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AChE

Acetylcholinesterase, also known as AChE, AChase or acetylhydrolase, is the primary cholinesterase in the body. It is an enzyme that catalyzes the breakdown of acetylcholine and some other choline esters that function as neurotransmitters. AChE is found at mainly neuromuscular junctions and in chemical synapses of the cholinergic type, where its activity serves to terminate synaptic transmission. It belongs to the carboxylesterase family of enzymes. It is the primary target of inhibition by organophosphorus compounds such as nerve agents and pesticides.

  • Polygalacic acid
    T376722338-71-2
    Polygalacic acid (Virgaureagenin G)(PA) significantly improves cholinergic system reactivity, as indicated by decreased acetylcholinesterase (AChE) activity, increases choline acetyltransferase (ChAT) activity, and elevates levels of acetylcholine (ACh) in the hippocampus and frontal cortex, PA also significantly ameliorates neuroinflammation and oxidative stress in mice; suggest that PA might exert a significant neuroprotective effect on cognitive impairment, driven in part by the modulation of cholinergic activity and neuroinflammation. Polygalacic acid shows significant postingestive effects on Spodoptera littoralis larvae.
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  • Nodakenin
    T3872495-31-8
    Nodakenin ((+)-Marmesinin) is a compound with anti-allergic and anti-inflammatory activities.
    • $100
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  • DL-Menthol
    T297989-78-1
    DL-Menthol ((±)-Menthol) is a racemic mixture of the monoterpene alcohols (–)-menthol and (+)-menthod, which have been found in Cannabis. (–)-Menthol is more common than (+)-menthol in nature and exhibits analgesic, antibacterial, and anticancer properties, as well as inhibits cholinesterase.2 (+)-Menthol inhibits the growth of F. verticillioides (MIC: 1.5 mM) but, unlike (–)-menthol, does not exhibit analgesic, antibacterial, anticancer, or cholinesterase inhibitory activities.
    • $42
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  • Diethyltoluamide
    T0731134-62-3
    Diethyltoluamide (DEET) is the most general active composition in insect repellents.
    • $41
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  • Methyl tridecanoate
    TN69191731-88-0
    Methyl tridecanoate is a natural product.
    • $42
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  • AChE/BChE/MAO-B-IN-1
    T608912416910-82-0
    AChE/BChE/MAO-B-IN-1 is a reversible, non-time-dependent inhibitor of AChE, BChE and MAO-B that crosses the blood-brain barrier and exhibits inhibitory effects on hAChE, hBChE and hMAO-B with IC50s of 7.31, 0.56 and 26.1 μM, respectively. 1 had a neuroprotective effect and was not significantly cytotoxic.
    • $195
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  • SEW06622
    T83616261349-28-4
    SEW06622 is a potent inhibitor of acetylcholinesterase (AChE) and beta-secretase-1 (BACE-1) and is a potential candidate for the treatment of Alzheimer's disease.
    • $195
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  • Histone acetyltransferase p300 Inhibitor 4c
    T775602103-99-3
    Histone acetyltransferase p300 Inhibitor 4c is a 2-aminothiazole derivative. Histone acetyltransferase p300 Inhibitor 4c inhibited hCA I, hCA II, AChE and BChE with Ki values of 0.008 ± 0.001, 0.124 ± 0.017, 0.129 ± 0.030 and 0.083 ± 0.041 µM. 0.017, 0.129 ± 0.030 and 0.083 ± 0.041 μM.
    • $195
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  • 1-[10-(pyridin-1-ium-1-yl)decyl]pyridin-1-ium dibromide
    T500666266-40-6
    1-[10-(pyridin-1-ium-1-yl)decyl]pyridin-1-ium dibromide is the inhibitor of human erythrocyte AChE.
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  • Corysamine chloride
    TN678311028-77-6
    Corysamine chloride (CORYSAMINE CHLORIDE(RG)) was identified to inhibit the activity of ACHE.
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  • Rovatirelin
    T34399204386-76-5In house
    Rovatirelin (S-0373) is a newly synthesized thyrotropin-releasing hormone (TRH) analog that ameliorates cytosine arabinoside-induced motor dysfunction in a rat model of spinal cerebellar degeneration via acetylcholine and dopamine neurotransmission.
    • $373 TargetMol
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  • Y13g dihydrochloride
    T60739L
    Y13g dihydrochloride is a potent inhibitor of interleukin 6 (IL-6) and acetylcholinesterase (AChE) (both targets of Alzheimer's disease (AD) progression are related). Y13g dihydrochloride reverses STZ-induced memory deficits and exhibits histopathology similar to normal animals.
    • $195
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  • Desoxypeganine
    TC0022495-59-0
    Desoxypeganine (Deoxypeganine) is an inhibitor of cholinesterase. It acting preferentially on butyrylcholinesterase, and as a selective inhibitor of monoamine oxidase A but not monoamine oxidase B.Desoxypeganine is being developed for its potential utility in the pharmacological treatment of alcohol abuse to reduce craving and depression in alcohol abusers, and might also be useful as a smoking cessation aid.
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  • (S)-Vamicamide
    T35033L151851-72-8In house
    (S)-Vamicamide is a novel anticholinergic compound.Vamicamide increases spontaneous locomotor activity in mice at 32 mg/kg or higher (p.o.) and inhibits tonic convulsions in mice at 100 mg/kg.CAS 번호13483-86-1
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  • TA-03
    T85855778-80-3
    TA-03 (7-Meota) is a potent inhibitor of AChE in treatment of cognitive manifestation of AD.
    • $133
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  • Ladostigil
    T32535209394-27-4In house
    Ladostigil (Ladostigil free base) is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO) with inhibitory effects on MAO-B and AChE, with IC50 values of 37.1 and 31.8 μM, respectively.Ladostigil possesses anti-inflammatory, antioxidant, and neuroprotective activities, and may be used in studies of depression and Alzheimer's disease.
    • $120
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  • Jatrorrhizine hydrochloride
    T2986960383-96-4
    Jatrorrhizine hydrochloride is a compound extracted from the roots of Berberis vulgaris with neuroprotective, antimicrobial, antiplasmodial, and antioxidant activities.Jatrorrhizine hydrochloride is an orally active and selective inhibitor of acetylcholinesterase (AChE), which inhibits norepinephrine (NE) uptake. It inhibits the uptake of norepinephrine (NE).
    • $50
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  • Chikusetsusaponin Ib
    TN244359252-87-8
    Chikusetsusaponin Ib (Chikusetsu saponin Ib) is an inhibitor of AChE and can be used in studies about anti-Alzheimer's diseases.
    • $117
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  • β-NETA
    T1419431059-54-8In house
    β-NETA (α-NETA) is a stable, noncompetitive, slowly reversible choline acetyltransferase (ChAT) inhibitor with an IC50 of 9 μM and is a potent chemokine-like receptor-1 (CMKLR1) antagonist. β-NETA has anti-cancer activity[1][2]. β-NETA weakly inhibits cholinesterase (IC50=84 µM) and acetylcholinesterase (IC50=300 µM).
    • $59
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  • Vamicamide
    T35033132373-81-0
    Vamicamide (FK 176) is a novel anticholinergic compound. Vamicamide increases spontaneous locomotor activity in mice at 32 mg/kg (p.o.) or higher and inhibits cataleptic convulsions in mice at 100 mg/kg.
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  • Donepezil
    T7041120014-06-4
    Donepezil (Aricept) is a piperidine-based, potent, specific, and reversible inhibitor of acetylcholinesterase (AChE). It can be used for the treatment of mild to moderate dementia of the Alzheimer's type.
    • $31
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  • Pralidoxime Chloride
    T111151-15-0
    Pralidoxime Chloride (2-PAM chloride) is a useful agent in the treatment of organophosphate poisoning. Pralidoxime binds to organophosphate-inactivated acetylcholinesterase, used to combat poisoning by organophosphates or acetylcholinesterase inhibitors (nerve agents).
    • $36
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  • Linarin
    T6S0653480-36-4
    1. Linarin (Acacetin-7-O-rutinoside) (acacetin-7-O-β-d-rutinoside) shows selective dose dependent inhibitory effect on acetylcholinesterase. 2. Linarin alleviates GalN/LPS-induced liver injury by suppressing TNF-α-mediated apoptotic pathways. 3. Linarin prevents A beta-induced neurotoxicity through the activation of PI3K/Akt, which subsequently inhibits GSK-3b and up-regulates Bcl-2. 4. The piperine significantly enhanced the oral absorption of Linarin in rats by inhibiting P-glycoprotein mediated cellular efflux during the intestinal absorption and likely simultaneously by inhibiting the metabolism of Linarin.
    • $47
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  • Diazinon
    T0998333-41-5
    Diazinon (Dimpylate) is a thiophosphoric acid ester, functioning as a nonsystemic organophosphate insecticide that effectively targets and controls a variety of pests including cockroaches, silverfish, ants, and fleas.
    • $66
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  • Neoeriocitrin
    TN112413241-32-2
    Neoeriocitrin is a natural product isolated from Drynaria Rhizome, shows activity on proliferation and osteogenic differentiation in MC3T3-E1. Neoeriocitrin is a potent acetylcholinesterase (AChE) inhibitor.
    • $112
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  • Vincosamide
    TN229823141-27-7
    Vincosamide is an alkaloid from Psychotria leiocarpa extract, inhibits the acetylcholinesterase (AChE) activity with anti-inflammatory activity. Vincosamide can effect relaxation of the supercoiled pBR322 plasmid DNA in the presence of Cu2+.
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    • Picfeltarraenin IB
      T4S102497230-46-1
      1. Picfeltarraenin IB and Picfeltarraenin IA displayes no cytotoxic activity in vitro human tumor cell line panel.
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    • 4-Methylbenzylidene camphor
      T746536861-47-9
      4-Methylbenzylidene camphor is an ultraviolet light blocker used in cosmetics and sunscreen preparations ,specifically UV B radiation, also has estrogenic activities.
      • $54
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    • Pitofenone hydrochloride
      T44661248-42-6
      Pitofenone hydrochloride (Pitophenone hydrochloride), a spasmolytic compound, inhibits the acetylcholinesterase (AChE) activity from bovine erythrocytes and from electric eel with Kis of 36 and 45 μM, respectively.
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    • Acephate
      T2254530560-19-1
      Acephate (Orthene) is an anticholinesterase insecticide with a weak inhibitory effect on AChE in rats, but it can effectively inhibit AChE in cockroaches.
      • $42
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    • Sophoflavescenol
      TN2217216450-65-6
      Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects , these effects might contribute to the antitumor activity without severe side effects. Sophoflaves
      • $657
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    • AChE-IN-3
      T403352713548-95-7
      AChE-IN-3 had inhibitory effect on AChE and stronger inhibitory effect on NO, with EC50 of 0.57 μM.
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    • (-)-Corynoxidine
      TN152757906-85-1
      (-)-Corynoxidine is an AChE inhibitor derived from tubers of Stephania succifera. Corynoxidine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus strains in different degrees.
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    • (±)-Hexanoylcarnitine chloride
      T218416920-35-0
      (±)-Hexanoylcarnitine chloride is a fatty acid metabolite that breaks down fatty acids into small compounds that can be utilized by the body. (±)-Hexanoylcarnitine chloride can be used as a biomarker of skeletal muscle toxicity in rats through specificity. (±)-Hexanoylcarnitine chloride has cholinergic activity.
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    • Hydroxytacrine maleate
      T21556118909-22-1
      Hydroxytacrine maleate (Velnacrine maleate) is a cholinesterase (cholinesterase) inhibitor that enhances memory in rodents and may be used in the study of Alzheimer's dementia of the Alzheimer type (SDAT).
      • $33
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    • Clozapine N-oxide dihydrochloride
      T721122250025-93-3
      Clozapine N-oxide dihydrochloride is a derivative of Clozapine and an agonist of human muscarinic design receptors (DREADDs) that crosses the blood-brain barrier.Clozapine N-oxide dihydrochloride induces activation of DREADD receptors hM3Dq and hM4Di. Clozapine N-oxide dihydrochloride induces activation of DREADD receptors hM3Dq and hM4Di.
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    • 1-Naphthyl acetate
      T19084830-81-9
      1-Naphthyl acetate is usually used in a rapid staining method for identification of macrophages. 1-Naphthyl acetate is a potent chromogenic substrate for the detection of erythrocyte acetylcholinesterase (AChE) activity. It has the potential to detect organophosphorus pesticide poisoning.
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    • O-Desmethyl Galanthamine
      TN678660755-80-8
      O-Desmethyl Galanthamine (Sanguinine) is galanthamine-type alkaloid and it is an acetylcholinesterase (AChE) inhibitor, with an IC50 1.83 μM.
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    • AChE/BuChE-IN-4
      T777581997158-25-4
      AChE/BuChE-IN-4 is a multi-target AChE/BuChE inhibitor with oral activity and blood-brain barrier permeability, with IC50 values of 2.08 and 7.41 μM for AChE and BuChE, respectively.
      • $107
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    • Leptomerine
      TN185822048-97-1
      Leptomerine (IC50 = 2.5 mM) shows potent anticholinesterasic activity.
      • $137
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    • (+)-Balanophonin
      TN1428215319-47-4
      (+)-Balanophonin is a natural phenolic compound isolated from Passiflora edulis with antioxidant, anti-inflammatory, anticancer and anti-neurodegenerative activities, cholinesterase inhibition, and marginal inhibition of OPM2 and RPMI-8226 cell proliferation.
      • $934
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    • CV-6209
      T27102100488-87-7
      CV-6209 is a selective and potent platelet-activating factor (PAF) antagonist with antiproliferative effects, partial inhibition of acetylcholine-induced hypotension, and inhibition of Paf-induced PMN or platelet aggregation.CV-6209 has an antiplasmodial effect against Helicobacter pylori, and can inhibit PAF-induced hypotension in rats.
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    • Itopride hydrochloride
      T1552122892-31-3
      Itopride hydrochloride (Ganaton) is an AChE and D2DR inhibitor.
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    • Simpinicline
      T40867753015-44-0
      Simpinicline (OC-02) (OC-02) is a highly selective nicotinic acetylcholine receptor (nAChR) agonist that activates the trigeminal parasympathetic pathway and can be used to treat dry eye.
      • $397
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    • Isomerazin
      TN17861088-17-1
      Isomerazin (Isomeranzin) has anti-inflammatory activity, it suppresses inflammation by inhibiting M1 macrophage polarization through the p65, NF-κB and ERK pathway.
      • $156
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    • ML352
      T217661649450-12-3
      ML352 is a selective and potent inhibitor of the presynaptic choline transporter (CHT), inhibits non-competitive choline uptake.
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    • Trimyristin
      T4852555-45-3
      Trimyristin (Tritetradecanoin) is primarily located in the membrane (predicted from logP) and adiposome. glyceryl trimyristate exists in all eukaryotes, ranging from yeast to humans. In humans, glyceryl trimyristate is involved in the metabolic disorder called de novo triacylglycerol biosynthesis glyceryl trimyristate pathway.
      • $39
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    • Fenchlorphos
      T1635299-84-3
      Fenchlorphos (Dermafos) is a cholinesterase inhibitor, used as an insecticide.
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    • Ethyl (triphenylphosphoranylidene) acetate
      T223291099-45-2
      Ethyl (triphenylphosphoranylidene) acetate ((Carbethoxymethylene)triphenylphosphorane) may act as an cholinesterase inhibitor that inhibits AChE and BChE.
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    • Galanthamine N-Oxide
      T11351134332-50-6
      Galanthamine N-Oxide, an alkaloid extracted from Zephyranthes concolor bulbs, effectively inhibits acetylcholinesterase (AChE) from electric eel with an EC50 of 26.2 μM. It acts as a significant inhibitor of substrate accommodation within the active sites of Torpedo californica AChE (TcAChE), human AChE (hAChE), and human BChE (hBChE) enzymes.
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