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AChE

Acetylcholinesterase, also known as AChE, AChase or acetylhydrolase, is the primary cholinesterase in the body. It is an enzyme that catalyzes the breakdown of acetylcholine and some other choline esters that function as neurotransmitters. AChE is found at mainly neuromuscular junctions and in chemical synapses of the cholinergic type, where its activity serves to terminate synaptic transmission. It belongs to the carboxylesterase family of enzymes. It is the primary target of inhibition by organophosphorus compounds such as nerve agents and pesticides.
Cat. No. Product name CAS No. Purity Chemical Structure
T61969 AChE/BChE-IN-10 98%
AChE/BChE-IN-10 is a potent dual inhibitor of AChE and BChE with IC50 values of 0.176, and 0.47 μM, respectively. AChE/BChE-IN-10 exhibits good blood brain barri...
T62360 AChE-IN-26 98%
AChE-IN-26 (compound 4a) is an AChE (acetylcholinesterase) inhibitor (IC50: 0.42 μM).
T60739L Y13g dihydrochloride T60739L 98%
Y13g dihydrochloride is a potent inhibitor of interleukin 6 (IL-6) and acetylcholinesterase (AChE) (both targets of Alzheimer's disease (AD) progression are rela...
T60891 AChE/BChE/MAO-B-IN-1 2416910-82-0 98%
AChE/BChE/MAO-B-IN-1 is a reversible, non-time-dependent inhibitor of AChE, BChE and MAO-B that crosses the blood-brain barrier and exhibits inhibitory effects o...
T77560 2-Amino-4-(4-chlorophenyl)thiazole 2103-99-3 98%
2-AMINO-4-(4-CHLOROPHENYL)THIAZOLE is a 2-aminothiazole derivative. 2-AMINO-4-(4-CHLOROPHENYL)THIAZOLE inhibited hCA I, hCA II, AChE and BChE with Ki values of 0...
T68084 Icopezil 145508-78-7 98%
Icopezil is a small molecule acetylcholinesterase in (AChE) inhibitor for the treatment of neurological disorders and can be used in the study of Alzheimer's dis...
T32535 Ladostigil 209394-27-4 98%
Ladostigil is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO) with inhibitory effects on MAO-B and AChE, with IC50 ...
TN2217 Sophoflavescenol 216450-65-6 98%
Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects , the...
T13446 (S)-Rivastigmine D6 tartrate 194930-00-2 98%
(R)-Rivastigmine D6 tartrate is the deuterium labeled (R)-Rivastigmine, and is an inhibitor of cholinesterase.
T15949 Mahanimbine 21104-28-9 98%
Mahanimbine is found in the roots, leaves and stems of Murraya koenigii and is an orally active alkaloid extracted from Murraya koenigii. Bifidobacterium bifidum...
T14194 β-NETA 31059-54-8 98%
α-NETA is a stable, noncompetitive, slowly reversible choline acetyltransferase (ChAT) inhibitor with an IC50 of 9 μM and is a potent chemokine-like receptor-1 (...
TN2131 Questin 3774-64-9 98%
Questin is an antimicrobial agent derived from Aspergillus florescens with an antimicrobial activity profile that inhibits V. harveyi, V. anguillarum, V. cholera...
T8306 Epiberberine chloride 889665-86-5 98%
Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor (IC50s: 1.07...
TN1858 Leptomerine 22048-97-1 98%
Leptomerine (IC50 = 2.5 mM) shows potent anticholinesterasic activity.
T2227 Hemicholinium 3 312-45-8 98%
Hemicholinium-3 is a potent and selective choline uptake blocker.
T3819 Ursolic acid acetate 7372-30-7 98%
Acetylursolic acid has cytotoxic activity, antimalarial activity, antitumor and anticancer activities. Acetylursolic acid has NO production inhibitory activities...
TN1124 Neoeriocitrin 13241-32-2 98%
Neoeriocitrin is a natural product isolated from Drynaria Rhizome, shows activity on proliferation and osteogenic differentiation in MC3T3-E1. Neoeriocitrin is a...
T0998 Diazinon 333-41-5 98%
Diazinon is a thiophosphoric acid ester, functioning as a nonsystemic organophosphate insecticide that effectively targets and controls a variety of pests includ...
T6478 Donepezil Hydrochloride 120011-70-3 98%
Donepezil is a selective and effective AChE inhibitor for bAChE and hAChE (IC50: 8.12/11.6 nM).
T2191 Tacrine hydrochloride (hydrate) 206658-92-6 98%
Tacrine hydrochloride hydrate is a cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxant...
AChE/BChE-IN-10
T61969
AChE/BChE-IN-10 is a potent dual inhibitor of AChE and BChE with IC50 values of 0.176, and 0.47 μM, respectively. AChE/BChE-IN-10 exhibits good blood brain barri...
AChE-IN-26
T62360
AChE-IN-26 (compound 4a) is an AChE (acetylcholinesterase) inhibitor (IC50: 0.42 μM).
Y13g dihydrochloride
T60739L
Y13g dihydrochloride is a potent inhibitor of interleukin 6 (IL-6) and acetylcholinesterase (AChE) (both targets of Alzheimer's disease (AD) progression are rela...
AChE/BChE/MAO-B-IN-1
T60891
AChE/BChE/MAO-B-IN-1 is a reversible, non-time-dependent inhibitor of AChE, BChE and MAO-B that crosses the blood-brain barrier and exhibits inhibitory effects o...
2-Amino-4-(4-chlorophenyl)thiazole
T77560
2-AMINO-4-(4-CHLOROPHENYL)THIAZOLE is a 2-aminothiazole derivative. 2-AMINO-4-(4-CHLOROPHENYL)THIAZOLE inhibited hCA I, hCA II, AChE and BChE with Ki values of 0...
Icopezil
T68084
Icopezil is a small molecule acetylcholinesterase in (AChE) inhibitor for the treatment of neurological disorders and can be used in the study of Alzheimer's dis...
Ladostigil
T32535
Ladostigil is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO) with inhibitory effects on MAO-B and AChE, with IC50 ...
Sophoflavescenol
TN2217
Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects , the...
(S)-Rivastigmine D6 tartrate
T13446
(R)-Rivastigmine D6 tartrate is the deuterium labeled (R)-Rivastigmine, and is an inhibitor of cholinesterase.
Mahanimbine
T15949
Mahanimbine is found in the roots, leaves and stems of Murraya koenigii and is an orally active alkaloid extracted from Murraya koenigii. Bifidobacterium bifidum...
β-NETA
T14194
α-NETA is a stable, noncompetitive, slowly reversible choline acetyltransferase (ChAT) inhibitor with an IC50 of 9 μM and is a potent chemokine-like receptor-1 (...
Questin
TN2131
Questin is an antimicrobial agent derived from Aspergillus florescens with an antimicrobial activity profile that inhibits V. harveyi, V. anguillarum, V. cholera...
Epiberberine chloride
T8306
Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor (IC50s: 1.07...
Leptomerine
TN1858
Leptomerine (IC50 = 2.5 mM) shows potent anticholinesterasic activity.
Hemicholinium 3
T2227
Hemicholinium-3 is a potent and selective choline uptake blocker.
Ursolic acid acetate
T3819
Acetylursolic acid has cytotoxic activity, antimalarial activity, antitumor and anticancer activities. Acetylursolic acid has NO production inhibitory activities...
Neoeriocitrin
TN1124
Neoeriocitrin is a natural product isolated from Drynaria Rhizome, shows activity on proliferation and osteogenic differentiation in MC3T3-E1. Neoeriocitrin is a...
Diazinon
T0998
Diazinon is a thiophosphoric acid ester, functioning as a nonsystemic organophosphate insecticide that effectively targets and controls a variety of pests includ...
Donepezil Hydrochloride
T6478
Donepezil is a selective and effective AChE inhibitor for bAChE and hAChE (IC50: 8.12/11.6 nM).
Tacrine hydrochloride (hydrate)
T2191
Tacrine hydrochloride hydrate is a cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxant...
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