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Search Results for " ddr2 "

Targets

16

Compounds

8

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T11279 FGFR1/DDR2 inhibitor 1 Discoidin Domain Receptor (DDR) , FGFR , Others
FGFR1/DDR2 inhibitor 1 is an inhibitor of discoindin domain receptor 2 (DDR2) and fibroblast growth factor receptor 1 (FGFR1), with IC50 values of 31.1 nM, 108.4 nM and 3.2 nM for FGFR1, KG-1, and DDR2, respectively.
T39047 DDR2-IN-1 DDR2-IN-1
DDR2-IN-1 (Compound 129) is recognized as a highly effective DDR2 inhibitor, displaying an IC50 value of 26 nM. It is a suitable choice for conducting osteoarthritis research.
T4349 Sitravatinib MG516,MGCD516 Discoidin Domain Receptor (DDR) , VEGFR , FLT , Trk receptor , TAM Receptor , c-Kit , Ephrin Receptor
Sitravatinib (MGCD516) (MGCD516) is an inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Met, c-Kit, PDGFRα/β, PDGFR, and Axl.
T17258 WRG-28 Discoidin Domain Receptor (DDR)
WRG-28 is a potent and selective, allosteric discoidin domain receptor 2 (ddr2) inhibitor(IC50 : 230 nM)
T10985 DDR Inhibitor Discoidin Domain Receptor (DDR)
DDR inhibitor is a potent discidin domain receptor (DDR) inhibitor. The IC50 of DDR2 is 3.3 nM, and DDR1 has 53% inhibition at 1.5 nM.
T3337 Ddr1-In-1 Discoidin Domain Receptor (DDR)
DDR1-IN-1 is an effective and specific DDR1 receptor tyrosine kinase inhibitor (IC50: 105 nM), about 3-fold selectivity over DDR2.
T2617 SNS-314 Mesylate SNS-314 Aurora Kinase
SNS-314 Mesylate (SNS-314) is an effective and specific Aurora A/B/C inhibitor (IC50: 9/31/3 nM). It is less inhibition of Trk A/B, Fms, Flt4, c-Raf, Axl, and DDR2.
T5402 DDR1-IN-2 DDR1 inhibitor 7rh Discoidin Domain Receptor (DDR)
DDR1-IN-2 (DDR1 inhibitor 7rh) (DDR1 inhibitor 7rh) is a potent, selective, ATP-competitive Discoidin domain receptor 1 (DDR1) inhibitor (IC50: 6.8 nM in cell-free kinase assays).
T6318 AZ 628 Apoptosis , Raf
AZ628 is a new pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 105 nM, 34 nM and 29 nM, also inhibits VEGFR2, DDR2, Lyn, Flt1, FMS, etc.
T32613 LCB 03-0110 dihydrochloride Src
LCB 03-0110 Dihydrochloride is a potent inhibitor of the c-Src kinase (IC50 = 1.3 nM) and tyrosine kinases in the BTK and SYK family, as well as in the DDR2 family. It inhibits LPS-induced activation of macrophages and T...
T39572 DDR1-IN-4 DDR1-IN-4
DDR1-IN-4 (Compound 2.45) is a highly potent inhibitor that selectively targets Discoidin Domain Receptor 1 (DDR1) autophosphorylation. This compound demonstrates exceptional efficacy with IC50 values of 29 nM and 1.9 μM...
T7862 VU6015929 Discoidin Domain Receptor (DDR)
VU6015929 is an inhibitor of active dual discoidin domain receptor 1/2 (DDR1/2)( IC50s of 4.67 nM and 7.39 nM, respectively).
T70202 DDR1-IN-1 dihydrochloride
DDR1-IN-1 dihydrochloride is a potent and selective DDR1 receptor tyrosine kinase inhibitor with an IC 50 of 105 nM ; 4-fold less potent for DDR2 (IC 50 = 413 nM) .
T79811 DDR1/2 inhibitor-2
DDR1/2 Inhibitor-2 (Example 31) serves as an inhibitor of DDR1/DDR2, exhibiting IC50 values below 100 nM. It is applicable in cancer and fibrotic disease research [1].
T12925 Sitravatinib malate MGCD516 malate,MG-516 malate TAM Receptor
Sitravatinib malate is an orally bioavailable receptor inhibitor of tyrosine kinase (RTK) (IC50s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT...
T10801 CHMFL-ABL/KIT-155 CHMFL-ABL-KIT-155 c-Kit
CHMFL-ABL/KIT-155 is a highly potent and orally active type II ABL/c-KIT dual kinase inhibitor (IC50s: 46 nM/75 nM). It arrests cell cycle progression and induces apoptosis.

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-03593 DDR2 Protein, Rhesus, Recombinant (His) Rhesus HEK293
Discoidin domain receptor 2 (DDR2) or CD167b (cluster of differentiation 167b) is a kind of protein tyrosine kinases associated with cell proliferation and tumor metastasis, and collagen, identified as a ligand for DDR2,...
TMPY-00773 DDR2 Protein, Human, Recombinant (hFc) Human HEK293
Discoidin domain receptor 2 (DDR2) or CD167b (cluster of differentiation 167b) is a kind of protein tyrosine kinases associated with cell proliferation and tumor metastasis, and collagen, identified as a ligand for DDR2,...
TMPY-03642 DDR2 Protein, Rhesus, Recombinant (hFc) Rhesus HEK293
Discoidin domain receptor 2 (DDR2) or CD167b (cluster of differentiation 167b) is a kind of protein tyrosine kinases associated with cell proliferation and tumor metastasis, and collagen, identified as a ligand for DDR2,...
TMPY-03625 DDR2 Protein, Human, Recombinant (His) Human HEK293
Discoidin domain receptor 2 (DDR2) or CD167b (cluster of differentiation 167b) is a kind of protein tyrosine kinases associated with cell proliferation and tumor metastasis, and collagen, identified as a ligand for DDR2,...
TMPY-03098 DDR2 Protein, Rat, Recombinant (hFc) Rat HEK293
Discoidin domain receptor 2 (DDR2) or CD167b (cluster of differentiation 167b) is a kind of protein tyrosine kinases associated with cell proliferation and tumor metastasis, and collagen, identified as a ligand for DDR2,...
TMPY-01728 DDR2 Protein, Mouse, Recombinant (His) Mouse HEK293
Discoidin domain receptor 2 (DDR2) or CD167b (cluster of differentiation 167b) is a kind of protein tyrosine kinases associated with cell proliferation and tumor metastasis, and collagen, identified as a ligand for DDR2,...
TMPY-03166 DDR2 Protein, Rat, Recombinant (His) Rat HEK293
Discoidin domain receptor 2 (DDR2) or CD167b (cluster of differentiation 167b) is a kind of protein tyrosine kinases associated with cell proliferation and tumor metastasis, and collagen, identified as a ligand for DDR2,...
TMPY-04361 DDR2 Protein, Human, Recombinant (aa 422-855, His & GST) Human Baculovirus-Insect Cells
Discoidin domain receptor 2 (DDR2) or CD167b (cluster of differentiation 167b) is a kind of protein tyrosine kinases associated with cell proliferation and tumor metastasis, and collagen, identified as a ligand for DDR2,...
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