Ligand for E3 Ligase

Cat. No.	Product name	CAS No.	Purity
T13958	VHL Ligand 8	2701565-76-4	98%
T13958	VHL Ligand 8 is a VHL ligand used to synthesize ARD-266, a highly potent and VHL E3 ligase-based androgen receptor (AR) PROTAC degrader. ARD-266 effectively indu...
T13141	Thalidomide D4	1219177-18-0	98%
T13141	Thalidomide D4 is a deuterium labeled Thalidomide, has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties.
T13981	β-Naphthoflavone-CH2-Br	1282513-77-2	98%
T13981	β-Naphthoflavone-CH2-Br is an arylhydrocarbon receptor (AhR) ligand. β-Naphthoflavone-CH2-Br used to synthesize the PROTAC β-NF-JQ1.
T18612	Bestatin-amido-Me	339186-54-8	98%
T18612	Bestatin-amido-Me, a derivative of Bestatin, acts as an IAP ligand and interacts with ABL inhibitor through a linker to produce SNIPER[1].
T18822	Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride	2245697-85-0	98%
T18822	Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate incorporating the Thalidomide-based cereblon ligand and a linker...
T13876	(S,R,S)-AHPC-propargyl	2098799-78-9	98%
T13876	(S,R,S)-AHPC-propargyl is a VHL ligand which is used in "click reaction" for PROTACs.
T18613	MV-1-NH-Me	2095244-62-3	98%
T18613	MV-1-NH-Me, the MV-1 based IAP ligand, binds to ABL inhibitor via a linker to form SNIPER[1].
T13104	TD-106	2250288-69-6	98%
T13104	TD-106 is a modulator of cereblon (CRBN), and can be used for targeted protein degradation. BRD4 PROTACs with TD-106 induce BRD4 degradation.
T5334	VL285	1448188-57-5	98%
T5334	VL285 is a potent VHL ligand, degrading HaloTag7 fusion proteins.
T7756	E3 Ligase Ligand-Linker Conjugates 2	1818885-63-0	98%
T7756	E3 Ligase Ligand-Linker Conjugates 2 is a synthetic E3 ligase ligand-linker conjugate combining a Pomalidomide-based cereblon ligand and a 4-unit PEG linker.
T36694	XY028-140	2229974-83-6	98%
T36694	XY028-140 is a selective CDK4/CDK6 degrade and inhibits both CDK4/6 expression and activity in cancer cells. XY028-140 is a PROTAC connected by ligands for Cereb...
T9809	E3 ligase Ligand 23	444287-56-3	98%
T9809	E3 ligase Ligand 23 is a cereblon binder and degrades Ikaros or Aiolos through ubiquitin proteasome.
T13877	(S,S,S)-AHPC hydrochloride	2115897-23-7	98%
T13877	(S,S,S)-AHPC hydrochloride is a VHL amino building block, is a ligand used as a negative control for (S,R,S)-AHPC. It is the VH032-based VHL ligand used in the r...
T60024	CFT7455	2504235-67-8	98%
T60024	CFT7455 is an anti-cancer agent showing high affinity to the cereblon E3 ligase with a Kd of 0.9 nM. CFT7455 is an orally active degrader of zinc finger transcri...
T15189	Thalidomide-O-amido-C4-N3	2098488-36-7	98%
T15189	Thalidomide-O-amido-C4-N3 is an E3 ligase ligand-linker conjugate incorporating the Thalidomide-based cereblon ligand and a linker.
T32043	HaloPROTAC3	1799506-07-2	98%
T32043	HaloPROTAC3 is a conjugate of ligands for E3 and 16-atom-length linker and a degrader of HaloTag fusion proteins.
T18831	Thalidomide-propargyl	2098487-39-7	98%
T18831	Thalidomide-propargyl is the Thalidomide-based Cereblon ligand used in the recruitment of Cereblon. Thalidomide-propargyl can be connected to the ligand for prot...
T18640	(S,R,S)-AHPC-C4-NH2 hydrochloride	2245697-83-8	98%
T18640	(S,R,S)-AHPC-C4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate incorporating the (S,R,S)-AHPC based VHL ligand and a linker.
T15190L	(S,R,S)-AHPC-PEG4-NH2	2010159-57-4	98%
T15190L	(S,R,S)-AHPC-PEG4-NH2 is a synthetic E3 ligase ligand-linker conjugate comprising a VHL ligand based on (S,R,S)-AHPC and a 4-unit PEG linker.
TQ0121	VH-298	2097381-85-4	98%
TQ0121	VH-298 is a potent inhibitor of VHL that stabilizes HIF-α and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL:HIF-α protein...