potentiator — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T28276	OV-potentiator-28	OV potentiator 28
	OV-potentiator-28 is a potentiator of cancer virotherapy. OV-potentiator-28 significantly enhances virus replication-associated luciferase expression, specifically in tumors.
T25173	Bradykinin potentiator-5	BPP-5a\,BPP 5a\,BPP5a\
	Bradykinin potentiator-5 is a peptide inflammatory mediator, causes blood vessels to dilate (enlarge), and therefore causes blood pressure to fall.
T76505	Bradykinin potentiator B
	Bradykinin Potentiator B (also known as Bradykinin Potentiating Peptide B), derived from the venom of Agkistrodon halys blomhoffi, serves as a potent ACE inhibitor. It effectively inhibits the activity of bradykinin inhi...
T76507	Bradykinin potentiator C
	Bradykinin Potentiator C, a potent inhibitor of angiotensin-converting enzyme (ACE) with an inhibitory concentration (IC 50) of 7.1 μM for rabbit lung ACE, is regarded as a prototype for functional peptides [1].
T63003	NMDA receptor potentiator-1
	NMDA receptor potentiator-1 (Compound 1368) is a subunit-selective NMDA receptor enhancer with IC50 values of 4 μM and 5 μM for NR2C and NR2D expression, respectively.
T23172	Polygodial	Tadeonal	Antifungal
	Polygodial (Tadeonal) is an antifungal potentiator and an antibiotic, particularly against Saccharomyces cerevisiae, Candida utilis, and Sclerotinia libertiana.		Antifungal
T23515	VU-29	VU 29	GluR
	VU-29 is a positive allosteric mGlu5 receptor modulator with EC50=9 nM and Ki=244 nM for rmGluR5. It is selective for mGluR5 relative to other mGluR subtypes (EC50: rmGluR1/rmGluR2=557 nM/1.5 μM; hmGluR4=154 nM).		GluR
T15820	Mibampator	LY451395	iGluR
	Mibampator (LY451395) is an effective and selective AMPA receptor potentiator.		iGluR
TQ0289	LY450108		iGluR
	LY450108 is a potentiator of the AMPA receptor that can be used in Parkinson's disease studies.		iGluR
T17238	VU0152100	VU152100	AChR
	VU0152100 is an effective and selective allosteric potentiator of M4 mAChR (EC50: 380 ± 93 nM).		AChR
T9499	Icenticaftor	QBW251	CFTR
	Icenticaftor (QBW251) is an orally active potentiator of CFTR channel.		CFTR
T2588	Ivacaftor	Ivacaftor (VX-770),VX-770	CFTR , Autophagy
	Ivacaftor (VX-770) (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells, respectively.		CFTR , Autophagy
T23513	VU10010	VU 10010	AChR
	VU10010 (VU 10010) is allosteric potentiator of M4 acetylcholine receptors.		AChR
T29123	VU0152099	VU 0152099,VU-0152099	AChR
	VU0152099 is a potent and selective M4 mAChR allosteric potentiator(EC50 = 380 ± 93 nM).		AChR
T7083	GLPG1837	ABBV-974	CFTR , Autophagy
	GLPG1837 (ABBV-974) is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.		CFTR , Autophagy
T14971	CIQ		NMDAR
	CIQ is a subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit. EC50 value: 2.7 μM for NR2C and 2.8 μM for NR2D.		NMDAR
T0086	Galanthamine hydrobromide	Galantamine hydrobromide,Galanthamine HBr	AChR , AChE
	Galanthamine hydrobromide (Galantamine hydrobromide), a long-acting and centrally active AChE inhibitor (IC50:410 nM), is an allosteric potentiator at neuronal nicotinic ACh receptors.		AChR , AChE
T4573	Cyclothiazide		GluR
	Cyclothiazide is a benzothiadiazide that acts as a potentiator of AMPA receptorsthat potently inhibits AMPA receptor desensitization, positively modulating its response to glutamic acid (EC50 = 3.8 M).		GluR
T8890	653-47 hydrochloride		Epigenetic Reader Domain
	653-47 hydrochloride is a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. It is also a very weak CREB inhibitor with IC50 of 26.3 μM.		Epigenetic Reader Domain
T61301	Chromenone 1		TGF-beta/Smad
	Chromenone 1 is a potent potentiator of osteogenic bone morphogenetic protein (BMP). Chromenone 1 induces a pronounced, kinase-independent, negative TGFβ feedback that enhances nuclear BMP-Smad signaling outputs.		TGF-beta/Smad