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Guanylate cyclase

Guanylate cyclase (also known as guanyl cyclase, guanylyl cyclase, or GC) is a lyase enzyme that converts guanosine triphosphate (GTP) to cyclic guanosine monophosphate (cGMP) and pyrophosphate. It is often part of the G protein signaling cascade that is activated by low intracellular calcium levels and inhibited by high intracellular calcium levels. In response to calcium levels, guanylate cyclase synthesizes cGMP from GTP. cGMP keeps cGMP-gated channels open, allowing for the entry of calcium into the cell.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T80067 Uroguanylin (human) 154525-25-4 98%
Uroguanylin (human)
Uroguanylin (human) serves as a natural ligand for the Guanylyl Cyclase C (GCC) receptor in metastatic colorectal cancer tumors and exhibits anti-tumor effects i...
T80150 Guanylin (mouse, rat) 145257-03-0 98%
Guanylin (mouse, rat)
Guanylin (mouse, rat), a peptide consisting of 15 amino acids, acts as an activator of intestinal guanylate cyclase and is utilized in diarrhea research [1].
T6968 Riociguat 625115-55-1 99.91%
Riociguat
Riociguat (BAY 632521) is a stimulator of guanylate cyclase which causes relaxation of vascular smooth muscle and is used to treat severe pulmonary arterial hype...
T17226 Vericiguat 1350653-20-1 99.71%
Vericiguat
Vericiguat (BAY1021189) is a potent and orally available guanylate cyclase stimulator.
T21607 Ataciguat 254877-67-3 99.57%
Ataciguat
Ataciguat (HMR-1766) (HMR-1766) is a potent and specific soluble guanylate cyclase (sGC) activator.
T67734 MCUF-651 2747162-85-0 99.57%
MCUF-651
MCUF-651 is a guanylyl cyclase A receptor positive allosteric modulators, EC50=0.45 μM.
T21712 BAY 41-8543 256498-66-5 99.49%
BAY 41-8543
BAY 41-8543 is a nitric oxide (NO)-independent stimulator of soluble guanylyl cyclase (sGC).
T4381 Lificiguat 170632-47-0 99.48%
Lificiguat
Lificiguat (YC-1) is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha)...
T16344 NS-2028 204326-43-2 99.44%
NS-2028
NS-2028 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor (IC50: 30 nM and 200 nM for basal and NO-stimulated enzyme activity). It is commonly used ...
T16383 Olinciguat 1628732-62-6 99.33%
Olinciguat
Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator. It also has concentration-dependent stimulation of sGC in purified rat and human enzyme assay...
T7201 Nelociguat 625115-52-8 99.15%
Nelociguat
Nelociguat (BAY60-4552)(BAY60-4552) is a soluble guanylate cyclase stimulator (sGC stimulator). Soluble guanylate cyclase (sGC) is a key enzyme in the nitric oxi...
T16569 Praliciguat 1628730-49-3 99.05%
Praliciguat
Praliciguat (IW-1973) stimulates sGC in HEK-293 cells (EC50: 197 nM). Praliciguat is an effective and orally active soluble guanylate cyclase stimulator. It also...
T34648 Sinitrodil 143248-63-9 99%
Sinitrodil
Sinitrodil (ITF-296) is a guanylate cyclase stimulant that may be used in the treatment of myocardial ischemia and angina pectoris.
T11852 Linaclotide 851199-59-2 98.71%
Linaclotide
Linaclotide developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation, and is a potent and selective guan...
T21576 LY83583 91300-60-6 98.71%
LY83583
LY83583 is a soluble guanylate cyclase competitive inhibitor with IC50 of 2 µM.
T19777 ODQ 41443-28-1 98.46%
ODQ
ODQ is an effective and selective soluble guanylyl cyclase (sGC) inhibitor.
T0006 Methylene Blue trihydrate 7220-79-3 97.61%
Methylene Blue trihydrate
Methylene Blue trihydrate (Basic blue 9) is a compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water o...
T9080 Plecanatide 467426-54-6 97.51%
Plecanatide
Plecanatide acetate is an analogue of Uroguanylin. It is an orally active guanylate cyclase-C (GC-C) receptor agonist.
T11424 Glutaminyl Cyclase Inhibitor 1 2110449-60-8 100%
Glutaminyl Cyclase Inhibitor 1
Glutaminyl Cyclase Inhibitor 1 is a glutaminyl cyclase inhibitor (IC50: 0.5 μM) that can be used to study neurological disorders.
T1984 Cinaciguat 329773-35-5
Cinaciguat
Cinaciguat (BAY 58-2667) (BAY 58-2667) is the first of a new class of soluble guanylate cyclase (sGC) activators in Clinicalal development for acute decompensate...
Uroguanylin (human)
T80067
Uroguanylin (human) serves as a natural ligand for the Guanylyl Cyclase C (GCC) receptor in metastatic colorectal cancer tumors and exhibits anti-tumor effects i...
Guanylin (mouse, rat)
T80150
Guanylin (mouse, rat), a peptide consisting of 15 amino acids, acts as an activator of intestinal guanylate cyclase and is utilized in diarrhea research [1].
Riociguat
T6968
Riociguat (BAY 632521) is a stimulator of guanylate cyclase which causes relaxation of vascular smooth muscle and is used to treat severe pulmonary arterial hype...
Vericiguat
T17226
Vericiguat (BAY1021189) is a potent and orally available guanylate cyclase stimulator.
Ataciguat
T21607
Ataciguat (HMR-1766) (HMR-1766) is a potent and specific soluble guanylate cyclase (sGC) activator.
MCUF-651
T67734
MCUF-651 is a guanylyl cyclase A receptor positive allosteric modulators, EC50=0.45 μM.
BAY 41-8543
T21712
BAY 41-8543 is a nitric oxide (NO)-independent stimulator of soluble guanylyl cyclase (sGC).
Lificiguat
T4381
Lificiguat (YC-1) is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha)...
NS-2028
T16344
NS-2028 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor (IC50: 30 nM and 200 nM for basal and NO-stimulated enzyme activity). It is commonly used ...
Olinciguat
T16383
Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator. It also has concentration-dependent stimulation of sGC in purified rat and human enzyme assay...
Nelociguat
T7201
Nelociguat (BAY60-4552)(BAY60-4552) is a soluble guanylate cyclase stimulator (sGC stimulator). Soluble guanylate cyclase (sGC) is a key enzyme in the nitric oxi...
Praliciguat
T16569
Praliciguat (IW-1973) stimulates sGC in HEK-293 cells (EC50: 197 nM). Praliciguat is an effective and orally active soluble guanylate cyclase stimulator. It also...
Sinitrodil
T34648
Sinitrodil (ITF-296) is a guanylate cyclase stimulant that may be used in the treatment of myocardial ischemia and angina pectoris.
Linaclotide
T11852
Linaclotide developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation, and is a potent and selective guan...
LY83583
T21576
LY83583 is a soluble guanylate cyclase competitive inhibitor with IC50 of 2 µM.
ODQ
T19777
ODQ is an effective and selective soluble guanylyl cyclase (sGC) inhibitor.
Methylene Blue trihydrate
T0006
Methylene Blue trihydrate (Basic blue 9) is a compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water o...
Plecanatide
T9080
Plecanatide acetate is an analogue of Uroguanylin. It is an orally active guanylate cyclase-C (GC-C) receptor agonist.
Glutaminyl Cyclase Inhibitor 1
T11424
Glutaminyl Cyclase Inhibitor 1 is a glutaminyl cyclase inhibitor (IC50: 0.5 μM) that can be used to study neurological disorders.
Cinaciguat
T1984
Cinaciguat (BAY 58-2667) (BAY 58-2667) is the first of a new class of soluble guanylate cyclase (sGC) activators in Clinicalal development for acute decompensate...
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TargetMol