T13958 |
VHL Ligand 8
|
2701565-76-4
|
98%
|
|
VHL Ligand 8 is a VHL ligand used to synthesize ARD-266, a highly potent and VHL E3 ligase-based androgen receptor (AR) PROTAC degrader. ARD-266 effectively indu...
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T13141 |
Thalidomide D4
|
1219177-18-0
|
98%
|
|
Thalidomide D4 is a deuterium labeled Thalidomide, has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties.
|
T13981 |
β-Naphthoflavone-CH2-Br
|
1282513-77-2
|
98%
|
|
β-Naphthoflavone-CH2-Br is an arylhydrocarbon receptor (AhR) ligand. β-Naphthoflavone-CH2-Br used to synthesize the PROTAC β-NF-JQ1.
|
T18612 |
Bestatin-amido-Me
|
339186-54-8
|
98%
|
|
Bestatin-amido-Me, a derivative of Bestatin, acts as an IAP ligand and interacts with ABL inhibitor through a linker to produce SNIPER[1].
|
T18822 |
Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride
|
2245697-85-0
|
98%
|
|
Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate incorporating the Thalidomide-based cereblon ligand and a linker...
|
T13876 |
(S,R,S)-AHPC-propargyl
|
2098799-78-9
|
98%
|
|
(S,R,S)-AHPC-propargyl is a VHL ligand which is used in "click reaction" for PROTACs.
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T18613 |
MV-1-NH-Me
|
2095244-62-3
|
98%
|
|
MV-1-NH-Me, the MV-1 based IAP ligand, binds to ABL inhibitor via a linker to form SNIPER[1].
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T13104 |
TD-106
|
2250288-69-6
|
98%
|
|
TD-106 is a modulator of cereblon (CRBN), and can be used for targeted protein degradation. BRD4 PROTACs with TD-106 induce BRD4 degradation.
|
T5334 |
VL285
|
1448188-57-5
|
98%
|
|
VL285 is a potent VHL ligand, degrading HaloTag7 fusion proteins.
|
T7756 |
E3 Ligase Ligand-Linker Conjugates 2
|
1818885-63-0
|
98%
|
|
E3 Ligase Ligand-Linker Conjugates 2 is a synthetic E3 ligase ligand-linker conjugate combining a Pomalidomide-based cereblon ligand and a 4-unit PEG linker.
|
T36694 |
XY028-140
|
2229974-83-6
|
98%
|
|
XY028-140 is a selective CDK4/CDK6 degrade and inhibits both CDK4/6 expression and activity in cancer cells. XY028-140 is a PROTAC connected by ligands for Cereb...
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T9809 |
E3 ligase Ligand 23
|
444287-56-3
|
98%
|
|
E3 ligase Ligand 23 is a cereblon binder and degrades Ikaros or Aiolos through ubiquitin proteasome.
|
T13877 |
(S,S,S)-AHPC hydrochloride
|
2115897-23-7
|
98%
|
|
(S,S,S)-AHPC hydrochloride is a VHL amino building block, is a ligand used as a negative control for (S,R,S)-AHPC. It is the VH032-based VHL ligand used in the r...
|
T60024 |
CFT7455
|
2504235-67-8
|
98%
|
|
CFT7455 is an anti-cancer agent showing high affinity to the cereblon E3 ligase with a Kd of 0.9 nM. CFT7455 is an orally active degrader of zinc finger transcri...
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T15189 |
Thalidomide-O-amido-C4-N3
|
2098488-36-7
|
98%
|
|
Thalidomide-O-amido-C4-N3 is an E3 ligase ligand-linker conjugate incorporating the Thalidomide-based cereblon ligand and a linker.
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T32043 |
HaloPROTAC3
|
1799506-07-2
|
98%
|
|
HaloPROTAC3 is a conjugate of ligands for E3 and 16-atom-length linker and a degrader of HaloTag fusion proteins.
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T18831 |
Thalidomide-propargyl
|
2098487-39-7
|
98%
|
|
Thalidomide-propargyl is the Thalidomide-based Cereblon ligand used in the recruitment of Cereblon. Thalidomide-propargyl can be connected to the ligand for prot...
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T18640 |
(S,R,S)-AHPC-C4-NH2 hydrochloride
|
2245697-83-8
|
98%
|
|
(S,R,S)-AHPC-C4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate incorporating the (S,R,S)-AHPC based VHL ligand and a linker.
|
T15190L |
(S,R,S)-AHPC-PEG4-NH2
|
2010159-57-4
|
98%
|
|
(S,R,S)-AHPC-PEG4-NH2 is a synthetic E3 ligase ligand-linker conjugate comprising a VHL ligand based on (S,R,S)-AHPC and a 4-unit PEG linker.
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TQ0121 |
VH-298
|
2097381-85-4
|
98%
|
|
VH-298 is a potent inhibitor of VHL that stabilizes HIF-α and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL:HIF-α protein...
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