phe-leu

L-Phenylalanyl-L-leucine is a leucine derivative applicable in biochemical experiments and drug synthesis studies.

{Boc}-Phe-Leu-Phe-Leu-Phe ({Boc}-FLFLF) is a selective antagonist of the formyl peptide receptor (FPR) family, effectively inhibiting receptor activity in response to formyl peptides.

Z-Phe-Leu-OH is a useful organic compound for research related to life sciences. The catalog number is T65512 and the CAS number is 4313-73-9.

{Boc}-Phe-Leu-Phe-Leu-Phe TFA is a selective antagonist of the formyl peptide receptor (FPR) family, effectively inhibiting FPR-mediated actions [1].

Z-Gly-Pro-Phe-Leu-CHO (Z-GPFL-CHO) is a tetrapeptide aldehyde that acts as a selective and potent proteasome inhibitor, with inhibition constants (Ki) of 1.5 µM for branched-chain amino acid-preferred, 2.3 µM for small neutral amino acid-preferred, and 40.5 µM for chymotrypsin-like activities, and an inhibitory concentration (IC50) of 3.1 µM for peptidyl-glutamyl peptide hydrolyzing activity [1].

N-Boc-Phe-Leu-Phe-Leu-Phe (Boc-FLFLF) is a formyl peptide receptor 1 (FPR1) antagonist that increases pain effects and inhibits the antinociceptive activity of annexin. Boc-FLFLF is extensively used in FPR research.

N-Formyl-Met-Leu-Phe-Lys (fMLFK) is a peptide that acts as a potent and selective agonist of FPR1, with EC50s of 3.5 nM for FPR1, 6.7 μM for FPR2, and 0.88 μM for FPR2-D2817.32G. This chemotactic peptide binds specifically to receptors on leukocyte membranes and its uptake can contribute to the quantitative assessment of neutrophils in localized inflammatory processes, independent of associated edema formation or microcirculatory compromise.

N-Formyl-Met-Leu-Phe (N-Formyl-MLF) (fMLF) is a synthetic peptide that acts as an agonist at formyl peptide receptors (FPR; Ki = 0.8 pM).

H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH is a water-soluble polypeptide that serves as a substrate for the enzymes cathepsin D, pepsin, and pepsinogen, with potential applications in biochemical analysis [1] [2].

Suc-Ala-Leu-Pro-Phe-pNA (Suc-ALPF-pNA), a substrate for FK-506 binding protein (FKBP) [1], is utilized to demonstrate the complex interactions essential for targeted biochemical assays.

GLF (H-Gly-Leu-Phe-OH), a tripeptide isolated from α-lactalbumin with immunostimulatory properties, prevents alopecia, epidermal thickening, and adipocyte layer thinning induced by the anticancer agent Etoposide [1].

N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFA (For-Nle-Leu-Phe-Nle-Tyr-Lys-OH (TFA)) (For-Nle-Leu-Phe-Nle-Tyr-Lys-OH TFA) is a formyl peptide receptor (FPR) agonist and a potent chemoattractant for human neutrophils, with its radioiodinated form retaining full biological activity.

N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFA is a formyl peptide receptor (FPR) agonist.

Acetyl Angiotensinogen (1-14), porcine Acetate is a peptide with the sequence AC-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-LEU-VAL-TYR-SER-OH. The protein encoded by the Angiotensinogen gene is known as pre-angiotensinogen or angiotensinogen precursor.

Leucyl-phenylalanine (H-LEU-PHE-OH) is a dipeptide compound that can be used for protein synthesis.

Antagonist G is an anticancer peptide and is also a broad spectrum neuropeptide growth factor antagonist.

Antho-rpamide II is a biologically active neuropeptide isolated from the sea anemone Anthopleura elegantissima.

Pro-Adrenomedullin(153-185),human, (C143H224N42O43), a peptide with the sequence H2N-SLPEAGPGRTLVSSKPQAHGAPAPPSGSAPHFL-OH, MW= 3219.6. Adrenomedullin (AM) is a ubiquitously expressed peptide initially isolated from phaechromyctoma in 19931. AM was initially identified as a vasodilator, some have cited this as the most potent endogenous vasodilatory peptide found in the body2. Differences in opinion regarding the ability of AM to relax vascular tone arises from the differences in the model system used3. Other effects of AM include increasing the tolerance of cells to oxidative stress and hypoxic injury and angiogenesis. AM is seen as a positive influence in diseases such as hypertension, myocardial infarction, chronic obstructive pulmonary disease and other cardiovascular diseases, whereas it can be seen as a negative factor in potentiating the potential of cancerous cells to extend their blood supply and cause cell proliferation.

Substance P (alligator), a neuropeptide derived from alligator, possesses a primary structure delineated as Arg-Pro-Arg-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 [1].

Z-LLF-CHO (Z-Leu-Leu-Phe-CHO) effectively inhibits the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex with a Ki value of 460 nM and also serves as an inhibitor of NF-κB nuclear translocation, as documented in references [1] [2].

Ser-parafluoroPhe-Aad-Leu-Arg-Asn-Pro-NH2 is a biologically active peptide. Structure-activity studies of the thrombin receptor-tethered ligand SFLLRNP highlighted the pivotal role of the Phe-2-phenyl group in receptor recognition, while substitution with para-fluorophenylalanine [(p-F)Phe] increased its activity.

Kisspeptin-10, a neuropeptide present in the brains, ovaries, and testes of zebrafish, plays a critical role in gonadal development and steroid expression. At a concentration of 10 ng/ml, it enhances the mRNA levels for the luteinizing hormone (Lh) receptor and both progestin receptor a (Pra) and Prb in zebrafish ovarian follicles. In female goldfish, doses of 0.1 and 1 µg/g of Kisspeptin-10 elevate serum levels of luteinizing hormone, with no similar effect observed in male goldfish.

[Leu144,Arg147]-PLP (139-151) is a mutated fragment of the myelin proteolipid protein (PLP), featuring substitutions of tryptophan to leucine and histidine to arginine at positions 144 and 147, respectively. Immunizing mice with this peptide (50 µg) mixed in complete Freund's adjuvant (CFA) elevates IL-4 levels in the spleen. While it suppresses Th1 cell activation in vitro, it does not do so in vivo; instead, it promotes the development of regulatory T cells. Preimmunization with [Leu144, Arg147]-PLP (139-151) postpones the onset of experimental autoimmune encephalomyelitis (EAE) triggered by encephalitogenic peptides from PLP (178-191), myelin oligodendrocyte glycoprotein (MOG) (92-106), or myelin basic protein (MBP) in mice.

Shepherdin is a synthetic peptide mirroring amino acids 79-87 of human survivin, acting as an inhibitor of the survivin-heat shock protein 90 (Hsp90) interaction. It specifically targets the N-terminal domain of Hsp90, blocking the survivin-Hsp90 interaction in human reticulocyte extracts at a 150 µM concentration. Conjugates of Shepherdin with cell-permeable peptides, such as penetratin or the HIV Tat sequence, exhibit anticancer properties both in vitro and in vivo.