HuR

HuRdegrader 2 (Compound 3) is a molecular glue that targets and degrades the RNA-binding protein Hu antigen R (HuR), achieving 30% degradation at 0.1 μM. It inhibits the proliferation of Colo-205 cancer cells with an IC50 of ≤200 nM. HuRdegrader 2 also shows high affinity for cereblon with an HTRF ratio < 0.02.

SRI-42127 is a novel small molecule inhibitor of the RNA regulatory factor HuR, which inhibits tumor growth, attenuates glial activation in a lipopolysaccharide-induced neuroinflammation model, and reduces neuropathic pain after nerve injury by inhibiting the neuroinflammatory response.

MG-HuR2 is a molecular glue degrader that targets the oncogenic RNA-binding protein HuR, with an IC50 of 0.5 μM. It holds potential for research on HuR-overexpressing malignancies, such as breast cancer.

Oxymethurea (CSI Paste) is a modified urea and can be used as in agricultural fields as a slow-release fertilizer.

Xanthurenic Acid (8-Hydroxykynurenic acid), a molecule arising from tryptophan metabolism by transamination of 3-hydroxykynurenine, activates mGlu2/3 Metabotropic glutamate receptors (mGlu2 and mGlu3).

Ashurbin is a natural product that can be used as a reference standard. The CAS number of Ashurbin is 61401-24-9.

Dasalinol is a natural compound isolated from the cedar (Cimicifuga acerina).

Compound 27b, also known as hURAT1 inhibitor 1, is an isomarine-derived, orally active inhibitor that targets both hURAT1 and GLUT9 with IC50 values of 0.16 μM and 4.47 μM, respectively. This compound exhibits significant anti-hyperuricemia effects and has demonstrated potent uric acid-lowering activity in a hyperuricemia mouse model at a dose of 10 mg/kg. Importantly, Compound 27b displays no notable in vitro cytotoxicity or in vivo hepatotoxicity, and possesses favorable pharmacokinetic (PK) characteristics.

hURAT1 inhibitor 2 (Compound 5) is an inhibitor of hURAT1 (uric acid transporter 1, SLC22A12) with an IC50 of 18 nM. It also exhibits some inhibitory activity against OATP1B1, with an IC50 of 0.73 μM. hURAT1 inhibitor 2 can be used in research related to hyperuricemia, gout, and other diseases associated with abnormal uric acid metabolism.

Holothurin A is a triterpene glycoside.

Holothurin B, as a part of a group of toxins, is originally isolated from the sea cucumber Actinopyga agassizi.

Holothurinogenin, as a lanosterol derivative, has toxic to nerve tissue.

Thurfyl Salicylate (tetrahydrofurfuryl Salicylate) is a redness preparation used for the treatment of musculoskeletal, joint, periarticular, and soft tissue pain.

Dhurrin (Standard) is a reference standard for research and analysis in studies involving Dhurrin. Dhurrin is a natural product

Clematiunicinoside E is a natural product from Clematis uncinata.

Clematomandshurica saponin B shows significant inhibitory activity on cyclooxygenase-2 (IC50 = 2.58 microM).

Dhurrin is a natural product

Cimidahurinine can attenuate Doxorubicin (DOX)-induced cardiotoxicity in a dose-dependent manner with EC50 values of 45.79 uM; it protects against cardiotoxicity by decreasing reactive oxygen species (ROS) accumulation and downregulating apoptosis-related Bax/Bcl-2 proteins.

Phyllanthurinolactone is a natural product for research related to life sciences. The catalog number is TN6277 and the CAS number is 168180-12-9.

Clemomandshuricoside B is a natural product for research related to life sciences. The catalog number is TN6587 and the CAS number is 905294-48-6.

Dehydrosulphurenic acid, a triterpenoid, can be isolated from Fomes officinalis ames [1].

Okicenone is an antibiotic, interferring with HuR RNA binding, HuR trafficking, T-cell activation and cytokine expression.

CMLD-2 is an inhibitor of HuR-ARE interaction (Ki: 350 nM) that competitively binds HuR protein and disrupts its interaction with adenine element-rich (ARE) mRNA targets.CMLD-2 induces apoptosis and exhibits antitumor effects through MAD2 downregulation. CMLD-2 (1-75 μM ; 24-72 h) had an inhibitory effect on the viability of thyroid cancer cells.CMLD-2 (20-30 μM ; 24-48 h) activated caspases and induced apoptosis in H1299 and A549 cells.CMLD-2 (30 μM ; 24-48 h) induced G1 cell cycle arrest in H1299 and A549 cells and mitochondrial perturbation. CMLD-2 (30 μM ; 24-48 h) reduced the expression of HuR and HuR-regulated mRNAs and proteins in H1299 cells.CMLD-2 (35 μM ; 72 h) decreased the directional migration ability of SW1736, 8505C, BCPAP and K1 cells.CMLD-2 induced the migration of SW1736, 8505C, BCPAP and K1 cells with a strong decrease in MAD2 mRNA levels.

KH-3 is a potent inhibitor (IC50: 0.35 μM) of the RNA-binding protein Hu antigen R (HuR) and exhibits anti-proliferative effects. KH-3 interferes with HuR-FOXQ1 Mrna interactions, inhibits breast cancer cell invasion, and delays lung colony formation.