PDGF-R, which may result i...
T3691 (Rac)-SAR131675 SAR131675 VEGFR
(Rac)-SAR131675 is an effective and specific VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity (IC50: 20 nmol/L) and VEGFR-3 autophosphorylation (IC50: 45 nmol/L) in HEK cells, respectively. SAR131675 is h...
T63459 Telatinib mesylate
Telatinib mesylate is a potent, orally active inhibitor of VEGFR2 (IC50: 6 nM), VEGFR3 (IC50: 4 nM), PDGFα (IC50: 15 nM) and c-Kit (IC50: 1 nM).
T2656 Fruquintinib HMPL-013 VEGFR
Fruquintinib (HMPL-013) is an orally available, small molecule inhibitor of vascular endothelial growth factor receptors (VEGFRs), with potential anti-angiogenic and antineoplastic activities.
T12925 Sitravatinib malate MGCD516 malate,MG-516 malate TAM Receptor
Sitravatinib malate is an orally bioavailable receptor inhibitor of tyrosine kinase (RTK) (IC50s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT...
T64176 Vandetanib trifluoroacetate
Vandetanib trifluoroacetate (D6474 trifluoroacetate) is an orally active and potent VEGFR2/KDR tyrosine kinase inhibitor with an IC50 value of 40 nM. Vandetanib trifluoroacetate also showed inhibition of VEGFR3/FLT4 and ...
T21641 Vandetanib hydrochloride
Vandetanib hydrochloride (D6474 hydrochloride) is a potent, orally active inhibitor of VEGFR2/KDR tyrosine kinase activity with IC 50 of 40 nM. Vandetanib hydrochloride also has some additional activity versus the tyrosi...
T3463 NVP-ACC789 ACC-789,ZK202650 VEGFR , PDGFR
ACC-789 (NVP-ACC789 (ZK202650); ZK-202650) is an effective, specific and orally active inhibitor of the VEGF receptor tyrosine kinases.
T2288 Motesanib AMG 706 VEGFR , c-Kit
Motesanib (AMG 706) is an orally bioavailable receptor tyrosine kinase inhibitor with potential antineoplastic activity. AMG 706 selectively targets and inhibits vascular endothelial growth factor (VEGFR), platelet-deriv...
T7611 ODM-203 VEGFR , FGFR
ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity
T2456 Tivozanib AV-951,KRN951 VEGFR , PDGFR , Ephrin Receptor
Tivozanib (KRN951) is an orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities.
T2288L Motesanib Diphosphate Motesanib,AMG 706 VEGFR , c-Kit
Motesanib Diphosphate (AMG 706) is the orally bioavailable diphosphate salt of a multiple-receptor tyrosine kinase inhibitor with potential antineoplastic activity.
T10157 Regorafénib N-oxyde (M2) Raf , VEGFR , c-RET , PDGFR , c-Kit , Drug Metabolite
Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, RET, Kit, and Raf-1 (IC50s: 13/4.2/46, 1.5, 22, 7, and 2.5 nM).
T8541 Lenvatinib mesylate E7080 (mesylate) VEGFR , FGFR , c-RET , PDGFR , c-Kit
Lenvatinib mesylate (E7080 (mesylate)) is an oral and multi-targeted inhibitor of VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, with potent antitumor activities.
T8402 Regorafenib Hydrochloride BAY73-4506 hydrochloride Raf , VEGFR , c-RET , PDGFR , Autophagy
Regorafenib Hydrochloride (BAY73-4506 hydrochloride) is a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity
T11638 Ilorasertib hydrochloride ABT-348 hydrochloride Aurora Kinase
Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s: 1 nM, 7 nM, 120 nM). It also suppresses RET tyrosine kinase,...

Compounds

AAL-993
T21593
Synonym:
Target: VEGFR
Chiauranib
T35570
Synonym: CS2164
Target: c-Fms, VEGFR, FLT, PDGFR, c-Kit, Aurora Kinase
Dovitinib lactate hydrate
T6479
Synonym: Dovitinib (TKI258) Lactate,Dovitinib Lactate,TKI258
Target: VEGFR, FGFR, FLT, PDGFR, c-Kit
Sitravatinib
T4349
Synonym: MG516,MGCD516
Target: Discoidin Domain Receptor (DDR), VEGFR, FLT, Trk receptor, TAM Receptor, c-Kit, Ephrin Receptor
VEGFR-3-IN-1
T72924
Synonym:
Target: VEGFR
Vandetanib
T1656
Synonym: ZD6474
Target: Apoptosis, EGFR, VEGFR, Autophagy
Lucitanib
T15185
Synonym: E-3810
Target: VEGFR, FGFR
SAR131675
T6012
Synonym: SAR 131675
Target: VEGFR
KRN-633
T6137
Synonym: KRN633
Target: VEGFR
ENMD-2076
T2358
Synonym:
Target: Apoptosis, VEGFR, FGFR, FLT, c-RET, PDGFR, Src, Aurora Kinase
TAK-593
T16975
Synonym:
Target: VEGFR, PDGFR
Axitinib
T1452
Synonym: AG-013736
Target: VEGFR, PDGFR, c-Kit
Vatalanib dihydrochloride
T6720
Synonym: CGP-797870 dihydrochloride,ZK-222584 dihydrochloride,Vatalanib 2HCl,PTK787 dihydrochloride,Vatalanib (PTK787) 2HCl,CGP-79787 dihydrochloride
Target: Apoptosis, VEGFR, PDGFR
Pazopanib Hydrochloride
T6930
Synonym: GW786034,Pazopanib HCl,GW786034 HCl,Votrient HCl,Armala
Target: c-Fms, VEGFR, FGFR, PDGFR, c-Kit, Autophagy
Lenvatinib
T0520
Synonym: E7080
Target: VEGFR, FGFR, c-RET, PDGFR, c-Kit
Nintedanib
T1777
Synonym: BIBF 1120,Intedanib
Target: VEGFR, FGFR, FLT, PDGFR, Src
Sorafenib
T0093L
Synonym: Bay 43-9006
Target: Apoptosis, Raf, VEGFR, FLT, Ferroptosis, PDGFR, c-Kit, Autophagy
Regorafenib monohydrate
T1792L
Synonym:
Target: Raf, VEGFR, c-RET, PDGFR, c-Kit, Autophagy
Telatinib
T6166
Synonym: Bay 57-9352
Target: VEGFR, PDGFR, c-Kit
Nintedanib esylate
T5001
Synonym: Intedanib,BIBF 1120 (esylate),Nintedanib Ethanesulfonate Salt,BIBF 1120
Target: VEGFR, FGFR, PDGFR
Sorafenib tosylate
T0093
Synonym: Bay 43-9006
Target: Apoptosis, Raf, VEGFR, FLT, Ferroptosis, PDGFR, c-Kit, Autophagy
Pazopanib
T0097L
Synonym: GW786034
Target: VEGFR, FGFR, PDGFR, c-Kit, Autophagy
(Rac)-SAR131675
T3691
Synonym: SAR131675
Target: VEGFR
Telatinib mesylate
T63459
Synonym:
Target:
Fruquintinib
T2656
Synonym: HMPL-013
Target: VEGFR
Sitravatinib malate
T12925
Synonym: MGCD516 malate,MG-516 malate
Target: TAM Receptor
Vandetanib trifluoroacetate
T64176
Synonym:
Target:
Vandetanib hydrochloride
T21641
Synonym:
Target:
NVP-ACC789
T3463
Synonym: ACC-789,ZK202650
Target: VEGFR, PDGFR
Motesanib
T2288
Synonym: AMG 706
Target: VEGFR, c-Kit
ODM-203
T7611
Synonym:
Target: VEGFR, FGFR
Tivozanib
T2456
Synonym: AV-951,KRN951
Target: VEGFR, PDGFR, Ephrin Receptor
Motesanib Diphosphate
T2288L
Synonym: Motesanib,AMG 706
Target: VEGFR, c-Kit
Regorafénib N-oxyde (M2)
T10157
Synonym:
Target: Raf, VEGFR, c-RET, PDGFR, c-Kit, Drug Metabolite
Lenvatinib mesylate
T8541
Synonym: E7080 (mesylate)
Target: VEGFR, FGFR, c-RET, PDGFR, c-Kit
Regorafenib Hydrochloride
T8402
Synonym: BAY73-4506 hydrochloride
Target: Raf, VEGFR, c-RET, PDGFR, Autophagy
Ilorasertib hydrochloride
T11638
Synonym: ABT-348 hydrochloride
Target: Aurora Kinase
Cat No. Product Name Synonyms Targets
T14055 5Z-7-Oxozeaenol FR148083,L783279,LL-Z 1640-2 VEGFR , FLT , MEK , MAPK , PDGFR , Antibiotic , Src
5Z-7-Oxozeaenol (FR148083) is a potent, irreversible and selective inhibitor of transforming growth factor (TGF)-β-activated kinase 1 with IC50 of 8.1 nM for TAK1 and low activity against MEK1 with IC50 of 411 nM, it is ...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-01936 VEGFR3/FLT4 Protein, Mouse, Recombinant (His) Mouse HEK293
Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belo...
TMPY-00949 VEGFR3/FLT4 Protein, Human, Recombinant (His) Human HEK293
Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belo...
TMPY-01937 VEGFR3/FLT4 Protein, Mouse, Recombinant (hFc) Mouse HEK293
Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belo...
TMPK-00445 VEGFR3/FLT4 Protein, Human, Recombinant (His & Avi) Human HEK293
Vascular endothelial growth factor (VEGF) and its receptors VEGF-R1, -R2 and -R3 play important roles in tumor angiogenesis and are associated with poor prognosis in several solid tumors.VEGF-R1, -R2 and -R3 were highly ...
TMPY-01069 VEGFR3/FLT4 Protein, Human, Recombinant (hFc) Human HEK293
Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belo...
TMPK-00446 VEGFR3/FLT4 Protein, Human, Recombinant (aa 25-776, His & Avi), Biotinylated Human HEK293
Vascular endothelial growth factor (VEGF) and its receptors VEGF-R1, -R2 and -R3 play important roles in tumor angiogenesis and are associated with poor prognosis in several solid tumors.VEGF-R1, -R2 and -R3 were highly ...
TMPY-06620 VEGFR3/FLT4 Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293
Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belo...
TargetMol