GTPγS

Mant-GTPγS, an effective GTP analog, displays strong competitive inhibition of adenylyl cyclase (AC). Additionally, it acts as a potent inhibitor of YdeH.

C-021 dihydrochloride is a potent CCR4 antagonist that effectively inhibits functional chemotaxis in humans and mice, with IC50 values of 140 nM and 39 nM, respectively.

C 021 dihydrochloride is a potent CCR4 antagonist. C-021 (4-Quinazolinamine, 2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-) dihydrochloride potently inhibits functional chemotaxis in humans and mice with IC50s of 140 nM and 39 nM, respectively. It effectively prevents human CCL22-derived [35S]GTPγS from binding to the receptor (IC50: 18 nM).

6-OAU (GTPL5846)(GTPL5846; 6-n-octylaminouracil) is a surrogate agonist of GPR84; activates human GPR84 in the presence of Gqi5 chimera in HEK293 cells with an EC50 of 105 nM in the PI assay.

GTPγS tetralithium (Guanosine 5'-[γ-thio]triphosphate tetralithium) is a G-protein activator, a non-hydrolyzable GTP analog that protects proteins from proteolytic degradation.GTPγS tetralithium is involved in the detection of cells expressing recombinant receptors and endogenous receptors. GTPγS tetralithium is involved in the detection of GPCR signaling in cells expressing recombinant receptors as well as in cells and tissues expressing endogenous receptors, and can be assayed to measure agonist-induced desensitization of two human polymorphic α2B-adrenoceptor variants.

GTPγS (Guanosine 5'-[γ-thio]triphosphate) acts as a G protein activator, protecting proteins from proteolytic degradation. It stimulates GLUT4 translocation in a tyrosine kinase-dependent manner, enhances phospholipase activity, and induces actin polymerization. The combination of GTPγS and G protein α is useful for studying kinase activity. Additionally, GTPγS can be included as a component of lysis buffers.

Rp-GTPαS tetrasodium is a thiophosphate analogue of Guanosine triphosphate (GTP) that can induce calcium ion release and secretion in rat peritoneal mast cells.

Sp-GTPαS tetrasodium is a thio-phosphorothioate analog of GTP, known for its enhanced metabolic stability compared to GTP.

GTPαS is a monomeric precursor used in nucleic acid synthesis.

Sp-2'-O-Me-GTPαS tetrasodium is a GTP analog. It is utilized in enzyme-catalyzed processes to incorporate phosphorothioate and modified 2'-OH groups into RNA.

Rp-2'-O-Me-GTPαS tetrasodium is a GTP analog with a modified 2'-OH group.

isoGTP (Isoguanosine-5'-O-triphosphate) sodium is an isomer of guanosine 5'-triphosphate and a phosphorylated form of Crotonoside. In reverse transcriptase assays, isoGTP sodium inhibits transcription and induces T-to-C mutations. It holds potential for research on substrate specificity of fructose phosphate kinase and mutT homolog 1 (MTH1).

Guanine-2'-deoxy-β-L-ribofuranosyl-5'-O-triphosphate (sodium) is an isomer of dGTP and functions as an inhibitor of telomerase, with an inhibition constant (Ki) of 15 μM for the human enzyme.

3'-O-Bn-GTP (3'-O-Benzyl-5'-O-guanosine triphosphate) sodium (CAP-164) is an analog of GTP. This compound demonstrates increased stability against esterases.

m7GTP sodium (7-Methyl-guanosine-5'-triphosphate sodium) is a structural analog of the mRNA cap that inhibits protein synthesis in vitro by binding to eIF4E (eukaryotic translation initiation factor), and is commonly used to study protein synthesis involving mRNA.

5′-Guanylyl methylenediphosphonate (sodium) serves as a GTP analogue and acts as a specific, competitive inhibitor of the GTP reaction in protein synthesis [1].

TNP-GTP, a fluorescent derivative of guanosine 5'-triphosphate (GTP), essential for protein synthesis and gluconeogenesis, exhibits an emission peak at 552 nm when excited at 410 nm in water. Its fluorescence intensity increases and emission peaks shift to 544 nm and 532 nm in 40% and 80% N,N-dimethylformamide, respectively, due to the solvent's lower polarity compared to water. As a potent inhibitor of glutamate dehydrogenase (Ki = 2.7 μM), TNP-GTP enhances fluorescence and shifts its emission to 545 nm upon binding to this enzyme, a process reversible by GTP addition. Additionally, it serves as an antagonist to purinergic P2X2 and P2X2/3 receptors (IC50s = 0.4 and 1.2 nM, respectively) and selectively inhibits rat soluble guanylyl cyclase (sGC; Ki = 11 nM) over bovine liver glutamate dehydrogenase (GDH; Ki = 2.7 µM) and the calmodulin-dependent B. pertussis adenylyl cyclase (AC) toxin, with inhibition constants of 20 µM and 320 µM in the presence of manganese and magnesium, respectively.

Acyclovir triphosphate sodium, a labeled modified deoxyoligonucleotide (dNTP), is capable of releasing pyrophosphate to generate fluorescence and is specifically utilized in applications such as gene synthesis and sequencing.

8-(2-Aminoethylthio)guanosine-5'-O-triphosphate (8-AET-GTP) is a derivative of GTP. GTP serves as an energy substrate in protein synthesis and gluconeogenesis.

Guanine-β-L-ribofuranosyl-5'-O-triphosphate (sodium) is an isomer of iso-guanosine-5'-O-triphosphate.

7-Deaza-7-propargylamino-dGTP sodium is the sodium salt form of 7-Deaza-7-propargylamino-dGTP. It is an analog of deoxyguanosine triphosphate dGTP and can be used in gene sequencing.

3′-Azido-ddGTP sodium is a labeled and modified deoxynucleoside triphosphate (dNTP) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing.

3'-Amino-3'-dGTP sodium is a labeled and modified deoxynucleoside triphosphate (dNTP) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing.

3'-Aminoacetyl-GTP sodium is a labeled and modified deoxynucleoside triphosphate (dNTP) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing.