t47d — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T5755	Aloesin		Tyrosinase
	Aloesin is a C-glycosylated chromone compound found in aloe (Liliaceae) that inhibits tyrosinase (IC50 = 0.9 mM), an enzyme responsible for catalyzing the first step of the conversion of tyrosine to melanin.		Tyrosinase
T9205	NCGC00378430		Phosphatase , Others
	NCGC00378430 is a potent SIX1/EYA2 interaction inhibitor that disrupts the SIX1/EYA2 complex, EMT, and Metastasis.		Phosphatase , Others
T8334	CADD522	MFCD00167693	Others
	CADD522 (MFCD00167693) is a potent inhibitor of runt-related transcription factor-2 (RUNX2)-DNA binding with an IC50 of 10 nM, with antitumor activity		Others
T4459	PK11000		DNA Alkylator/Crosslinker
	PK11000 is a p53 targeting compound, has anti-tumor activities through activation of unstable p53.		DNA Alkylator/Crosslinker
T36857	Estrone sulfate sodium	Estrone 3-sulfate (sodium salt),17β-Estrone 3-sulfate	Endogenous Metabolite
	Estrone sulfate sodium (17β-Estrone 3-sulfate) is an endogenous steroid and an estrogen ester that is biologically inactive. It is converted by steroid sulfatase into estrone . Estrone sulfate sodium has been investigate...		Endogenous Metabolite
T5858	Sertindole	Lu 23-174	Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , Autophagy
	Sertindole (Lu 23-174) is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 2.7, 20, 0.14, and 6 nM, respectively)
T7311	Oxyphenisatin acetate		Autophagy
	Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468.		Autophagy
T41233	Cis-22a		Calcium Channel , TRP/TRPV Channel
	Cis-22a is a TRPV6 inhibitor (IC50 = 0.32 μM), which exhibits selectivity against related TRPV channels and calcium channels. cis-22a displays antiproliferative effects on T47D human breast cancer cells.		Calcium Channel , TRP/TRPV Channel
T10390	Asperphenamate		Others , Antifungal
	Asperphenamate is a fungal metabolite of Aspergillus flatiipes. The IC50s for T47D cells, MDA-MB-231 cells, and HL-60 cells are 92.3 μM, 96.5 μM, and 97.9 μM. Asperphenamate shows an anticancer effect.		Others , Antifungal
T79397	Neutrophil elastase inhibitor 4
	Neutrophil elastase inhibitor 4 (compound 4f) is a competitive inhibitor of human neutrophil elastase (HNE) with IC50 of 42.30 nM and Ki of 8.04 nM. It prompts apoptosis in T47D cells and inhibits the proliferation of T4...
T13685	ERD-308		Others
	ERD-308 induces >95% of ER degradation at concentrations as low as 5 nM in both cell lines (DC50 (concentration causing 50% of protein degradation) of 0.17 nM and 0.43 nM in MCF-7 and T47D ER+ cells, respectively).ERD-30...		Others
T79383	ER degrader 7
	ER degrader 7 (Compound 35t) is a selective degrader of both ERα and ERβ, and possesses activity as a tubulin polymerization inhibitor. It exhibits potent cell viability inhibition, with IC50 values of 0.06 μM for MCF-7,...
T63744	Autophagy inducer 4
	Autophagy inducer 4 is a Mannich base derivative based on Magnolol and can be used as an anticancer agent. autophagy inducer 4 induces autophagy and thus inhibits cancer cells. autophagy inducer 4 is 76 times more toxic ...
T36539	Nocardamine
	Nocardamine is a ferrioxamine siderophore that has been found inStreptomycesand has diverse biological activities.1,2,3,4It chelates iron in a chrome azurol S assay (IC50= 9.9 μM).1Nocardamine inhibitsM. smegmatisandM. b...
T36427	PACAP (6-27) (human, chicken, mouse, ovine, porcine, rat) (trifluoroacetate salt)		PACAP
	Pituitary adenylate cyclase-activating peptide (PACAP) (6-27) is a PACAP receptor antagonist with IC50 values of 1,500, 600, and 300 nM, respectively, for rat PAC1, rat VPAC1, and human VPAC2 recombinant receptors expres...		PACAP
T36195	CAY10744
	CAY10744 is a topoisomerase II-α poison.1 It inhibits topoisomerase II-α by 78.9% when used at a concentration of 20 μM. CAY10744 is selective for topoisomerase II-α over topoisomerase I providing 100 and 0% inhibition, ...
T36462	CAY10770	CAY10770
	CAY10770 is an inhibitor of the cytochrome P450 (CYP) isoform CYP4Z1 (IC50= 5.9 μM).1It is selective for CYP4Z1 over CYP4A11, CYP4F2, CYP4F3a, CYP4F3b (IC50s = 187-282 μM) but does inhibit CYP4F8 and CYP4F12 (IC50s = 167...
TN5164	Trans-Hinokiresinol		IL Receptor , TNF , NOS , LTR
	Hinokiresinol is a novel inhibitor of LTB4 binding to the human neutrophils, it has antiallergic effect, it inhibits IgE-induced mouse passive cutaneous anaphylaxis reaction. Hinokiresinol (trans-hinokiresinol) and nyaso...		IL Receptor , TNF , NOS , LTR
T35676	17β-hydroxy Exemestane
	17β-hydroxy Exemestane is the primary active metabolite of exemestane . It is formed by metabolism of exemestane by the cytochrome P450 (CYP) isoforms CYP1A and CYP4A11. 17β-hydroxy Exemestane is an aromatase inhibitor (...
T36308	PF-06843195
	PF-06843195 is a selective PI3Kα inhibitor, demonstrating potent activity with an IC50 of 18 nM in Rat1 fibroblasts and Kis for PI3Kα and PI3Kδ less than 0.018 nM and 0.28 nM, respectively, in biochemical kinase assays. ...