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Metabolism FABP

FABP

The fatty-acid-binding proteins (FABPs) are a family of transport proteins for fatty acids and other lipophilic substances such as eicosanoids and retinoids. These proteins are thought to facilitate the transfer of fatty acids between extra- and intracellular membranes. Some family members are also believed to transport lipophilic molecules from outer cell membrane to certain intracellular receptors such as PPAR. The FABPs are intracellular carriers that “solubilize” the endocannabinoid anandamide (AEA), transporting AEA to the breakdown by FAAH, and compounds that bind to FABPs block AEA breakdown, raising its level. The cannabinoids (THC and CBD) are also discovered to bind human FABPs (1, 3, 5, and 7) that function as intracellular carriers, as THC and CBD inhibit the cellular uptake and catabolism of AEA by targeting FABPs. Competition for FABPs may in part or wholly explain the increased circulating levels of endocannabinoids reported after consumption of cannabinoids. Levels of fatty-acid-binding protein have been shown to decline with ageing in the mouse brain, possibly contributing to age-associated decline in synaptic activity.
Cat No. product name
T11257 FABP-IN-1
T11258 FABP5-IN-1 FABP5-IN-1 shows potent antinociceptive effects. FABP5-IN-1 is a selective and high affinity fatty acid binding protein 5 (FABP5) inhibitor with a Ki value of 1...
T12852 SBFI-26 SBFI-26 is a selective and competitive fatty acid binding proteins FABP5 and FABP7 inhibitor(FABP5 and FABP7 with Kis of 0.9 µM and 0.4 µM, respectively), wit...
T4534 BMS309403 BMS-309403 is an effective, selective and cell-permeable inhibitor of fatty acid binding protein 4 (FABP4) with a Ki of less than 2 nM.
FABP-IN-1
T11257CAS 2132990-90-8
FABP5-IN-1
T11258CAS 2132990-98-6
FABP5-IN-1 shows potent antinociceptive effects. FABP5-IN-1 is a selective and high affinity fatty acid binding protein 5 (FABP5) inhibitor with a Ki value of 1...
SBFI-26
T12852CAS 1541207-06-0
SBFI-26 is a selective and competitive fatty acid binding proteins FABP5 and FABP7 inhibitor(FABP5 and FABP7 with Kis of 0.9 µM and 0.4 µM, respectively), wit...
BMS309403
T4534CAS 300657-03-8
BMS-309403 is an effective, selective and cell-permeable inhibitor of fatty acid binding protein 4 (FABP4) with a Ki of less than 2 nM.