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Search Results for " prostaglandin e2 (pge2) "

20

Compounds

Cat No. Product Name Synonyms Targets
T5014 Prostaglandin E2 PGE2,Dinoprostone,Prostaglandin E2 (PGE2) Endogenous Metabolite , Prostaglandin Receptor
Prostaglandin E2 (PGE2) is a naturally occurring hormone involved in a variety of physiological processes in the body, including smooth muscle contraction and relaxation, regulation of vasodilatation and constriction, re...
T83779 EP4 Antagonist 14 Prostaglandin E2 Receptor 4 Antagonist 14,PGE2 Receptor 4 Antagonist 14
EP4 antagonist 14 is a prostaglandin E2 receptor subtype EP4 antagonist, demonstrating an IC50 of 1.1 nM in a HEK293 human receptor reporter assay and blocking β-arrestin recruitment due to PGE2 with an IC50 of 0.9 nM. A...
T15259 Evatanepag CP-533536 free acid Prostaglandin Receptor
Evatanepag (CP-533536 free acid) is an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation with EC50 of 0.3 nM.CP-533536 demonstrated the ability to heal fractures when administered l...
TN2091 Polygalacin D Apoptosis , IAP
Polygalacin D shows anti- proliferation, anti-inflammary, and hepatoprotective activities, it can inhibit the expression of lipopolysaccharide (LPS)-induced iNOS and COX-2 protein and mRNA without an appreciable cytotoxi...
T35610 2,5-dimethyl Celecoxib Apoptosis , Wnt/beta-catenin , Prostaglandin Receptor
2,5-dimethyl Celecoxib is a derivative of celecoxib that does not inhibit COX-2 (IC50 = >100 μM).1 It does inhibit microsomal prostaglandin E synthase-1 (mPGES-1) in HeLa cells (IC50 = 15.6 μM) and reduces prostaglandin ...
T3926 Echinatin Retrochalcone Free radical scavengers
Echinatin (Retrochalcone) disturb the mitochondrial energy transfer reactions and membrane permeability, at a low concentration cause deterioration of respiratory control and oxidative phosphorylation of isolated rat liv...
T27981 MB-28767 M&B 28767,MB28767 Others
MB-28767 is an agonist of prostaglandin E2 (PGE2) receptor.
T38342 11-deoxy Prostaglandin E2 11-deoxy Prostaglandin E2 Others
11-deoxy Prostaglandin E2 (11-deoxy PGE2) is a stable, synthetic analog of PGE2 . In contrast to PGE2 which has bronchodilation effects, 11-deoxy PGE2 is a powerful bronchoconstrictor and contracts human respiratory trac...
T84585 11-deoxy-16,16-dimethyl Prostaglandin E2 11-deoxy-16,16-dimethyl PGE2 Others
11-Deoxy-16,16-dimethyl Prostaglandin E2 (11-deoxy-16,16-dimethyl PGE2) is a stable synthetic analog of Prostaglandin E2 (PGE2), acting as an agonist for both EP2 and EP3 receptors. It effectively inhibits gastric acid s...
T84587 15(R)-Prostaglandin E2 15-epi PGE2 Others
15(R)-Prostaglandin E2, the C-15 epimer of the more physiologically abundant 15(S)-PGE2 (sc-201225) isomer, is produced mainly from arachidonic acid (sc-200770) via the action of COX and PGES enzymes. Present in nearly a...
TN1871 Ligustroside EGFR , Lipoxygenase , COX
Ligustroside shows little antioxidant, and anti-inflammatory properties, it shows a significant inhibition effect on prostaglandin E2 (PGE2)-release. Ligustroside shows moderate antiviral activities against parainfluenza...
T36168 8-iso-16-cyclohexyl-tetranor Prostaglandin E2 8-iso-16-cyclohexyl-tetranor Prostaglandin E2 Others
8-iso Prostaglandin E2 (8-iso PGE2) is one of several isoprostanes produced from polyunsaturated fatty acids during lipid peroxidation. 8-iso-16-cyclohexyl-tetranor PGE2 is a synthetic analog of 8-iso PGE2. There are no ...
T36728 9-deoxy-9-methylene Prostaglandin E2 9-deoxy-9-methylene Prostaglandin E2 Others
9-deoxy-9-methylene Prostaglandin E2 (9-deoxy-9-methylene PGE2) is a stable, isosteric analog of PGE2 . 9-deoxy-9-methylene PGE2 retains the biological profile of PGE2 with fewer side effects. In the rat 9-deoxy-9-methyl...
T37839 20-hydroxy Prostaglandin E2 20-hydroxy Prostaglandin E2 Others
20-hydroxy Prostaglandin E2 (20-hydroxy PGE2) is a product of cytochrome P450 metabolism of PGE2 . ω-Oxidation at C-20 followed by β-oxidation and the loss of up to four carbons from the lower side chain is a prominent m...
T84651 20-ethyl Prostaglandin E2 20-ethyl PGE2 Others
20-Ethyl Prostaglandin E2 (20-ethyl PGE2) is an analog of Prostaglandin E2 (PGE2) characterized by an extended ω-chain due to two additional methylene carbon atoms. Compared to unoprostone, a clinically approved glaucoma...
T84561 15(R)-15-methyl Prostaglandin A2 15(R)-15-methyl PGA2 Others
Arbaprostil, a synthetic analog of prostaglandin E2 (PGE2) known as 15(R)-15-methyl prostaglandin E2, was developed for its cytoprotective activity. In the commercial production of bulk arbaprostil, one potential impurit...
T69755 Evatanepag sodium Others
Evatanepag, also known as CP-533536, is an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation. CP-533536 demonstrated the ability to heal fractures when administered locally as a sin...
T37918 Prostaglandin E2 isopropyl ester Prostaglandin E2 isopropyl ester Others
Prostaglandin E2 (PGE2) isopropyl ester is a more lipophilic form of the free acid, PGE2. PG esters have enhanced lipid solubility compared to their parent compounds. They are generally hydrolyzed to the free acid by end...
T84584 Prostaglandin E2 Ethanolamide PGE2 ethanolamide Others
Prostaglandin E2 Ethanolamide (PGE 2 -EA), an analog of PGE2, is enzymatically synthesized through COX-2 oxygenation of endocannabinoids. It has the potential to modulate the production of the proinflammatory cytokine TN...
T84557 Prostaglandin E2 serinol amide PGE2-SA Others
Prostaglandin E2 Serinol Amide acts as a weak inhibitor against the hydrolysis of [3H]2-oleoylglycerol, but it is non-hydrolyzable and cannot produce PGE2. Consequently, it is unable to inhibit leukotriene B4 biosynthesi...

Compounds

Prostaglandin E2
T5014
Synonym: PGE2,Dinoprostone,Prostaglandin E2 (PGE2)
Target: Endogenous Metabolite, Prostaglandin Receptor
EP4 Antagonist 14
T83779
Synonym: Prostaglandin E2 Receptor 4 Antagonist 14,PGE2 Receptor 4 Antagonist 14
Target:
Evatanepag
T15259
Synonym: CP-533536 free acid
Target: Prostaglandin Receptor
Polygalacin D
TN2091
Synonym:
Target: Apoptosis, IAP
2,5-dimethyl Celecoxib
T35610
Synonym:
Target: Apoptosis, Wnt/beta-catenin, Prostaglandin Receptor
Echinatin
T3926
Synonym: Retrochalcone
Target: Free radical scavengers
MB-28767
T27981
Synonym: M&B 28767,MB28767
Target: Others
11-deoxy Prostaglandin E2
T38342
Synonym: 11-deoxy Prostaglandin E2
Target: Others
11-deoxy-16,16-dimethyl Prostaglandin E2
T84585
Synonym: 11-deoxy-16,16-dimethyl PGE2
Target: Others
15(R)-Prostaglandin E2
T84587
Synonym: 15-epi PGE2
Target: Others
Ligustroside
TN1871
Synonym:
Target: EGFR, Lipoxygenase, COX
8-iso-16-cyclohexyl-tetranor Prostaglandin E2
T36168
Synonym: 8-iso-16-cyclohexyl-tetranor Prostaglandin E2
Target: Others
9-deoxy-9-methylene Prostaglandin E2
T36728
Synonym: 9-deoxy-9-methylene Prostaglandin E2
Target: Others
20-hydroxy Prostaglandin E2
T37839
Synonym: 20-hydroxy Prostaglandin E2
Target: Others
20-ethyl Prostaglandin E2
T84651
Synonym: 20-ethyl PGE2
Target: Others
15(R)-15-methyl Prostaglandin A2
T84561
Synonym: 15(R)-15-methyl PGA2
Target: Others
Evatanepag sodium
T69755
Synonym:
Target: Others
Prostaglandin E2 isopropyl ester
T37918
Synonym: Prostaglandin E2 isopropyl ester
Target: Others
Prostaglandin E2 Ethanolamide
T84584
Synonym: PGE2 ethanolamide
Target: Others
Prostaglandin E2 serinol amide
T84557
Synonym: PGE2-SA
Target: Others
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TargetMol