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Search Results for " dna-strand "

Targets

78

Compounds

8

Natural Products

49

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T12019 Methylproamine Others
Methylproamine is a DNA-binding radioprotector , acts by repair of transient radiation-induced oxidative species on DNA.
T9168 NSC 617145 NSC617145,NSC-617145 DNA/RNA Synthesis
NSC 617145 (NSC617145) is an inhibitor of WRN helicase that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner.
T5363 Tempo 2,2,6,6-Tetramethylpiperidinooxy Free radical scavengers , Reactive Oxygen Species , DNA/RNA Synthesis , Mitochondrial Metabolism
Tempo (2,2,6,6-Tetramethylpiperidinooxy) has a wide range of applications including use as a free radical scavenger, a reagent in organic synthesis and as a structural probe in electron spin resonance spectroscopy.
T24925 UNC-2170 UNC2170 Maleate,UNC-2170 Maleate,UNC 2170 Maleate Others
UNC-2170 (UNC2170 Maleate) is the methyl-lysine binding protein, 53BP1 ligand.
T14858 Calicheamicin Calicheamicin γ1 Others
Calicheamicin (Calicheamicin γ1) is an antitumor antibiotic and is a DNA synthesis inhibitor. It also is a cytotoxic agent that causes double-strand DNA breaks.
T1798 RITA NSC 652287,RITA (NSC 652287) Mdm2 , DNA Alkylator/Crosslinker , p53 , Autophagy
RITA (NSC-652287)(NSC-652287) induced cross-links of both DNA-DNA and DNA-protein with no detectable DNA single-strand breaks. RITA, like nutlin-3, can disrupt the p53/Mdm2 interaction.
T9497 Niraparib tosylate monohyrate PARP
Niraparib, also know as MK-4827, is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. MK4827 inhibits PARP activity, enhancing the accumulation of DNA strand breaks and promoting...
T3353 Niraparib hydrochloride MK-4827 hydrochloride,MK-4827 (hydrochloride) Apoptosis , Others , PARP
Niraparib hydrochloride (MK-4827 hydrochloride) is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. Niraparib hydrochloride inhibits PARP activity, enhancing the accumulation of...
T6588 Mitoxantrone mitozantrone Topoisomerase , PKC
Mitoxantrone (mitozantrone) is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisome...
T6336 Amonafide NSC308847,AS1413,Nafidimide,AS1413,Quinamed Topoisomerase
Amonafide (NSC-308847,AS1413)(AS1413) produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage.
T11600 IBR2 Isoquinoline DNA/RNA Synthesis
IBR2 (Isoquinoline) is a potent and specific RAD51 inhibitor known for its ability to suppress RAD51-mediated DNA double-strand break repair. By interfering with RAD51 multimerization, accelerating proteasome-mediated RA...
T11332 FUBP1-IN-1 FUBP1–IN-1 Others
FUBP1 - in-1, with an IC50 value of 11.0 M, is an effective FUSE binding protein 1 (FUBP1) inhibitor that can interfere with the binding of FUBP1 to its SINGLE-strand target DNA FUSE sequence.
T1055 Ifosfamide NSC109724,Isophosphamide DNA Alkylator/Crosslinker , DNA/RNA Synthesis
Ifosfamide (NSC-109724) alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. Ifosfamide is a synthetic analog of the nitrogen mustard cyclophosphamide with antineoplastic acti...
T9760 IC 86621 DNA-PK
IC 86621 is a selective and reversible ATP-competitive inhibitor of DNA-PK with an IC50 of 120 nM. IC 86621 increases DNA double-strand break(DSB)-induced antitumor activity with an EC50 of 68 µM for DNA-PK mediated cell...
T4047 Bisantrene CL216942 Topoisomerase
Bisantrene (CL216942) is an anthracenyl bishydrazone with antineoplastic activity. Bisantrene intercalates with and disrupts the configuration of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and ...
T9430 Venadaparib NOV140101,IDX-1197 PARP
Venadaparib (NOV140101) (IDX-1197) is a potent, selective and orally active PARP inhibitor with IC50s of 1.4 nM and 1.0 nM for PARP1 and PARP2, respectively. Venadaparib is insensitive to PARP-5. Venadaparib prevents the...
T11067 VX-984 M9831 DNA-PK
VX-984 (M9831) is an oral, selective DNA-PK inhibitor that can cross the blood-brain barrier. VX-984 inhibited the conjugation of non-homologous terminal NHEJ and acted on DSBs to break DNA double strand. VX-984 is commo...
T50098 TIQ-A PARP
TIQ-A is a PARP1 inhibitor which involved in DNA single-strand break repair via the base excision repair pathway. PARP1 is triggered by DNA damage and its excessive activation has been proposed as a causative factor in m...
T21320 Methoxyamine HCl TRC102,TRC 102,Methoxyamine,TRC-102 Others
Methoxyamine HCl (Methoxyamine) covalently binds to apurinic/apyrimidinic (AP) DNA damage sites and inhibits base excision repair (BER), which may result in an increase in DNA strand breaks and apoptosis. Methoxyamine is...
T3615 Evofosfamide TH-302 Apoptosis , Others
Evofosfamide (TH-302) is a hypoxia-activated prodrug of the cytotoxin bromo-isophosphoramide mustard (Br-IPM) conjugated with 2-nitroimidazole, with potential antineoplastic activity. When exposed to hypoxic conditions, ...
T3157 COH29 RNR Inhibitor COH29 DNA/RNA Synthesis
COH29 (RNR Inhibitor COH29) is an orally available, aromatically substituted thiazole and inhibitor of the human ribonucleotide reductase (RNR), with potential antineoplastic activity. Upon oral administration, the RNR i...
T15826 Lometrexol LY 264618,DDATHF DHFR
Lometrexol (LY 264618), an antipurine Antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol can further inhibit ...
T0893 Tinidazole CP12574 Antibacterial , Antibiotic
Tinidazole (CP12574)a is a 5-nitroimidazole derivative with the antiprotozoal property. Although the mechanism of action has not been fully elucidated, it has been suggested that tinidazole is metabolized and yields nitr...
T1600 Doxifluridine Ro 21-9738,AMC 0101,5'-DFUR,5-Fluoro-5'-deoxyuridine Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis
Doxifluridine (AMC 0101) is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, designed to circumvent the rapid degradation of 5-FU by...
T1408 Capecitabine Xeloda,Capecitibine,Capiibine,RO 09-1978 Apoptosis , Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis
Capecitabine (Capecitibine) is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moie...
T24555 NSC666715 NSC 666715,NSC-666715
NSC666715 is the strand-displacement activity of DNA polymerase inhibitor.
T15200 Edotecarin PF 804950,J 107088 Topoisomerase
Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).
T28293 Pamiparib maleate BGB290,BGB 290,BGB-29 maleat 0
Pamiparib is a highly potent and selective PARP inhibitor. BGB-290 selectively binds to PARP and prevents PARP-mediated repair of single-strand DNA breaks via the base-excision repair (BER) pathway. This enhances the acc...
T21303 Etoposide Phosphate Eposin Etopophos Vepesid VP16
Etoposide phosphate is a phosphate salt of Etoposide, which binds to the enzyme topoisomerase II, then induces double-strand DNA breaks and inhibits DNA repair, leading to decreased DNA synthesis and tumor cell prolifera...
T23654 Afeletecan free base BAY 56-3722,BAY56-3722,BAY-563722,Afeletecan
Afeletecan is a water-soluble camptothecin derivative. Afeletecan stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. Both the initial cleavage reaction and religation steps ...
T20907 DBC 3,4,5,6-Dibenzocarbazole
DBC, a ubiquitous environmental pollutant, induces significant DNA strand break levels and micronuclei in HepG2 cells.
T71482 Penclomedine
Penclomedine is an antineoplastic agent which alkylates and crosslinks DNA, resulting in DNA strand breaks and inhibition of DNA and RNA synthesis.
T16283 Neocarzinostatin 5-HT Receptor
Neocarzinostatin is an effective DNA-damaging, anti-tumor antibiotic. It recognizes double-stranded DNA bulge and induces DNA double strand breaks (DSBs). Neocarzinostatin leads to apoptosis. Neocarzinostatin has potenti...
T21323 Picoplatin NX 473,AMD-473,AMD473,NX-473,NX473,AMD 473
Picoplatin has a broad spectrum of antineoplastic activity and is designed to overcome platinum drug resistance. Picoplatin alkylates DNA, forming both intra- and inter-strand cross-linkages, resulting in the inhibition ...
T79330 PARP-1-IN-13 PARP
PARP-1-IN-13 (Compound 19c) is a potent PARP-1 inhibitor with an IC50 of 26 nM, hindering DNA single-strand break repair and exacerbating DNA double-strand breaks. It induces apoptosis in cancer cells via the mitochondri...
T68985 Amonafide L-malate
Amonafide L-malate is the malate salt of amonafide, an imide derivative of naphthalic acid, with potential antineoplastic activity. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in DNA double-s...
T70533 Amonafide dihydrochloride
Amonafide dihydrochloride is the dihydrochloride salt of amonafide, an imide derivative of naphthalic acid. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in protein-associated strand breaks and...
T69862 Afeletecan HCl
Afeletecan, also known as BAY 56-3722, is a water-soluble camptothecin derivative conjugated to a carbohydrate moiety exhibiting antineoplastic activity. BAY 56-3722 stabilizes the topoisomerase I-DNA covalent complex a...
T70115 Pamiparib hydrate
Pamiparib, also known as BGB-290, is a highly potent and selective PARP inhibitor with favorable drug metabolism and pharmacokinetic properties. BGB-290 selectively binds to PARP and prevents PARP-mediated repair of sin...
T68672 Amsacrine lactate
Amsacrine lactate is an aminoacridine derivative with potential antineoplastic activity. Although its mechanism of action is incompletely defined, amsacrine may intercalate into DNA and inhibit topoisomerase II, resultin...
T68673 Amsacrine gluconate
Amsacrine gluconate is an aminoacridine derivative with potential antineoplastic activity. Although its mechanism of action is incompletely defined, amsacrine may intercalate into DNA and inhibit topoisomerase II, result...
T68671 Amsacrine Isothionate
Amsacrine Isothionate is an aminoacridine derivative with potential antineoplastic activity. Although its mechanism of action is incompletely defined, amsacrine may intercalate into DNA and inhibit topoisomerase II, resu...
T68971 Ormaplatin
Ormaplatin is a platinum(IV) analogue with antineoplastic activity. Ormaplatin alkylates DNA, forming both inter- and intra-strand platinum-DNA crosslinks, which result in inhibition of DNA replication and transcription ...
T40345 AV-153
AV-153 is a 1,4-dihydropyridine derivative with antimutagenic properties. It intercalates into DNA at single strand breaks, resulting in reduced DNA damage and stimulation of DNA repair in human cells in vitro. AV-153 al...
T76109 Nuclease S1
Nuclease S1 is a specific endonuclease that degrades single stranded DNA (ssDNA) and RNA. Nuclease S1 can also remove protruding single-strand ends from double-stranded DNA [1] [2] .
T40933 Bromochloroacetonitrile
Bromochloroacetonitrile is a chemical compound that is formed as a by-product during the chlorine disinfection process of water that contains natural organic material. This compound exhibits direct mutagenic activity and...
T38962 MC-SN38 MC-SN38
MC-SN38 is a drug-linker conjugate composed of a potent microtubule-disrupting agent SN38 and a non-cleavable MC linker to make antibody drug conjugate (ADC). SN-38, an active metabolite of the Topoisomerase I inhibitor ...
T68675 Porfiromycin
Porfiromycin is a n N-methyl derivative of the antineoplastic antibiotic mitomycin C isolated from the bacterium Streptomyces ardus and other Streptomyces bacterial species. Bioreduced porfiromycin generates oxygen radic...
T19149 5-BrdUTP sodium salt 5-Bromo-2'-deoxyuridine 5'-triphosphate sodium salt Others
5-BrdUTP sodium salt is a TdT substrate that can be used to label the DNA double-strand breaks.
T70229 Laromustine
Laromustine is a sulfonyl hydrazine prodrug with antineoplastic activity. Laromustine releases the DNA chloroethylating agent 90CE after entering the blood stream; 90CE chloroethylates alkylates the 06 position of guanin...

Compounds

Methylproamine
T12019
Synonym:
Target: Others
NSC 617145
T9168
Synonym: NSC617145,NSC-617145
Target: DNA/RNA Synthesis
Tempo
T5363
Synonym: 2,2,6,6-Tetramethylpiperidinooxy
Target: Free radical scavengers, Reactive Oxygen Species, DNA/RNA Synthesis, Mitochondrial Metabolism
UNC-2170
T24925
Synonym: UNC2170 Maleate,UNC-2170 Maleate,UNC 2170 Maleate
Target: Others
Calicheamicin
T14858
Synonym: Calicheamicin γ1
Target: Others
RITA
T1798
Synonym: NSC 652287,RITA (NSC 652287)
Target: Mdm2, DNA Alkylator/Crosslinker, p53, Autophagy
Niraparib tosylate monohyrate
T9497
Synonym:
Target: PARP
Niraparib hydrochloride
T3353
Synonym: MK-4827 hydrochloride,MK-4827 (hydrochloride)
Target: Apoptosis, Others, PARP
Mitoxantrone
T6588
Synonym: mitozantrone
Target: Topoisomerase, PKC
Amonafide
T6336
Synonym: NSC308847,AS1413,Nafidimide,AS1413,Quinamed
Target: Topoisomerase
IBR2
T11600
Synonym: Isoquinoline
Target: DNA/RNA Synthesis
FUBP1-IN-1
T11332
Synonym: FUBP1–IN-1
Target: Others
Ifosfamide
T1055
Synonym: NSC109724,Isophosphamide
Target: DNA Alkylator/Crosslinker, DNA/RNA Synthesis
IC 86621
T9760
Synonym:
Target: DNA-PK
Bisantrene
T4047
Synonym: CL216942
Target: Topoisomerase
Venadaparib
T9430
Synonym: NOV140101,IDX-1197
Target: PARP
VX-984
T11067
Synonym: M9831
Target: DNA-PK
TIQ-A
T50098
Synonym:
Target: PARP
Methoxyamine HCl
T21320
Synonym: TRC102,TRC 102,Methoxyamine,TRC-102
Target: Others
Evofosfamide
T3615
Synonym: TH-302
Target: Apoptosis, Others
COH29
T3157
Synonym: RNR Inhibitor COH29
Target: DNA/RNA Synthesis
Lometrexol
T15826
Synonym: LY 264618,DDATHF
Target: DHFR
Tinidazole
T0893
Synonym: CP12574
Target: Antibacterial, Antibiotic
Doxifluridine
T1600
Synonym: Ro 21-9738,AMC 0101,5'-DFUR,5-Fluoro-5'-deoxyuridine
Target: Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis
Capecitabine
T1408
Synonym: Xeloda,Capecitibine,Capiibine,RO 09-1978
Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis
NSC666715
T24555
Synonym: NSC 666715,NSC-666715
Target:
Edotecarin
T15200
Synonym: PF 804950,J 107088
Target: Topoisomerase
Pamiparib maleate
T28293
Synonym: BGB290,BGB 290,BGB-29 maleat 0
Target:
Etoposide Phosphate
T21303
Synonym: Eposin Etopophos Vepesid VP16
Target:
Afeletecan free base
T23654
Synonym: BAY 56-3722,BAY56-3722,BAY-563722,Afeletecan
Target:
DBC
T20907
Synonym: 3,4,5,6-Dibenzocarbazole
Target:
Penclomedine
T71482
Synonym:
Target:
Neocarzinostatin
T16283
Synonym:
Target: 5-HT Receptor
Picoplatin
T21323
Synonym: NX 473,AMD-473,AMD473,NX-473,NX473,AMD 473
Target:
PARP-1-IN-13
T79330
Synonym:
Target: PARP
Amonafide L-malate
T68985
Synonym:
Target:
Amonafide dihydrochloride
T70533
Synonym:
Target:
Afeletecan HCl
T69862
Synonym:
Target:
Pamiparib hydrate
T70115
Synonym:
Target:
Amsacrine lactate
T68672
Synonym:
Target:
Amsacrine gluconate
T68673
Synonym:
Target:
Amsacrine Isothionate
T68671
Synonym:
Target:
Ormaplatin
T68971
Synonym:
Target:
AV-153
T40345
Synonym:
Target:
Nuclease S1
T76109
Synonym:
Target:
Bromochloroacetonitrile
T40933
Synonym:
Target:
MC-SN38
T38962
Synonym: MC-SN38
Target:
Porfiromycin
T68675
Synonym:
Target:
5-BrdUTP sodium salt
T19149
Synonym: 5-Bromo-2'-deoxyuridine 5'-triphosphate sodium salt
Target: Others
Laromustine
T70229
Synonym:
Target:
1 2
Cat No. Product Name Synonyms Targets
TN1637 Eurycomalactone Anti-infection , NF-κB
Eurycomalactone is a natural product isolated from Eurycoma longifolia Jack., acts as a potent NF-κB inhibitor( IC50 of 0.5 μM). Eurycomalactone inhibits protein synthesis, depletes cyclin D1, but does not affect TNFα-in...
T6116 Bleomycin Sulfate Blenoxane,NSC125066 DNA/RNA Synthesis , Antibiotic
Bleomycin Sulfate (Blenoxane) is a glycopeptide antibiotic, an inhibitor of DNA synthesis. Bleomycin Sulfate causes DNA strand breaks but not RNA strand breaks. Bleomycin Sulfate has antitumor activity.
T6228 Irinotecan CPT-11,Topotecin,(+)-Irinotecan Topoisomerase , Autophagy
Irinotecan (CPT-11) is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religati...
TN1170 1-Cinnamoylpyrrolidine Platelet aggregation
1-Cinnamoylpyrrolidine, a natural product prepared from Piper caninum, can be used as a DNA strand breaking agent, inducing the relaxation of the plasmid pBR322 DNA superhelix in the presence of Cu2+. 1-Cinnamoylpyrrolid...
T5780 HYPOCRELLIN B Apoptosis , Parasite , Antifungal
HYPOCRELLIN B are photosensitive pigments isolated from Hypocrella bambusae Sacc. Hypocrellin B causes DNA strand breakage, induces apoptosis in ovarian cancer cells, and inhibits proliferation of Staphylococcus by incre...
T2S2172 Nerolidol (±)-Nerolidol,Peruviol Others , Endogenous Metabolite , Antibacterial , Parasite , Antifungal
Nerolidol (Peruviol) shows sedative effects in animals, oxidative process plays a crucial role on neuronal pathological consequence. Nerolidol is mainly related to ROS and DNA single strand breaks generated by the presen...
T82046 Irisquinone
Irisquinone, a natural anticancer agent, also acts as a radiation sensitizer for cancer therapies. It diminishes glutathione (GSH) levels and hampers the repair of single-strand DNA breaks [1] [2] [3].
T35770 Cylindrospermopsin
Cylindrospermopsin, a tricyclic uracil derivative, is a cyanobacterial toxin that was first discovered in an algal bloom contaminating a local drinking supply on Palm Island in Queensland, Australia after an outbreak of ...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPH-00039 Single-strand DNA-binding protein Protein, Agrobacterium fabrum, Recombinant (His & Myc) Agrobacterium fabrum E. coli
TMPH-03304 GRIN1 Protein, Rat, Recombinant (His) Rat E. coli
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via tran...
TMPH-01127 COMMD5 Protein, Human, Recombinant (His) Human E. coli
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via tran...
TMPH-03105 Calreticulin Protein, Pig, Recombinant (His) Sus scrofa (Pig) Yeast
Involved in DNA double-strand break (DSB) repair and recombination. Promotes the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase.
TMPH-03470 GyrB Protein, Salmonella typhi, Recombinant (His & Myc) Salmonella typhi E. coli
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favor...
TMPH-03132 AVPR2 Protein, Pig, Recombinant (His & SUMO) Sus scrofa (Pig) E. coli
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favor...
TMPH-03440 RAD52 Protein, S. cerevisiae, Recombinant (His & SUMO) Saccharomyces cerevisiae E. coli
Involved in DNA double-strand break (DSB) repair and recombination. Promotes the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase.
TMPH-00488 Glycoprotein hormones alpha chain Protein, Canine, Recombinant (His) Canine Yeast
Important in genetic recombination, DNA repair, and replication. Possesses pairing and strand-transfer activity. Interacts with dda and gene 32 proteins.
TMPH-00491 PNLIPRP1 Protein, Canine, Recombinant (His) Canine Yeast
Single-stranded DNA-binding protein that participates in viral DNA replication, formation of concatemers, recombination and repair of double-stranded breaks. Coats the lagging-strand ssDNA as the replication fork advance...
TMPH-02643 Enteropeptidase Protein, Mouse, Recombinant (His & Myc) Mouse HEK293
Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that ...
TMPH-00492 PNLIPRP1 Protein, Canine, Recombinant (His & SUMO) Canine E. coli
Single-stranded DNA-binding protein that participates in viral DNA replication, formation of concatemers, recombination and repair of double-stranded breaks. Coats the lagging-strand ssDNA as the replication fork advance...
TMPH-00490 G-CSF Protein, Canine, Recombinant (His & SUMO) Canine E. coli
Single-stranded DNA-binding protein that participates in viral DNA replication, recombination, and repair (Probable). Coats the lagging-strand ssDNA as the replication fork advances. Stimulates the activities of viral DN...
TMPH-03265 CMKLR2 Protein, Rat, Recombinant (His) Rat in vitro E. coli expression system
Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the ...
TMPH-01124 MMP-13 Protein, Human, Recombinant (His & SUMO) Human E. coli
DNA polymerase that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in DNA. MMEJ is an error-prone repair pathw...
TMPH-01291 ERVK-7 Protein, Human, Recombinant (His) Human in vitro E. coli expression system
Single-stranded DNA-dependent ATPase and 5' to 3' DNA helicase. Involved in the repair of DNA cross-links and double-strand break (DSB) resistance. Participates in FANCD2-mediated repair. Forms a complex with POLN polyme...
TMPH-02380 RPB5 Protein, Kluyveromyces marxianus, Recombinant (His) Kluyveromyces marxianus E. coli
Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficien...
TMPH-01690 TIM14 Protein, Human, Recombinant (GST) Human E. coli
Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair. Mediates glutamate, aspartate or serine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is t...
TMPH-01123 CTHRC1 Protein, Human, Recombinant (aa 31-243, hFc) Human HEK293
DNA polymerase that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in DNA. MMEJ is an error-prone repair pathw...
TMPH-02407 Peroxidase Protein, Lentinula edodes, Recombinant (His & Myc) Lentinula edodes E. coli
It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks.
TMPH-01130 C1QTNF3 Protein, Human, Recombinant (His & Myc) Human Baculovirus
Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination.
TMPH-00444 GSTP1 Protein, Cricetulus longicaudatus, Recombinant (His & Myc) Chinese hamster E. coli
Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Is recruited to DNA ends by the Ku70/Ku80 heterodimer and is involved in DNA non-homologous end joining (NHEJ) required for double-strand br...
TMPH-00584 Beta-lactamase CTX-M-1 Protein, E. coli, Recombinant (His) E. coli E. coli
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a he...
TMPH-00583 Rep Protein, E. coli, Recombinant (GST) E. coli E. coli
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a he...
TMPH-02295 UAP1 Protein, Human, Recombinant (His) Human Yeast
ATP-dependent DNA helicase that unwinds single- and double-stranded DNA in a 3'-5' direction. Participates in DNA replication and repair. Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwin...
TMPY-02798 NEIL1 Protein, Human, Recombinant (His) Human E. coli
NEIL1 is a member of DNA glycosylases. DNA glycosylases are a family homologous to the bacterial Fpg/Nei family. They play a role in base excision repair which is the mechanism by which damaged bases in DNA are removed a...
TMPH-00919 MGAT4A Protein, Human, Recombinant (His & Myc) Human HEK293
ATP-dependent DNA helicase that unwinds single- and double-stranded DNA in a 3'-5' direction. Participates in DNA replication and repair. Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwin...
TMPJ-00918 HMGB2 Protein, Human, Recombinant (His) Human Human Cells
High Mobility Group Protein B2 (HMGB2) belongs to the non-histone chromosomal high-mobility group protein family. Members of this family are chromatin-associated and widely spread in the nucleus of higher eukaryotic cell...
TMPH-02079 SPTLC2 Protein, Human, Recombinant (His & SUMO) Human E. coli
Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a...
TMPH-02078 Semenogelin-1/SEMG1 Protein, Human, Recombinant (His & SUMO) Human E. coli
Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a...
TMPH-00493 IL-13 Protein, Canine, Recombinant (His) Canine E. coli
Highly processive DNA-dependent RNA polymerase that catalyzes the transcription of class II and class III viral genes. Recognizes a specific promoter sequence and enters first into an 'abortive phase' where very short tr...
TMPY-04368 Chk1 Protein, Human, Recombinant (GST) Human Baculovirus-Insect Cells
CHK1 / CHEK1 contains 1 protein kinase domain and belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, NIM1 subfamily. It is a member of checkpoint kinases (Chks). Chks Checkpoint kinases (Chks)...
TMPY-04433 Chk1 Protein, Mouse, Recombinant (His & GST) Mouse Baculovirus-Insect Cells
CHK1 / CHEK1 contains 1 protein kinase domain and belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, NIM1 subfamily. It is a member of checkpoint kinases (Chks). Chks Checkpoint kinases (Chks)...
TMPH-01602 LAMA5 Protein, Human, Recombinant (His & SUMO) Human E. coli
Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohe...
TMPH-00558 30S ribosomal protein S11 Protein, E. coli, Recombinant (His) E. coli E. coli
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state. This makes better substrates for topoisomerase IV (Pa...
TMPH-01978 SFTPA1 Protein, Human, Recombinant (B2M & His & Myc) Human in vitro E. coli expression system
Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA f...
TMPH-02635 EEF1AKMT2 Protein, Mouse, Recombinant (His) Mouse E. coli
Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA f...
TMPY-03395 PC4/SUB1 Protein, Human, Recombinant (His) Human E. coli
SUB1 belongs to the transcriptional coactivator PC4 family. It is a general coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptio...
TMPY-02421 PARP3 Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
Poly(ADP-ribose) polymerase 3 (PARP3) is an important member of the PARP family and shares high structural similarities with both PARP1 and PARP2. Poly(ADP-ribose) polymerase 3 (PARP3), a critical player in cellular resp...
TMPH-01458 Human herpesvirus 6B (HHV-6 variant B) (strain Z29) Protein U22 (His) HHV-6B in vitro E. coli expression system
Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes...
TMPH-00664 EPSP synthase Protein, E. coli O157:H7, Recombinant (His & Myc) E. coli E. coli
Conjugative DNA transfer (CDT) is the unidirectional transfer of ssDNA plasmid from a donor to a recipient cell. It is the central mechanism by which antibiotic resistance and virulence factors are propagated in bacteria...
TMPY-02543 PCNA Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
Proliferating Cell Nuclear Antigen (PCNA) is a protein only expressed in normal proliferate cells and cancer cells. It is central to both DNA replication and repair. One of the well-established functions for PCNA is its ...
TMPH-01131 Complement C4-B Protein, Human, Recombinant (His & SUMO) Human E. coli
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs,...
TMPH-01125 COMMD4 Protein, Human, Recombinant (GST) Human E. coli
Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B an...
TMPH-00586 Beta-lactamase TEM Protein, E. coli, Recombinant (His) E. coli Yeast
One of the 2 subunits of integration host factor (IHF), a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Binds to hundreds of transcriptional...
TMPH-00468 Interferon-inducible MxA protein Protein, Danio rerio, Recombinant (His) Danio rerio (Zebrafish) E. coli
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors a...
TMPH-00780 CACNA1C Protein, Guinea Pig, Recombinant (His) Guinea pig in vitro E. coli expression system
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded o...
TMPH-01150 Human coronavirus HKU1 (isolate N2) Spike glycoprotein (His) HCoV-HKU1 E. coli
E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair protein...
TMPH-01522 HIV-2 (subtype A, isolate ROD) Protein Vpx (His) HIV-2 Yeast
Presents phospholipase and nuclease activities, depending on the different physiological conditions. Interaction with Mitoguardin (MIGA1 or MIGA2) affects the dimer conformation, facilitating the lipase activity over the...
TMPH-00564 FabG Protein, E. coli, Recombinant (His & Myc) E. coli E. coli
Toxic component of a type II toxin-antitoxin (TA) system. A sequence-specific endoribonuclease it inhibits protein synthesis by cleaving mRNA and inducing bacterial stasis. It is stable, single-strand specific with mRNA ...
Single-strand DNA-binding protein Protein, Agrobacterium fabrum, Recombinant (His & Myc)
TMPH-00039
Species: Agrobacterium fabrum
Expression System: E. coli
GRIN1 Protein, Rat, Recombinant (His)
TMPH-03304
Species: Rat
Expression System: E. coli
COMMD5 Protein, Human, Recombinant (His)
TMPH-01127
Species: Human
Expression System: E. coli
Calreticulin Protein, Pig, Recombinant (His)
TMPH-03105
Species: Sus scrofa (Pig)
Expression System: Yeast
GyrB Protein, Salmonella typhi, Recombinant (His & Myc)
TMPH-03470
Species: Salmonella typhi
Expression System: E. coli
AVPR2 Protein, Pig, Recombinant (His & SUMO)
TMPH-03132
Species: Sus scrofa (Pig)
Expression System: E. coli
RAD52 Protein, S. cerevisiae, Recombinant (His & SUMO)
TMPH-03440
Species: Saccharomyces cerevisiae
Expression System: E. coli
Glycoprotein hormones alpha chain Protein, Canine, Recombinant (His)
TMPH-00488
Species: Canine
Expression System: Yeast
PNLIPRP1 Protein, Canine, Recombinant (His)
TMPH-00491
Species: Canine
Expression System: Yeast
Enteropeptidase Protein, Mouse, Recombinant (His & Myc)
TMPH-02643
Species: Mouse
Expression System: HEK293
PNLIPRP1 Protein, Canine, Recombinant (His & SUMO)
TMPH-00492
Species: Canine
Expression System: E. coli
G-CSF Protein, Canine, Recombinant (His & SUMO)
TMPH-00490
Species: Canine
Expression System: E. coli
CMKLR2 Protein, Rat, Recombinant (His)
TMPH-03265
Species: Rat
Expression System: in vitro E. coli expression system
MMP-13 Protein, Human, Recombinant (His & SUMO)
TMPH-01124
Species: Human
Expression System: E. coli
ERVK-7 Protein, Human, Recombinant (His)
TMPH-01291
Species: Human
Expression System: in vitro E. coli expression system
RPB5 Protein, Kluyveromyces marxianus, Recombinant (His)
TMPH-02380
Species: Kluyveromyces marxianus
Expression System: E. coli
TIM14 Protein, Human, Recombinant (GST)
TMPH-01690
Species: Human
Expression System: E. coli
CTHRC1 Protein, Human, Recombinant (aa 31-243, hFc)
TMPH-01123
Species: Human
Expression System: HEK293
Peroxidase Protein, Lentinula edodes, Recombinant (His & Myc)
TMPH-02407
Species: Lentinula edodes
Expression System: E. coli
C1QTNF3 Protein, Human, Recombinant (His & Myc)
TMPH-01130
Species: Human
Expression System: Baculovirus
GSTP1 Protein, Cricetulus longicaudatus, Recombinant (His & Myc)
TMPH-00444
Species: Chinese hamster
Expression System: E. coli
Beta-lactamase CTX-M-1 Protein, E. coli, Recombinant (His)
TMPH-00584
Species: E. coli
Expression System: E. coli
Rep Protein, E. coli, Recombinant (GST)
TMPH-00583
Species: E. coli
Expression System: E. coli
UAP1 Protein, Human, Recombinant (His)
TMPH-02295
Species: Human
Expression System: Yeast
NEIL1 Protein, Human, Recombinant (His)
TMPY-02798
Species: Human
Expression System: E. coli
MGAT4A Protein, Human, Recombinant (His & Myc)
TMPH-00919
Species: Human
Expression System: HEK293
HMGB2 Protein, Human, Recombinant (His)
TMPJ-00918
Species: Human
Expression System: Human Cells
SPTLC2 Protein, Human, Recombinant (His & SUMO)
TMPH-02079
Species: Human
Expression System: E. coli
Semenogelin-1/SEMG1 Protein, Human, Recombinant (His & SUMO)
TMPH-02078
Species: Human
Expression System: E. coli
IL-13 Protein, Canine, Recombinant (His)
TMPH-00493
Species: Canine
Expression System: E. coli
Chk1 Protein, Human, Recombinant (GST)
TMPY-04368
Species: Human
Expression System: Baculovirus-Insect Cells
Chk1 Protein, Mouse, Recombinant (His & GST)
TMPY-04433
Species: Mouse
Expression System: Baculovirus-Insect Cells
LAMA5 Protein, Human, Recombinant (His & SUMO)
TMPH-01602
Species: Human
Expression System: E. coli
30S ribosomal protein S11 Protein, E. coli, Recombinant (His)
TMPH-00558
Species: E. coli
Expression System: E. coli
SFTPA1 Protein, Human, Recombinant (B2M & His & Myc)
TMPH-01978
Species: Human
Expression System: in vitro E. coli expression system
EEF1AKMT2 Protein, Mouse, Recombinant (His)
TMPH-02635
Species: Mouse
Expression System: E. coli
PC4/SUB1 Protein, Human, Recombinant (His)
TMPY-03395
Species: Human
Expression System: E. coli
PARP3 Protein, Human, Recombinant (His & GST)
TMPY-02421
Species: Human
Expression System: Baculovirus-Insect Cells
Human herpesvirus 6B (HHV-6 variant B) (strain Z29) Protein U22 (His)
TMPH-01458
Species: HHV-6B
Expression System: in vitro E. coli expression system
EPSP synthase Protein, E. coli O157:H7, Recombinant (His & Myc)
TMPH-00664
Species: E. coli
Expression System: E. coli
PCNA Protein, Human, Recombinant (His)
TMPY-02543
Species: Human
Expression System: Baculovirus-Insect Cells
Complement C4-B Protein, Human, Recombinant (His & SUMO)
TMPH-01131
Species: Human
Expression System: E. coli
COMMD4 Protein, Human, Recombinant (GST)
TMPH-01125
Species: Human
Expression System: E. coli
Beta-lactamase TEM Protein, E. coli, Recombinant (His)
TMPH-00586
Species: E. coli
Expression System: Yeast
Interferon-inducible MxA protein Protein, Danio rerio, Recombinant (His)
TMPH-00468
Species: Danio rerio (Zebrafish)
Expression System: E. coli
CACNA1C Protein, Guinea Pig, Recombinant (His)
TMPH-00780
Species: Guinea pig
Expression System: in vitro E. coli expression system
Human coronavirus HKU1 (isolate N2) Spike glycoprotein (His)
TMPH-01150
Species: HCoV-HKU1
Expression System: E. coli
HIV-2 (subtype A, isolate ROD) Protein Vpx (His)
TMPH-01522
Species: HIV-2
Expression System: Yeast
FabG Protein, E. coli, Recombinant (His & Myc)
TMPH-00564
Species: E. coli
Expression System: E. coli
TargetMol