Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

Cholinesterase (ChE)

Cholinesterases, including acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), are enzymes essential for the regulation of acetylcholine levels in the nervous system. AChE plays a critical role in terminating neurotransmission at synapses, while BChE helps modulate acetylcholine activity in other tissues. These enzymes are vital for normal neurological function, and their inhibition can lead to serious health issues, but they also serve as targets for therapeutic drugs in the treatment of neurological diseases like Alzheimer's.

Swertianolin
T5S225423445-00-3
1. Swertianolin (Bellidifolin-8-O-Glucoside), mangiferin, rhodenthoside A-C, isoorientin, isovitexin, and amarogentin would serve as potential chemotaxonomic markers to differentiate Gentianaceae species. 2. Swertianolin and swertiamarin show significant hepatoprotective effect in the liver damage model induced by alpha-naphthylisot hiocyanate. 3. Swertianolin shows anti-acetylcholinesterase activity effects. 4. Swertianolin shows that it can scavenge superoxide and hydroxyl radicals with the studying method of the autoxidation of Pyrogallol and afenton.
  • $53
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Timosaponin AIII
T339541059-79-4
Timosaponin AIII (Timosaponin A3) induces autophagy in HeLa cells followed by apoptotic cell death (IC50: 10 μM). The Timosaponin AIII cellular response is mediated via inhibition of mTORC1 and induction of ER stress (IC50: 2.5 μM, BT474 cells; 6 μM, MDAMB231). The Timosaponin AIII pro-apoptotic response is selective for tumor cells over normal cells but autophagy is induced in both.
  • $30
In Stock
Size
QTY
Physostigmine Salicylate
T013057-64-7
Physostigmine, a parasympathomimetic alkaloid, is a reversible cholinesterase inhibitor. It extracts from the Calabar bean.
  • $50
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Clozapine N-oxide dihydrochloride
T721122250025-93-3
Clozapine N-oxide dihydrochloride, a derivative of Clozapine and an agonist of human muscarinic design receptors (DREADDs), crosses the blood-brain barrier and activates DREADD receptors hM3Dq and hM4Di.
  • $46
In Stock
Size
QTY
Vamicamide
T35033132373-81-0In house
Vamicamide (FK 176) is a novel anticholinergic compound. Vamicamide increases spontaneous locomotor activity in mice at 32 mg kg (p.o.) or higher and inhibits cataleptic convulsions in mice at 100 mg kg.
  • $373 TargetMol
In Stock
Size
QTY
Simpinicline
T40867753015-44-0In house
Simpinicline (OC-02) (OC-02) is a highly selective nicotinic acetylcholine receptor (nAChR) agonist that activates the trigeminal parasympathetic pathway and can be used to treat dry eye.
  • $397 TargetMol
In Stock
Size
QTY
Rovatirelin
T34399204386-76-5In house
Rovatirelin (S-0373) is a newly synthesized thyrotropin-releasing hormone (TRH) analog that ameliorates cytosine arabinoside-induced motor dysfunction in a rat model of spinal cerebellar degeneration via acetylcholine and dopamine neurotransmission.
  • $373 TargetMol
In Stock
Size
QTY
Donepezil
T7041120014-06-4
Donepezil (Aricept) is a piperidine-based, potent, specific, and reversible inhibitor of acetylcholinesterase (AChE). It can be used for the treatment of mild to moderate dementia of the Alzheimer's type.
  • $31
In Stock
Size
QTY
Lobetyolinin
TN1876142451-48-7
Lobetyolinin is a compound from Codonopsis pilosula with acetylcholinesterase (AChE) inhibitory and antiarrhythmic activities.
  • $106
In Stock
Size
QTY
O-Desmethyl Galanthamine
TN678660755-80-8
O-Desmethyl Galanthamine (Sanguinine) is a galanthamine-type alkaloid and an acetylcholinesterase (AChE) inhibitor with an IC50 of 1.83 μM.
  • $52
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Vincosamide
TN229823141-27-7
Vincosamide is an alkaloid from Psychotria leiocarpa extract, inhibits the acetylcholinesterase (AChE) activity with anti-inflammatory activity. Vincosamide can effect relaxation of the supercoiled pBR322 plasmid DNA in the presence of Cu2+.
  • $148
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Kuwanon U
TN7715123702-95-4
Kuwanon U (4'-methoxykuwanon E), a compound from Morus alba, is a cholinesterase inhibitor with antimicrobial activity, inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), and exerts its inhibitory effect by preventing ATP binding in the cytoplasmic domain of SERCA1, which can be used in the study of diabetes mellitus and bacterial infections.
  • $679
In Stock
Size
QTY
Ursolic acid acetate
T38197372-30-7
Ursolic acid acetate (Acetylursolic acid) has cytotoxic activity, antimalarial activity, antitumor and anticancer activities. Acetylursolic acid has NO production inhibitory activities. Acetylursolic acid has inhibition against both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes.
  • $68
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Neoeriocitrin
TN112413241-32-2
Neoeriocitrin is a natural product isolated from Drynaria Rhizome, shows activity on proliferation and osteogenic differentiation in MC3T3-E1. Neoeriocitrin is a potent acetylcholinesterase (AChE) inhibitor.
  • $112
In Stock
Size
QTY
kuwanon G
T3S161275629-19-5
1. Kuwanon G (Moracenin B) as dual inhibitors of PTP1B and α-glucosidase enzymes, as well as insulin sensitizers, it may potentially be utilized as an effective treatment for Type II diabetes mellitus. 2. Kuwanon G has anti-inflammatory activity, it can attenuate atherosclerosis through inhibiting foam cell formation and inflammatory response. 3. Kuwanon G is a potent inhibitor of Mycobacterium tuberculosis protein tyrosine phosphatase B. 4. Kuwanon G shows acetylcholinesterase (AChE) and butyrylcholinesterase(BChE) inhibitory activities, it may be a promising candidate for preventive and therapeutic agents for Alzheimer's disease. 5. Kuwanon G prevents the pathological progression of allergic asthma through the inhibition of lung destruction by inflammation and immune stimulation. 6. Kuwanon G has antibacterial activity against oral pathogens. 7. Kuwanon G is a specific antagonist for the GRP-preferring receptor and can be useful for studying the physiological and pathological role of GRP.
  • $60
In Stock
Size
QTY
Jatrorrhizine chloride
T49126681-15-8
Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 hippocampal neurons.
  • $31
In Stock
Size
QTY
Arjunolic acid
TN1403465-00-9
Arjunolic acid has antioxidant, anti-inflammatory, antinociceptive and anticholinesterasic (AChE and BuChE) activities, it may as promising targets for the development of innovative multi-functional medicines for Alzheimer desease treatment.
  • $197
In Stock
Size
QTY
Epiberberine
T5S23616873-09-2
1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf MEK1 ERK1 2 and AMPKα Akt pathways during 3T3-L1 adipocyte differentiation. 3. Epiberberine, as the brightest FSA emitter among the alkaloids, can also serve as an efficient conformation probe for HTG DNA and discriminate the DNA G-quadruplex from the RNA counterpart.
  • $31
In Stock
Size
QTY
Loganin
T275918524-94-2
Loganin (Loganoside), an iridoid glucoside, has been reported to be an inhibitor of Cox-1 and also noted to suppress TNF-α formation. This compound also has displayed potent free-radical-scavenging activity and inhibitory effects on melanogenesis.
  • $40
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Donepezil Hydrochloride
T6478120011-70-3
Donepezil HCl(Aricept) is a selective and effective AChE inhibitor for bAChE and hAChE (IC50: 8.12 11.6 nM).
  • $44
In Stock
Size
QTY
Buntanetap
T17312116839-68-0
Buntanetap ((+)-Phenserine) is an orally active inhibitor of polyneurotoxic proteins (TINAPs) for the study of neurological disorders, endocrine and metabolic disorders, and cardiovascular diseases.
  • $197
In Stock
Size
QTY
Corydaline
T5S2360518-69-4
1. Corydaline (Corydalin), an isoquinoline alkaloid, is one of the major active constituents in a new prokinetic botanical agent. 2. Corydaline promotes gastric emptying and small intestinal transit and facilitates gastric accommodation. 3. Corydaline exhibits the anti-acetylcholinesterase, antiallergic, and antinociceptive activities. 4. Corydaline has potent inhibition of CYP2C19 and CYP2C9.
  • $55
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Galanthamine
T4S1725357-70-0
Galanthamine (Galantamine) is an acetylcholinesterase (AChE)inhibitor(IC50 : 500 nM), can reduce brain damage induced by hypoxia-ischemia.
  • $50
In Stock
Size
QTY
Acetylcholinesterase
T761309000-81-1
Acetylcholinesterase (ACHE) is an enzyme found in the neuromuscular junction and cholinergic synapses. It catalyzes the hydrolysis of acetylcholine, terminating synaptic neuronal transmission and signal propagation. ACHE can be used for research on biosensors.
  • $29
In Stock
Size
QTY