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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T79945 | Ferroptosis-IN-1 | Ferroptosis | |
Ferroptosis-IN-1, a diterpene derived from A. campylantha, functions as a ferroptosis inhibitor with an EC50 of 10 μM and is utilized in the study of neuroinflammatory diseases [1]. | |||
T11631 | IFSP1 | Ferroptosis | |
iFSP1, a potent, selective, and glutathione-independent ferroptosis suppressor protein 1 (FSP1) (AIFM2) inhibitor with an EC50 of 103 nM, sensitizes diverse human cancer cell lines to ferroptosis inducers like (1S,3R)-RS... | |||
T77762 | ROS-generating agent 1 | Apoptosis , Ferroptosis , ROS Kinase | |
Ros-generating agent 1 has anticancer activity and generates ROS by covalently modifying Sec-498 residues of TrxR. ROS-generating agent 1 reduces intracellular TrxR protein levels and promotes ROs-dependent apoptosis and... | |||
T4309 | CIL56 | CA3 | Ferroptosis , ROS |
CIL56 (CA3) is a small molecule that induces cellular ferroptosis through the production of iron-dependent reactive oxygen species (ROS). It also induces accumulation of long-chain saturated, monounsaturated, and polyuns... | |||
T82408 | Ferroptosis-IN-3 | Ferroptosis | |
Ferroptosis-IN-3 (Compound 25), a ferroptosis inhibitor, demonstrates potent activity by inhibiting RSL3-induced ferroptosis in HT-1080 cells (EC50: 8.6 nM). It exhibits radical scavenging abilities against DPPH and ABTS... | |||
T36515 | RC363 | ||
RC363 is an inhibitor of ferroptosis and a derivative of the antioxidant and hypocholesterolemic agent probucol .1It reduces 2,2-diphenyl-1-picrylhydrazyl radicals by approximately 40% in a cell-free assay when used at a... | |||
T36516 | RC574 | RC574 | |
RC574 is an inhibitor of ferroptosis and a derivative of the antioxidant and hypocholesterolemic agent probucol .1It inhibits glutamate-induced cell death in HT22 cells (IC50= 276.2 nM) and mouse primary cortical neurons... | |||
T79294 | NC-R17 | Glutathione Peroxidase | |
NC-R17, an RSL3-based noncovalent GPX4 degrader implicated in ferroptosis, demonstrates anti-tumor activity and is utilized in the design of noncovalent GPX4-targeted proteolysis targeting chimeras (PROTACs) [1]. | |||
T63729 | GPX4-IN-3 | ||
GPX4-IN-3 (26a) is a potent inhibitor of glutathione peroxidase 4 (GPX4), selectively inducing ferroptosis. It demonstrates a 71.7% inhibition rate of GPX4 at a concentration of 1 μM [1]. | |||
T35994 | Erastin2 | Erastin2 | |
Erastin2 is a ferroptosis inducer and an inhibitor of the system xc- cystine/glutamate transporter.[1] [2] It inhibits glutamate release in CCF-STTG1 cells (IC50 = 0.0035 181M).[2] It induces cell death in HAP1 cells... | |||
T79777 | GPX4-IN-7 | Ferroptosis | |
GPX4-IN-7 (Compound 31), an indirubin derivative, serves as a ferroptosis inducer in colon cancer treatment. Exhibiting potent antitumor properties, it inhibits HCT-116 cell growth with an IC50 of 0.49 μM. This compound ... | |||
T80847 | W1131 TFA | STAT | |
W1131 TFA is a potent STAT3 inhibitor inducing ferroptosis, effectively halting cancer progression in subcutaneous xenograft, organoid, and PDX models of gastric cancer. Besides mitigating chemoresistance to 5-FU in canc... | |||
T37851 | Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) | ||
Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) is an inducer of ferroptosis.1 It induces ferroptosis, but not apoptosis or necroptosis, in NB1 cancer cells when used at a concentration of 3 μM.1 Chlorido[N,N... | |||
T73558 | W1131 | ||
W1131, a potent STAT3 inhibitor, effectively triggers ferroptosis and suppresses cancer progression across various models including gastric cancer cell subcutaneous xenograft, organoids, and patient-derived xenograft (PD... | |||
T37248 | Pantothenate Kinase Inhibitor | ||
Pantothenate Kinase Inhibitor (PANKi) is a reversible inhibitor of pantothenate kinase (PanK; IC50s = 70, 92, and 25 nM for PanK1β, PanK2, and PanK3, respectively), the rate-limiting enzyme in the synthesis of coenzyme A... | |||
T37805 | JKE-1716 | ||
JKE-1716 is an inhibitor of glutathione peroxidase 4 (GPX4) and a derivative of the GPX4 inhibitor ML-210 .1JKE-1716 reduces viability of LOX-IMVI cancer cells in a concentration-dependent manner and in a panel of additi... | |||
T80052 | Cathepsin B | ||
Cathepsin B, a cysteine protease, plays a role in various forms of programmed cell death, such as apoptosis, pyroptosis, ferroptosis, necroptosis, and autophagic cell death [1]. | |||
T79359 | Anticancer agent 147 | Ferroptosis | |
Compound 6j (Anticancer agent 147), a sophoridine derivative and ferroptosis inducer, promotes intracellular accumulation of Fe2+, reactive oxygen species (ROS), and malondialdehyde (MDA), enhances endoplasmic reticulum ... | |||
T79042 | RIP1 kinase inhibitor 5 | RIP kinase | |
RIP1 kinase inhibitor 5 (example 1) serves as a potent regulator of tumor immunity by inhibiting RIP1, functioning similarly to SIR1-365 (compound 13) in suppressing necrosis and ferroptosis [2]. | |||
T83886 | IcFSP1 TFA | ||
icFSP1, an inhibitor of ferroptosis suppressor protein 1 (FSP1), promotes condensation and phase separation of FSP1 in cellular environments at 2.5 µM concentration but does not affect FSP1's enzymatic function in cell-f... |