dnmt1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8967	SW155246		DNA Methyltransferase
	SW155246 is a potent and selective inhibitor of DNMT1 (DNA methyltransferase 1; IC50 of 1.2 μM). SW155246 induces re-expression of the tumor suppressor geneRASSF1 in A549 cells.		DNA Methyltransferase
T11469	GSK-3484862		DNA Methyltransferase
	GSK-3484862 is a non-covalent Dnmt1 inhibitor. It induces DNA hypomethylation to against cancer.		DNA Methyltransferase
T2210	Genipin	(+)-Genipin	Others , Autophagy
	Genipin ((+)-Genipin), an active aglycone derived from an iridoid glycoside called geniposide, is found in the fruit of Gardenia jasminoides Ellis.		Others , Autophagy
T7194	CM-272		Apoptosis , DNA Methyltransferase , Histone Methyltransferase
	CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.
T16813	RX-3117	fluorocyclopentenylcytosine,TV-1360	Nucleoside Antimetabolite/Analog
	RX-3117 (fluorocyclopentenylcytosine) is a novel a cytidine analog. RX-3117 displays anticancer activity in several cancer cell lines, including gemcitabine-resistant variants.		Nucleoside Antimetabolite/Analog
T15080	DC-05		DNA Methyltransferase , Histone Methyltransferase
	DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 and a Kd: 10.3 μM and 1.09 μM, respectively).		DNA Methyltransferase , Histone Methyltransferase
T9573	GSK3685032		DNA Methyltransferase
	GSK3685032 is a non-covalent and selective DNMT1 inhibitor(IC50 = 36 nM). The inhibitory effect is time-independent and reversible. GSK3685032 induces loss of DNA methylation and transcriptional activation and inhibits c...		DNA Methyltransferase
T1904	SGI-1027	DNA Methyltransferase Inhibitor II,SGI1027	Apoptosis , DNA Methyltransferase
	SGI-1027 (DNA Methyltransferase Inhibitor II) is an effective and selective inhibitor of DNA methyltransferase (DNMT). The IC50 of SGI-1027(SGI1027) against DNMT1, DNMT3A, and DNMT3B are 6, 8, 7.5 μM, respectively.		Apoptosis , DNA Methyltransferase
T60322	Procainamide	Biocoryl,Novocainamide	DNA Methyltransferase
	Procainamide (Novocainamide) is a specific and potent DNA methyltransferase 1 ( DNMT1 ) inhibitor. Procainamide is a Class 1A antiarrhythmic agent. Procainamide has the potential for the research of cancer and arrhythmia...		DNA Methyltransferase
T12261	NSC232003		E1/E2/E3 Enzyme
	NSC232003 is a highly potent and cell-permeable inhibitor of UHRF1.		E1/E2/E3 Enzyme
T3606	γ-Oryzanol	Gamma-Oryzanol,Oliver,Gammariza	DNA Methyltransferase
	γ-Oryzanol (Gamma-Oryzanol) is a natural nutrient extract isolated from rice bran oil that contains a mixture of sterols and ferulic acids, which may aid in the destruction of free radicals in the skin. It has recently b...		DNA Methyltransferase
T15081	DC_517		DNA Methyltransferase
	DC_517 is an inhibitor of DNA methyltransferase 1 (DNMT1) ( IC50: 1.7 μM; Kd: 0.91 μM).		DNA Methyltransferase
T11682	Isofistularin-3		Others
	Isofistularin-3, a direct DNA-competitive DNMT1 inhibitor with an IC50 of 13.5 μM, functions as a DNA demethylating agent, leading to cell cycle arrest and increased sensitivity to TRAIL in cancer cells. Additionally, it...		Others
T74887	GSK3735967
	GSK3735967 is a selective, reversible, non-nucleoside inhibitor targeting DNMT1, demonstrating an IC50 value of 40 nM. It features a planar dicyanopyridine core designed to specifically interact with DNMT1-bound hemimeth...
T39648	(R)-GSK-3685032
	(R)-GSK-3685032 is the R-enantiomer of GSK-3685032. GSK-3685032 is a first-in-class, non-time-dependent, non-covalent, reversible, selective DNMT1 inhibitor with an IC 50 of 0.036 μM. GSK-3685032 induces robust loss of D...
T11185	EML741		Histone Methyltransferase
	EML741 also inhibits DNMT1 (IC50, 3.1 μM), with no effect on DNMT3a or DNMT3b. EML741 exhibits low cell toxicity, and is membrane permeable and blood-brain barrier penetrated. EML741 is a histone lysine methyltransferase...		Histone Methyltransferase
T10840L	CM-579		DNA Methyltransferase , Histone Methyltransferase
	CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.		DNA Methyltransferase , Histone Methyltransferase
T81432	PNMT-IN-1
	PNMT-IN-1 (inhibitor 4) is a selective second generation inhibitor [1] of phenylethanolamine N-methyltransferase (PNMT), exhibiting a Ki value of 1.2 nM and an IC50 value of 81 nM. Additionally, it disrupts the activity ...
T73257	USP7-IN-9
	USP7-IN-9, a potent inhibitor of ubiquitin-specific protease 7 (USP7) with an IC50 of 40.8 nM, effectively induces apoptosis and arrests cell progression at the G0/G1 and S phases in RS4;11 cells. It decreases the protei...
T10840	CM-579 trihydrochloride (1846570-40-8 free base)	CM-579 trihydrochloride	DNA Methyltransferase
	CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wide range of cancer cells.		DNA Methyltransferase