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Ligand for E3 Ligase

FilterHomePROTACLigand for E3 Ligase
  • Pomalidomide-PEG4-C2-NH2
    T179162225940-52-1
    Pomalidomide-PEG4-C2-NH2 (E3 Ligase Ligand-Linker Conjugates 22) is a synthesized E3 ligase ligand-linker conjugate incorporating the Pomalidomide-based cereblon ligand and 4-unit PEG linker.
    • $30
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  • E3 ligase Ligand 23
    T9809444287-56-3In house
    E3 ligase Ligand 23 is a cereblon binding agent that degrades Ikaros or Aiolos via the ubiquitin proteasome.
    • $51
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    TargetMol | Inhibitor Sale
  • VH-298
    TQ01212097381-85-4
    VH-298 is a potent inhibitor of VHL that stabilizes HIF-α and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL:HIF-α protein-protein interaction downstream of HIF-α hydroxylation by PHD enzymes.
    • $39
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    TargetMol | Citations Cited
  • Thalidomide
    T021350-35-1
    Thalidomide (Thalomid) is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic properties.
    • $50
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    TargetMol | Citations Cited
  • (S,R,S)-AHPC-C4-NH2 hydrochloride
    T186402245697-83-8
    (S,R,S)-AHPC-C4-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 28) is a synthesized E3 ligase ligand-linker conjugate incorporating the (S,R,S)-AHPC based VHL ligand and a linker.
    • $53
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    TargetMol | Inhibitor Sale
  • Thalidomide-5-methyl
    T4050340313-92-6
    Thalidomide-5-methyl is the Thalidomide-based cereblon (CRBN) ligand. Thalidomide-5-methyl is used in the recruitment of CRBN protein.
    • $195
    In Stock
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    TargetMol | Inhibitor Sale
  • Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride
    T188192376990-30-4
    Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride incorporates an E3 ligase ligand and a linker. Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride can be used as an immunomodulator for the treatment of cancer.
    • $30
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    TargetMol | Inhibitor Sale
  • VL285
    T53341448188-57-5
    VL285 is a potent VHL ligand, degrading HaloTag7 fusion proteins.
    • $41
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    TargetMol | Inhibitor Sale
  • (S,R,S)-AHPC-propargyl
    T138762098799-78-9
    (S,R,S)-AHPC-propargyl is a VHL ligand which is used in click reaction for PROTACs.
    • $83
    5 days
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  • MV-1-NH-Me
    T186132095244-62-3
    MV-1-NH-Me, an MV-1-derived IAP ligand, connects to an ABL inhibitor through a linker, resulting in the formation of SNIPER[1].
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  • (S,R,S)-AHPC-PEG1-N3
    T179202101200-09-1
    (S,R,S)-AHPC-PEG1-N3 (E3 ligase Ligand-Linker Conjugates 3) is a synthesized E3 ligase ligand-linker conjugate. (S,R,S)-AHPC-PEG1-N3 incorporates the (S,R,S)-AHPC based VHL ligand and 1-unit PEG linker used in PROTAC technology.
    • $33
    In Stock
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  • β-Naphthoflavone-CH2-Br
    T139811282513-77-2
    β-Naphthoflavone-CH2-Br is an arylhydrocarbon receptor (AhR) ligand. β-Naphthoflavone-CH2-Br used to synthesize the PROTAC β-NF-JQ1.
    • $249
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  • Pomalidomide-PEG4-Ph-NH2
    T77561818885-63-0
    Pomalidomide-PEG4-Ph-NH2 is a synthetic E3 ligase ligand-linker conjugate combining a Pomalidomide-based cereblon ligand and a 4-unit PEG linker.
    • $30
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  • HaloPROTAC3
    T320431799506-07-2
    HaloPROTAC3 (HaloPROTAC-3) is a conjugate of ligands for E3 and 16-atom-length linker and a degrader of HaloTag fusion proteins.
    • $112
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  • Thalidomide-O-amido-C4-N3
    T151892098488-36-7
    Thalidomide-O-amido-C4-N3 (Cereblon Ligand-Linker Conjugates 4) is an E3 ligase ligand-linker conjugate incorporating the Thalidomide-based cereblon ligand and a linker.
    • $51
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  • Bestatin-amido-Me
    T18612339186-54-8
    Bestatin-amido-Me, a derivative of Bestatin, acts as an IAP ligand and interacts with ABL inhibitor through a linker to produce SNIPER[1].
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  • Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride
    T188222245697-85-0
    Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate incorporating the Thalidomide-based cereblon ligand and a linker.
    • $49
    5 days
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  • CFT7455
    T600242504235-67-8
    CFT7455 (Cemsidomide) is an anti-cancer agent showing high affinity to the cereblon E3 ligase with a Kd of 0.9 nM. CFT7455 is an orally active degrader of zinc finger transcription factors Ikaros (IKZF1), and Aiolos (IKZF3).
    • $79
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  • (S,R,S)-AHPC-PEG4-NH2
    T15190L2010159-57-4
    (S,R,S)-AHPC-PEG4-NH2 (VHL Ligand-Linker Conjugates 4) is a synthetic E3 ligase ligand-linker conjugate comprising a VHL ligand based on (S,R,S)-AHPC and a 4-unit PEG linker.
    • $39
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  • (S,S,S)-AHPC hydrochloride
    T138772115897-23-7
    (S,S,S)-AHPC hydrochloride is a von Hippel-Lindau (VHL) aminoblock. (S,S,S)-AHPC (Compound 27) is often used as a negative control for (S,R,S)-AHPC. (S,R,S)-AHPC is a VHL ligand based on VH032 and can be used to recruit VHL proteins.
    • $40
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  • VHL Ligand 8
    T139582701565-76-4
    VHL Ligand 8, a VHL ligand essential for synthesizing ARD-266, acts as a highly potent VHL E3 ligase-based androgen receptor (AR) PROTAC degrader. It efficiently facilitates the degradation of AR protein in AR-positive prostate cancer cell lines LNCaP, VCaP, and 22Rv1, exhibiting DC50 values ranging from 0.2-1 nM [1].
    • $1,490
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  • (S,R,S)-AHPC hydrochloride
    T42071448189-80-7
    (S,R,S)-AHPC hydrochloride (Protein degrader 1 hydrochloride) is a building block in the synthesis of proteolysis-targeting chimera technologies (PROTACs).
    • $48
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  • Thalidomide-propargyl
    T188312098487-39-7
    Thalidomide-propargyl, a Thalidomide-derived Cereblon ligand, facilitates the recruitment of Cereblon. It can be attached to the protein ligand via a linker, producing IMiD-containing PROTACs.
    • $39
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  • TD-106
    T131042250288-69-6
    TD-106 is a modulator of cereblon (CRBN), and can be used for targeted protein degradation. BRD4 PROTACs with TD-106 induce BRD4 degradation.
    • $318
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