polygonum

(E Z)-Polydatin (Polydatin), is a natural precursor and glycoside form of resveratrol with a monocrystalline structure. While it is isolated from the bark of Picea sitchensis or Polygonum cuspidatum, Polydatin may be detected in grape, peanut, hop cones, red wines, hop pellets, cocoa-containing products, chocolate products and many daily diets. Polydatin possesses anti-inflammatory, immunoregulatory, anti-oxidative and anti-tumor activities. It is shown to mediate a cytotoxic action on colorectal cancer cells by inducing cell arrest and apoptosis.

Triacetylresveratrol (Acetyl-trans-resveratrol) has anti-cancer activity,it inhibits the phosphorylation of STAT3 and NFκB, down-regulates Mcl-1, and up-regulates Bim and Puma in pancreatic cancer cells.

Polydatin (Piceid), the glycoside of Resveratrol, is originally isolated from the Chinese herb Polygonum cuspidatum. The compound can inhibit platelet aggregation and elevate the ratios of LDL-C HDL-C and TC HDL-C. In the myocardial cell, white blood cell, vascular smooth muscle cell, and endothelial cell, Polydatin can inhibit ICAM-1 expression, elevate Ca2+, weaken white blood cell-endothelial cell adhesion, and activate KATP channels.

Katacine inhibits of oxygen consumption and suppresses the speed of electrons transfer from oxidation substrates via respiratory chain of mitochondria to molecular oxygen.Katacine is a mixture of polymers of A-type proanthocyanidins at various stages of p

1. Orientin (Luteolin-8-glucoside) may be regarded as a candidate therapeutic agent for treatment of vascular inflammatory diseases via inhibition of the HMGB1 signaling pathway. 2. Orientin protects vascular barrier integrity by inhibiting hyperpermeability, expression of CAMs, and adhesion and migration of leukocytes, thereby endorsing its usefulness as a therapy for vascular inflammatory diseases. 3. Orientin has neuroprotection effect by the intracellular mediation of caspase activity; may alleviate cognitive deficits and oxidative stress in AD mice; can exert antidepressant-like effects on CUMS mice, specifically by improving central oxidative stress, neurotransmission, and neuroplasticity.

Isoorientin (Homoorientin) has antioxidant activity.

Torachrysone-8-O-b-D-glucoside exhibits alpha-glucosidase inhibitory activities and may be utilized for managing type 2 diabetes.

2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside (Astragalus polyphenols) is a compound isolated from the roots of Polygonum species, which inhibits the formation of 5-HETE, HHT, and thromboxane B2.

Avicularin (Fenicularin) has anti-allergic, anti-inflammatory, hepatoprotective, antioxidant, anti-tumor and other activities. It ameliorates human hepatocellular carcinoma by modulating the activities of NF-κB(p65), COX-2, and PPAR-γ. In LPS-stimulated RAW 264.7 macrophages, it exerts anti-inflammatory activity by inhibiting the ERK signaling pathway.

Vanicoside A, a protein kinase C (PKC) inhibitor, is derived from Polygonum pensylvanicum [1].

Emoghrelin, extracted from Heshouwu (Polygonum multiflorum), promotes the secretion of growth hormone by activating the ghrelin receptor [1].

Quercetin-3-O-(6 -O-ecaffeoyl)-β-D-galactopyranoside, a flavonoid glycoside, is isolated from Polygonum viscosum.

Vincetoxicoside B, isolated from Polygonum paleaceum Wall. Vincetoxicoside B , quercetin, kaempferol , and (-)-epicatechin show synergistic antifungal activities with the FICI values <0.5.

3''-O-Galloylmyricitrin is a natural product

Brevifolincarboxylic acid is a natural product isolated from Polygonum capitatum, it has inhibitory effect on the aryl hydrocarbon receptor (AhR). Brevifolincarboxylic acid is an α-glucosidase inhibitor with an IC50 of 323.46 μM.

Lanatoside B is a natural product from Polygonum lapathifolium.

12-Hydroxyisodrimenin is a natural product for research related to life sciences. The catalog number is TN2599 and the CAS number is 218780-16-6.

2-Desoxy-4-epi-pulchellin has potent in vitro cytotoxicities against the K562, MCF-7, Hela, DU145, U937, H1975, SGC-7901, A549, MOLT-4, and HL60 cell lines with IC50 values ranging from 0.10 to 46.7uM, while it shows significant antiviral (H1N1 and H3N2) activities, it also displays significant antimycobacterial activity (IC50=7.6 uM).

2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflammation and oxidative stress for preservation of BBB integrity. 2-Methoxystypandrone concomitant

2''-O-Galloylmyricitrin is a natural product for research related to life sciences. The catalog number is TN2785 and the CAS number is 56939-52-7.

24-Methylenecycloartanone is a natural product from Polygonum bistorta.

3,5,7-Trihydroxychromone exhibits weak antiangiogenic activity.

1. 3''-Galloylquercitrin possesses the activity for PTK inhibition.

3-Oxotirucalla-7,24-dien-21-oic acid, the first known compound isolated from Polygonum spp., can also be obtained from the roots of Black Cohosh. This compound demonstrated potent cytotoxicity against MCF-7 cell lines.