nav1.8 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8579	Nav1.8-IN-1	5-(4-Chlorophenyl)-N-[[2-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]pyridine-3-carboxamide,CHEMBL1270208	Sodium Channel
	Nav1.8-IN-1 (CHEMBL1270208) is an inhibitor of human NaV1.8		Sodium Channel
T77693	Nav1.8-IN-4		Sodium Channel
	Nav1.8-IN-4 is a potent Nav1.8 channel inhibitor with potential analgesic activity.Nav1.8-IN-4 can be used for pain and neurological related disorders.		Sodium Channel
T62422	Nav1.8-IN-2
	Nav1.8-IN-2 (compound 35A) is a potent inhibitor of Nav1.8 (IC50: 0.4 nM). Nav1.8-IN-2 can be used in studies of pain disorders, cough, acute and chronic pruritus.
T2024	A-803467	A 803467,A803467	Sodium Channel
	A-803467 is a selective NaV1.8 channel blocker.		Sodium Channel
T4490	PF-01247324		Sodium Channel
	PF-01247324 is a selective and orally bioavailable Nav1.8 channel blocker (IC50: 196 nM).		Sodium Channel
T12424	PF-06305591	PF-6305591	Others
	PF-06305591 is an effective and selective blocker of voltage-gated sodium channel NaV1.8 (IC50 = 15 nM).		Others
T62000	ABBV-318
	ABBV-318 can be used as small molecule Nav1.7/Nav1.8 blockers for the treatment of pain, with IC50 values of 2.8 μM for hNav1.7 and 3.8 μM for hNav1.8. ABBV-318 can be used to study pain-related disorders.
T12421	PF-04885614		Sodium Channel
	PF-04885614 is a potent inhibitor of NaV1.8, has potential for neurological and neurodevelopmental diseases treatment.		Sodium Channel
T15174	DSP-2230		Sodium Channel
	DSP-2230 is a selective blocker of Nav1.7/Nav1.8.		Sodium Channel
TN1254	3'-Methoxydaidzein		Sodium Channel
	3'-Methoxydaidzein is a dual isoflavone and Sodium Channel inhibitor. 3'-Methoxydaidzein inhibited NaV1.7, NaV1.8 and NaV1.3 with IC50 of 181 nM, 397 nM and 505 nM, respectively. 3'-Methoxydaidzein was specific for colla...		Sodium Channel
T9683	VX-150		Sodium Channel
	VX-150 is a highly selective NaV1.8 inhibitor relative to the other sodium channel subtypes (>400-fold).		Sodium Channel
T16514	PF 04531083		Others , Sodium Channel
	PF 04531083 is a selective blocker of the NaV1.8 channel. PF 04531083 can be used for neuropathic and inflammatory pain studies.		Others , Sodium Channel
T69552	Suzetrigine	VX-548	Sodium Channel
	Suzetrigine（VX-548） is an orally active and specific NaV1.8 inhibitor. Suzetrigine has analgesic activity and can be used to study acute pain and neurotransmission.		Sodium Channel
T37688	Cyfluthrin		Reactive Oxygen Species , Sodium Channel
	Cyfluthrin binds to voltage-sensitive sodium channel such as Nav 1.8 sodium channel and modify their gating kinetics, thereby disrupting nerve function of pests.		Reactive Oxygen Species , Sodium Channel
T7336	ICA-121431	2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl	Sodium Channel
	ICA-121431 (2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl) is a nanomolar potent small molecule Nav1.7 channel inhibitor with IC50 of 19 nM for rat Nav1.7, with little or no activity against human Nav1.5 or Nav1.7 channels.		Sodium Channel
T23136	PF 04885614		Others
	NaV1.8 inhibitor		Others
T78955	Analgesic agent-2		Sodium Channel
	Analgesic Agent-2, a selective orally active inhibitor of the NaV1.8 channel, demonstrates an IC50 of 50.18 nM in HEK293 cells that stably express the human NaV1.8 channel, indicating its potential for analgesic activity...		Sodium Channel
T80435	Heteropodatoxin-1		Potassium Channel
	Heteropodatoxin-1 (HpTx1), a spider peptide toxin, acts as an inhibitor of the Kv4.2 current, while concurrently inhibiting Nav1.7 and activating Nav1.9 channels. However, it has no effect on Nav1.8 channels [1].		Potassium Channel
T60761	PF-06305591 dihydrate
	PF-06305591 dihydrate is a potent and highly selective voltage gated sodium channel NaV1.8 blocker (IC 50 = 15 nM) with an excellent preclinical in vitro ADME and safety profile [1].
TP1968	ProTx-I	ProTx I
	Selective CaV3.1 channel blocker (IC50 values are 0.2 and 31.8 μM for hCaV3.1 and hCaV3.2 respectively). Also reversibly inhibits NaV1.8 and blocks KV2.1 channels.