zanthoxylum

Ombuin has anti-inflammary activity, it inhibits some macrophage functions involved in the inflammatory process.

Xanthoxylin (Xanthoxyline) is a borneol and camphor tasting compound and can be found in a number of food items such as fats and oils, herbs and spices, pomegranate, and sweet orange. Derivatives of Xanthoxylin have antispasmodic activity.

L-Citronellol ((S)-(-)-beta-Citronellol) is a small molecule compound isolated from geranium with antifungal activity, affecting fungal membranes.L-Citronellol acts synergistically with amphotericin B against Candida yeast.

Methyl (E)-cinnamate exhibits antifungal and antibacterial activity, inhibiting Staphylococcus aureus, Salmonella, Penicillium, Fusarium, and other microorganisms, and is widely used in biochemical experiments and drug synthesis research.

Nitidine is a bioactive plant benzophenanthridine alkaloid isolated from the root of Zanthoxylum nitidum. It shows anticancer, neuroprotective, antimalarial, anti-HIV, analgesic, anti-inflammatory and antifungal activities.

Hydroxy-Epsilon-Sanshool is an alkyl amide isolated from Zanthoxylum bungeanum. Hydroxy-Epsilon-Sanshool produces key tingling and numbing chemosensation.

Sanshool is a natural product isolated from Zanthoxylum bungeanum. Sanshool improves UVB-induced skin photodamage by targeting JAK2/STAT3-dependent autophagy.

Sanshodiol is a natural product of Zanthoxylum, Rutaceae. The catalog number is T3833 and the CAS number is 54854-91-0. Sanshodiol can be used as a reference standard.

Collinin is a coumarin that has been found in Z. schinifolium and has diverse biological activities.1,2,3,4 It is active against drug-susceptible and -resistant strains of M. tuberculosis (MIC50s = 3.13-6.25 μg/ml).1 Collinin inhibits LPS-induced nitric oxide (NO) production (IC50 = 5.9 μM) and reduces COX-2 protein levels in RAW 264.7 cells.2 It completely inhibits aggregation of isolated rabbit platelets induced by arachidonic acid , collagen, or platelet activating factor (PAF) when used at a concentration of 100 μM.3 Dietary administration of collinin (0.05% w/w) reduces the number of mice with tumors and the number of tumors per mouse in a mouse model of colitis-related carcinogenesis.4 |1. Kim, S., Seo, H., Al Mahmud, H., et al. In vitro activity of collinin isolated from the leaves of Zanthoxylum schinifolium against multidrug- and extensively drug-resistant Mycobacterium tuberculosis. Phytomedicine 46, 104-110 (2018).|2. Nguyen, P.-H., Zhao, B.T., Kim, O., et al. Anti-inflammatory terpenylated coumarins from the leaves of Zanthoxylum schinifolium with α-glucosidase inhibitory activity. J. Nat. Med. 70(2), 276-281 (2016).|3. I.S., C., Lin, Y.C., Tsai, I.L., et al. Coumarins and anti-platelet aggregation constituents from Zanthoxylum schinifolium. Phytochemistry 39(5), 1091-1097 (1995).|4. Kohno, H., Suzuki, R., Curini, M., et al. Dietary administration with prenyloxycoumarins, auraptene and collinin, inhibits colitis-related colon carcinogenesis in mice. Int. J. Cancer 118(12), 2936-2942 (2006).

1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721 cells in vitro in a time- and dose-dependent manner and identifies efficacy in vivo in a mouse model of HCC.

(-)-Asarinin (Eleutheroside B4) shows antibacterial activity.

Angoline hydrochloride (6-Methoxyldihydrochelerythrine) is an IL-6/STAT3 signaling pathway inhibitor isolated from Zanthoxylum nitidum with anticancer activity and inhibits STAT3 signaling.

Dihydronitidine, an alkaloid, can be extracted from Zanthoxylum rhoifolium [1].

Hydroxy-α-sanshool is an alkyl amide isolated from the pepper. It acts as a TRPA1 covalent and TRPV1 non-covalent agonist (EC50s: 69 and 1.1 μM).

Haplopine shows photo-activated antimicrobial activity against S. aureus. It exhibits potent melanogenesis-inhibitory activities with almost no toxicity to the cells.

Hydroxy-β-sanshool is a pungent compound obtained from Zanthoxylum piperitum.

Hydroxy-γ-sanshool is a pungent compound, it can cause oral numbness.

gamma-Fagarine possesses moderate levels of anti-HCV activities with IC50 values being 20.4 ± 0.4 ug ml, respectively. It has sister chromatid exchanges (SCEs)-inducing activity

Schinifoline is a quinolone derivative extracted from Zanthoxylum schinifolium Sieb with cytotoxic activity that promotes radiosensitization of cancer cells, affects the cell cycle and apoptosis.

Decarine has high antibacterial activity against mycobacterial, gram-positive and gram-negative bacteria, and low cytotoxicity towards human macrophages.Decarine inhibits fMLP CB-induced elastase release with IC(50) values < or = 5.53 microg mL.

Kobusin, a bisepoxylignan compound isolated from Pnonobio biondii Pamp, demonstrates CFTR and CaCC chloride channel activation properties while exhibiting inhibitory effects on ANO1/CaCC channels.

Robustine is a natural product, exhibits inhibitory potency against human phosphodiesterase 5 (hPDE5A) in vitro.

Evofolin B is a natural compound isolated from the stem bark of Zanthoxylum ailanthoides. Evofolin B has an inhibitory effect on the superoxide anion produced by human neutrophils in response to formyl-L-methionine-L-leucine-L-phenylalanine/cytochalasin B (fMLP/CB).

2,3-Di(3',4'-methylenedioxybenzyl)-2-buten-4-olide is a natural product (catalog number TN2692, CAS number 137809-97-3) used in life sciences research.