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Ligand for E3 Ligase

Cat. No. Product name CAS No. Purity Chemical Structure
T13958 VHL Ligand 8 2701565-76-4 98%
VHL Ligand 8 is a VHL ligand used to synthesize ARD-266, a highly potent and VHL E3 ligase-based androgen receptor (AR) PROTAC degrader. ARD-266 effectively indu...
T13141 Thalidomide D4 1219177-18-0 98%
Thalidomide D4 is a deuterium labeled Thalidomide, has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties.
T13981 β-Naphthoflavone-CH2-Br 1282513-77-2 98%
β-Naphthoflavone-CH2-Br is an arylhydrocarbon receptor (AhR) ligand. β-Naphthoflavone-CH2-Br used to synthesize the PROTAC β-NF-JQ1.
T18612 Bestatin-amido-Me 339186-54-8 98%
Bestatin-amido-Me, a derivative of Bestatin, acts as an IAP ligand and interacts with ABL inhibitor through a linker to produce SNIPER[1].
T18822 Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride 2245697-85-0 98%
Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate incorporating the Thalidomide-based cereblon ligand and a linker...
T13876 (S,R,S)-AHPC-propargyl 2098799-78-9 98%
(S,R,S)-AHPC-propargyl is a VHL ligand which is used in "click reaction" for PROTACs.
T18613 MV-1-NH-Me 2095244-62-3 98%
MV-1-NH-Me, the MV-1 based IAP ligand, binds to ABL inhibitor via a linker to form SNIPER[1].
T13104 TD-106 2250288-69-6 98%
TD-106 is a modulator of cereblon (CRBN), and can be used for targeted protein degradation. BRD4 PROTACs with TD-106 induce BRD4 degradation.
T5334 VL285 1448188-57-5 98%
VL285 is a potent VHL ligand, degrading HaloTag7 fusion proteins.
T7756 E3 Ligase Ligand-Linker Conjugates 2 1818885-63-0 98%
E3 Ligase Ligand-Linker Conjugates 2 is a synthetic E3 ligase ligand-linker conjugate combining a Pomalidomide-based cereblon ligand and a 4-unit PEG linker.
T36694 XY028-140 2229974-83-6 98%
XY028-140 is a selective CDK4/CDK6 degrade and inhibits both CDK4/6 expression and activity in cancer cells. XY028-140 is a PROTAC connected by ligands for Cereb...
T9809 E3 ligase Ligand 23 444287-56-3 98%
E3 ligase Ligand 23 is a cereblon binder and degrades Ikaros or Aiolos through ubiquitin proteasome.
T13877 (S,S,S)-AHPC hydrochloride 2115897-23-7 98%
(S,S,S)-AHPC hydrochloride is a VHL amino building block, is a ligand used as a negative control for (S,R,S)-AHPC. It is the VH032-based VHL ligand used in the r...
T60024 CFT7455 2504235-67-8 98%
CFT7455 is an anti-cancer agent showing high affinity to the cereblon E3 ligase with a Kd of 0.9 nM. CFT7455 is an orally active degrader of zinc finger transcri...
T15189 Thalidomide-O-amido-C4-N3 2098488-36-7 98%
Thalidomide-O-amido-C4-N3 is an E3 ligase ligand-linker conjugate incorporating the Thalidomide-based cereblon ligand and a linker.
T32043 HaloPROTAC3 1799506-07-2 98%
HaloPROTAC3 is a conjugate of ligands for E3 and 16-atom-length linker and a degrader of HaloTag fusion proteins.
T18831 Thalidomide-propargyl 2098487-39-7 98%
Thalidomide-propargyl is the Thalidomide-based Cereblon ligand used in the recruitment of Cereblon. Thalidomide-propargyl can be connected to the ligand for prot...
T18640 (S,R,S)-AHPC-C4-NH2 hydrochloride 2245697-83-8 98%
(S,R,S)-AHPC-C4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate incorporating the (S,R,S)-AHPC based VHL ligand and a linker.
T15190L (S,R,S)-AHPC-PEG4-NH2 2010159-57-4 98%
(S,R,S)-AHPC-PEG4-NH2 is a synthetic E3 ligase ligand-linker conjugate comprising a VHL ligand based on (S,R,S)-AHPC and a 4-unit PEG linker.
TQ0121 VH-298 2097381-85-4 98%
VH-298 is a potent inhibitor of VHL that stabilizes HIF-α and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL:HIF-α protein...
VHL Ligand 8
T13958
VHL Ligand 8 is a VHL ligand used to synthesize ARD-266, a highly potent and VHL E3 ligase-based androgen receptor (AR) PROTAC degrader. ARD-266 effectively indu...
Thalidomide D4
T13141
Thalidomide D4 is a deuterium labeled Thalidomide, has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties.
β-Naphthoflavone-CH2-Br
T13981
β-Naphthoflavone-CH2-Br is an arylhydrocarbon receptor (AhR) ligand. β-Naphthoflavone-CH2-Br used to synthesize the PROTAC β-NF-JQ1.
Bestatin-amido-Me
T18612
Bestatin-amido-Me, a derivative of Bestatin, acts as an IAP ligand and interacts with ABL inhibitor through a linker to produce SNIPER[1].
Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride
T18822
Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate incorporating the Thalidomide-based cereblon ligand and a linker...
(S,R,S)-AHPC-propargyl
T13876
(S,R,S)-AHPC-propargyl is a VHL ligand which is used in "click reaction" for PROTACs.
MV-1-NH-Me
T18613
MV-1-NH-Me, the MV-1 based IAP ligand, binds to ABL inhibitor via a linker to form SNIPER[1].
TD-106
T13104
TD-106 is a modulator of cereblon (CRBN), and can be used for targeted protein degradation. BRD4 PROTACs with TD-106 induce BRD4 degradation.
VL285
T5334
VL285 is a potent VHL ligand, degrading HaloTag7 fusion proteins.
E3 Ligase Ligand-Linker Conjugates 2
T7756
E3 Ligase Ligand-Linker Conjugates 2 is a synthetic E3 ligase ligand-linker conjugate combining a Pomalidomide-based cereblon ligand and a 4-unit PEG linker.
XY028-140
T36694
XY028-140 is a selective CDK4/CDK6 degrade and inhibits both CDK4/6 expression and activity in cancer cells. XY028-140 is a PROTAC connected by ligands for Cereb...
E3 ligase Ligand 23
T9809
E3 ligase Ligand 23 is a cereblon binder and degrades Ikaros or Aiolos through ubiquitin proteasome.
(S,S,S)-AHPC hydrochloride
T13877
(S,S,S)-AHPC hydrochloride is a VHL amino building block, is a ligand used as a negative control for (S,R,S)-AHPC. It is the VH032-based VHL ligand used in the r...
CFT7455
T60024
CFT7455 is an anti-cancer agent showing high affinity to the cereblon E3 ligase with a Kd of 0.9 nM. CFT7455 is an orally active degrader of zinc finger transcri...
Thalidomide-O-amido-C4-N3
T15189
Thalidomide-O-amido-C4-N3 is an E3 ligase ligand-linker conjugate incorporating the Thalidomide-based cereblon ligand and a linker.
HaloPROTAC3
T32043
HaloPROTAC3 is a conjugate of ligands for E3 and 16-atom-length linker and a degrader of HaloTag fusion proteins.
Thalidomide-propargyl
T18831
Thalidomide-propargyl is the Thalidomide-based Cereblon ligand used in the recruitment of Cereblon. Thalidomide-propargyl can be connected to the ligand for prot...
(S,R,S)-AHPC-C4-NH2 hydrochloride
T18640
(S,R,S)-AHPC-C4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate incorporating the (S,R,S)-AHPC based VHL ligand and a linker.
(S,R,S)-AHPC-PEG4-NH2
T15190L
(S,R,S)-AHPC-PEG4-NH2 is a synthetic E3 ligase ligand-linker conjugate comprising a VHL ligand based on (S,R,S)-AHPC and a 4-unit PEG linker.
VH-298
TQ0121
VH-298 is a potent inhibitor of VHL that stabilizes HIF-α and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL:HIF-α protein...
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