tempo

Tempo (2,2,6,6-Tetramethylpiperidinooxy) has a wide range of applications including use as a free radical scavenger, a reagent in organic synthesis and as a structural probe in electron spin resonance spectroscopy.

Mito-TEMPO, a mitochondria-targeted superoxide dismutase mimetic, scavenges superoxide and alkyl radicals, preventing mitochondrial oxidation, necrosis, and apoptosis.

Acid-PEG5-TEMPO is a PEG-based linker for PROTACs, joining two essential ligands crucial for PROTAC molecule formation, and facilitates selective protein degradation using the ubiquitin-proteasome system within cells.

4-isocyanato TEMPO can be used in related research in the field of life sciences. Its product number is T35644 and CAS number is 88418-69-3.

4-carboxy TEMPO is a nitroxide and spin label. Nitroxides such as 4-carboxy TEMPO react with reactive oxygen species (ROS) and can be used with electron spin resonance (ESR) spectroscopy to monitor ROS production in vivo., It has also been used to study flavin-photosensitized damage in inner mitochondrial membranes.

N3-TEMPO, a click chemistry reagent featuring an azide group, exhibits significant potential in facilitating connections among nucleic acids, lipids, proteins, and various molecules. Its application across numerous research domains is attributed to advantageous traits such as high yield, high specificity, and simplicity [1].

4-palmitamido TEMPO is a lipid-soluble spin label that integrates into vesicles and cell membranes. It is utilized to examine the encapsulation of molecules within phosphatidylcholine vesicles.

4-Amino-TEMPO is employed as a spin label to detect free radicals and the damage they cause. It mimics the activity of superoxide dismutase and can easily penetrate cells, thus safeguarding them against oxidative damage induced by H2O2. Moreover, 4-Amino-TEMPO demonstrates significant radioprotective properties, effectively shielding DNA from oxidative stress damage caused by UV irradiation by maintaining a positive charge. Additionally, 4-Amino-TEMPO serves as a highly selective oxidation catalyst and is extensively used in the development of various specialty chemicals, including fragrances and pesticides.

Tempone is an aminooxyalkane that acts as a free radical scavenger and reacts with reactive oxygen species (ROS). Intravenous Tempone reduces mean arterial pressure in spontaneously hypertensive rats.

Tempol (Tanol) is a superoxide scavenger. It has anti-inflammatory, neuroprotective and analgesic effects.

MitoTEMPOL is a mitochondria-targeted antioxidant that prevents septal dysfunction by reversing sepsis-induced decreases in mitochondrial function, activation of protein hydrolysis pathways, and reductions in myosin heavy chain content, as well as eliminating cytokine-induced increases in muscle cell superoxide production and decreases in cell size.

MitoTEMPO is a mitochondria-targeted superoxide dismutase mimetic that possesses superoxide and alkyl radical scavenging properties.[1] This compound combines the antioxidant piperidine nitroxide TEMPO with the lipophilic cation triphenylphosphonium, which allows it to pass through lipid bilayers and accumulate in mitochondria. Mitochondrial targeting of superoxide scavenging via mitoTEMPO has been examined for potential therapeutic benefit to a variety of mitochondrial dysfunctions arising from excessive reactive oxygen species.[2][3][4]

Tempoacmcta is a peptide.

Temporin A, a short alpha-helical antimicrobial peptide derived from the skin of Rana temporaria, exhibits a wide-ranging efficacy against Gram-positive bacteria. It directly interacts with the cell membrane of microorganisms and remains non-toxic to erythrocytes at antimicrobial concentrations. Additionally, Temporin A demonstrates antifungal properties against yeast-like Candida albicans.

Temporin L, a potent antimicrobial peptide, exhibits activity against Gram-negative bacteria and yeast strains, as well as demonstrating antiendotoxin properties.

Temporin B, an antimicrobial peptide, is effective against Legionella pneumophila [1].

Temporin C is an antimicrobial peptide effective against *Legionella pneumophila* [1].

Temporin F exhibits antimicrobial activity against Legionella pneumophila [1].

Temporin G, an antimicrobial peptide, exhibits activity against Legionella pneumophila [1].

Temporin K, an antimicrobial peptide, exhibits effectiveness against Legionella pneumophila [1].

Temporin-GHc exhibits antibacterial activity with an MBIC50 of 6 μM and antibiofilm activity with an MBEC50 of 25 μM at 24 h [1].

Temporin SHF is an antimicrobial peptide with broad-spectrum antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and yeast, and is non-hemolytic. Its mechanism of action is to disrupt the accumulation of acyl chains in the anionic lipid bilayer of microorganisms, resulting in the formation and disintegration of microbial membrane cracks. This compound has application potential in antibacterial development.