sprague-dawley

Ziprasidone hydrochloride (CP-88059 hydrochloride) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of antipsychotic activity.

2H-Naphth[2′,1′:4,5]indeno[1,2-d][1,3]dioxole, pregn-4-ene-3,20-dione deriv showed high local anti-inflammatory potency and high lung selectivity when tested on Sprague Dawley rats.

The inhibitory effect of Methyl L-histidinate dihydrochloride (L-Histidine methyl ester dihydrochloride) on histidine decarboxylase in Sprague-Dawley rat stomach assessed as decrease in 14CO2 production with activty value of 1.8 μM

VPC171 is a novel adenosine A1 receptor positive allosteric modulator (PAM).

Metyrapone (NSC-25265) is an inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.

Treloxinate is an effective lipid-lowering agent. It specifically influences the triglyceride levels in Sprague-Dawley rats, while impacting both triglyceride and cholesterol levels in Wistar rats.

MiADMSA (Monoisoamyl DMSA) is a lipophilic chelating agent that has shown potential as a chelator detoxifier for arsenic and several heavy metals, including lead, mercury, cadmium, and gallium arsenide. It mitigates oxidative stress induced by sodium tungstate and improves liver and immune system alterations caused by chronic copper poisoning in Sprague Dawley rats. Additionally, MiADMSA protects human keratinocytes ['HaCaT'] from arsenic-induced oxidative stress.

Trimethylolpropane caprate has developmental toxicity in Sprague-Dawley rats.

Sepimostat dimethanesulfonate (FUT-187), a chemical compound, demonstrates neuroprotective properties by antagonizing NR2B N-methyl-D-aspartate receptors at the NR2B subunit's Ifenprodil-binding site. This compound effectively inhibits Ifenprodil binding, exhibiting a Ki value of 27.7 μM[1].

Ensartinib (X-396) is a potent and orally active dual ALK MET inhibitor for the treatment of ALK-positive non-small cell lung cancer (NSCLC).

Neophytadiene is a diterpene compound extracted from Turbinaria ornate, with anti-inflammatory, antidepressant, anxiolytic-like, anticonvulsant, antioxidant, and cardioprotective effects. It inhibits LPS-induced inflammation in RAW 264.7 macrophages and Sprague-Dawley rats and can be used in neurological disease research.

NHE3-IN-3 (Compound 1) is a potent inhibitor of isoform 3 of the Na+ H+ exchanger (NHE3), exhibiting pIC50 values of 6.2 and 6.6 against human and rat NHE3, respectively, and demonstrates exceptional oral bioavailability of 98% in Sprague–Dawley rats [1].

The truncated glucagon-like peptides GLP-1(7-37) is naturally occurring peptide product of the preproglucagon gene that are synthesized primarily in the intestine and acts as incretin that are released from the intestine into the bloodstream in response to food and stimulate insulin secretion. GLP-1(7-37) produced a dose-related enhancement of the glucose-stimulated increase in plasma insulin concentration and an increased rate of glucose infusion in Sprague-Dawley Rats at a dosing rang of 0.5, 5, or 50 pmol min kg. Further, infusion of GLP-1(7-37) for 60 mins produced a small transitory increase in plasma insulin concentration in fasted rats and fed rats and a slight transitory decrease in plasma glucose concentration. Moreover, GLP-1(7-37) (5 pmol min kg IV) infusion for 6 h in Sprague-Dawley rats produced a sustained increase in plasma insulin concentration relative to levels in rats infused with vehicle[1].

DS-1558 is a potent and orally available GPR40 agonist.DS-1558 was found to have potent glucose lowering effects during an oral glucose tolerance test in ZDF rats. DS-1558 significantly and dose-dependently improved hyperglycemia and increased insulin secretion during the oral glucose tolerance test in Zucker fatty rats, the model of insulin resistance and glucose intolerance. DS-1558 not only increased the glucose-stimulated insulin secretion by GLP-1 but also potentiated the maximum insulinogenic effects of GLP-1 after an intravenous glucose injection in normal Sprague Dawley rats.

Big endothelin-1 (rat 1-39), a 39-residue peptide, induces diuretic and natriuretic responses in conscious Sprague-Dawley rats and elevates blood pressure in mice [1].

(+)-Osbeckic acid, extracted from Tartary Buckwheat, acts as a vasorelaxant and demonstrates a significant vasorelaxant effect in Sprague-Dawley rat thoracic aorta rings, with an EC50 value of 887 μM [1].

CK-963 is an activator of cardiac troponin (cTnC) with a K i of 11.5 μM, exhibiting activity in enhancing cardiac contractility in Sprague-Dawley rats [1].

Triptolide palmitate, a derivative of Triptolide, exhibits cytotoxicity against cancer cells MCF-7 and A549, with IC50 values of 7.5 and 6.4 μM, respectively. It has a half-life (T1 2) of 50.4 minutes in Sprague Dawley rats and can be utilized as a drug carrier [1].

Recainam (Wy-42362) hydrochloride, an orally active anti-arrhythmic agent, exhibits Class I electrophysiological properties and effectively suppresses complex ventricular arrhythmias. It has demonstrated favorable pharmacokinetic characteristics in Sprague Dawley rats .

Ajugasterone C shows significant inhibitory effect at 100 mg kg dose on rat paw oedema development due to carrageenan-induced inflammation in Sprague Dawley rats.

Eutypenes I (Compound 9) inhibits the secretion of VEGF-A, hampers the activation of VEGFR, and disrupts its downstream Erk Akt signaling pathway. It also suppresses the migration of HMEC-1 cells and demonstrates anti-angiogenic activity in a Sprague-Dawley rat model.